{"id":10825,"date":"2026-03-26T16:06:30","date_gmt":"2026-03-26T07:06:30","guid":{"rendered":"https:\/\/readtrends.com\/ko\/prostate-hybrid-ctc-biomarker\/"},"modified":"2026-03-26T16:06:30","modified_gmt":"2026-03-26T07:06:30","slug":"prostate-hybrid-ctc-biomarker","status":"publish","type":"post","link":"https:\/\/readtrends.com\/ko\/prostate-hybrid-ctc-biomarker\/","title":{"rendered":"\ud608\uc561\uc11c \uc804\ub9bd\uc120\uc554 \uc804\uc774 \ub2e8\uc11c \ubc1c\uacac\u2026 CD45\u207aKRT18\u207a \ud558\uc774\ube0c\ub9ac\ub4dc \uc21c\ud658\uc138\ud3ec \uc8fc\ubaa9"},"content":{"rendered":"<article>\n<p>\ud575\uc2ec \uc694\uc57d: \uad6d\ub9bd\uc554\uc13c\ud130 \uc815\uc7ac\uc601 \ube44\ub1e8\uae30\uc554\uc13c\ud130\uc7a5 \uc5f0\uad6c\ud300\uc740 \ub2e8\uc77c\uc138\ud3ec RNA \uc2dc\ud000\uc2f1(scRNA-seq)\uacfc \uc21c\ud658\uc885\uc591\uc138\ud3ec(CTC) \ubd84\uc11d\uc744 \uacb0\ud569\ud574 \ud608\uc561 \uc18d\uc5d0\uc11c \uc804\ub9bd\uc120\uc554 \uc804\uc774 \uac00\ub2a5\uc131\uc744 \uc2dc\uc0ac\ud558\ub294 &#8216;CD45\u207aKRT18\u207a \ud558\uc774\ube0c\ub9ac\ub4dc \uc21c\ud658\uc138\ud3ec&#8217;\ub97c \ud655\uc778\ud588\ub2e4. \uc5f0\uad6c\ub294 \uc804\ub9bd\uc120\uc554\uc758 \uc804\uc774 \uc608\uce21\uc744 \uc704\ud55c \ubd84\uc790\uc801 \uc9c0\ud45c\ub85c \uc774 \uc138\ud3ec\uc758 \uc720\uc804\uc790 \ubc1c\ud604 \ud328\ud134\uc774 \uc720\uc6a9\ud560 \uc218 \uc788\uc74c\uc744 \ubcf4\uc600\uace0, \uc561\uccb4\uc0dd\uac80 \uae30\ubc18 \uc815\ubc00\uc758\ub8cc \ubc1c\uc804\uc5d0 \uae30\uc5ec\ud560 \uac00\ub2a5\uc131\uc774 \uc81c\uc2dc\ub410\ub2e4. \uc5f0\uad6c \uacb0\uacfc\ub294 \ud559\uc220\uc9c0 THERANOSTICS\uc5d0 \ucd5c\uadfc \uac8c\uc7ac\ub410\uc73c\uba70, \ud5a5\ud6c4 \uc784\uc0c1 \uc801\uc6a9\uc744 \uc704\ud574 \ucd94\uac00 \uac80\uc99d\uc774 \uc694\uad6c\ub41c\ub2e4.<\/p>\n<h2>\ud575\uc2ec \uc0ac\uc2e4<\/h2>\n<ul>\n<li>\uc5f0\uad6c \uc8fc\uccb4\ub294 \uad6d\ub9bd\uc554\uc13c\ud130 \ube44\ub1e8\uae30\uc554\uc13c\ud130(\uc13c\ud130\uc7a5 \uc815\uc7ac\uc601)\uc640 \uc5f0\uc138\ub300\ud559\uad50 \uc758\uacfc\ub300\ud559 \ud55c\ud604\ud638 \uad50\uc218\ud300\uc758 \uacf5\ub3d9\uc5f0\uad6c\ub85c \uc9c4\ud589\ub410\ub2e4.<\/li>\n<li>\uc804\ub9bd\uc120\uc554\uc740 \uad6d\ub0b4\uc5d0\uc11c \uc5f0\ud3c9\uade0 \ubc1c\uc0dd\ub960\uc774 \uc57d 13% \uc99d\uac00\ud558\uba70, \ucd5c\uadfc \ud1b5\uacc4\uc5d0\uc11c \ub0a8\uc131\uc554 1\uc704(\ud3d0\uc554 \ucd94\uc6d4)\ub97c \uae30\ub85d\ud588\ub2e4.<\/li>\n<li>\uc804\ub9bd\uc120\uc554 \ud658\uc790\uc758 \uc57d 25~30%\ub294 \uce58\ub8cc \ud6c4 \uc7ac\ubc1c\uc744 \uacbd\ud5d8\ud558\uba70 \uadf8\uc911 \uc77c\ubd80\ub294 \uc804\uc774\uc131 \uc804\ub9bd\uc120\uc554\uc73c\ub85c \uc9c4\ud589\ud55c\ub2e4.<\/li>\n<li>\uc5f0\uad6c\uc9c4\uc740 scRNA-seq\uacfc CTC \ubd84\uc11d\uc744 \ud1b5\ud569\ud574 \ud608\uc561 \ub0b4 CD45\u207aKRT18\u207a \ud45c\uc9c0\uc790\uc758 \ud558\uc774\ube0c\ub9ac\ub4dc \uc21c\ud658\uc138\ud3ec\ub97c \uc2dd\ubcc4\ud588\ub2e4.<\/li>\n<li>\ud574\ub2f9 \ud558\uc774\ube0c\ub9ac\ub4dc \uc138\ud3ec\ub294 \ub2e8\ubc31\uc9c8 \ud569\uc131 \uad00\ub828 \uc720\uc804\uc790 \ubc1c\ud604\uc740 \uc99d\uac00\ud588\uc73c\ub098 \uc138\ud3ec \uc5d0\ub108\uc9c0 \uc0dd\uc131 \uad00\ub828 \uc720\uc804\uc790\ub294 \uac10\uc18c\ud558\ub294 \ud2b9\uc9d5\uc801 \ud328\ud134\uc744 \ubcf4\uc600\ub2e4.<\/li>\n<li>\uc720\uc804\uc790 \ubc1c\ud604 \ud504\ub85c\ud30c\uc77c\uc740 EMT(\uc0c1\ud53c-\uac04\uc5fd \uc804\uc774) \uad00\ub828 \ubcc0\ud654\uc640 \uc5f0\uad00\ub418\uc5c8\uace0, \uc5f0\uad6c\uc9c4\uc774 \uac1c\ubc1c\ud55c \ubd84\uc11d \ubaa8\ub378\uc740 \uc804\uc774 \uc5ec\ubd80 \uc608\uce21\uc5d0\uc11c \ub192\uc740 \uc815\ud655\ub3c4\ub97c \ubcf4\uc600\ub2e4.<\/li>\n<li>\uc5f0\uad6c \uacb0\uacfc\ub294 \ud608\uc561 \uae30\ubc18 \uc561\uccb4\uc0dd\uac80\uc73c\ub85c \uc804\uc774 \uc704\ud5d8\uc744 \uc608\uce21\ud558\ub294 \uc0c8\ub85c\uc6b4 \ubd84\uc790\uc9c0\ud45c \uac1c\ubc1c \uac00\ub2a5\uc131\uc744 \uc2dc\uc0ac\ud55c\ub2e4.<\/li>\n<\/ul>\n<h2>\uc0ac\uac74 \ubc30\uacbd<\/h2>\n<p>\uc804\ub9bd\uc120\uc554\uc740 \uc870\uae30 \uc9c4\ub2e8\uacfc \uce58\ub8cc\uc758 \ubc1c\ub2ec\ub85c \uc804\uccb4 \uc0dd\uc874\uc728\uc774 \uac1c\uc120\ub410\uc9c0\ub9cc, \uc77c\ubd80 \ud658\uc790\uc5d0\uc11c \uc7ac\ubc1c\uacfc \uc804\uc774\uac00 \uc5ec\uc804\ud788 \ud070 \ubb38\uc81c\ub85c \ub0a8\uc544 \uc788\ub2e4. \ud2b9\ud788 \uad6d\ub0b4 \ubc1c\uc0dd\ub960\uc740 \ube60\ub974\uac8c \uc99d\uac00\ud574 \ucd5c\uadfc \ud1b5\uacc4\uc5d0\uc11c\ub294 \ub0a8\uc131\uc554 \ubc1c\uc0dd 1\uc704\ub97c \uae30\ub85d\ud558\ub294 \ub4f1 \uc720\ubcd1\ub960 \ubcc0\ud654\uac00 \ub450\ub4dc\ub7ec\uc9c4\ub2e4. \uc804\uc774\uc131 \uc804\ub9bd\uc120\uc554\uc73c\ub85c\uc758 \uc9c4\ud589\uc740 \uce58\ub8cc \uc635\uc158\uacfc \uc608\ud6c4\uc5d0 \uc911\ub300\ud55c \uc601\ud5a5\uc744 \ubbf8\uce58\uc9c0\ub9cc, \uc774\ub97c \uc608\uce21\ud560 \uc218 \uc788\ub294 \uc2e0\ub8b0\uc131 \ub192\uc740 \ud608\uc561 \uae30\ubc18 \uc9c0\ud45c\ub294 \uc81c\ud55c\uc801\uc774\uc5c8\ub2e4. \uc804\ud1b5\uc801 \uc870\uc9c1 \uc0dd\uac80\uc740 \uce68\uc2b5\uc801\uc774\uace0 \ubc18\ubcf5\uc801 \ubaa8\ub2c8\ud130\ub9c1\uc5d0 \uc81c\ud55c\uc774 \uc788\uc5b4, \ud608\uc561\uc73c\ub85c \uc554 \uc0c1\ud0dc\ub97c \ud3c9\uac00\ud558\ub294 \uc561\uccb4\uc0dd\uac80\uc5d0 \ub300\ud55c \uc218\uc694\uac00 \ucee4\uc9c0\uace0 \uc788\ub2e4.<\/p>\n<p>\uc21c\ud658\uc885\uc591\uc138\ud3ec(CTC)\ub294 \uc6d0\ubc1c \uc885\uc591\uc5d0\uc11c \uc720\ub9ac\ub418\uc5b4 \ud608\ub958\ub97c \ud1b5\ud574 \uc804\uc774 \uac00\ub2a5\uc131\uc744 \ubc18\uc601\ud558\ub294 \uc9c0\ud45c\ub85c \uad00\uc2ec\uc744 \ubc1b\uc544\uc654\ub2e4. \ud558\uc9c0\ub9cc CTC\uc758 \uc774\uc9c8\uc131\uacfc \ub4dc\ubb38 \ube48\ub3c4\ub85c \uc778\ud574 \ud45c\uc900\ud654\ub41c \uc784\uc0c1 \uc801\uc6a9\uae4c\uc9c0\ub294 \uae30\uc220\uc801\u00b7\ubd84\uc11d\uc801 \ud55c\uacc4\uac00 \uc874\uc7ac\ud588\ub2e4. \ub2e8\uc77c\uc138\ud3ec \uae30\uc220(scRNA-seq)\uc740 \uc138\ud3ec \uc218\uc900\uc5d0\uc11c \uc720\uc804\uc790 \ubc1c\ud604\uc758 \ub2e4\uc591\uc131\uc744 \ubc1d\ud788\ub294 \ub3c4\uad6c\ub85c, \uc554\uc138\ud3ec\uc640 \uba74\uc5ed\uc138\ud3ec\uc758 \uc0c1\ud638\uc791\uc6a9\uc744 \uc815\ubc00\ud558\uac8c \ubd84\uc11d\ud560 \uc218 \uc788\ub2e4. \uc774\ubc88 \uc5f0\uad6c\ub294 \uc774\ub7ec\ud55c \ucd5c\uc2e0 \ubd84\uc790\uae30\ubc95\uc744 \ud65c\uc6a9\ud574 \ud608\uc561 \ub0b4 \ub4dc\ubb38 \uc138\ud3ec \uc9d1\ub2e8\uc758 \uc804\uc774 \uad00\ub828\uc131\uc744 \uaddc\uba85\ud558\ub824\ub294 \uc2dc\ub3c4\ub77c\ub294 \uc810\uc5d0\uc11c \uc758\ubbf8\uac00 \ud06c\ub2e4.<\/p>\n<h2>\uc8fc\uc694 \uc0ac\uac74(\uc5f0\uad6c \ubc29\ubc95\uacfc \uacb0\uacfc)<\/h2>\n<p>\uc5f0\uad6c\ud300\uc740 \uc804\ub9bd\uc120\uc554 \ud658\uc790\uc758 \ud608\uc561\uc5d0\uc11c \uc21c\ud658\uc138\ud3ec\ub97c \ucc44\ucde8\ud558\uace0 scRNA-seq\uacfc \ud45c\uc9c0\uc790 \uae30\ubc18 \ubd84\uc11d\uc744 \uacb0\ud569\ud574 \uc138\ud3ec \uc720\ud615\uc744 \ubd84\ub958\ud588\ub2e4. \ubd84\uc11d \uacfc\uc815\uc5d0\uc11c \uc804\ud615\uc801 \uba74\uc5ed\uc138\ud3ec \ud45c\uc9c0\uc790(CD45)\uc640 \uc0c1\ud53c\uc138\ud3ec \ud45c\uc9c0\uc790(KRT18)\ub97c \ub3d9\uc2dc\uc5d0 \uc9c0\ub2cc \ud558\uc774\ube0c\ub9ac\ub4dc \uc21c\ud658\uc138\ud3ec(CD45\u207aKRT18\u207a)\ub97c \ud655\uc778\ud588\ub2e4. \uc774 \uc138\ud3ec\ub4e4\uc740 \uc885\uc591\uc138\ud3ec\uc640 \uba74\uc5ed\uc138\ud3ec\uc758 \ud2b9\uc9d5\uc744 \ub3d9\uc2dc\uc5d0 \ub098\ud0c0\ub0b4\ub294 \ubcf5\ud569\uc801 \ud45c\ud604\ud615\uc744 \ubcf4\uc600\ub2e4.<\/p>\n<p>\uc720\uc804\uc790 \ubc1c\ud604 \ud328\ud134\uc744 \uc2ec\uce35 \ubd84\uc11d\ud55c \uacb0\uacfc, \ud558\uc774\ube0c\ub9ac\ub4dc \uc138\ud3ec\ub294 \ub2e8\ubc31\uc9c8 \ud569\uc131\uacfc \uad00\ub828\ub41c \uc720\uc804\uc790 \ud65c\ub3d9\uc774 \uc99d\uac00\ud55c \ubc18\uba74, \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544\u00b7\uc5d0\ub108\uc9c0 \ub300\uc0ac \uad00\ub828 \uc720\uc804\uc790\ub294 \uc0c1\ub300\uc801\uc73c\ub85c \ub0ae\uac8c \ubc1c\ud604\ub410\ub2e4. \uc774\ub7ec\ud55c \uc804\uc0ac\uccb4 \ubcc0\ud654\ub294 \uc885\uc591\uacfc \uba74\uc5ed\uacc4\uc758 \uc0c1\ud638\uc791\uc6a9 \uacfc\uc815\uc5d0\uc11c \ub098\ud0c0\ub098\ub294 \ud2b9\uc9d5\uc73c\ub85c \ud574\uc11d\ub410\ub2e4. \ub610\ud55c EMT \uad00\ub828 \uacbd\ub85c\uc640\uc758 \uc5f0\uacc4\uc131\ub3c4 \uad00\ucc30\ub418\uc5b4 \uc804\uc774 \uad00\ub828 \uc0dd\ubb3c\ud559\uc801 \ubcc0\ud654\ub97c \ubc18\uc601\ud558\ub294 \ub2e8\uc11c\ub85c \ud310\ub2e8\ub410\ub2e4.<\/p>\n<p>\uc5f0\uad6c\uc9c4\uc740 \ud558\uc774\ube0c\ub9ac\ub4dc \uc138\ud3ec\uc758 \uc720\uc804\uc790 \ubc1c\ud604\uc744 \ubc14\ud0d5\uc73c\ub85c \uc804\uc774 \uc5ec\ubd80\ub97c \uc608\uce21\ud558\ub294 \ubaa8\ub378\uc744 \uad6c\ucd95\ud588\uace0, \ub0b4\ubd80 \uac80\uc99d \uacb0\uacfc &#8216;\ub192\uc740 \uc815\ud655\ub3c4&#8217;\ub97c \ubcf4\uc600\ub2e4\uace0 \ubcf4\uace0\ud588\ub2e4. \uc5f0\uad6c\ub294 \ud608\uc561 \uac80\uc0ac\ub9cc\uc73c\ub85c \uc804\uc774 \uc704\ud5d8\uc744 \ucd94\uc815\ud560 \uc218 \uc788\ub294 \ubd84\uc790\uc9c0\ud45c\uc758 \uac00\ub2a5\uc131\uc744 \uc81c\uc2dc\ud588\uc73c\ub098, \uc800\uc790\uac00 \ubc1d\ud78c \ubc14\uc640 \uac19\uc774 \ub300\uaddc\ubaa8 \uc678\ubd80 \uac80\uc99d\uacfc \uc804\ud5a5\uc801 \uc5f0\uad6c\uac00 \ud544\uc694\ud558\ub2e4.<\/p>\n<h2>\ubd84\uc11d \ubc0f \uc758\ubbf8<\/h2>\n<p>\uccab\uc9f8, \uc774\ubc88 \uc5f0\uad6c\ub294 \uc561\uccb4\uc0dd\uac80\uc758 \uc801\uc6a9 \ubc94\uc704\ub97c \ud655\uc7a5\ud560 \uc7a0\uc7ac\ub825\uc744 \ubcf4\uc5ec\uc900\ub2e4. \ud608\uc561\uc5d0\uc11c \ub4dc\ubb38 \ud558\uc774\ube0c\ub9ac\ub4dc \uc138\ud3ec\ub97c \uaddc\uba85\ud558\uace0 \uc774\ub4e4\uc758 \uc804\uc0ac\uccb4 \ud2b9\uc9d5\uc744 \uc804\uc774 \uc608\uce21\uc5d0 \uc5f0\uacb0\ud55c \uc810\uc740, \ube44\uce68\uc2b5\uc801 \ubc29\uc2dd\uc73c\ub85c \ud658\uc790\uc758 \uc804\uc774 \uc704\ud5d8\uc744 \ucd94\uc801\ud558\ub294 \ub370 \uc911\uc694\ud55c \uc804\ud658\uc810\uc774 \ub420 \uc218 \uc788\ub2e4. \ud2b9\ud788 \ubc18\ubcf5\uc801 \ubaa8\ub2c8\ud130\ub9c1\uc774 \uc6a9\uc774\ud55c \ud608\uc561 \uae30\ubc18 \uac80\uc0ac\ub294 \uce58\ub8cc \ubc18\uc751 \ucd94\uc801\uacfc \uc870\uae30 \uac1c\uc785\uc5d0 \uc720\ub9ac\ud558\ub2e4.<\/p>\n<p>\ub458\uc9f8, \ud558\uc774\ube0c\ub9ac\ub4dc \uc138\ud3ec\uac00 \uc885\uc591-\uba74\uc5ed\uacc4 \uc0c1\ud638\uc791\uc6a9\uc744 \ubc18\uc601\ud55c\ub2e4\ub294 \uc810\uc740 \uba74\uc5ed\ud658\uacbd\uc744 \uace0\ub824\ud55c \ub9de\ucda4\ud615 \uce58\ub8cc \uc804\ub7b5 \uc218\ub9bd\uc758 \ub2e8\uc11c\ub97c \uc81c\uacf5\ud55c\ub2e4. \uba74\uc5ed \ud2b9\uc131\uc744 \ub3d9\uc2dc\uc5d0 \uc9c0\ub2cc \uc21c\ud658\uc138\ud3ec\uc758 \uc874\uc7ac\ub294 \uc804\uc774 \uacfc\uc815\uc5d0\uc11c \uba74\uc5ed\uacc4\uac00 \uc5b4\ub5a4 \uc5ed\ud560\uc744 \ud558\ub294\uc9c0\ub97c \uc124\uba85\ud560 \ucd94\uac00 \uc5f0\uad6c\uc758 \ucd9c\ubc1c\uc810\uc774 \ub41c\ub2e4. \ub2e4\ub9cc, \uc774 \uc138\ud3ec\ub4e4\uc774 \uc9c1\uc811\uc801\uc73c\ub85c \uc804\uc774\ub97c \ucd09\uc9c4\ud558\ub294\uc9c0 \ub610\ub294 \uc804\uc774\uc758 \uacb0\uacfc\ub85c \uc0dd\uc131\ub418\ub294\uc9c0\uc5d0 \ub300\ud55c \uae30\uc804 \uaddc\uba85\uc774 \ub0a8\uc544 \uc788\ub2e4.<\/p>\n<p>\uc14b\uc9f8, \uc784\uc0c1\uc801 \ud65c\uc6a9\uc744 \uc704\ud574\uc120 \uc678\ubd80 \ucf54\ud638\ud2b8\uc5d0 \ub300\ud55c \uac80\uc99d\uacfc \ud45c\uc900\ud654\ub41c \uac80\ucd9c\ubc95 \uac1c\ubc1c\uc774 \uc120\ud589\ub3fc\uc57c \ud55c\ub2e4. \ud604\uc7ac \ubcf4\uace0\ub41c &#8216;\ub192\uc740 \uc815\ud655\ub3c4&#8217;\ub294 \uc5f0\uad6c \ub0b4 \uac80\uc99d \uacb0\uacfc\ub85c \ud574\uc11d\ud574\uc57c \ud558\uba70, \ub2e4\uc591\ud55c \ud658\uc790\uad70(\uc778\uc885\u00b7\uc9c8\ud658 \ub2e8\uacc4\u00b7\uce58\ub8cc \uc774\ub825)\uc5d0 \uc801\uc6a9 \uac00\ub2a5\ud55c\uc9c0 \ud655\uc778\uc774 \ud544\uc218\uc801\uc774\ub2e4. \ub610\ud55c \uac80\uc0ac \ubbfc\uac10\ub3c4\u00b7\ud2b9\uc774\ub3c4, \ube44\uc6a9\u00b7\uc2dc\uc57d \ud45c\uc900\ud654 \ub4f1 \ud604\uc2e4\uc801 \ubcc0\uc218\ub3c4 \ud568\uaed8 \uace0\ub824\ub3fc\uc57c \uc784\uc0c1 \ub3c4\uc785\uc774 \uac00\ub2a5\ud558\ub2e4.<\/p>\n<h2>\ube44\uad50 \ubc0f \ub370\uc774\ud130<\/h2>\n<figure>\n<table>\n<thead>\n<tr>\n<th>\ud56d\ubaa9<\/th>\n<th>\uc218\uce58\/\ube44\uad50<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\uad6d\ub0b4 \uc804\ub9bd\uc120\uc554 \uc5f0\ud3c9\uade0 \uc99d\uac00\uc728<\/td>\n<td>\uc57d 13%<\/td>\n<\/tr>\n<tr>\n<td>\uc804\ub9bd\uc120\uc554 \ud658\uc790 \uc7ac\ubc1c\ub960<\/td>\n<td>\uc57d 25~30%<\/td>\n<\/tr>\n<tr>\n<td>\uc5f0\uad6c \uacb0\uacfc(\ubaa8\ub378)<\/td>\n<td>\uc804\uc774 \uc608\uce21\uc5d0\uc11c \uc5f0\uad6c \ub0b4 \ub192\uc740 \uc815\ud655\ub3c4(\uc815\ub7c9\uc218\uce58 \ubbf8\uacf5\uac1c)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n<p>\uc704 \ud45c\ub294 \ubcf8 \uae30\uc0ac\uc5d0\uc11c \ub2e4\ub8ec \ud575\uc2ec \uc218\uce58\uc640 \uc5f0\uad6c \uacb0\uacfc\uc758 \uc694\uc57d\uc774\ub2e4. \uc5f0\uad6c\uc9c4\uc740 \ubaa8\ub378\uc758 \uc815\ud655\ub3c4\ub97c \ubcf4\uace0\ud588\uc9c0\ub9cc, \uacf5\uac1c\ub41c \uc218\uce58(\uac10\ub3c4\u00b7\ud2b9\uc774\ub3c4\u00b7AUC \ub4f1)\ub294 \uc6d0\ubb38\uc5d0\uc11c \uad6c\uccb4\uc801\uc73c\ub85c \uc81c\uc2dc\ub418\uc9c0 \uc54a\uc544 \uc678\ubd80 \ube44\uad50\uc5d0\ub294 \ud55c\uacc4\uac00 \uc788\ub2e4. \ub530\ub77c\uc11c \uc218\uce58 \ube44\uad50\ub294 \ud5a5\ud6c4 \ubc1c\ud45c\ub420 \uc0c1\uc138\ud55c \uc11c\ud50c\ub9ac\uba3c\ud2b8\ub098 \ud6c4\uc18d \uc5f0\uad6c\uc5d0\uc11c \uac00\ub2a5\ud574\uc9c8 \uc804\ub9dd\uc774\ub2e4.<\/p>\n<h2>\ubc18\uc751 \ubc0f \uc778\uc6a9<\/h2>\n<p>\uc5f0\uad6c\uc9c4\uc758 \uc124\uba85\uacfc \ud568\uaed8 \uc678\ubd80 \ubc18\uc751\ub3c4 \uc8fc\ubaa9\ub41c\ub2e4. \uc815\uc7ac\uc601 \uc13c\ud130\uc7a5\uc740 \uc5f0\uad6c \uc758\uc758\uc640 \uae30\ub300\ub97c \uc694\uc57d\ud558\uba70 \ud5a5\ud6c4 \uc801\uc6a9 \uac00\ub2a5\uc131\uc744 \uc5b8\uae09\ud588\ub2e4.<\/p>\n<blockquote>\n<p>&#8220;\ud608\uc561 \uc18d \ud558\uc774\ube0c\ub9ac\ub4dc \uc21c\ud658\uc138\ud3ec\ub294 \uc885\uc591\uacfc \uba74\uc5ed\uacc4 \uac04 \uc0c1\ud638\uc791\uc6a9\uc744 \ubcf4\uc5ec\uc8fc\ub294 \uc911\uc694\ud55c \uc0dd\ubb3c\ud559\uc801 \ub2e8\uc11c\uac00 \ub420 \uc218 \uc788\ub2e4.&#8221;<\/p>\n<p><cite>\uc815\uc7ac\uc601 \uad6d\ub9bd\uc554\uc13c\ud130 \ube44\ub1e8\uae30\uc554\uc13c\ud130\uc7a5(\uc5f0\uad6c\ucc45\uc784\uc790)<\/cite><\/p><\/blockquote>\n<p>\uacf5\ub3d9\uc5f0\uad6c\ub97c \uc218\ud589\ud55c \uc5f0\uc138\ub300 \uce21\uc740 \uc784\uc0c1 \uc801\uc6a9 \uc804 \ub300\uaddc\ubaa8 \uac80\uc99d\uc758 \ud544\uc694\uc131\uc744 \uac15\uc870\ud588\ub2e4. \uc784\uc0c1 \uc801\uc6a9 \ub2e8\uacc4\uc5d0\uc11c \uc694\uad6c\ub418\ub294 \ucd94\uac00 \uac80\uc99d\uacfc \ud45c\uc900\ud654 \uc791\uc5c5\uc5d0 \ub300\ud55c \uc5b8\uae09\uc774 \uc774\uc5b4\uc84c\ub2e4.<\/p>\n<blockquote>\n<p>&#8220;\ub300\uaddc\ubaa8 \uc804\ud5a5\uc801 \ucf54\ud638\ud2b8 \uac80\uc99d\uacfc \uac80\ucd9c\ubc95 \ud45c\uc900\ud654\uac00 \uc120\ud589\ub3fc\uc57c \uc784\uc0c1\uc5d0\uc11c \ud65c\uc6a9\ud560 \uc218 \uc788\uc744 \uac83\uc774\ub2e4.&#8221;<\/p>\n<p><cite>\ud55c\ud604\ud638 \uc5f0\uc138\ub300\ud559\uad50 \uc758\uacfc\ub300\ud559(\uacf5\ub3d9\uc5f0\uad6c\uc790)<\/cite><\/p><\/blockquote>\n<h2>\n<aside>\n<details>\n<summary>\uc6a9\uc5b4\/\ubc29\ubc95\ub860<\/summary>\n<p>scRNA-seq(\ub2e8\uc77c\uc138\ud3ec RNA \uc2dc\ud000\uc2f1)\uc740 \uac1c\ubcc4 \uc138\ud3ec \uc218\uc900\uc5d0\uc11c \uc804\uc0ac\uccb4(\uc720\uc804\uc790 \ubc1c\ud604)\ub97c \ubd84\uc11d\ud574 \uc138\ud3ec \uc885\ub958\uc640 \uc0c1\ud0dc\ub97c \ubc1d\ud788\ub294 \uae30\uc220\uc774\ub2e4. \uc21c\ud658\uc885\uc591\uc138\ud3ec(CTC)\ub294 \uc6d0\ubc1c \uc885\uc591\uc5d0\uc11c \uc720\ub9ac\ub3fc \ud608\ub958\ub97c \ud1b5\ud574 \uc774\ub3d9\ud558\ub294 \uc554\uc138\ud3ec\ub85c, \uc804\uc774 \uac00\ub2a5\uc131\uc744 \ubc18\uc601\ud558\ub294 \uc0dd\ubb3c\ud559\uc801 \ud45c\uc9c0\ub85c \uc5f0\uad6c\ub41c\ub2e4. CD45\ub294 \uc8fc\ub85c \ubc31\ud608\uad6c \ub4f1 \uba74\uc5ed\uc138\ud3ec\uc5d0\uc11c \ubc1c\ud604\ub418\ub294 \ud45c\uc9c0\uc790\uc774\uace0 KRT18\uc740 \uc0c1\ud53c\uc138\ud3ec(\uc885\uc591\uc138\ud3ec \ud3ec\ud568)\uc5d0\uc11c \ubc1c\ud604\ub418\ub294 \ucf00\ub77c\ud2f4\uc774\ub2e4. EMT(\uc0c1\ud53c-\uac04\uc5fd \uc804\uc774)\ub294 \uc554\uc138\ud3ec\uac00 \uc774\ub3d9\uc131\u00b7\uce68\uc2b5\uc131\uc744 \ud68d\ub4dd\ud574 \uc804\uc774\uac00 \uac00\ub2a5\ud574\uc9c0\ub294 \uc0dd\ubb3c\ud559\uc801 \uacfc\uc815\uc73c\ub85c, \uc720\uc804\uc790\u00b7\ub2e8\ubc31\uc9c8 \uc218\uc900\uc758 \ubcc0\ud654\uac00 \ub3d9\ubc18\ub41c\ub2e4.<\/p>\n<\/details>\n<\/aside>\n<\/h2>\n<h2>\ubd88\ud655\uc2e4\ud55c \ubd80\ubd84<\/h2>\n<ul>\n<li>\uc784\uc0c1 \uc801\uc6a9 \uc2dc\uc810: \ud604\uc7ac\ub85c\uc120 \uc774 \ubd84\uc790\uc9c0\ud45c\uc758 \uc784\uc0c1 \uc801\uc6a9 \uac00\ub2a5 \uc2dc\uc810\uc774 \ubd88\uba85\uc774\uba70, \ucd94\uac00 \uc804\ud5a5\uc801 \uac80\uc99d\uc774 \ud544\uc694\ud558\ub2e4.<\/li>\n<li>\ubaa8\ub378 \uc131\ub2a5\uc758 \ubc94\uc6a9\uc131: \ubcf4\uace0\ub41c &#8216;\ub192\uc740 \uc815\ud655\ub3c4&#8217;\uac00 \ub2e4\uc591\ud55c \ud658\uc790\uad70\uacfc \uc678\ubd80 \ucf54\ud638\ud2b8\uc5d0\uc11c \ub3d9\uc77c\ud558\uac8c \uc7ac\ud604\ub418\ub294\uc9c0\ub294 \ud655\uc778\ub418\uc9c0 \uc54a\uc558\ub2e4.<\/li>\n<li>\uae30\uc804\uc758 \uc778\uacfc\uc131: \ud558\uc774\ube0c\ub9ac\ub4dc \uc138\ud3ec\uac00 \uc804\uc774\ub97c \ucd09\uc9c4\ud558\ub294 \uc9c1\uc811\uc801 \uae30\uc804\uc778\uc9c0, \uc544\ub2c8\uba74 \uc804\uc774 \uacfc\uc815\uc758 \uacb0\uacfc\uc778\uc9c0 \uba85\ud655\ud558\uc9c0 \uc54a\ub2e4.<\/li>\n<\/ul>\n<h2>\ucd1d\ud3c9<\/h2>\n<p>\uc774\ubc88 \uc5f0\uad6c\ub294 \ud608\uc561\uc5d0\uc11c \ucc44\ucde8\ud55c \ud76c\uadc0 \uc138\ud3ec \uc9d1\ub2e8\uc758 \uc804\uc0ac\uccb4\uc801 \ud2b9\uc131\uc744 \ud1b5\ud574 \uc804\ub9bd\uc120\uc554 \uc804\uc774 \uac00\ub2a5\uc131\uc744 \ucd94\uc815\ud560 \uc218 \uc788\uc74c\uc744 \ubcf4\uc5ec\uc900 \uc758\ubbf8 \uc788\ub294 \uc9c4\uc804\uc774\ub2e4. \ud2b9\ud788 CD45\u207aKRT18\u207a \ud558\uc774\ube0c\ub9ac\ub4dc \uc21c\ud658\uc138\ud3ec\ub77c\ub294 \uac1c\ub150\uc740 \uc885\uc591-\uba74\uc5ed\uacc4 \uc0c1\ud638\uc791\uc6a9\uc744 \ubc18\uc601\ud558\ub294 \uc0c8\ub85c\uc6b4 \ubd84\uc790\uc801 \ub2e8\uc11c\ub85c \uc8fc\ubaa9\ub41c\ub2e4. \ub2e4\ub9cc \uc784\uc0c1 \uc801\uc6a9\uc744 \uc704\ud574\uc120 \uc678\ubd80 \ub300\uaddc\ubaa8 \uac80\uc99d\uacfc \uac80\ucd9c\ubc95 \ud45c\uc900\ud654, \ube44\uc6a9\u00b7\ud6a8\uc6a9\uc131 \ud3c9\uac00\uac00 \ud544\uc694\ud558\ub2e4.<\/p>\n<p>\uacb0\ub860\uc801\uc73c\ub85c \uc774 \uc5f0\uad6c\ub294 \uc561\uccb4\uc0dd\uac80 \uae30\ubc18\uc758 \ub9de\ucda4\ud615 \uc804\ub9bd\uc120\uc554 \uad00\ub9ac \uc804\ub7b5 \uac1c\ubc1c\uc5d0 \uae30\uc5ec\ud560 \uc218 \uc788\ub294 \ucd08\uae30 \uc99d\uac70\ub97c \uc81c\uc2dc\ud588\ub2e4. \ud5a5\ud6c4 \ud6c4\uc18d \uc5f0\uad6c\uac00 \uacb0\uacfc\ub97c \uc7ac\ud604\ud558\uace0 \uc9c4\ub2e8\uc801\u00b7\uc608\ud6c4\uc801 \uac00\uce58\ub97c \ud655\uc99d\ud560 \uacbd\uc6b0, \ube44\uce68\uc2b5\uc801 \uac80\uc0ac\ub85c\uc11c \ud658\uc790 \uad00\ub9ac \ubc29\uc2dd\uc5d0 \uc2e4\uc9c8\uc801 \ubcc0\ud654\ub97c \uac00\uc838\uc62c \uac00\ub2a5\uc131\uc774 \uc788\ub2e4.<\/p>\n<h2>\ucd9c\ucc98<\/h2>\n<ul>\n<li><a href=\"https:\/\/m.health.chosun.com\/svc\/news_view.html?contid=2026032603252\" target=\"_blank\" rel=\"noopener\">\uc870\uc120\uc77c\ubcf4(\uc5b8\ub860) \u2014 \uc6d0\ubb38 \ubcf4\ub3c4<\/a><\/li>\n<li><a href=\"https:\/\/www.theranostics-journal.org\" target=\"_blank\" rel=\"noopener\">THERANOSTICS(\ud559\uc220\uc9c0) \u2014 \uc6d0\ubb38 \uac8c\uc7ac \ud559\uc220\uc9c0<\/a><\/li>\n<\/ul>\n<\/article>\n","protected":false},"excerpt":{"rendered":"<p>\ud575\uc2ec \uc694\uc57d: \uad6d\ub9bd\uc554\uc13c\ud130 \uc815\uc7ac\uc601 \ube44\ub1e8\uae30\uc554\uc13c\ud130\uc7a5 \uc5f0\uad6c\ud300\uc740 \ub2e8\uc77c\uc138\ud3ec RNA \uc2dc\ud000\uc2f1(scRNA-seq)\uacfc \uc21c\ud658\uc885\uc591\uc138\ud3ec(CTC) \ubd84\uc11d\uc744 \uacb0\ud569\ud574 \ud608\uc561 \uc18d\uc5d0\uc11c \uc804\ub9bd\uc120\uc554 \uc804\uc774 \uac00\ub2a5\uc131\uc744 \uc2dc\uc0ac\ud558\ub294 &#8216;CD45\u207aKRT18\u207a \ud558\uc774\ube0c\ub9ac\ub4dc \uc21c\ud658\uc138\ud3ec&#8217;\ub97c \ud655\uc778\ud588\ub2e4. \uc5f0\uad6c\ub294 \uc804\ub9bd\uc120\uc554\uc758 \uc804\uc774 \uc608\uce21\uc744 \uc704\ud55c \ubd84\uc790\uc801 \uc9c0\ud45c\ub85c \uc774 \uc138\ud3ec\uc758 \uc720\uc804\uc790 \ubc1c\ud604 \ud328\ud134\uc774 \uc720\uc6a9\ud560 \uc218 \uc788\uc74c\uc744 \ubcf4\uc600\uace0, \uc561\uccb4\uc0dd\uac80 \uae30\ubc18 \uc815\ubc00\uc758\ub8cc \ubc1c\uc804\uc5d0 \uae30\uc5ec\ud560 \uac00\ub2a5\uc131\uc774 \uc81c\uc2dc\ub410\ub2e4. \uc5f0\uad6c \uacb0\uacfc\ub294 \ud559\uc220\uc9c0 THERANOSTICS\uc5d0 \ucd5c\uadfc \uac8c\uc7ac\ub410\uc73c\uba70, \ud5a5\ud6c4 \uc784\uc0c1 \uc801\uc6a9\uc744 \uc704\ud574 &#8230; <a title=\"\ud608\uc561\uc11c \uc804\ub9bd\uc120\uc554 \uc804\uc774 \ub2e8\uc11c \ubc1c\uacac\u2026 CD45\u207aKRT18\u207a \ud558\uc774\ube0c\ub9ac\ub4dc \uc21c\ud658\uc138\ud3ec \uc8fc\ubaa9\" class=\"read-more\" href=\"https:\/\/readtrends.com\/ko\/prostate-hybrid-ctc-biomarker\/\" aria-label=\"\ud608\uc561\uc11c \uc804\ub9bd\uc120\uc554 \uc804\uc774 \ub2e8\uc11c \ubc1c\uacac\u2026 CD45\u207aKRT18\u207a \ud558\uc774\ube0c\ub9ac\ub4dc \uc21c\ud658\uc138\ud3ec \uc8fc\ubaa9\uc5d0 \ub300\ud574 \ub354 \uc790\uc138\ud788 \uc54c\uc544\ubcf4\uc138\uc694\">\ub354 \uc77d\uae30<\/a><\/p>\n","protected":false},"author":1,"featured_media":10821,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"rank_math_title":"\uc804\ub9bd\uc120\uc554 \uc804\uc774 \ub2e8\uc11c '\ud608\uc561 \ud558\uc774\ube0c\ub9ac\ub4dc \uc138\ud3ec' \ubc1c\uacac | \uba54\ub514\ub9ac\ud3ec\ud2b8","rank_math_description":"\uad6d\ub9bd\uc554\uc13c\ud130 \uc5f0\uad6c\ud300\uc774 \ud608\uc561 \ub0b4 CD45\u207aKRT18\u207a \ud558\uc774\ube0c\ub9ac\ub4dc \uc21c\ud658\uc138\ud3ec\ub97c \uaddc\uba85\ud574 \uc804\ub9bd\uc120\uc554 \uc804\uc774 \uac00\ub2a5\uc131\uc744 \uc608\uce21\ud558\ub294 \ubd84\uc790\uc9c0\ud45c\ub85c \uc81c\uc2dc\ud588\ub2e4. \uc561\uccb4\uc0dd\uac80 \ubc1c\uc804 \uac00\ub2a5\uc131\uacfc \ud5a5\ud6c4 \uac80\uc99d \ud544\uc694\uc131\uc744 \uc815\ub9ac\ud569\ub2c8\ub2e4.","rank_math_focus_keyword":"\uc804\ub9bd\uc120\uc554,\uc21c\ud658\uc885\uc591\uc138\ud3ec,\ud558\uc774\ube0c\ub9ac\ub4dc\uc138\ud3ec,\uc561\uccb4\uc0dd\uac80,EMT,scRNA-seq","footnotes":""},"categories":[2],"tags":[],"class_list":["post-10825","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-top-stories"],"_links":{"self":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/posts\/10825","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/comments?post=10825"}],"version-history":[{"count":0,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/posts\/10825\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/media\/10821"}],"wp:attachment":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/media?parent=10825"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/categories?post=10825"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/tags?post=10825"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}