{"id":984,"date":"2025-09-04T17:05:02","date_gmt":"2025-09-04T17:05:02","guid":{"rendered":"https:\/\/readtrends.com\/en\/week-1-nfl-picks-florio-simms\/"},"modified":"2025-09-04T17:05:02","modified_gmt":"2025-09-04T17:05:02","slug":"week-1-nfl-picks-florio-simms","status":"publish","type":"post","link":"https:\/\/readtrends.com\/en\/week-1-nfl-picks-florio-simms\/","title":{"rendered":"PFT Week 1 2025 NFL picks: Florio vs. Simms"},"content":{"rendered":"<article>\n<p>Mike Florio and Chris Simms publish their straight-up and against-the-spread Week 1 2025 NFL picks on September 4, 2025, previewing tonight&#8217;s season opener in Philadelphia and projecting winners and scores across every matchup.<\/p>\n<h2>Key Takeaways<\/h2>\n<ul>\n<li>Florio and Simms provide both straight-up and spread-aware picks for every Week 1 game (published Sept. 4, 2025).<\/li>\n<li>They disagree on seven matchups; Simms selects seven underdogs to win straight up.<\/li>\n<li>Opening night: Eagles vs. Cowboys at Lincoln Financial Field, with both analysts favoring Philadelphia.<\/li>\n<li>Several emotionally charged matchups highlighted, including Colts&#8217; first regular-season game after owner Jim Irsay&#8217;s passing.<\/li>\n<li>Notable consensus picks include Patriots over Raiders and Broncos over Titans.<\/li>\n<li>Picks include exact final-score forecasts for each game, useful for early betting markets and fan debate.<\/li>\n<\/ul>\n<h3>Verified Facts<\/h3>\n<p>The picks were posted on September 4, 2025. Both analysts made a full slate of straight-up score projections; the published list includes the following matchups and predicted final scores from Florio and Simms.<\/p>\n<figure>\n<table>\n<thead>\n<tr>\n<th>Game<\/th>\n<th>Florio<\/th>\n<th>Simms<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Cowboys at Eagles<\/td>\n<td>Eagles 30, Cowboys 17<\/td>\n<td>Eagles 27, Cowboys 20<\/td>\n<\/tr>\n<tr>\n<td>Chiefs at Chargers<\/td>\n<td>Chiefs 21, Chargers 17<\/td>\n<td>Chiefs 28, Chargers 24<\/td>\n<\/tr>\n<tr>\n<td>Buccaneers at Falcons<\/td>\n<td>Buccaneers 30, Falcons 24<\/td>\n<td>Falcons 23, Buccaneers 20<\/td>\n<\/tr>\n<tr>\n<td>Bengals at Browns<\/td>\n<td>Bengals 31, Browns 17<\/td>\n<td>Bengals 27, Browns 24<\/td>\n<\/tr>\n<tr>\n<td>Dolphins at Colts<\/td>\n<td>Colts 23, Dolphins 20<\/td>\n<td>Dolphins 24, Colts 21<\/td>\n<\/tr>\n<tr>\n<td>Panthers at Jaguars<\/td>\n<td>Jaguars 24, Panthers 20<\/td>\n<td>Jaguars 28, Panthers 20<\/td>\n<\/tr>\n<tr>\n<td>Raiders at Patriots<\/td>\n<td>Patriots 23, Raiders 17<\/td>\n<td>Patriots 23, Raiders 17<\/td>\n<\/tr>\n<tr>\n<td>Cardinals at Saints<\/td>\n<td>Cardinals 21, Saints 17<\/td>\n<td>Cardinals 24, Saints 20<\/td>\n<\/tr>\n<tr>\n<td>Steelers at Jets<\/td>\n<td>Steelers 24, Jets 10<\/td>\n<td>Steelers 20, Jets 16<\/td>\n<\/tr>\n<tr>\n<td>Giants at Commanders<\/td>\n<td>Commanders 27, Giants 17<\/td>\n<td>Giants 21, Commanders 17<\/td>\n<\/tr>\n<tr>\n<td>Titans at Broncos<\/td>\n<td>Broncos 28, Titans 20<\/td>\n<td>Broncos 28, Titans 17<\/td>\n<\/tr>\n<tr>\n<td>49ers at Seahawks<\/td>\n<td>49ers 27, Seahawks 20<\/td>\n<td>Seahawks 23, 49ers 20<\/td>\n<\/tr>\n<tr>\n<td>Lions at Packers<\/td>\n<td>Packers 24, Lions 20<\/td>\n<td>Lions 28, Packers 27<\/td>\n<\/tr>\n<tr>\n<td>Texans at Rams<\/td>\n<td>Rams 24, Texans 20<\/td>\n<td>Texans 24, Rams 20<\/td>\n<\/tr>\n<tr>\n<td>Ravens at Bills<\/td>\n<td>Ravens 30, Bills 27<\/td>\n<td>Ravens 30, Bills 21<\/td>\n<\/tr>\n<tr>\n<td>Vikings at Bears<\/td>\n<td>Vikings 24, Bears 20<\/td>\n<td>Bears 23, Vikings 20<\/td>\n<\/tr>\n<\/tbody>\n<\/table><figcaption>Week 1 straight-up score predictions from Mike Florio and Chris Simms (published Sept. 4, 2025).<\/figcaption><\/figure>\n<p>The article notes that Simms favors seven underdogs to win outright; Florio and Simms still reach identical outcomes on numerous games, including Patriots over Raiders and Broncos over Titans.<\/p>\n<h3>Context &#038; Impact<\/h3>\n<p>Early-week picks like these shape conversation for bettors, fantasy players and fans ahead of kickoff. Exact-score projections are often used to compare market lines and can influence casual betting decisions even if they are not formal lines.<\/p>\n<p>The opening-night game in Philadelphia carries extra spectacle: the Eagles will raise a banner while hosting the Cowboys, and both analysts give Philly the edge. Separately, the Colts&#8217; Week 1 subplot \u2014 their first regular-season game after owner Jim Irsay&#8217;s passing \u2014 was flagged as a potential emotional influence on performance.<\/p>\n<p>Agreeing and diverging picks highlight where analysts see volatility: Simms&#8217; underdog choices suggest he expects more early-season upsets, while Florio leans toward a few cleaner favorites with larger margins in his scorelines.<\/p>\n<h3>Official Statements<\/h3>\n<blockquote>\n<p>\u201cWe\u2019re back, baby.\u201d<\/p>\n<p><cite>PFT \/ Mike Florio (opening line)<\/cite><\/p><\/blockquote>\n<aside>\n<details>\n<summary>How to read straight-up vs. spread picks<\/summary>\n<p>Straight-up picks predict the outright game winner and often include final-score forecasts. Against-the-spread (ATS) picks judge whether a team covers the betting spread set by sportsbooks. This piece reports straight-up score predictions; bettors should check current lines before wagering.<\/p>\n<\/details>\n<\/aside>\n<h3>Unconfirmed<\/h3>\n<ul>\n<li>Any injuries, late roster changes or weather conditions that emerge before kickoff could alter likely outcomes; those specifics were not part of the published picks.<\/li>\n<li>Future trades or last-minute coaching decisions are not reflected in these projections.<\/li>\n<\/ul>\n<h3>Bottom Line<\/h3>\n<p>Florio and Simms offer a full Week 1 roadmap with clear areas of agreement and seven meaningful disagreements that will be watched closely as games unfold. Their exact-score forecasts provide a quick reference for bettors and fans, but real-world factors (injuries, weather, in-game momentum) can upend any preseason or early-week prediction.<\/p>\n<h3>Sources<\/h3>\n<ul>\n<li><a href=\"https:\/\/profootballtalk.nbcsports.com\" target=\"_blank\" rel=\"noopener\">ProFootballTalk \/ NBC Sports<\/a><\/li>\n<li><a href=\"https:\/\/www.nbcsports.com\" target=\"_blank\" rel=\"noopener\">NBC Sports<\/a><\/li>\n<\/ul>\n<\/article>\n","protected":false},"excerpt":{"rendered":"<p>Mike Florio and Chris Simms publish their straight-up and against-the-spread Week 1 2025 NFL picks on September 4, 2025, previewing tonight&#8217;s season opener in Philadelphia and projecting winners and scores across every matchup. Key Takeaways Florio and Simms provide both straight-up and spread-aware picks for every Week 1 game (published Sept. 4, 2025). They disagree &#8230; <a title=\"PFT Week 1 2025 NFL picks: Florio vs. Simms\" class=\"read-more\" href=\"https:\/\/readtrends.com\/en\/week-1-nfl-picks-florio-simms\/\" aria-label=\"Read more about PFT Week 1 2025 NFL picks: Florio vs. Simms\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":981,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"rank_math_title":"PFT Week 1 2025 NFL Picks: Florio vs. Simms | NBC Sports","rank_math_description":"Mike Florio and Chris Simms publish straight-up Week 1 2025 NFL picks (Sept. 4), disagreeing on seven games and projecting full final scores across the slate.","rank_math_focus_keyword":"NFL Week 1,Florio,Simms,predictions,NFL picks","footnotes":""},"categories":[2],"tags":[],"class_list":["post-984","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-top-stories"],"_links":{"self":[{"href":"https:\/\/readtrends.com\/en\/wp-json\/wp\/v2\/posts\/984","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/readtrends.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/readtrends.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/readtrends.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/readtrends.com\/en\/wp-json\/wp\/v2\/comments?post=984"}],"version-history":[{"count":0,"href":"https:\/\/readtrends.com\/en\/wp-json\/wp\/v2\/posts\/984\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/readtrends.com\/en\/wp-json\/wp\/v2\/media\/981"}],"wp:attachment":[{"href":"https:\/\/readtrends.com\/en\/wp-json\/wp\/v2\/media?parent=984"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/readtrends.com\/en\/wp-json\/wp\/v2\/categories?post=984"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/readtrends.com\/en\/wp-json\/wp\/v2\/tags?post=984"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}