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Lead A team led by Yifan Cheng and David Julius reports (Nature, 25 March 2026) high-resolution structures and local energetic measurements that explain how the cold receptor TRPM8 senses temperature. Using cryo-EM of cell-derived membrane vesicles together with hydrogen–deuterium exchange mass spectrometry (HDX–MS), the authors capture two interconverting architectures—a canonical “fully swapped” and a newly … Read more

On March 25, 2026 at Oracle Park, the San Francisco Giants’ season opener against the New York Yankees was marred on-screen by a digitally inserted bright-red Adobe advertisement, creating a visible “green-screen” glitch when players stood in front of it. The effect was most noticeable during the bottom of the first inning on left-handed hitters … Read more

Apple released tvOS 26.4 on March 25, 2026, bringing a small but notable set of changes to the Apple TV software that are available on models dating back to 2015. The update introduces a new content-discovery section called Genius Browse, a new Continuous Audio Connection setting to address format handoffs, in-player subtitle styling controls, and … Read more

Lead: Defense and intelligence officials briefed members of Congress behind closed doors on Wednesday as the war in Iran nears the one-month mark, prompting sharp frustration from both Republicans and Democrats. Lawmakers at the House Armed Services Committee pressed for clarity on President Donald Trump s strategy, including whether US ground troops might be deployed … Read more

Lead U.S. President Donald Trump asserted on Wednesday that Iran remains interested in negotiations, even as Tehran publicly rejected an initial ceasefire proposal. China’s foreign minister, Wang Yi, described a “glimmer of hope” after diplomatic outreach to Turkey and Egypt, saying both Tehran and Washington have signalled a readiness to return to talks. Meanwhile, heavy … Read more

Lead On March 25, 2026 at Oracle Park in San Francisco, the New York Yankees opened the major-league season with a 7-0 road victory over the San Francisco Giants. Max Fried set the tone with 6 1/3 shutout innings, while José Caballero produced a key RBI single in a five-run second inning. The game doubled … Read more

Lead Police in Utah are investigating a third allegation of domestic violence involving reality TV personality Taylor Frankie Paul and her ex-partner Dakota Mortensen, sources told The Times on March 25, 2026. The West Jordan Police Department says Mortensen filed a report in February alleging an incident took place in early–mid 2024. Draper Police are … Read more

Lead: Teams from Walt Disney Co. and OpenAI met in Los Angeles on Monday evening to discuss a collaboration tied to Sora, OpenAI’s AI video tool. Roughly 30 minutes after that meeting, Disney staff were informed that OpenAI would discontinue Sora; OpenAI made the decision public on Tuesday. The cancellation terminates a proposed three-year, $1 … Read more

Lead A Nature study (Nagaraja et al., 25 March 2026) reports that repeated colonic injury leaves a durable epigenetic imprint in colonic stem cells that raises the likelihood of tumour outgrowth. Using a mouse DSS model (acute, chronic and recovery stages) and joint single-cell chromatin/transcriptome profiling of 52,540 cells from 23 animals, the team found … Read more

On March 25, 2026, a Jefferson County Family Court judge in Louisville ordered the arrest of former Kentucky governor Matt Bevin after finding him in contempt for failing to produce financial records. The ruling came days before a scheduled trial to determine whether Mr. Bevin owes child support to his estranged son, Jonah Bevin. Judge … Read more

Lead On March 25, 2026, U.S. Immigration and Customs Enforcement (ICE) agents were observed conducting identification checks and assisting with passenger screening at several major airports, including Hartsfield‑Jackson Atlanta, Phoenix Sky Harbor and LaGuardia. The deployment follows agents being sent to airports earlier in the week amid a persistent shortage of Transportation Security Administration (TSA) … Read more

Lead: Notebookcheck’s recent laboratory Wi‑Fi test found a Dell XPS 16 equipped with an Intel Core Ultra 325 and an LG Display 1–120Hz panel running nearly 27 hours on a 70Wh battery. The unit, shown at CES in January, used a variable refresh LCD designed to lower power draw, with idle consumption measured as low … Read more

On Wednesday, March 25, 2026 at Oracle Park in San Francisco, the New York Yankees opened the MLB regular season with a 7-0 victory over the San Francisco Giants. New York built a five-run second inning and added insurance runs later, while starter Max Fried settled into 6 1/3 scoreless innings. Logan Webb allowed seven … Read more

House Republicans left a classified briefing on Wednesday, March 25, 2026, expressing growing frustration with the Trump administration’s explanations for U.S. military action in Iran. Lawmakers on the House Armed Services Committee said Department of Defense officials did not provide clear answers on objectives, timeline, the potential use of ground forces or the expected cost, … Read more

On March 25, 2026, the U.S. ordered roughly 2,000 soldiers from the Army’s 82nd Airborne Division and announced nearly 7,000 additional Army and Marine forces bound for the Middle East, signaling a renewed possibility of ground operations linked to the Iran conflict. The move follows two Marine Expeditionary Unit deployments dispatched on March 13 and … Read more