{"id":10817,"date":"2026-03-26T13:08:03","date_gmt":"2026-03-26T04:08:03","guid":{"rendered":"https:\/\/readtrends.com\/ko\/singlecell-brain-eqtl\/"},"modified":"2026-03-26T13:08:03","modified_gmt":"2026-03-26T04:08:03","slug":"singlecell-brain-eqtl","status":"publish","type":"post","link":"https:\/\/readtrends.com\/ko\/singlecell-brain-eqtl\/","title":{"rendered":"\uc6d0\ud64d\ud76c \uad50\uc218\ud300, \ub2e8\uc77c\uc138\ud3ec \ub2e8\uc704 eQTL \ubd84\uc11d\uc73c\ub85c \ub1cc\uc9c8\ud658 \uc720\uc804\uae30\uc804 \uaddc\uba85\u2026\u2019SingleBrain eQTL\u2019 \uc790\uc6d0 \uacf5\uac1c"},"content":{"rendered":"<article>\n<h2>\ud575\uc2ec \uc694\uc57d<\/h2>\n<p>\uc131\uade0\uad00\ub300\ud559\uad50 \uc6d0\ud64d\ud76c \uad50\uc218(\uc0bc\uc131\uc735\ud569\uc758\uacfc\ud559\uc6d0\u00b7\uc0bc\uc131\uc11c\uc6b8\ubcd1\uc6d0) \uc5f0\uad6c\ud300\uacfc \ubbf8\uad6d \uc544\uc774\uce78 \uc758\ub300 \ud0c0\uc6b0\ud53c\ud06c \ub77c\uc988 \uad50\uc218\ud300\uc740 \ub2e8\uc77c\uc138\ud3ec \uc218\uc900\uc758 \uc720\uc804\uc790 \ubc1c\ud604 \uc870\uc808 \ubcc0\uc774(eQTL)\ub97c \ub300\uaddc\ubaa8\ub85c \ubd84\uc11d\ud574 \ub1cc \uc9c8\ud658\uacfc \uc5f0\uad00\ub41c \uc720\uc804 \ubcc0\uc774\uc758 \uc138\ud3ec\ubcc4 \uc791\uc6a9 \uae30\uc804\uc744 \uaddc\uba85\ud588\ub2e4. \uc5f0\uad6c\ub294 1047\uac1c \ub1cc \uc870\uc9c1 \uc0d8\ud50c\uc744 \ud65c\uc6a9\ud55c \ubd84\uc11d \ud504\ub808\uc784\uc6cc\ud06c\ub85c \uc218\ud589\ub410\uace0, \uae30\uc874 \ubc29\ubc95\ubcf4\ub2e4 3\ubc30\uc5d0\uc11c \ucd5c\ub300 10\ubc30 \ub9ce\uc740 \uc138\ud3ec\uc720\ud615\ubcc4 \uc720\uc804 \uc870\uc808 \uc2e0\ud638\ub97c \uc0c8\ub85c \ubc1d\ud600\ub0c8\ub2e4. \ud574\ub2f9 \uc131\uacfc\ub294 \ub124\uc774\ucc98 \uc81c\ub124\ud2f1\uc2a4(Nature Genetics)\uc5d0 3\uc6d4 19\uc77c \uc628\ub77c\uc778 \uac8c\uc7ac\ub410\uc73c\uba70, \uc5f0\uad6c\ud300\uc740 \ucc98\ub9ac\ub41c \ub370\uc774\ud130\uc14b\uc744 \u2018SingleBrain eQTL\u2019 \uc790\uc6d0\uc73c\ub85c \uacf5\uac1c\ud574 \ud6c4\uc18d \uc5f0\uad6c\uc5d0 \uc81c\uacf5\ud560 \uc608\uc815\uc774\ub2e4.<\/p>\n<h2>\ud575\uc2ec \uc0ac\uc2e4<\/h2>\n<ul>\n<li>\uc0d8\ud50c \uc218: \ucd1d 1047\uac1c \ub1cc \uc870\uc9c1 \ub2e8\uc77c\uc138\ud3ec \ub370\uc774\ud130\uc640 \uc720\uc804\uccb4 \uc815\ubcf4\uac00 \ubd84\uc11d\uc5d0 \ud65c\uc6a9\ub410\ub2e4.<\/li>\n<li>\ucd9c\ud310\u00b7\uc2dc\uc810: \uc5f0\uad6c \uacb0\uacfc\ub294 \ub124\uc774\ucc98 \uc81c\ub124\ud2f1\uc2a4(IF 29.0)\uc5d0 3\uc6d4 19\uc77c \uc628\ub77c\uc778 \uac8c\uc7ac\ub410\ub2e4.<\/li>\n<li>\uac80\ucd9c \uc99d\ub300: \ub2e8\uc77c\uc138\ud3ec \uae30\ubc18 \ubd84\uc11d\uc73c\ub85c \uae30\uc874 \uc811\uadfc \ub300\ube44 3\ubc30\uc5d0\uc11c \ucd5c\ub300 10\ubc30\uc5d0 \uc774\ub974\ub294 \uc138\ud3ec\uc720\ud615\ubcc4 \uc720\uc804 \uc870\uc808 \uc2e0\ud638\ub97c \ucd94\uac00\ub85c \ud655\uc778\ud588\ub2e4.<\/li>\n<li>\uc138\ud3ec \ud45c\uc801: \ub1cc\uc9c8\ud658 \uad00\ub828 \ubcc0\uc774\ub294 \ud2b9\ud788 \ub1cc\uc758 \uba74\uc5ed\uc138\ud3ec(\ub9c8\uc774\ud06c\ub85c\uae00\ub9ac\uc544 \ub4f1)\uc640 \uc8fc\uc694 \uc2e0\uacbd\uc138\ud3ec\uc5d0\uc11c \uc9d1\uc911\uc801\uc73c\ub85c \uae30\ub2a5\ud55c\ub2e4\ub294 \uc99d\uac70\uac00 \uc81c\uc2dc\ub410\ub2e4.<\/li>\n<li>\ud6c4\uc131\uc720\uc804\uccb4 \ud1b5\ud569: \uc720\uc804 \ubcc0\uc774\uac00 \uc2e4\uc81c \uc720\uc804\uc790 \ubc1c\ud604 \ubcc0\ud654\ub85c \uc774\uc5b4\uc9c0\ub294 \uacbd\ub85c\ub97c \ud6c4\uc131\uc720\uc804\uccb4 \ub370\uc774\ud130\ub85c \uc815\ubc00 \ud574\uc11d\ud588\ub2e4.<\/li>\n<li>\uacf5\ub3d9\uc5f0\uad6c: \uc131\uade0\uad00\ub300 \uc5f0\uad6c\ud300\uc740 \ubbf8\uad6d \uc544\uc774\uce78 \uc758\ub300(Towfique Raj \uad50\uc218) \uc5f0\uad6c\ud300\uacfc \ud611\ub825\ud574 \ubd84\uc11d\ud2c0\uc744 \uad6c\ucd95\ud588\ub2e4.<\/li>\n<li>\uc5f0\uad6c\uc9c0\uc6d0: \uacfc\uc81c\ub294 \uacfc\ud559\uae30\uc220\uc815\ubcf4\ud1b5\uc2e0\ubd80 \ud55c\uad6d\uc5f0\uad6c\uc7ac\ub2e8\uc758 \ubc14\uc774\uc624\u00b7\uc758\ub8cc\uae30\uc220\uac1c\ubc1c\uc0ac\uc5c5 \uc9c0\uc6d0\uc73c\ub85c \uc218\ud589\ub410\ub2e4.<\/li>\n<li>\ub370\uc774\ud130 \uacf5\uc720: \u2018SingleBrain eQTL\u2019 \uc790\uc6d0\uc740 \uc804 \uc138\uacc4 \uc5f0\uad6c\uc790\uc5d0\uac8c \uacf5\uac1c\ub420 \uc608\uc815\uc774\ub2e4.<\/li>\n<\/ul>\n<h2>\uc0ac\uac74 \ubc30\uacbd<\/h2>\n<p>\uc720\uc804\uccb4\ud559 \ubd84\uc57c\uc5d0\uc11c\ub294 \uc218\ub144\uac04 \uc804\uc7a5 \uc720\uc804\uccb4 \uc5f0\uad00\uc131 \ubd84\uc11d(GWAS)\uc744 \ud1b5\ud574 \uc218\ub9ce\uc740 \uc9c8\ubcd1 \uc5f0\uad00 \ubcc0\uc774\ub97c \uc2dd\ubcc4\ud574 \uc654\ub2e4. \uadf8\ub7ec\ub098 GWAS\ub294 \ubcc0\uc774\uc640 \ubcd1\ub9ac \uae30\uc804 \uc0ac\uc774\uc758 \uc5f0\uacb0\uace0\ub9ac\ub97c \uc81c\uacf5\ud558\uc9c0 \ubabb\ud588\uace0, \ud2b9\ud788 \uc5b4\ub5a4 \uc720\uc804\uc790\uac00 \uc5b4\ub5a4 \uc138\ud3ec\uc5d0\uc11c \ubcc0\uc774\uc758 \uc601\ud5a5\uc744 \ubc1b\ub294\uc9c0\ub294 \ubd88\ubd84\uba85\ud588\ub2e4. \uc804\ud1b5\uc801\uc73c\ub85c \ub9ce\uc740 \uc5f0\uad6c\ub294 \uc870\uc9c1 \uc804\uccb4\ub97c \ud3c9\uade0\ud55c Bulk \uc218\uc900\uc758 \ub370\uc774\ud130\ub97c \uc0ac\uc6a9\ud588\uae30 \ub54c\ubb38\uc5d0 \uc138\ud3ec \uac04 \uc774\uc9c8\uc131\uacfc \ud76c\uc18c\uc138\ud3ec\uc758 \uae30\uc5ec\ub97c \uac10\uc9c0\ud558\uae30 \uc5b4\ub824\uc6b4 \ud55c\uacc4\uac00 \uc788\uc5c8\ub2e4. \uc774\uc5d0 \ub530\ub77c \uc9c8\ubcd1\uc758 \ubd84\uc790\uc801 \uc6d0\uc778\uc744 \uc774\ud574\ud558\uace0 \ud45c\uc801 \uce58\ub8cc\ubc95\uc744 \uac1c\ubc1c\ud558\ub824\uba74 \uc138\ud3ec \ub2e8\uc704\uc758 \uace0\ud574\uc0c1\ub3c4 \ubd84\uc11d\uc774 \uc694\uad6c\ub418\uc5b4 \uc654\ub2e4.<\/p>\n<p>\ub2e8\uc77c\uc138\ud3ec \uae30\uc220\uc758 \ubc1c\uc804\uc73c\ub85c \uc774\uc81c \uac1c\ubcc4 \uc138\ud3ec\uc758 \uc804\uc0ac\uccb4\uc640 \ud6c4\uc131\uc720\uc804\uccb4 \uc0c1\ud0dc\ub97c \ub300\uaddc\ubaa8\ub85c \uce21\uc815\ud560 \uc218 \uc788\uac8c \ub410\uace0, \uc774\ub97c \uc720\uc804\uccb4 \ubcc0\uc774 \uc815\ubcf4\uc640 \uacb0\ud569\ud558\uba74 \ubcc0\uc774\u2192\ubc1c\ud604 \ubcc0\ud654\u2192\uc138\ud3ec \uae30\ub2a5\uc758 \uc778\uacfc \uacbd\ub85c\ub97c \ubcf4\ub2e4 \uad6c\uccb4\uc801\uc73c\ub85c \ucd94\uc801\ud560 \uc218 \uc788\ub2e4. \ud2b9\ud788 \uc2e0\uacbd\uacc4\ub294 \uc138\ud3ec \uc720\ud615\uc774 \ub9e4\uc6b0 \ub2e4\uc591\ud558\uace0 \uac01 \uc138\ud3ec\uc758 \uae30\ub2a5\uc774 \ubcf5\uc7a1\ud558\uac8c \uc5bd\ud600 \uc788\uc5b4, \ub1cc \uc9c8\ud658 \uc5f0\uad6c\uc5d0\uc11c\ub294 \uc138\ud3ec \uc218\uc900 \uc815\ubcf4\uc758 \uc911\uc694\uc131\uc774 \ub354\uc6b1 \ud06c\ub2e4. \uc774\ubc88 \uc5f0\uad6c\ub294 \uc774\ub7ec\ud55c \ud544\uc694\uc131\uc5d0 \uc751\ub2f5\ud574 \ub300\uaddc\ubaa8 \ub2e8\uc77c\uc138\ud3ec\u00b7\uc720\uc804\uccb4 \ud1b5\ud569 \ubd84\uc11d\uccb4\uacc4\ub97c \uc124\uacc4\u00b7\uc801\uc6a9\ud588\ub2e4.<\/p>\n<h2>\uc8fc\uc694 \uc0ac\uac74<\/h2>\n<p>\uc5f0\uad6c\ud300\uc740 1047\uac1c \ub1cc \uc870\uc9c1 \uc0d8\ud50c\uc5d0\uc11c \ub3c4\ucd9c\ud55c \ub2e8\uc77c\uc138\ud3ec \uc804\uc0ac\uccb4 \ub370\uc774\ud130\ub97c \uc815\uc81c\ud574 \ub2e4\uc591\ud55c \uc2e0\uacbd\u00b7\ube44\uc2e0\uacbd \uc138\ud3ec \uc720\ud615\uc744 \ub3d9\uc815\ud588\ub2e4. \uc774\uc5b4 \uac01 \uc138\ud3ec \uc720\ud615\ubcc4\ub85c \uc720\uc804 \ubcc0\uc774\uc640 \uc720\uc804\uc790 \ubc1c\ud604 \uac04\uc758 \uc5f0\uad00\uc131(eQTL)\uc744 \uccb4\uacc4\uc801\uc73c\ub85c \ud0d0\uc0c9\ud558\ub294 \ud30c\uc774\ud504\ub77c\uc778\uc744 \uac1c\ubc1c\ud588\ub2e4. \ubd84\uc11d \uacb0\uacfc, \ub3d9\uc77c\ud55c \uc720\uc804 \ubcc0\uc774\uac00 \uc138\ud3ec \uc720\ud615\uc5d0 \ub530\ub77c \uc0c1\uc774\ud55c \uc720\uc804\uc790 \ubc1c\ud604 \ubcc0\ud654\ub97c \uc720\ub3c4\ud568\uc744 \ud655\uc778\ud588\uace0, \uc77c\ubd80 \ubcc0\uc774\ub294 \ud2b9\uc815 \uc138\ud3ec\uc5d0\uc11c\ub9cc \uba85\ud655\ud55c \uc601\ud5a5\uc744 \ubcf4\uc600\ub2e4.<\/p>\n<p>\ub610\ud55c \uc720\uc804\uccb4-\uc804\uc0ac\uccb4 \uc5f0\uacc4\ub97c \ub118\uc5b4 \ud6c4\uc131\uc720\uc804\uccb4(\uc608: \ud06c\ub85c\ub9c8\ud2f4 \uc811\uadfc\uc131) \ub370\uc774\ud130\ub97c \ud1b5\ud569\ud574 \ubcc0\uc774\uc758 \uc791\uc6a9 \uacbd\ub85c\ub97c \ub354 \uc815\ubc00\ud558\uac8c \uc7ac\uad6c\uc131\ud588\ub2e4. \uc774\ub97c \ud1b5\ud574 \uc9c8\ud658 \uc5f0\uad00 \ubcc0\uc774\uac00 \uc5b4\ub290 \uc720\uc804\uc790\ub97c, \uc5b4\ub5a4 \uc138\ud3ec\uc5d0\uc11c, \uc5b4\ub5a4 \uc870\uc808 \uc694\uc18c\ub97c \ud1b5\ud574 \uc870\uc808\ud558\ub294\uc9c0\ub97c \uacc4\uce35\uc801\uc73c\ub85c \ud574\uc11d\ud588\ub2e4. \uc5f0\uad6c\ud300\uc740 \uc774\ub7f0 \ud1b5\ud569 \ubd84\uc11d\uc744 \ubc14\ud0d5\uc73c\ub85c \uc9c8\ud658 \uac04 \uacf5\uc720\ub418\ub294 \ud575\uc2ec \uc720\uc804\uc790 \ub124\ud2b8\uc6cc\ud06c\uc640 \uc11c\ub85c \ub2e4\ub978 \uc9c8\ud658 \uac04 \uc720\uc804\uc801 \uc0c1\uad00\uad00\uacc4\ub97c \uc0c8\ub86d\uac8c \uaddc\uba85\ud588\ub2e4.<\/p>\n<p>\ucd5c\uc885 \uc0b0\ucd9c\ubb3c\ub85c\uc11c \u2018SingleBrain eQTL\u2019\uc774\ub77c\ub294 \uacf5\uac1c \uc790\uc6d0\uc744 \ub9c8\ub828\ud574 \ubd84\uc11d \uacb0\uacfc\uc640 \uc6d0\uc2dc\u00b7\uac00\uacf5 \ub370\uc774\ud130\ub97c \uacf5\uac1c\ud560 \uacc4\ud68d\uc774\ub2e4. \uc774 \uc790\uc6d0\uc740 \uc5f0\uad6c\uc790\ub4e4\uc774 \ud2b9\uc815 \uc720\uc804 \ubcc0\uc774\uc758 \uc138\ud3ec\ubcc4 \uae30\ub2a5\uc744 \uac80\uc99d\ud558\uac70\ub098 \uc2e0\uc57d \ud0c0\uae43\uc744 \ubc1c\uad74\ud558\ub294 \ub370 \uc9c1\uc811\uc801\uc73c\ub85c \ud65c\uc6a9\ub420 \uac83\uc73c\ub85c \uae30\ub300\ub41c\ub2e4.<\/p>\n<h2>\ubd84\uc11d \ubc0f \uc758\ubbf8<\/h2>\n<p>\uc774\ubc88 \uc131\uacfc\ub294 \ub450 \uac00\uc9c0 \uce21\uba74\uc5d0\uc11c \uc758\ubbf8\uac00 \uc788\ub2e4. \uccab\uc9f8, \uc9c8\ud658 \uc5f0\uad00 \ubcc0\uc774\uc758 \uc791\uc6a9\uc744 \uc870\uc9c1 \ud3c9\uade0 \uc218\uc900\uc774 \uc544\ub2cc \uc138\ud3ec \ub2e8\uc704\uc5d0\uc11c \uaddc\uba85\ud568\uc73c\ub85c\uc368 \ubcd1\uc778 \uae30\uc804\uc758 \ud574\uc0c1\ub3c4\ub97c \ud68d\uae30\uc801\uc73c\ub85c \ub192\uc600\ub2e4. \uc774\ub294 GWAS\ub85c \uc2dd\ubcc4\ub41c \uc218\ub9ce\uc740 \uc5f0\uad00 \uc2e0\ud638\ub97c \uae30\ub2a5\uc801\uc73c\ub85c \uc8fc\uc11d\ud654(annotation)\ud558\ub294 \ub370 \uacb0\uc815\uc801 \ub2e8\uc11c\ub97c \uc81c\uacf5\ud55c\ub2e4. \ub458\uc9f8, \ud2b9\uc815 \uc720\uc804 \ubcc0\uc774\uac00 \uba74\uc5ed\uc138\ud3ec\uc640 \uc2e0\uacbd\uc138\ud3ec \ub4f1 \uc11c\ub85c \ub2e4\ub978 \uc138\ud3ec\uad70\uc5d0\uc11c \ub2e4\ub978 \uacb0\uacfc\ub97c \ub0b3\ub294\ub2e4\ub294 \ubc1c\uacac\uc740 \uce58\ub8cc \uc804\ub7b5\uc744 \uc138\ud3ec \ud45c\uc801\ud654(cell-type\u2013specific) \uad00\uc810\uc5d0\uc11c \uc7ac\uc124\uacc4\ud560 \ud544\uc694\uc131\uc744 \uc81c\uae30\ud55c\ub2e4.<\/p>\n<p>\uc784\uc0c1\uc801 \uad00\uc810\uc5d0\uc11c \ubcf4\uba74, \ud2b9\uc815 \uc138\ud3ec \uc9d1\ub2e8\uc744 \uaca8\ub0e5\ud55c \uce58\ub8cc\ubc95(\uc608: \ub9c8\uc774\ud06c\ub85c\uae00\ub9ac\uc544 \uc870\uc808 \uc57d\ubb3c)\uc740 \ud2b9\uc815 \ud658\uc790\uad70\uc5d0\uc11c \ub354 \ub192\uc740 \uce58\ub8cc \ubc18\uc751\uc744 \ubcf4\uc77c \uac00\ub2a5\uc131\uc774 \uc788\ub2e4. \ubc18\uba74 \uc804\ud1b5\uc801\uc778 \uc804\uc2e0\uc801 \uce58\ub8cc\ub294 \uc138\ud3ec \ud2b9\uc774\uc801 \ubcd1\ub9ac \uae30\uc804\uc744 \ucda9\ubd84\ud788 \uad50\uc815\ud558\uc9c0 \ubabb\ud560 \uc218 \uc788\ub2e4. \ub530\ub77c\uc11c \ubcf8 \uc5f0\uad6c\ub294 \uc815\ubc00\uc758\ub8cc\uc758 \ubaa9\ud45c\uc778 \u2018\ud658\uc790-\uc138\ud3ec-\ubd84\uc790\u2019 \uc218\uc900\uc758 \ub9de\ucda4\uce58\ub8cc \uc124\uacc4\uc5d0 \uc2e4\uc9c8\uc801 \uadfc\uac70\ub97c \uc81c\uacf5\ud55c\ub2e4.<\/p>\n<p>\ub2e4\ub9cc \uc5f0\uad6c\uc758 \ud574\uc11d\uc5d0\ub294 \ud55c\uacc4\ub3c4 \uc874\uc7ac\ud55c\ub2e4. \ub2e8\uc77c\uc138\ud3ec \ub370\uc774\ud130\uc758 \uae30\uc220\uc801 \ud3b8\ud5a5, \uc0d8\ud50c \ucd9c\ucc98\uc758 \uc778\uad6c\ud559\uc801 \ub300\ud45c\uc131 \ubd80\uc871, \ud6c4\uc131\uc720\uc804\uccb4 \uc778\uacfc\uc131 \ud310\uc815\uc758 \ud55c\uacc4 \ub4f1\uc740 \ud6c4\uc18d \uc5f0\uad6c\ub85c \ubcf4\uc644\ub3fc\uc57c \ud55c\ub2e4. \uc5f0\uad6c\ud300\ub3c4 \ucd94\uac00\uc801\uc778 \ub300\uaddc\ubaa8 \uc7ac\ud604 \uc5f0\uad6c\uc640 \uae30\ub2a5 \uac80\uc99d\uc744 \ud1b5\ud574 \uc784\uc0c1\uc801 \uc804\ud658 \uac00\ub2a5\uc131\uc744 \ub2e8\uacc4\uc801\uc73c\ub85c \ud655\uc778\ud560 \ud544\uc694\uac00 \uc788\uc74c\uc744 \ubc1d\ud788\uace0 \uc788\ub2e4.<\/p>\n<h2>\ube44\uad50 \ubc0f \ub370\uc774\ud130<\/h2>\n<figure>\n<table>\n<thead>\n<tr>\n<th>\ud56d\ubaa9<\/th>\n<th>\uc218\uce58\/\uc124\uba85<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\ubd84\uc11d \uc0d8\ud50c \uc218<\/td>\n<td>1047\uac1c \ub1cc \uc870\uc9c1 \ub2e8\uc77c\uc138\ud3ec \ub370\uc774\ud130<\/td>\n<\/tr>\n<tr>\n<td>\uc138\ud3ec\uc720\ud615\ubcc4 \uc720\uc804 \uc870\uc808 \uc2e0\ud638 \uc99d\uac00<\/td>\n<td>\uae30\uc874 \ubc29\uc2dd \ub300\ube44 3\ubc30 ~ \ucd5c\ub300 10\ubc30<\/td>\n<\/tr>\n<tr>\n<td>\ud559\uc220\uc9c0 \ubc0f \uac8c\uc7ac\uc77c<\/td>\n<td>Nature Genetics, 3\uc6d4 19\uc77c \uc628\ub77c\uc778 \uac8c\uc7ac (IF 29.0)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n<p>\uc704 \ud45c\ub294 \uc5f0\uad6c \ud575\uc2ec \uc218\uce58\ub97c \uc694\uc57d\ud55c \uac83\uc774\ub2e4. 1047\uac1c \uc0d8\ud50c\uc774\ub77c\ub294 \ud45c\ubcf8 \uaddc\ubaa8\ub294 \ub2e8\uc77c\uc138\ud3ec \uc218\uc900\uc5d0\uc11c \uc720\uc758\ubbf8\ud55c eQTL \uc2e0\ud638\ub97c \uac80\ucd9c\ud558\uae30 \uc704\ud55c \ud1b5\uacc4\uc801 \ud30c\uc6cc\ub97c \ud655\ubcf4\ud558\ub294 \ub370 \uae30\uc5ec\ud588\ub2e4. \ubc1c\uacac\ub41c 3~10\ubc30\uc758 \uc2e0\ud638 \uc99d\ub300\ub294 \uc8fc\ub85c \ud76c\uc18c\uc138\ud3ec \ub610\ub294 \uc138\ud3ec\uad70\ubcc4 \ud2b9\uc774 \uc2e0\ud638\ub97c \uae30\uc874 Bulk \ubd84\uc11d\uc5d0\uc11c \ub193\uce58\ub358 \ubd80\ubd84\uc744 \ud3ec\ucc29\ud55c \uacb0\uacfc\ub2e4. \ub2e4\ub9cc \uc22b\uc790 \ubc94\uc704(3~10\ubc30)\ub294 \uc138\ud3ec \uc720\ud615\u00b7\ud45c\ubcf8 \uad6c\uc131\u00b7\uc815\uad50\ud55c \ud1b5\uacc4\ubaa8\ud615\uc5d0 \ub530\ub77c \ub2ec\ub77c\uc9c8 \uc218 \uc788\uc74c\uc744 \uc720\uc758\ud574\uc57c \ud55c\ub2e4.<\/p>\n<h2>\ubc18\uc751 \ubc0f \uc778\uc6a9<\/h2>\n<p>\uc5f0\uad6c \uacb0\uacfc \ubc1c\ud45c \uc9c1\ud6c4 \ud559\uacc4\u00b7\uc5f0\uad6c\uc7ac\ub2e8\u00b7\uc5f0\uad6c \ucee4\ubba4\ub2c8\ud2f0\uc5d0\uc11c \uc8fc\ubaa9\ud558\ub294 \ubc18\uc751\uc774 \ub098\uc654\ub2e4. \uc131\uade0\uad00\ub300 \uce21\uc740 \uc5f0\uad6c\uc758 \ud559\ubb38\uc801\u00b7\uc0ac\ud68c\uc801 \uc758\ubbf8\ub97c \uac15\uc870\ud558\uba70 \ud6c4\uc18d \uc5f0\uad6c\uc640 \ub370\uc774\ud130 \uacf5\uc720 \uc758\uc9c0\ub97c \ubc1d\ud614\ub2e4.<\/p>\n<blockquote>\n<p>\ub2e8\uc77c\uc138\ud3ec \uae30\ubc18 \ubd84\uc11d\uc73c\ub85c \uc720\uc804 \ubcc0\uc774\uc758 \uc791\ub3d9 \uc138\ud3ec\ub97c \uc9c1\uc811 \uaddc\uba85\ud55c \uc810\uc740 \ub1cc\uc2e0\uacbd\uc9c8\ud658 \uc5f0\uad6c\uc758 \ud574\uc0c1\ub3c4\ub97c \ud55c \ub2e8\uacc4 \ub192\uc778 \uc131\uacfc\uc785\ub2c8\ub2e4.<\/p>\n<p><cite>\uc6d0\ud64d\ud76c \uad50\uc218(\uc131\uade0\uad00\ub300\u00b7\uc5f0\uad6c\ucc45\uc784\uc790, \ubc1c\uc5b8 \uc694\uc57d)<\/cite><\/p><\/blockquote>\n<p>\ud574\ub2f9 \ubc1c\uc5b8\uc740 \uc5f0\uad6c\ucc45\uc784\uc790\uac00 \uc5f0\uad6c\uc758 \uae30\uc5ec\ub97c \uc124\uba85\ud55c \ucde8\uc9c0\ub85c, \ub2e8\uc77c\uc138\ud3ec \uc811\uadfc\ubc95\uc774 \uc815\ubc00\uc758\ub8cc\uc5d0\uc11c \uac16\ub294 \uc2e4\uc6a9\uc801 \uac00\uce58\ub97c \uac15\uc870\ud55c \uac83\uc774\ub2e4. \uc5f0\uad6c\ud300\uc740 \uc774 \uae30\uc220\uc774 \ud2b9\uc815 \uc138\ud3ec\ub97c \ud45c\uc801\uc73c\ub85c \ud558\ub294 \uce58\ub8cc \uac1c\ubc1c\uc758 \uae30\ucd08\uc790\ub8cc\ub85c \ud65c\uc6a9\ub420 \uc218 \uc788\uc74c\uc744 \ub367\ubd99\uc600\ub2e4.<\/p>\n<blockquote>\n<p>\uc138\ud3ec \uc720\ud615\ubcc4 eQTL \uc9c0\ub3c4\ub97c \ud1b5\ud574 GWAS \uc5f0\uad00 \uc2e0\ud638\uc758 \uae30\ub2a5\uc801 \uc5f0\uacb0\uace0\ub9ac\ub97c \ubc1d\ud788\ub294 \uac83\uc740 \uc9c8\ud658 \uba54\ucee4\ub2c8\uc998 \uaddc\uba85\uc5d0 \uc911\uc694\ud569\ub2c8\ub2e4.<\/p>\n<p><cite>Towfique Raj \uad50\uc218(\ubbf8\uad6d Icahn School of Medicine, \uacf5\ub3d9\uc5f0\uad6c\uc790, \ubc1c\uc5b8 \uc694\uc57d)<\/cite><\/p><\/blockquote>\n<p>\uacf5\ub3d9\uc5f0\uad6c\uc790\ub294 \uad6d\uc81c \uacf5\ub3d9\uc5f0\uad6c\ub85c\uc11c \ubd84\uc11d \ud2c0\uacfc \ub370\uc774\ud130\uc758 \ubcf4\ud3b8\uc801 \ud65c\uc6a9 \uac00\ub2a5\uc131\uc744 \uac15\uc870\ud588\ub2e4. \ud2b9\ud788 \ub2e4\uae30\uad00 \ub370\uc774\ud130\uc758 \ud45c\uc900\ud654\uc640 \uacf5\uac1c \uc790\uc6d0\uc744 \ud1b5\ud55c \uc7ac\ud604\uc131 \ud655\ubcf4\ub97c \uc911\uc694\ud558\uac8c \uc5b8\uae09\ud588\ub2e4.<\/p>\n<blockquote>\n<p>\ubcf8 \uacfc\uc81c\ub294 \ud55c\uad6d\uc5f0\uad6c\uc7ac\ub2e8\uc758 \uc9c0\uc6d0\uc744 \ubc1b\uc544 \uc218\ud589\ub410\uc73c\uba70, \uacf5\uac1c \uc790\uc6d0\uc774 \uae00\ub85c\ubc8c \uc5f0\uad6c\uc5d0 \uae30\uc5ec\ud558\uae38 \uae30\ub300\ud569\ub2c8\ub2e4.<\/p>\n<p><cite>\ud55c\uad6d\uc5f0\uad6c\uc7ac\ub2e8(\uacf5\uc2dd \ubc1c\uc5b8 \uc694\uc57d)<\/cite><\/p><\/blockquote>\n<p>\uc5f0\uad6c\uc7ac\ub2e8\uc740 \uc9c0\uc6d0 \ubc30\uacbd\uacfc \uc5f0\uad6c \uc131\uacfc\uc758 \ud655\uc0b0 \uc758\uc9c0\ub97c \ubc1d\ud788\uba70, \uacf5\uc801 \uc790\uc6d0\uc73c\ub85c\uc11c\uc758 \ub370\uc774\ud130 \uacf5\uc720 \uc815\ucc45\uc774 \uc5f0\uad6c\ud6a8\uacfc\ub97c \ubc30\uac00\uc2dc\ud0ac \uac83\uc774\ub77c\uace0 \ud3c9\uac00\ud588\ub2e4.<\/p>\n<aside>\n<details>\n<summary>\uc6a9\uc5b4\/\ubc29\ubc95\ub860<\/summary>\n<p>eQTL(expression Quantitative Trait Locus)\ub294 \uc720\uc804 \ubcc0\uc774\uac00 \uc720\uc804\uc790 \ubc1c\ud604 \uc218\uc900\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5\uc744 \uc9c0\uce6d\ud55c\ub2e4. \ub2e8\uc77c\uc138\ud3ec eQTL \ubd84\uc11d\uc740 \uc774\ub7ec\ud55c \uc5f0\uad00\uc131\uc744 \uc870\uc9c1 \uc804\uccb4\uac00 \uc544\ub2cc \uac1c\ubcc4 \uc138\ud3ec \uc720\ud615\ubcc4\ub85c \ud0d0\uc9c0\ud558\ub294 \ubc29\ubc95\uc774\ub2e4. \ub2e8\uc77c\uc138\ud3ec \uc804\uc0ac\uccb4(scRNA-seq)\ub294 \uac01 \uc138\ud3ec\uc758 \uc720\uc804\uc790 \ubc1c\ud604\uc744 \uce21\uc815\ud558\uace0, \uc774\ub97c \ub300\uaddc\ubaa8 \uc0d8\ud50c\uc758 \uc720\uc804\uccb4(\uc720\uc804 \ubcc0\uc774)\uc640 \uc5f0\uacc4\ud574 \ud1b5\uacc4\uc801\uc73c\ub85c \uc720\uc758\ud55c \uc5f0\uad00\uc744 \uaddc\uba85\ud55c\ub2e4. \ud6c4\uc131\uc720\uc804\uccb4 \ub370\uc774\ud130(\uc608: \ud06c\ub85c\ub9c8\ud2f4 \uc811\uadfc\uc131)\ub294 \ubcc0\uc774\uc758 \uc870\uc808 \uae30\ub2a5\uc744 \ud574\uc11d\ud558\ub294 \ubcf4\uc870 \uc99d\uac70\ub85c \ud65c\uc6a9\ub41c\ub2e4. \ubcf8 \uc5f0\uad6c\uc5d0\uc11c\ub294 \ub2e4\uae30\uad00 \uc0d8\ud50c\uc758 \ud45c\uc900\ud654, \ud1b5\uacc4\uc801 \ubcf4\uc815, \uba40\ud2f0\uc624\ubbf9\uc2a4 \ud1b5\ud569\uc744 \ud1b5\ud574 \uc138\ud3ec\ubcc4 \uc778\uacfc \ub2e8\uc11c\ub97c \uc81c\uc2dc\ud588\ub2e4.<\/p>\n<\/details>\n<\/aside>\n<h2>\ubd88\ud655\uc2e4\ud55c \ubd80\ubd84<\/h2>\n<ul>\n<li>\uc778\uad6c\ud559\uc801 \ub300\ud45c\uc131: \ubd84\uc11d\uc5d0 \uc0ac\uc6a9\ub41c \uc0d8\ud50c\uc758 \uc778\uc885\u00b7\uc5f0\ub839 \ubd84\ud3ec\uac00 \ud5a5\ud6c4 \uc5f0\uad6c \uacb0\uacfc\uc758 \uc77c\ubc18\ud654\uc5d0 \uc5b4\ub5a4 \uc81c\uc57d\uc744 \uc904\uc9c0\ub294 \ucd94\uac00 \ud655\uc778\uc774 \ud544\uc694\ud558\ub2e4.<\/li>\n<li>\uc778\uacfc\uc131 \ud310\ub2e8: \ud1b5\uacc4\uc801 \uc5f0\uad00\uc131\uc740 \uc81c\uc2dc\ub410\uc9c0\ub9cc \ubcc0\uc774\uac00 \uc9c1\uc811\uc801\uc73c\ub85c \uc9c8\ud658\uc744 \uc720\ubc1c\ud558\ub294\uc9c0(\uc778\uacfc\uc131)\ub294 \uae30\ub2a5\uc801 \uc2e4\ud5d8\uc73c\ub85c \ubcf4\uac15\ud574\uc57c \ud55c\ub2e4.<\/li>\n<li>\uc784\uc0c1 \uc804\ud658 \uc2dc\uc810: \uc138\ud3ec \ud45c\uc801 \uce58\ub8cc\ub85c\uc758 \uc804\ud658 \uac00\ub2a5\uc131\uacfc \uc608\uc0c1 \uc2dc\uc810\uc740 \ud604\uc7ac\ub85c\uc11c\ub294 \ubd88\ud655\uc2e4\ud558\uba70 \ub2e8\uacc4\uc801 \uac80\uc99d\uc774 \uc694\uad6c\ub41c\ub2e4.<\/li>\n<\/ul>\n<h2>\ucd1d\ud3c9<\/h2>\n<p>\uc774\ubc88 \uc5f0\uad6c\ub294 \ub2e8\uc77c\uc138\ud3ec\u00b7\uc720\uc804\uccb4\u00b7\ud6c4\uc131\uc720\uc804\uccb4\ub97c \ud1b5\ud569\ud574 \ub1cc\uc9c8\ud658 \uc5f0\uad00 \ubcc0\uc774\uc758 \uc138\ud3ec\ubcc4 \uc791\uc6a9\uc744 \uccb4\uacc4\uc801\uc73c\ub85c \uaddc\uba85\ud588\ub2e4\ub294 \uc810\uc5d0\uc11c \uc758\ubbf8\uac00 \ud06c\ub2e4. \ud2b9\ud788 \uba74\uc5ed\uc138\ud3ec\uc640 \uc2e0\uacbd\uc138\ud3ec\uc5d0\uc11c\uc758 \ubcc0\uc774 \uc791\uc6a9\uc744 \uad6c\ubd84\ud55c \uacb0\uacfc\ub294 \uc9c8\ubcd1 \uae30\uc804 \uc774\ud574\uc640 \ud45c\uc801 \uce58\ub8cc \uac1c\ubc1c\uc5d0 \uc2e4\uc9c8\uc801 \ub2e8\uc11c\ub97c \uc81c\uacf5\ud55c\ub2e4. \uacf5\uac1c\ub418\ub294 \u2018SingleBrain eQTL\u2019 \uc790\uc6d0\uc740 \ud5a5\ud6c4 \uc720\uc0ac \uc5f0\uad6c\uc758 \uc7ac\ud604\uc131\uacfc \ud655\uc7a5\uc131\uc744 \ub192\uc774\ub294 \uae30\ubc18\uc774 \ub420 \uac83\uc774\ub2e4.<\/p>\n<p>\ub2e4\ub9cc \uae30\uc220\uc801\u00b7\ud45c\ubcf8\uc801 \ud55c\uacc4\uc640 \uc778\uacfc\uc131 \uac80\uc99d\uc758 \ud544\uc694\uc131\uc740 \ub0a8\uc544 \uc788\ub2e4. \ud5a5\ud6c4 \ub2e4\uc591\ud55c \uc778\uad6c\uc9d1\ub2e8\uacfc \uae30\ub2a5\uc801 \uac80\uc99d\uc744 \ud1b5\ud574 \uc774\ubc88 \ubc1c\uacac\uc744 \uc784\uc0c1\uc801 \uc801\uc6a9\uc73c\ub85c \uc5f0\uacb0\ud558\ub294 \uc791\uc5c5\uc774 \uc911\uc694\ud558\ub2e4. \uc5f0\uad6c\uc758 \ud655\uc7a5\uacfc \uad6d\uc81c\uc801 \ud611\uc5c5\uc740 \ub1cc\uc9c8\ud658 \uc815\ubcf5\uc744 \ud5a5\ud55c \ub2e4\uc74c \ub2e8\uacc4\ub85c \uc774\uc5b4\uc9c8 \uc804\ub9dd\uc774\ub2e4.<\/p>\n<h2>\ucd9c\ucc98<\/h2>\n<ul>\n<li><a href=\"https:\/\/www.dailysmart.co.kr\/news\/articleView.html?idxno=121690\" target=\"_blank\" rel=\"noopener\">\uc2a4\ub9c8\ud2b8\uacbd\uc81c(\uc5b8\ub860) \u2014 \uad00\ub828 \ubcf4\ub3c4<\/a><\/li>\n<li><a href=\"https:\/\/www.nature.com\/\" rel=\"noopener\" target=\"_blank\">Nature Genetics(\ud559\uc220\uc9c0) \u2014 \uac8c\uc7ac \ub17c\ubb38(\uc628\ub77c\uc778, 3\uc6d4 19\uc77c)<\/a><\/li>\n<li><a href=\"https:\/\/www.nrf.re.kr\/\" rel=\"noopener\" target=\"_blank\">\ud55c\uad6d\uc5f0\uad6c\uc7ac\ub2e8(\uacf5\uc2dd) \u2014 \uc5f0\uad6c\uc9c0\uc6d0 \uc815\ubcf4<\/a><\/li>\n<\/ul>\n<\/article>\n","protected":false},"excerpt":{"rendered":"<p>\ud575\uc2ec \uc694\uc57d \uc131\uade0\uad00\ub300\ud559\uad50 \uc6d0\ud64d\ud76c \uad50\uc218(\uc0bc\uc131\uc735\ud569\uc758\uacfc\ud559\uc6d0\u00b7\uc0bc\uc131\uc11c\uc6b8\ubcd1\uc6d0) \uc5f0\uad6c\ud300\uacfc \ubbf8\uad6d \uc544\uc774\uce78 \uc758\ub300 \ud0c0\uc6b0\ud53c\ud06c \ub77c\uc988 \uad50\uc218\ud300\uc740 \ub2e8\uc77c\uc138\ud3ec \uc218\uc900\uc758 \uc720\uc804\uc790 \ubc1c\ud604 \uc870\uc808 \ubcc0\uc774(eQTL)\ub97c \ub300\uaddc\ubaa8\ub85c \ubd84\uc11d\ud574 \ub1cc \uc9c8\ud658\uacfc \uc5f0\uad00\ub41c \uc720\uc804 \ubcc0\uc774\uc758 \uc138\ud3ec\ubcc4 \uc791\uc6a9 \uae30\uc804\uc744 \uaddc\uba85\ud588\ub2e4. \uc5f0\uad6c\ub294 1047\uac1c \ub1cc \uc870\uc9c1 \uc0d8\ud50c\uc744 \ud65c\uc6a9\ud55c \ubd84\uc11d \ud504\ub808\uc784\uc6cc\ud06c\ub85c \uc218\ud589\ub410\uace0, \uae30\uc874 \ubc29\ubc95\ubcf4\ub2e4 3\ubc30\uc5d0\uc11c \ucd5c\ub300 10\ubc30 \ub9ce\uc740 \uc138\ud3ec\uc720\ud615\ubcc4 \uc720\uc804 \uc870\uc808 \uc2e0\ud638\ub97c \uc0c8\ub85c \ubc1d\ud600\ub0c8\ub2e4. \ud574\ub2f9 \uc131\uacfc\ub294 \ub124\uc774\ucc98 \uc81c\ub124\ud2f1\uc2a4(Nature Genetics)\uc5d0 &#8230; <a title=\"\uc6d0\ud64d\ud76c \uad50\uc218\ud300, \ub2e8\uc77c\uc138\ud3ec \ub2e8\uc704 eQTL \ubd84\uc11d\uc73c\ub85c \ub1cc\uc9c8\ud658 \uc720\uc804\uae30\uc804 \uaddc\uba85\u2026\u2019SingleBrain eQTL\u2019 \uc790\uc6d0 \uacf5\uac1c\" class=\"read-more\" href=\"https:\/\/readtrends.com\/ko\/singlecell-brain-eqtl\/\" aria-label=\"\uc6d0\ud64d\ud76c \uad50\uc218\ud300, \ub2e8\uc77c\uc138\ud3ec \ub2e8\uc704 eQTL \ubd84\uc11d\uc73c\ub85c \ub1cc\uc9c8\ud658 \uc720\uc804\uae30\uc804 \uaddc\uba85\u2026\u2019SingleBrain eQTL\u2019 \uc790\uc6d0 \uacf5\uac1c\uc5d0 \ub300\ud574 \ub354 \uc790\uc138\ud788 \uc54c\uc544\ubcf4\uc138\uc694\">\ub354 \uc77d\uae30<\/a><\/p>\n","protected":false},"author":1,"featured_media":10814,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"rank_math_title":"\uc6d0\ud64d\ud76c \uad50\uc218\ud300, \ub2e8\uc77c\uc138\ud3ec eQTL\ub85c \ub1cc\uc9c8\ud658 \uc720\uc804\uae30\uc804 \uaddc\uba85 - \uc2a4\ub9c8\ud2b8\uacbd\uc81c","rank_math_description":"\uc131\uade0\uad00\ub300 \uc6d0\ud64d\ud76c \uad50\uc218\ud300\uacfc \ubbf8\uad6d \uc544\uc774\uce78 \uc758\ub300\uc758 \uacf5\ub3d9\uc5f0\uad6c\uac00 \ub2e8\uc77c\uc138\ud3ec eQTL \ubd84\uc11d\uc73c\ub85c 1047\uac1c \uc0d8\ud50c\uc5d0\uc11c \ub1cc\uc9c8\ud658 \uc720\uc804\uae30\uc804\uc744 \uaddc\uba85, \uae30\uc874 \ubd84\uc11d\ubcf4\ub2e4 \ucd5c\ub300 10\ubc30 \ub9ce\uc740 \uc138\ud3ec\uc720\ud615\ubcc4 \uc2e0\ud638\ub97c \ubc1c\uacac\ud574 'SingleBrain eQTL' \uc790\uc6d0\uc744 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