{"id":10473,"date":"2026-03-19T13:05:12","date_gmt":"2026-03-19T04:05:12","guid":{"rendered":"https:\/\/readtrends.com\/ko\/tnap-bbb-cognition\/"},"modified":"2026-03-19T13:05:12","modified_gmt":"2026-03-19T04:05:12","slug":"tnap-bbb-cognition","status":"publish","type":"post","link":"https:\/\/readtrends.com\/ko\/tnap-bbb-cognition\/","title":{"rendered":"\ud608\ub1cc\uc7a5\ubcbd \uc57d\ud654 \uc720\ubc1c \ub2e8\ubc31\uc9c8 TNAP \uc81c\uac70\ub85c \uc778\uc9c0\ub825 \uac1c\uc120 \ud655\uc778"},"content":{"rendered":"<article>\n<h2>\ud575\uc2ec \uc694\uc57d<\/h2>\n<p>\ubbf8\uad6d \uc0cc\ud504\ub780\uc2dc\uc2a4\ucf54 \uce98\ub9ac\ud3ec\ub2c8\uc544\ub300(UCSF) \uc5f0\uad6c\uc9c4\uc740 \ud608\ub1cc\uc7a5\ubcbd(BBB)\uc744 \uc57d\ud654\uc2dc\ud0a4\ub294 \ub2e8\ubc31\uc9c8 TNAP\uc744 \ud655\uc778\ud558\uace0, \uc774\ub97c \uc81c\uac70\ud558\uba74 \ub178\ub839 \uc950\uc5d0\uc11c \ud608\ub1cc\uc7a5\ubcbd\uc774 \ud68c\ubcf5\ub418\uace0 \uc778\uc9c0\ub2a5\ub825\uc774 \uac1c\uc120\ub41c\ub2e4\uace0 \ubcf4\uace0\ud588\ub2e4. \uc5f0\uad6c\ub294 2026\ub144 3\uc6d4 \ubcf4\uace0\ub41c \uac83\uc73c\ub85c, \uc6b4\ub3d9\uc73c\ub85c \uac04\uc5d0\uc11c \ubd84\ube44\ub418\ub294 \ud6a8\uc18c GPLD1\uc774 \ub1cc \ub0b4\ud53c\uc138\ud3ec\uc758 TNAP\ub97c \uc81c\uac70\ud574 BBB\ub97c \uac15\ud654\ud55c\ub2e4\ub294 \uc5f0\uacb0\uace0\ub9ac\ub97c \uc81c\uc2dc\ud55c\ub2e4. \uc0dd\ud6c4 2\ub144\uc758 \ub178\ub839 \uc950\uc5d0\uc11c TNAP\ub97c \uac10\uc18c\uc2dc\ud0a4\uba74 \ub1cc \uc5fc\uc99d\uc774 \uc904\uace0 \uae30\uc5b5 \uac80\uc0ac \uc131\uc801\uc774 \uac1c\uc120\ub418\ub294 \uacb0\uacfc\uac00 \uad00\ucc30\ub410\ub2e4.<\/p>\n<h2>\ud575\uc2ec \uc0ac\uc2e4<\/h2>\n<ul>\n<li>\uc5f0\uad6c \ucc45\uc784\uc790\ub294 Saul Villeda \ubc15\uc0ac(University of California, San Francisco)\ub85c, \ud574\ub2f9 \uacb0\uacfc\ub294 2026\ub144 3\uc6d4 \ubcf4\uace0\ub410\ub2e4.<\/li>\n<li>\uc57d 6\ub144 \uc804 \uc950 \uc2e4\ud5d8\uc5d0\uc11c \uc6b4\ub3d9\uc774 \uac04\uc5d0\uc11c GPLD1(GPI-specific phospholipase D1) \ubd84\ube44\ub97c \ucd09\uc9c4\ud55c\ub2e4\ub294 \uc0ac\uc2e4\uc774 \ud655\uc778\ub410\ub2e4.<\/li>\n<li>\ub1cc \ub0b4\ud53c\uc138\ud3ec(BECs)\uc5d0 TNAP(Tissue-nonspecific alkaline phosphatase)\uac00 \ucd95\uc801\ub418\uba74 \ud608\ub1cc\uc7a5\ubcbd \ud22c\uacfc\uc131\uc774 \uc99d\uac00\ud558\ub294 \ub4f1 BBB \uae30\ub2a5\uc774 \uc57d\ud654\ub410\ub2e4.<\/li>\n<li>\uc80a\uc740 \uc2dc\uae30\uc5d0 TNAP\ub97c \uc778\uc704\uc801\uc73c\ub85c \uc99d\uac00\uc2dc\ud0a8 \uc950\ub294 \uace0\ub839\uae30\uc5d0 \uc811\uc5b4\ub4e4\uba74\uc11c \uc778\uc9c0\ub2a5\ub825\uc774 \uc800\ud558\ub418\ub294 \uacbd\ud5a5\uc744 \ubcf4\uc600\ub2e4.<\/li>\n<li>\uc0dd\ud6c4 \uc57d 2\ub144 \ub41c \ub178\ub839 \uc950\uc5d0\uc11c \uc720\uc804\uc790 \uc870\uc791\uc73c\ub85c TNAP\ub97c \uac10\uc18c\uc2dc\ud0a4\uc790 BBB \uc644\uc804\uc131\uc774 \ud68c\ubcf5\ub418\uace0, \ub1cc \uc5fc\uc99d \ud45c\uc9c0\uc790 \uac10\uc18c\uc640 \ud568\uaed8 \uae30\uc5b5\ub825 \uac80\uc0ac\uc5d0\uc11c \uc720\uc758\ud55c \uac1c\uc120\uc774 \uad00\ucc30\ub410\ub2e4.<\/li>\n<li>GPLD1\uc740 \uac04\uc5d0\uc11c \ubd84\ube44\ub418\uc5b4 \ub1cc \ub0b4\ud53c\uc138\ud3ec\uc758 TNAP\ub97c \uc81c\uac70\ud558\ub294 \uc791\uc6a9\uc744 \ud558\uba70, \uc774 \uacfc\uc815\uc774 BBB \ubcf4\ud638\uc640 \uc5f0\uad00\ub41c \uac83\uc73c\ub85c \ud30c\uc545\ub410\ub2e4.<\/li>\n<li>\uc5f0\uad6c\uc9c4\uc740 TNAP \uc81c\uac70 \ub610\ub294 GPLD1 \uc791\uc6a9\uc744 \ubaa8\ubc29\ud558\ub294 \uc804\ub7b5\uc774 \ub178\ud654 \uad00\ub828 \uc778\uc9c0\uc800\ud558\ub97c \uc644\ud654\ud560 \uc7a0\uc7ac\uc801 \uce58\ub8cc \ud45c\uc801\uc774 \ub420 \uc218 \uc788\ub2e4\uace0 \uc81c\uc548\ud588\ub2e4.<\/li>\n<\/ul>\n<h2>\uc0ac\uac74 \ubc30\uacbd<\/h2>\n<p>\ud608\ub1cc\uc7a5\ubcbd(BBB)\uc740 \ub1cc\uc640 \ud608\ub958 \uc0ac\uc774\uc758 \uc120\ud0dd\uc801 \uc7a5\ubcbd\uc73c\ub85c, \ud608\uc561 \ub0b4 \uc720\ud574\ubb3c\uc9c8\uacfc \uba74\uc5ed\uc138\ud3ec\uc758 \uacfc\ub3c4\ud55c \uc720\uc785\uc744 \ucc28\ub2e8\ud574 \uc911\ucd94\uc2e0\uacbd\uacc4\ub97c \ubcf4\ud638\ud55c\ub2e4. \ub178\ud654 \uacfc\uc815\uc5d0\uc11c BBB\uc758 \ubbf8\uc138\uad6c\uc870\uc640 \uae30\ub2a5\uc774 \uc190\uc0c1\ub418\uba74 \ub2e8\ubc31\uc9c8\u00b7\uc5fc\uc99d\ubb3c\uc9c8\uc758 \uc720\uc785\uc774 \uc99d\uac00\ud558\uace0, \uc774\ub294 \uc2e0\uacbd \uc5fc\uc99d\uacfc \uc2dc\ub0c5\uc2a4 \uae30\ub2a5 \uc800\ud558\ub85c \uc774\uc5b4\uc838 \uc778\uc9c0\ub2a5\ub825 \uac10\uc18c\uc640 \uc5f0\uad00\ub41c\ub2e4. \uc774\uc804 \uc5f0\uad6c\ub4e4\uc5d0\uc11c\ub294 \uc6b4\ub3d9\uc774 \uc804\uc2e0 \ub300\uc0ac\uacfc\uc815\uc744 \ud1b5\ud574 \ub1cc \uac74\uac15\uc5d0 \uae0d\uc815\uc801 \uc601\ud5a5\uc744 \uc900\ub2e4\ub294 \uc99d\uac70\uac00 \ub204\uc801\ub418\uc5b4 \uc654\uace0, GPLD1\uc774 \uc6b4\ub3d9 \ud6c4 \uac04\uc5d0\uc11c \uc99d\uac00\ud574 \ub1cc \uae30\ub2a5\uc5d0 \uc601\ud5a5\uc744 \uc900\ub2e4\ub294 \ubcf4\uace0\uac00 \uc788\uc5c8\ub2e4. \uc774\ubc88 \uc5f0\uad6c\ub294 \uadf8 \uc5f0\uacb0\uace0\ub9ac\uc5d0\uc11c TNAP\ub77c\ub294 \ubd84\uc790\uac00 BBB\uc758 \ucde8\uc57d\uc131\uc744 \uc9c1\uc811\uc801\uc73c\ub85c \ub192\uc774\ub294 \uc694\uc18c\uc784\uc744 \uaddc\uba85\ud568\uc73c\ub85c\uc368, \uc6b4\ub3d9\u00b7\uac04 \ub300\uc0ac\u00b7BBB\u00b7\uc778\uc9c0 \uae30\ub2a5\uc744 \uc787\ub294 \ubd84\uc790\uacbd\ub85c\ub97c \ubcf4\ub2e4 \uad6c\uccb4\ud654\ud588\ub2e4.<\/p>\n<p>\ud608\ub1cc\uc7a5\ubcbd \uc190\uc0c1\uc740 \uc54c\uce20\ud558\uc774\uba38\ubcd1 \ub4f1 \uc5ec\ub7ec \uc2e0\uacbd\ud1f4\ud589\uc131 \uc9c8\ud658\uc758 \ubcd1\ud0dc\uc0dd\ub9ac\uc5d0\uc11c \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ucc28\uc9c0\ud55c\ub2e4\ub294 \uad00\ucc30\uc774 \uc788\uc5b4, BBB\ub97c \ubcf4\ud638\ud558\uac70\ub098 \ubcf5\uc6d0\ud558\ub294 \uc804\ub7b5\uc740 \uce58\ub9e4 \uc608\ubc29\u00b7\uce58\ub8cc \uc5f0\uad6c\uc5d0\uc11c \uc7a5\uae30\uc801 \uad00\uc2ec\uc0ac\ub2e4. \uadf8\ub7ec\ub098 BBB\ub294 \ub9e4\uc6b0 \ubcf5\uc7a1\ud55c \uc138\ud3ec\u00b7\ubd84\uc790 \ub124\ud2b8\uc6cc\ud06c\ub85c \uad6c\uc131\ub3fc \uc788\uc5b4, \ud55c \ubd84\uc790\uc758 \uc870\uc791\uc774 \uc804\uc2e0\uc801\u00b7\uc7a5\uae30\uc801 \uc601\ud5a5\uc73c\ub85c \uc774\uc5b4\uc9c8 \uac00\ub2a5\uc131\ub3c4 \uc788\uc5b4 \uc2e0\uc911\ud55c \uac80\uc99d\uc774 \ud544\uc694\ud558\ub2e4.<\/p>\n<h2>\uc8fc\uc694 \uc0ac\uac74<\/h2>\n<p>\uc5f0\uad6c\uc9c4\uc740 \uc950 \ubaa8\ub378\uc5d0\uc11c TNAP\uc758 \ucd95\uc801\uc774 \ub1cc \ub0b4\ud53c\uc138\ud3ec\uc5d0\uc11c \uad00\ucc30\ub418\ub294 \uc591\uc0c1\uc744 \uba3c\uc800 \uaddc\uba85\ud588\ub2e4. TNAP \ucd95\uc801\uc740 \ud608\uad00 \ud22c\uacfc\uc131 \uc99d\uac00\uc640 \uc5f0\uad00\ub410\uace0, \uc5fc\uc99d\uc131 \uc0ac\uc774\ud1a0\uce74\uc778 \uc99d\uac00 \ubc0f \ubbf8\uc138\uc544\uad50\uc138\ud3ec \ud65c\uc131\ud654\uc640 \uac19\uc740 \ub1cc \uc5fc\uc99d \uc9c0\ud45c\uc758 \uc0c1\uc2b9\uc73c\ub85c \uc774\uc5b4\uc84c\ub2e4. \uc5f0\uad6c\ud300\uc740 \uc80a\uc740 \uc950\uc5d0\uac8c TNAP \ubc1c\ud604\uc744 \uc778\uc704\uc801\uc73c\ub85c \ub192\uc774\ub294 \uc2e4\ud5d8\uc744 \uc218\ud589\ud588\uace0, \ud574\ub2f9 \uc950\ub294 \uc131\uccb4 \uc774\ud6c4 \ub178\ub839\uae30\uc5d0 \uc811\uc5b4\ub4e4\uba70 \uae30\uc5b5 \uad00\ub828 \uacfc\uc81c \uc218\ud589 \ub2a5\ub825\uc774 \ub0ae\uc544\uc9c0\ub294 \uacbd\ub85c\ub97c \ubcf4\uc600\ub2e4.<\/p>\n<p>\ubc18\ub300\ub85c \uc0dd\ud6c4 \uc57d 2\ub144 \ub41c \ub178\ub839 \uc950\uc5d0\uc11c \uc720\uc804\uc790 \uc870\uc791\uc744 \ud1b5\ud574 TNAP\ub97c \uac10\uc18c\uc2dc\ud0a4\uc790 BBB \ud1b5\uacfc\uc131\uc774 \uac1c\uc120\ub418\uace0, \uc5fc\uc99d \ud45c\uc9c0\uc790\uc640 \ubbf8\uc138\uc544\uad50\uc138\ud3ec \ud65c\uc131\ub3c4\uac00 \uac10\uc18c\ud588\uc73c\uba70 \ud45c\uc900\ud654\ub41c \uae30\uc5b5\ub825 \uac80\uc0ac\uc5d0\uc11c \uc131\uacfc\uac00 \ud5a5\uc0c1\ub410\ub2e4. \uc5f0\uad6c\ub294 \ub610\ud55c \uc6b4\ub3d9\uc73c\ub85c \uc720\ub3c4\ub418\ub294 GPLD1\uc774 \uac04\uc5d0\uc11c \ubd84\ube44\ub3fc \ub1cc\ub85c \uc791\uc6a9, TNAP\ub97c \uc81c\uac70\ud568\uc73c\ub85c\uc368 BBB\ub97c \ubcf4\ud638\ud55c\ub2e4\ub294 \uae30\uc804\uc744 \uc81c\uc2dc\ud588\ub2e4. \uc774 \uc77c\ub828\uc758 \uc2e4\ud5d8\uc73c\ub85c TNAP\uc758 \ucd95\uc801\uc774 \uc6d0\uc778 \uc694\uc778\uc778\uc9c0 \uc5ec\ubd80\uc640 GPLD1\uc758 \ubcf4\ud638 \uc5ed\ud560\uc774 \uc0c1\ud638 \uc5f0\uacb0\ub3fc \uc788\ub2e4\ub294 \uc99d\uac70\uac00 \ubcf4\uac15\ub410\ub2e4.<\/p>\n<h2>\ubd84\uc11d \ubc0f \uc758\ubbf8<\/h2>\n<p>\uc774\ubc88 \uacb0\uacfc\ub294 \ub178\ud654 \uad00\ub828 BBB \ubd95\uad34\uc640 \uc778\uc9c0\uc800\ud558 \uc0ac\uc774\uc5d0 \uad6c\uccb4\uc801 \ubd84\uc790 \uc5f0\uacb0\uace0\ub9ac\uac00 \uc874\uc7ac\ud560 \uc218 \uc788\uc74c\uc744 \uc2dc\uc0ac\ud55c\ub2e4. TNAP\uac00 BBB \ud22c\uacfc\uc131\uc744 \ub192\uc774\ub294 \uc791\uc6a9\uc744 \ud55c\ub2e4\uba74, \uc774\ub97c \ud45c\uc801\uc73c\ub85c \ud558\ub294 \uc57d\ubb3c\uc774\ub098 GPLD1\uc744 \ubaa8\ubc29\ud558\ub294 \uce58\ub8cc\ubc95\uc740 \ub178\ub144\uae30 \uc778\uc9c0\uae30\ub2a5 \ubcf4\uc874 \uc804\ub7b5\uc73c\ub85c \ubc1c\uc804\ud560 \uc218 \uc788\ub2e4. \uadf8\ub7ec\ub098 \ub3d9\ubb3c \ubaa8\ub378\uc5d0\uc11c \uad00\ucc30\ub41c \ud6a8\ub2a5\uc774 \uc778\uac04\uc5d0\uc11c \ub3d9\uc77c\ud558\uac8c \uc7ac\ud604\ub420\uc9c0\ub294 \ubcc4\ub3c4\uc758 \uac80\uc99d\uc774 \ud544\uc694\ud558\ub2e4. \uc778\uac04 BBB\ub294 \uad6c\uc870\uc801\u00b7\ub300\uc0ac\uc801 \ucc28\uc774\uac00 \uc788\uace0, TNAP \uc870\uc808\uc774 \uc804\uc2e0\uc801\uc73c\ub85c \ubbf8\uce58\ub294 \uc601\ud5a5(\uc608: \uace8\uaca9\uacc4, \uac04 \uae30\ub2a5 \ub4f1)\ub3c4 \uace0\ub824\ud574\uc57c \ud55c\ub2e4.<\/p>\n<p>\uc784\uc0c1\uc801 \uc804\ud658\uc744 \uc704\ud574\uc11c\ub294 \uba3c\uc800 \uc778\uac04 \uc870\uc9c1 \ub610\ub294 \uc720\ub3c4\ub9cc\ub2a5\uc904\uae30\uc138\ud3ec(iPSC) \uae30\ubc18 BBB \ubaa8\ub378\uc5d0\uc11c TNAP \ucd95\uc801\uacfc GPLD1 \uc791\uc6a9\uc744 \ud655\uc778\ud558\ub294 \ub2e8\uacc4\uac00 \ud544\uc694\ud558\ub2e4. \uc548\uc804\uc131 \uce21\uba74\uc5d0\uc11c\ub294 TNAP\uc758 \uc815\uc0c1 \uc0dd\ub9ac\uc801 \uc5ed\ud560\uc744 \uc800\ud574\ud558\uc9c0 \uc54a\uc73c\uba74\uc11c \uad6d\uc18c\uc801\uc73c\ub85c BBB\ub97c \ubcf4\uc874\ud558\uac70\ub098 \ubcf5\uc6d0\ud560 \uc218 \uc788\ub294 \ubc29\ubc95 \uac1c\ubc1c\uc774 \uad00\uac74\uc774 \ub420 \uac83\uc774\ub2e4. \uc5f0\uad6c\uc9c4\uc758 \uc81c\uc548\ucc98\ub7fc \uc6b4\ub3d9 \uc720\ubc1c GPLD1 \uc99d\uac00\uac00 \uc790\uc5f0\uc801 \ubcf4\ud638\uae30\uc804\uc774\ub77c\uba74, \uc0dd\ud65c\uc2b5\uad00 \uac1c\uc785\uacfc \ubd84\uc790\uce58\ub8cc\ub97c \uacb0\ud569\ud55c \ub2e4\uac01\uc801 \uc811\uadfc\uc774 \ud604\uc2e4\uc801 \ub300\uc548\uc774 \ub420 \uc218 \uc788\ub2e4.<\/p>\n<h2>\ube44\uad50 \ubc0f \ub370\uc774\ud130<\/h2>\n<figure>\n<table>\n<thead>\n<tr>\n<th>\uc870\uac74<\/th>\n<th>BBB \uc644\uc804\uc131<\/th>\n<th>\ub1cc \uc5fc\uc99d<\/th>\n<th>\uc778\uc9c0 \uc131\ub2a5<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\uc815\uc0c1 \uc80a\uc740 \uc950<\/td>\n<td>\ub192\uc74c<\/td>\n<td>\ub0ae\uc74c<\/td>\n<td>\uc815\uc0c1<\/td>\n<\/tr>\n<tr>\n<td>\uc80a\uc740 \uc950 + TNAP \uc99d\uac00<\/td>\n<td>\uac10\uc18c<\/td>\n<td>\uc99d\uac00<\/td>\n<td>\ud6c4\uae30 \uc778\uc9c0\uc800\ud558<\/td>\n<\/tr>\n<tr>\n<td>\ub178\ub839(2\ub144) \uc950<\/td>\n<td>\uac10\uc18c<\/td>\n<td>\uc99d\uac00<\/td>\n<td>\uac10\uc18c<\/td>\n<\/tr>\n<tr>\n<td>\ub178\ub839(2\ub144) \uc950 + TNAP \uac10\uc18c<\/td>\n<td>\ubd80\ubd84 \ud68c\ubcf5<\/td>\n<td>\uac10\uc18c<\/td>\n<td>\uac1c\uc120<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n<p>\uc704 \ud45c\ub294 \uc5f0\uad6c \uacb0\uacfc\ub97c \ub2e8\uc21c \ube44\uad50\ud55c \uc815\ub9ac\ub85c, \uac01 \ud56d\ubaa9\uc740 \uc5f0\uad6c\uc9c4\uc774 \ubcf4\uace0\ud55c \uacbd\ud5a5\uc744 \uc9c8\uc801 \uc218\uc900\uc73c\ub85c \uc694\uc57d\ud55c \uac83\uc774\ub2e4. \uc2e4\ud5d8\uc801 \uc815\ub7c9\uac12(\uc608: BBB \ud22c\uacfc\uc131 \uc218\uce58, \uc5fc\uc99d\uc131 \uc0ac\uc774\ud1a0\uce74\uc778 \ub18d\ub3c4, \uc778\uc9c0 \uacfc\uc81c \uc810\uc218)\uc740 \uc6d0\ubb38\uc5d0 \uc81c\uc2dc\ub41c \uc808\ub300\uac12\uc744 \ud655\uc778\ud574\uc57c \ud558\uba70, \uc5ec\uae30\uc11c\ub294 \uacbd\ud5a5 \ube44\uad50\uc5d0 \ucd08\uc810\uc744 \ub9de\ucdc4\ub2e4.<\/p>\n<h2>\ubc18\uc751 \ubc0f \uc778\uc6a9<\/h2>\n<p>\uacf5\uc2dd \ubc1c\ud45c\uc640 \uc5f0\uad6c\uc9c4 \ud574\uc124\uc740 \uc5f0\uad6c \uacb0\uacfc\uc758 \uc758\uc758\ub97c \uac15\uc870\ud558\uba74\uc11c\ub3c4 \uc778\uac04 \uc801\uc6a9\uc744 \uc704\ud55c \ucd94\uac00 \uc5f0\uad6c \ud544\uc694\uc131\uc744 \ubd84\uba85\ud788 \ud588\ub2e4.<\/p>\n<blockquote>\n<p>\uc774\ubc88 \uc5f0\uad6c\ub294 \ud608\ub1cc\uc7a5\ubcbd \uc57d\ud654\uc758 \uc0c8\ub85c\uc6b4 \ubd84\uc790\uc801 \uc5f0\uacb0\uace0\ub9ac\ub97c \uc81c\uc2dc\ud55c\ub2e4. TNAP \uc870\uc808\uc740 \ub178\ud654\uc131 \uc778\uc9c0\uc800\ud558\uc758 \uc7a0\uc7ac\uc801 \uac1c\uc785\uc810\uc774 \ub420 \uc218 \uc788\ub2e4.<\/p>\n<p><cite>Saul Villeda \ubc15\uc0ac, UCSF(\uc5f0\uad6c\ucc45\uc784\uc790)<\/cite><\/p><\/blockquote>\n<p>\uad6d\ub0b4\uc678 \uc804\ubb38\uac00\ub4e4\uc740 \uae30\uc804 \uaddc\uba85\uc758 \uac00\uce58\ub97c \uc778\uc815\ud558\uba74\uc11c\ub3c4 \uc804\uc784\uc0c1\u00b7\uc784\uc0c1 \uc804\ud658\uc5d0\uc11c\uc758 \ub3c4\uc804 \uacfc\uc81c\ub97c \uc9c0\uc801\ud588\ub2e4.<\/p>\n<blockquote>\n<p>\ub3d9\ubb3c \ub370\uc774\ud130\ub294 \uc720\ub9dd\ud558\uc9c0\ub9cc \uc778\uac04\uc5d0\uc11c\uc758 \ubc1c\ud604 \ud328\ud134\uacfc \uc548\uc804\uc131 \ud504\ub85c\ud30c\uc77c \ud655\uc778\uc774 \uc6b0\uc120\ub3fc\uc57c \ud55c\ub2e4.<\/p>\n<p><cite>\ub3c5\ub9bd \uc2e0\uacbd\uacfc\ud559\uc790(\uc804\ubb38\uac00 \uacac\ud574)<\/cite><\/p><\/blockquote>\n<p>\uc77c\ubc18 \ub300\uc911\uacfc \uc6b4\ub3d9 \uad00\ub828 \ucee4\ubba4\ub2c8\ud2f0\uc5d0\uc11c\ub294 \uc6b4\ub3d9\uc774 \ub1cc \ubcf4\ud638\uc5d0 \uae30\uc5ec\ud55c\ub2e4\ub294 \uae30\uc874 \uc778\uc2dd\uc774 \uc774\ubc88 \uc5f0\uad6c\ub85c \ubcf4\uac15\ub410\ub2e4\ub294 \ubc18\uc751\uc774 \ub098\uc654\ub2e4.<\/p>\n<blockquote>\n<p>\uc6b4\ub3d9\uc774 \uac04\uc744 \ud1b5\ud574 \ub1cc\ub97c \ub3d5\ub294\ub2e4\ub294 \uc124\uba85\uc740 \uc774\ud574\ud558\uae30 \uc26c\uc6cc \uacf5\uac10\uc774 \ucef8\ub2e4.<\/p>\n<p><cite>SNS \uc0ac\uc6a9\uc790 \ubc18\uc751<\/cite><\/p><\/blockquote>\n<aside>\n<details>\n<summary>\uc6a9\uc5b4\/\ubc29\ubc95\ub860<\/summary>\n<p>TNAP\uc740 tissue-nonspecific alkaline phosphatase\uc758 \uc57d\uc790\ub85c, \uc5ec\ub7ec \uc870\uc9c1\uc5d0\uc11c \ubc1c\ud604\ub418\ub294 \uc54c\uce7c\ub9ac\uc131 \uc778\uc0b0\ubd84\ud574\ud6a8\uc18c \uacc4\uc5f4 \ub2e8\ubc31\uc9c8\uc774\ub2e4. GPLD1\uc740 GPI-specific phospholipase D1\ub85c, GPI(glycosylphosphatidylinositol) \uacb0\ud569 \ub2e8\ubc31\uc9c8\uc744 \uc808\ub2e8\ud574 \uc774\ub4e4\uc744 \uc138\ud3ec\ub9c9\uc5d0\uc11c \ubd84\ub9ac\ud560 \uc218 \uc788\ub294 \ud6a8\uc18c\ub85c \uc54c\ub824\uc838 \uc788\ub2e4. \ud608\ub1cc\uc7a5\ubcbd(BBB)\uc740 \ub1cc \ubaa8\uc138\ud608\uad00\uc758 \ub0b4\ud53c\uc138\ud3ec, \uae30\uc800\ub9c9, \ubcc4\uc544\uad50\uc138\ud3ec \ubc1c\uc544\uc885 \ub4f1\uc73c\ub85c \uad6c\uc131\ub41c \ubcf5\ud569 \uad6c\uc870\ub85c, \uc120\ud0dd\uc801 \ud22c\uacfc\uc131\uc744 \ud1b5\ud574 \uc911\ucd94\uc2e0\uacbd\uacc4\uc758 \ud56d\uc0c1\uc131\uc744 \uc720\uc9c0\ud55c\ub2e4. \uc5f0\uad6c\uc5d0\uc11c\ub294 \uc720\uc804\uc790 \uc870\uc791\uacfc \uc0dd\ud654\ud559\uc801 \ubd84\uc11d, \ud45c\uc900\ud654\ub41c \ud589\ub3d9 \uac80\uc0ac \ub4f1\uc744 \uacb0\ud569\ud574 TNAP\uc758 \uc5ed\ud560\uacfc GPLD1\uc758 \uc601\ud5a5\uc744 \uaddc\uba85\ud588\ub2e4. \uc774\ub7ec\ud55c \ubc29\ubc95\ub860\uc740 \ub3d9\ubb3c \ubaa8\ub378\uc5d0\uc11c \ubd84\uc790\uc801 \uc778\uacfc\uad00\uacc4\ub97c \ud0d0\uc0c9\ud558\ub294 \ub370 \uc801\ud569\ud558\uc9c0\ub9cc \uc778\uac04 \uc801\uc6a9\uc744 \uc704\ud574\uc11c\ub294 \ucd94\uac00\uc801 \ubaa8\ub378 \uac80\uc99d\uc774 \ud544\uc694\ud558\ub2e4.<\/p>\n<\/details>\n<\/aside>\n<h2>\ubd88\ud655\uc2e4\ud55c \ubd80\ubd84<\/h2>\n<ul>\n<li>\uc778\uac04\uc5d0\uc11c TNAP \ucd95\uc801\uacfc GPLD1 \uc791\uc6a9\uc774 \uc950\uc640 \ub3d9\uc77c\ud55c \uc591\uc0c1\uc73c\ub85c \ub098\ud0c0\ub098\ub294\uc9c0\ub294 \uc544\uc9c1 \ud655\uc778\ub418\uc9c0 \uc54a\uc558\ub2e4.<\/li>\n<li>TNAP\ub97c \uac10\uc18c\uc2dc\ud0ac \ub54c \uc7a5\uae30\uc801\u00b7\uc804\uc2e0\uc801 \uc548\uc804\uc131(\uc608: \uace8\uaca9\uacc4\ub098 \uac04 \uae30\ub2a5 \uc601\ud5a5)\uc5d0 \ub300\ud55c \ub370\uc774\ud130\uac00 \ubd80\uc871\ud558\ub2e4.<\/li>\n<li>\uc5f0\uad6c\uc5d0\uc11c \uc0ac\uc6a9\ub41c \uad6c\uccb4\uc801 \uae30\uc5b5\ub825 \uac80\uc0ac \ud56d\ubaa9\uacfc \uc815\ub7c9\uc801 \uc218\uce58\ub294 \uc6d0\ubb38 \uc790\ub8cc\uc758 \uc0c1\uc138\uac12 \ud655\uc778\uc774 \ud544\uc694\ud558\ub2e4.<\/li>\n<li>GPLD1\uc744 \uc57d\ub9ac\ud559\uc801\uc73c\ub85c \ubaa8\ubc29\ud588\uc744 \ub54c\uc758 \uc804\ub2ec \ubc29\ubc95\uacfc \ub1cc\uad6d\uc18c\uc131 \ud655\ubcf4 \uc5ec\ubd80\ub294 \ubd88\ud655\uc2e4\ud558\ub2e4.<\/li>\n<\/ul>\n<h2>\ucd1d\ud3c9<\/h2>\n<p>UCSF \uc5f0\uad6c\ub294 \ub178\ud654\uc5d0 \ub530\ub978 \ud608\ub1cc\uc7a5\ubcbd \uc57d\ud654\uc758 \ubd84\uc790\uc801 \uae30\ubc18\uc73c\ub85c TNAP\ub97c \uc9c0\ubaa9\ud568\uc73c\ub85c\uc368, BBB \ubcf4\ud638\ub97c \ud1b5\ud55c \uc778\uc9c0\uae30\ub2a5 \ubcf4\uc874 \uc5f0\uad6c\uc758 \uc0c8 \ubc29\ud5a5\uc744 \uc81c\uc2dc\ud588\ub2e4. \uc6b4\ub3d9\uc73c\ub85c \uc720\ub3c4\ub418\ub294 GPLD1\uc774 TNAP\ub97c \uc81c\uac70\ud574 BBB\ub97c \uac15\ud654\ud55c\ub2e4\ub294 \uc5f0\uacb0\uace0\ub9ac\ub294 \uc0dd\ud65c\uc2b5\uad00\uacfc \ubd84\uc790\uce58\ub8cc\ub97c \uc787\ub294 \ud765\ubbf8\ub85c\uc6b4 \uac00\uc124\uc744 \ub4b7\ubc1b\uce68\ud55c\ub2e4.<\/p>\n<p>\ub2e4\ub9cc \ud604\uc7ac \uc99d\uac70\ub294 \uc8fc\ub85c \uc950 \ubaa8\ub378\uc5d0 \uae30\ubc18\ud558\uba70, \uc778\uac04 \uc801\uc6a9\uc744 \uc704\ud55c \uc870\uc9c1 \uc218\uc900\uc758 \ud655\uc778\uacfc \uc548\uc804\uc131 \uac80\uc99d\uc774 \ud544\uc218\uc801\uc774\ub2e4. \ud5a5\ud6c4 \uc5f0\uad6c\ub294 \uc778\uac04 \uc720\ub798 \ubaa8\ub378\uacfc \uc7a5\uae30 \ucd94\uc801, \uadf8\ub9ac\uace0 TNAP\u00b7GPLD1 \uacbd\ub85c\uc758 \uc804\uc2e0\uc801 \uc601\ud5a5\uc744 \uc885\ud569\uc801\uc73c\ub85c \ud3c9\uac00\ud558\ub294 \ubc29\ud5a5\uc73c\ub85c \uc9c4\ud589\ub3fc\uc57c \ud55c\ub2e4.<\/p>\n<h2>\ucd9c\ucc98<\/h2>\n<ul>\n<li><a href=\"http:\/\/www.whosaeng.com\/169018\" target=\"_blank\" rel=\"noopener\">\ud6c4\uc0dd\uc2e0\ubcf4 \ubcf4\ub3c4<\/a> (\uc5b8\ub860 \ubcf4\ub3c4)<\/li>\n<li><a href=\"https:\/\/www.ucsf.edu\" target=\"_blank\" rel=\"noopener\">University of California, San Francisco<\/a> (\ud559\uacc4\u00b7\uc5f0\uad6c\uae30\uad00)<\/li>\n<\/ul>\n<\/article>\n","protected":false},"excerpt":{"rendered":"<p>\ud575\uc2ec \uc694\uc57d \ubbf8\uad6d \uc0cc\ud504\ub780\uc2dc\uc2a4\ucf54 \uce98\ub9ac\ud3ec\ub2c8\uc544\ub300(UCSF) \uc5f0\uad6c\uc9c4\uc740 \ud608\ub1cc\uc7a5\ubcbd(BBB)\uc744 \uc57d\ud654\uc2dc\ud0a4\ub294 \ub2e8\ubc31\uc9c8 TNAP\uc744 \ud655\uc778\ud558\uace0, \uc774\ub97c \uc81c\uac70\ud558\uba74 \ub178\ub839 \uc950\uc5d0\uc11c \ud608\ub1cc\uc7a5\ubcbd\uc774 \ud68c\ubcf5\ub418\uace0 \uc778\uc9c0\ub2a5\ub825\uc774 \uac1c\uc120\ub41c\ub2e4\uace0 \ubcf4\uace0\ud588\ub2e4. \uc5f0\uad6c\ub294 2026\ub144 3\uc6d4 \ubcf4\uace0\ub41c \uac83\uc73c\ub85c, \uc6b4\ub3d9\uc73c\ub85c \uac04\uc5d0\uc11c \ubd84\ube44\ub418\ub294 \ud6a8\uc18c GPLD1\uc774 \ub1cc \ub0b4\ud53c\uc138\ud3ec\uc758 TNAP\ub97c \uc81c\uac70\ud574 BBB\ub97c \uac15\ud654\ud55c\ub2e4\ub294 \uc5f0\uacb0\uace0\ub9ac\ub97c \uc81c\uc2dc\ud55c\ub2e4. \uc0dd\ud6c4 2\ub144\uc758 \ub178\ub839 \uc950\uc5d0\uc11c TNAP\ub97c \uac10\uc18c\uc2dc\ud0a4\uba74 \ub1cc \uc5fc\uc99d\uc774 \uc904\uace0 \uae30\uc5b5 \uac80\uc0ac \uc131\uc801\uc774 \uac1c\uc120\ub418\ub294 \uacb0\uacfc\uac00 \uad00\ucc30\ub410\ub2e4. \ud575\uc2ec \uc0ac\uc2e4 &#8230; <a title=\"\ud608\ub1cc\uc7a5\ubcbd \uc57d\ud654 \uc720\ubc1c \ub2e8\ubc31\uc9c8 TNAP \uc81c\uac70\ub85c \uc778\uc9c0\ub825 \uac1c\uc120 \ud655\uc778\" class=\"read-more\" href=\"https:\/\/readtrends.com\/ko\/tnap-bbb-cognition\/\" aria-label=\"\ud608\ub1cc\uc7a5\ubcbd \uc57d\ud654 \uc720\ubc1c \ub2e8\ubc31\uc9c8 TNAP \uc81c\uac70\ub85c \uc778\uc9c0\ub825 \uac1c\uc120 \ud655\uc778\uc5d0 \ub300\ud574 \ub354 \uc790\uc138\ud788 \uc54c\uc544\ubcf4\uc138\uc694\">\ub354 \uc77d\uae30<\/a><\/p>\n","protected":false},"author":1,"featured_media":10467,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"rank_math_title":"TNAP \uc81c\uac70\ub85c \ud608\ub1cc\uc7a5\ubcbd \ud68c\ubcf5\u00b7\uc778\uc9c0 \uac1c\uc120 \ud655\uc778 \u2014 \ub514\uc9c0\ud138\ub274\uc2a4","rank_math_description":"UCSF \uc5f0\uad6c\uc9c4\uc774 TNAP \ucd95\uc801\uc774 \ud608\ub1cc\uc7a5\ubcbd\uc744 \uc57d\ud654\uc2dc\ud0a4\uace0 \uc778\uc9c0\uc800\ud558\uc640 \uc5f0\uacb0\ub41c\ub2e4\ub294 \uc0ac\uc2e4\uc744 \uaddc\uba85\ud588\ub2e4. GPLD1\uac00 TNAP\ub97c \uc81c\uac70\ud574 BBB\ub97c \uac15\ud654\ud558\ub294 \uae30\uc804\uacfc \uce58\ub8cc \uac00\ub2a5\uc131\uc744 \uc81c\uc2dc\ud55c\ub2e4.","rank_math_focus_keyword":"TNAP,\ud608\ub1cc\uc7a5\ubcbd,GPLD1,\uc778\uc9c0\ub825,UCSF","footnotes":""},"categories":[2],"tags":[],"class_list":["post-10473","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-top-stories"],"_links":{"self":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/posts\/10473","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/comments?post=10473"}],"version-history":[{"count":0,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/posts\/10473\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/media\/10467"}],"wp:attachment":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/media?parent=10473"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/categories?post=10473"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/tags?post=10473"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}