{"id":12789,"date":"2026-07-03T23:02:29","date_gmt":"2026-07-03T14:02:29","guid":{"rendered":"https:\/\/readtrends.com\/ko\/kaist-smart-prodrug\/"},"modified":"2026-07-03T23:02:29","modified_gmt":"2026-07-03T14:02:29","slug":"kaist-smart-prodrug","status":"publish","type":"post","link":"https:\/\/readtrends.com\/ko\/kaist-smart-prodrug\/","title":{"rendered":"\uce58\ub9e4\ub97c \uc77c\uc73c\ud0a4\ub358 \ubb3c\uc9c8\uc774 \uc57d\uc774 \ub410\ub2e4\u2026KAIST, \ubcd1\ub4e0 \ub1cc\uc5d0\uc11c\ub9cc \uc791\ub3d9\ud558\ub294 &#8216;\uc2a4\ub9c8\ud2b8 \uce58\ub8cc\uc81c&#8217; \uac1c\ubc1c"},"content":{"rendered":"<article>\n<h2>\ud575\uc2ec \uc694\uc57d<\/h2>\n<p>KAIST \ud654\ud559\uacfc \uc784\ubbf8\ud76c \uad50\uc218 \uc5f0\uad6c\ud300\uc774 \uc54c\uce20\ud558\uc774\uba38\ubcd1 \ud658\uc790\uc758 \ub1cc\uc5d0\uc11c \uacfc\ub3c4\ud558\uac8c \uc0dd\uc131\ub418\ub294 \uacfc\uc0b0\ud654\uc218\uc18c(H\u2082O\u2082)\ub97c \uc774\uc6a9\ud574 \ubcd1\ub4e0 \ubd80\uc704\uc5d0\uc11c\ub9cc \ud65c\uc131\ud654\ub418\ub294 \uc804\uad6c\uc57d\ubb3c(prodrug)\uc744 \uac1c\ubc1c\ud588\ub2e4. \uc5f0\uad6c\ud300\uc774 \ub9cc\ub4e0 \uc804\uad6c\uc57d\ubb3c(BE-1, BE-2)\uc740 \uc815\uc0c1 \ub1cc\uc5d0\uc11c\ub294 \uac70\uc758 \ubc18\uc751\ud558\uc9c0 \uc54a\ub2e4\uac00 H\u2082O\u2082\ub97c \ub9cc\ub098 \ud65c\uc131\ud615(AP-1, AP-2)\uc73c\ub85c \uc804\ud658\ub418\uba70, \ub3d9\ubb3c\uc2e4\ud5d8\uc5d0\uc11c \ud608\uc561-\ub1cc\uc7a5\ubcbd(BBB) \ud1b5\uacfc\uc640 \uc778\uc9c0\uae30\ub2a5 \ud68c\ubcf5 \ud6a8\uacfc\ub97c \ud655\uc778\ud588\ub2e4. \uc774\ubc88 \uc131\uacfc\ub294 \uacfc\uc0b0\ud654\uc218\uc18c\ub97c \uc81c\uac70 \ub300\uc0c1\uc5d0\uc11c &#8216;\uce58\ub8cc \uc2a4\uc704\uce58&#8217;\ub85c \uc804\ud658\ud55c \uc5ed\ubc1c\uc0c1\uc774\ub77c\ub294 \uc810\uc5d0\uc11c \ucc28\uc138\ub300 \uc54c\uce20\ud558\uc774\uba38 \uce58\ub8cc \uc804\ub7b5\uc758 \uac00\ub2a5\uc131\uc744 \uc81c\uc2dc\ud55c\ub2e4.<\/p>\n<h2>\ud575\uc2ec \uc0ac\uc2e4<\/h2>\n<ul>\n<li>\uc5f0\uad6c\uae30\uad00: KAIST \ud654\ud559\uacfc(\uc784\ubbf8\ud76c \uad50\uc218) \uc8fc\ub3c4, \uc804\ub0a8\ub300 \uae40\ubbfc\uadfc \uad50\uc218, KRIBB \uc774\ucca0\ud638\u00b7\uae40\uacbd\uc2ec \ubc15\uc0ac, KBSI \uc774\uc601\ud638 \ubc15\uc0ac \ub4f1\uacfc \uacf5\ub3d9 \uc5f0\uad6c.<\/li>\n<li>\uc8fc\uc694 \uc131\uacfc: \uacfc\uc0b0\ud654\uc218\uc18c(H\u2082O\u2082)\uc5d0 \ubc18\uc751\ud574 \ud65c\uc131\ud615 \uc57d\ubb3c(AP-1, AP-2)\ub85c \uc804\ud658\ub418\ub294 \uc804\uad6c\uc57d\ubb3c(BE-1, BE-2) \uac1c\ubc1c.<\/li>\n<li>\ud559\uc220 \uac8c\uc7ac: \ub17c\ubb38\uc740 2026\ub144 5\uc6d4 31\uc77c \uad6d\uc81c\ud559\uc220\uc9c0 Small(IF 12.1)\uc5d0 \uc628\ub77c\uc778 \uac8c\uc7ac\ub428. \ub17c\ubb38\uba85\uc740 &#8220;A Prodrug Approach for Activity-Based Chemical Modulation toward Multiple Pathological Targets in Alzheimer&#8217;s Disease.&#8221;<\/li>\n<li>\ub3d9\ubb3c\uc2e4\ud5d8 \uacb0\uacfc: \uc804\uad6c\uc57d\ubb3c\uc774 BBB\ub97c \ud1b5\uacfc\ud574 \ub1cc \ub0b4\uc5d0\uc11c \ud65c\uc131\ud654\ub418\uc5c8\uace0, \ud574\ub9c8\uc758 \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4\uc640 \uc544\ubc00\ub85c\uc774\ub4dc \ubca0\ud0c0 \ucd95\uc801\uc774 \uac10\uc18c\ud588\uc73c\uba70 \ud589\ub3d9\uc2dc\ud5d8\uc5d0\uc11c \uc778\uc9c0\uae30\ub2a5\uc774 \uac1c\uc120\ub428.<\/li>\n<li>\uc791\ub3d9 \uc6d0\ub9ac: \uc9c8\ubcd1 \uc0c1\ud0dc\uc5d0\uc11c \uc99d\ub300\ub418\ub294 \ud65c\uc131\uc0b0\uc18c(\uacfc\uc0b0\ud654\uc218\uc18c)\ub97c \uc57d\ubb3c \ud65c\uc131\ud654\uc758 \ud2b8\ub9ac\uac70\ub85c \ud65c\uc6a9, \uc815\uc0c1 \uc870\uc9c1\uc5d0 \ub300\ud55c \uc57d\ubb3c \ub178\ucd9c\u00b7\ubd80\uc791\uc6a9\uc744 \ucd5c\uc18c\ud654\ud558\ub3c4\ub85d \uc124\uacc4.<\/li>\n<\/ul>\n<h2>\uc0ac\uac74 \ubc30\uacbd<\/h2>\n<p>\uc54c\uce20\ud558\uc774\uba38\ubcd1\uc740 \uc544\ubc00\ub85c\uc774\ub4dc \ubca0\ud0c0 \ub2e8\ubc31\uc9c8\uc758 \uc751\uc9d1\uacfc \uc2e0\uacbd\uc138\ud3ec \uc190\uc0c1, \uadf8\ub9ac\uace0 \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4 \uc99d\uac00\uac00 \ubcf5\ud569\uc801\uc73c\ub85c \uc791\uc6a9\ud574 \ubc1c\ubcd1\u00b7\uc9c4\ud589\ub418\ub294 \uac83\uc73c\ub85c \uc54c\ub824\uc838 \uc788\ub2e4. \ud2b9\ud788 \ud65c\uc131\uc0b0\uc18c\uc885(ROS) \uc911 \uacfc\uc0b0\ud654\uc218\uc18c\ub294 \ubcd1\ub4e0 \ub1cc\uc5d0\uc11c \uc0c1\ub300\uc801\uc73c\ub85c \uacfc\ub2e4 \uc0dd\uc131\ub418\uc5b4 \uc138\ud3ec \uc190\uc0c1\uc744 \ucd09\uc9c4\ud558\uc9c0\ub9cc, \uae30\uc874 \uce58\ub8cc \uc5f0\uad6c\uc758 \ub9ce\uc740 \ubd80\ubd84\uc740 \uc774\ub97c \uc81c\uac70\ud558\ub294 \ucabd\uc5d0 \uc9d1\uc911\ub3fc \uc654\ub2e4. \ubc18\ubcf5\ub41c \uc784\uc0c1 \uc2e4\ud328\uc640 \ud45c\uc801 \ub2e8\ubc31\uc9c8 \ud558\ub098\ub9cc\uc744 \uaca8\ub0e5\ud55c \uc804\ub7b5\uc758 \ud55c\uacc4\uac00 \ub4dc\ub7ec\ub098\uba74\uc11c, \uc9c8\ubcd1 \ud2b9\uc774\uc801 \ud658\uacbd\uc744 \uc774\uc6a9\ud574 \uc57d\ubb3c\uc758 \uc791\ub3d9\uc744 \uc81c\uc5b4\ud558\ub294 \uc811\uadfc\ubc95\uc774 \uc8fc\ubaa9\ubc1b\uae30 \uc2dc\uc791\ud588\ub2e4.<\/p>\n<p>\uc804\uad6c\uc57d\ubb3c(prodrug)\uc740 \uc0dd\uccb4 \ub0b4 \ud2b9\uc815 \ud658\uacbd\uc5d0\uc11c\ub9cc \ud65c\uc131\ud615 \uc57d\ubb3c\ub85c \uc804\ud658\ub418\ub294 \uc57d\ubb3c \uc124\uacc4 \uac1c\ub150\uc73c\ub85c, \uacfc\uac70\uc5d0\ub294 \uc8fc\ub85c \ud6a8\uc18c\u00b7pH\u00b7\uc800\uc0b0\uc18c \ud658\uacbd\uc744 \ud65c\uc6a9\ud55c \uc0ac\ub840\uac00 \uc5f0\uad6c\ub3fc \uc654\ub2e4. \uc774\ubc88 \uc5f0\uad6c\ub294 \uacfc\uc0b0\ud654\uc218\uc18c\ub97c \ud65c\uc131\ud654 \uc2e0\ud638\ub85c \uc0bc\uc544 \ub1cc\uc9c8\ud658 \ud2b9\uc774\uc801 \uc870\uac74\uc5d0\uc11c\ub9cc \uc791\ub3d9\ud558\ub294 \uc804\uad6c\uc57d\ubb3c \ud50c\ub7ab\ud3fc\uc744 \uc81c\uc2dc\ud588\ub2e4\ub294 \uc810\uc5d0\uc11c \uae30\uc874 \uc804\uad6c\uc57d\ubb3c \uc5f0\uad6c\uc640 \ucc28\ubcc4\ud654\ub41c\ub2e4. \uc5f0\uad6c\uc5d0\ub294 \ud569\uc131\ud654\ud559, \uc0dd\ud654\ud559\uc801 \ubd84\uc11d, \ud589\ub3d9\uc2e0\uacbd\uacfc\ud559\uc744 \uc544\uc6b0\ub974\ub294 \ub2e4\ud559\uc81c\uc801 \uc811\uadfc\uc774 \uc801\uc6a9\ub410\ub2e4.<\/p>\n<h2>\uc8fc\uc694 \uc0ac\uac74<\/h2>\n<p>\uc5f0\uad6c\ud300\uc740 \uba3c\uc800 \uacfc\uc0b0\ud654\uc218\uc18c\uc5d0 \uc120\ud0dd\uc801\uc73c\ub85c \ubc18\uc751\ud558\ub294 \uae30\uc804\uc73c\ub85c BE-1\uacfc BE-2\ub77c\ub294 \uc804\uad6c\uc57d\ubb3c\uc744 \uc124\uacc4\u00b7\ud569\uc131\ud588\ub2e4. \ub450 \ubb3c\uc9c8\uc740 \ud22c\uc5ec \uc9c1\ud6c4\uc5d0\ub294 \uc57d\ud6a8\uac00 \ubbf8\ubbf8\ud558\uc9c0\ub9cc, H\u2082O\u2082 \ub18d\ub3c4\uac00 \ub192\uc740 \ubcd1\ubcc0 \ud658\uacbd\uc5d0\uc11c \ud654\ud559\ubc18\uc751\uc744 \uac70\uccd0 \ud65c\uc131\ud615 \ubd84\uc790(AP-1, AP-2)\ub85c \uc804\ud658\ub418\ub3c4\ub85d \uc124\uacc4\ub410\ub2e4. \ud569\uc131 \ud6c4 in vitro \ubd84\uc11d\uc744 \ud1b5\ud574 H\u2082O\u2082 \uc874\uc7ac \ud558\uc5d0\uc11c \uc804\ud658\uc774 \uc77c\uc5b4\ub0a8\uc744 \ud655\uc778\ud588\ub2e4.<\/p>\n<p>\uc774\uc5b4 \ub3d9\ubb3c\uc2e4\ud5d8\uc5d0\uc11c \uc804\uad6c\uc57d\ubb3c\uc758 \uc57d\ub3d9\ud559\uc801 \ud2b9\uc131\uacfc BBB \ud22c\uacfc\uc131\uc744 \ud3c9\uac00\ud588\ub2e4. \uc5f0\uad6c\ud300\uc740 \uc804\uad6c\uc57d\ubb3c\uc774 \ud608\uc911\uc5d0\uc11c \uc548\uc815\ud558\uac8c \uc6b4\ubc18\ub418\uba70 BBB\ub97c \ud1b5\uacfc\ud574 \ub1cc\uc2e4\uc9c8\uc5d0 \ub3c4\ub2ec\ud55c \ub4a4, \ub1cc \ub0b4 \uacfc\uc0b0\ud654\uc218\uc18c\uc5d0 \uc758\ud574 \ud65c\uc131\ud615\uc73c\ub85c \uc804\ud658\ub418\ub294 \uac83\uc744 \uac80\uc99d\ud588\ub2e4. \ud65c\uc131\ud615 \uc57d\ubb3c\uc740 \uc544\ubc00\ub85c\uc774\ub4dc \ubca0\ud0c0 \ub2e8\ubc31\uc9c8\uc758 \uc751\uc9d1\uc744 \uc5b5\uc81c\ud558\uace0, \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4\ub97c \uc9c1\uc811\uc801\uc73c\ub85c \uc644\ud654\ud558\ub294 \uc791\uc6a9\uc744 \ubcf4\uc600\ub2e4.<\/p>\n<p>\ud589\ub3d9\ud559\uc801 \ud3c9\uac00\uc5d0\uc11c\ub294 \uc54c\uce20\ud558\uc774\uba38 \ubaa8\ub378 \uc0dd\uc950\uc5d0\uac8c \uc7a5\uae30\uac04 \ucc98\uce58\ud55c \uacb0\uacfc, \ud574\ub9c8\uc758 \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4 \uc9c0\ud45c \uac10\uc18c\uc640 \ud568\uaed8 \uc544\ubc00\ub85c\uc774\ub4dc \ubca0\ud0c0 \ucd95\uc801 \uac10\uc18c\uac00 \uad00\ucc30\ub418\uc5c8\uace0, \uc0c8\ub85c\uc6b4 \ubb3c\uccb4 \uc778\uc9c0 \ud14c\uc2a4\ud2b8\uc640 \ubbf8\ub85c \uc2dc\ud5d8\uc5d0\uc11c \uae30\uc5b5\u00b7\ud559\uc2b5 \uc131\ub2a5\uc774 \uac1c\uc120\ub418\uc5c8\ub2e4. \uc5f0\uad6c\ud300\uc740 \uc774\ub7ec\ud55c \uacb0\uacfc\ub97c \ud1b5\ud574 \uc804\uad6c\uc57d\ubb3c \uc811\uadfc\ubc95\uc774 \ub2e8\uc21c \ud56d\uc0b0\ud654\uc81c \uc774\uc0c1\uc73c\ub85c \ubcd1\ub9ac\uc801 \uc751\uc9d1 \uacfc\uc815\uc744 \uc5b5\uc81c\ud558\ub294 \ub2e4\uc911 \ud45c\uc801 \ud6a8\uacfc\ub97c \uac16\ub294\ub2e4\uace0 \uc124\uba85\ud588\ub2e4.<\/p>\n<h2>\ubd84\uc11d \ubc0f \uc758\ubbf8<\/h2>\n<p>\uc774\ubc88 \uc5f0\uad6c\ub294 \uc9c8\ubcd1 \ud2b9\uc774\uc801 \ud654\ud559\ud658\uacbd\uc744 \uc57d\ubb3c \ud65c\uc131\ud654 \uc2e0\ud638\ub85c \uc804\ud658\ud558\ub294 \uac1c\ub150\uc801 \uc804\ud658\uc744 \uc81c\uc2dc\ud55c\ub2e4. \uacfc\uc0b0\ud654\uc218\uc18c\ub294 \uc804\ud1b5\uc801\uc73c\ub85c \uc81c\uac70 \ub300\uc0c1\uc774\uc5c8\uc9c0\ub9cc, \uc5f0\uad6c\ud300\uc740 \uc774\ub97c &#8216;\uce58\ub8cc \uc2a4\uc704\uce58&#8217;\ub85c \uc7ac\ud574\uc11d\ud574 \uc57d\ubb3c\uc758 \uc120\ud0dd\uc131\uacfc \uc548\uc804\uc131\uc744 \ub3d9\uc2dc\uc5d0 \ub192\uc774\ub294 \uc124\uacc4\ub97c \uc81c\uc2dc\ud588\ub2e4. \uc774\ub294 \ud45c\uc801 \ub2e8\ubc31\uc9c8 \ud558\ub098\ub9cc\uc744 \uaca8\ub0e5\ud558\ub294 \uae30\uc874 \uc804\ub7b5\uc758 \ud55c\uacc4\ub97c \ubcf4\uc644\ud558\ub294 \ubc29\uc2dd\uc774\ub2e4.<\/p>\n<p>\uc784\uc0c1 \uac1c\ubc1c \uad00\uc810\uc5d0\uc11c \uc911\uc694\ud55c \uc7a5\uc810\uc740 \uc815\uc0c1 \uc870\uc9c1\uc5d0\uc11c \uc57d\ubb3c\uc774 \ube44\ud65c\uc131 \uc0c1\ud0dc\ub85c \uc720\uc9c0\ub41c\ub2e4\ub294 \uc810\uc774\ub2e4. \ub9ce\uc740 \uc2e0\uacbd\uacc4 \uc57d\ubb3c\uc740 BBB \ud22c\uacfc\uc640 \uc804\uc2e0 \ubd80\uc791\uc6a9\uc73c\ub85c \uc784\uc0c1 \uac1c\ubc1c\uc5d0 \uc2e4\ud328\ud588\ub294\ub370, \uc804\uad6c\uc57d\ubb3c \ud50c\ub7ab\ud3fc\uc740 \ubcd1\ubcc0 \uc601\uc5ed\uc5d0\uc11c\ub9cc \ud65c\uc131\ud654\ub3fc \uce58\ub8cc \ud6a8\uacfc\ub294 \uc720\uc9c0\ud558\uba74\uc11c \uc804\uc2e0 \ub3c5\uc131\uc744 \ub0ae\ucd9c \uac00\ub2a5\uc131\uc774 \uc788\ub2e4. \ub2e4\ub9cc \ub3d9\ubb3c\ubaa8\ub378 \uc131\uacf5\uc774 \uace7\ubc14\ub85c \uc0ac\ub78c\uc5d0\uc11c\uc758 \uc548\uc804\uc131\u00b7\ud6a8\ub2a5\uc744 \ubcf4\uc7a5\ud558\uc9c0\ub294 \uc54a\ub294\ub2e4.<\/p>\n<p>\ub610\ud55c \ud65c\uc131\ud654 \ud6c4 \uc57d\ubb3c\uc774 \uc544\ubc00\ub85c\uc774\ub4dc \ubca0\ud0c0 \uc751\uc9d1\uc744 \uc5b5\uc81c\ud588\ub2e4\ub294 \uacb0\uacfc\ub294 \ub2e8\uc77c \ud45c\uc801 \uc5b5\uc81c \uc774\uc0c1\uc758 \ubcd1\ub9ac \uc218\uc815 \uac00\ub2a5\uc131\uc744 \uc2dc\uc0ac\ud55c\ub2e4. \uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4 \uc644\ud654\uc640 \uc751\uc9d1 \uc5b5\uc81c\uac00 \ubcd1\ub9ac \uacbd\ub85c\uc758 \uc11c\ub85c \ub2e4\ub978 \ucd95\uc5d0 \ub3d9\uc2dc\uc5d0 \uc791\uc6a9\ud558\uba74 \uc784\uc0c1\uc801 \uc774\ub4dd\uc774 \ub354 \ud074 \uc218 \uc788\ub2e4. \ub2e4\ub9cc \uc5b4\ub5a4 \ud658\uc790\uad70\uc5d0\uc11c, \uc5b4\ub5a4 \ubcd1\uae30\uc5d0\uc11c \uac00\uc7a5 \ud6a8\uacfc\uc801\uc77c\uc9c0\ub294 \ucd94\uac00 \uc5f0\uad6c\uac00 \ud544\uc694\ud558\ub2e4.<\/p>\n<h2>\ube44\uad50 \ubc0f \ub370\uc774\ud130<\/h2>\n<figure>\n<table>\n<thead>\n<tr>\n<th>\uad6c\ubd84<\/th>\n<th>\uc804\uad6c\uc57d\ubb3c(BE-1\/BE-2)<\/th>\n<th>\ud65c\uc131\uccb4(AP-1\/AP-2)<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\ud65c\uc131\ud654 \ud2b8\ub9ac\uac70<\/td>\n<td>\uacfc\uc0b0\ud654\uc218\uc18c(H\u2082O\u2082)<\/td>\n<td>\uc774\ubbf8 \ud65c\uc131\ud654\ub41c \uce58\ub8cc\uc131\ubd84<\/td>\n<\/tr>\n<tr>\n<td>\uc815\uc0c1\uc870\uc9c1 \ubc18\uc751<\/td>\n<td>\uac70\uc758 \ube44\ud65c\uc131<\/td>\n<td>\ud574\ub2f9 \uc5c6\uc74c<\/td>\n<\/tr>\n<tr>\n<td>\ubaa9\ud45c \ubcd1\ub9ac<\/td>\n<td>\uc0b0\ud654 \uc2a4\ud2b8\ub808\uc2a4\u00b7\uc544\ubc00\ub85c\uc774\ub4dc \uc751\uc9d1<\/td>\n<td>\uc0b0\ud654 \uc644\ud654\u00b7\uc751\uc9d1 \uc5b5\uc81c<\/td>\n<\/tr>\n<tr>\n<td>\ub3d9\ubb3c\uc2e4\ud5d8 \uacb0\uacfc<\/td>\n<td>BBB \ud1b5\uacfc \ubc0f \ub1cc \ub0b4 \uc804\ud658 \ud655\uc778<\/td>\n<td>\uc778\uc9c0\uae30\ub2a5 \uac1c\uc120 \uad00\ucc30<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n<p>\uc704 \ud45c\ub294 \uc5f0\uad6c\ud300\uc774 \ubcf4\uace0\ud55c \uc804\uad6c\uc57d\ubb3c\uacfc \ud65c\uc131\uccb4\uc758 \uc124\uacc4\u00b7\uae30\ub2a5\uc801 \ucc28\uc774\ub97c \uc694\uc57d\ud55c \uac83\uc774\ub2e4. \uc218\uce58\ud654\ub41c \ud6a8\ub2a5(\uc608: \ucd95\uc801 \uac10\uc18c \ube44\uc728 \ub4f1)\uc740 \uc6d0\ubb38 \ub17c\ubb38\uc744 \ud1b5\ud574 \uc0c1\uc138\ud788 \ud655\uc778\ud560 \ud544\uc694\uac00 \uc788\ub2e4.<\/p>\n<h2>\ubc18\uc751 \ubc0f \uc778\uc6a9<\/h2>\n<p>\uc5f0\uad6c \ubc1c\ud45c \uc9c1\ud6c4 \uc5f0\uad6c\ud300\uacfc \uacf5\ub3d9\uc5f0\uad6c\uc790\ub4e4\uc740 \uc774\ubc88 \uc811\uadfc\ubc95\uc758 \uc758\ubbf8\ub97c \uc124\uba85\ud588\ub2e4.<\/p>\n<blockquote>\n<p>&#8220;\uadf8\ub3d9\uc548 \uc81c\uac70 \ub300\uc0c1\uc73c\ub85c\ub9cc \uc5ec\uaca8\uc84c\ub358 \uacfc\uc0b0\ud654\uc218\uc18c\ub97c \uc57d\uc744 \uc791\ub3d9\uc2dc\ud0a4\ub294 \uc2e0\ud638\ub85c \ud65c\uc6a9\ud588\ub2e4\ub294 \uc810\uc5d0\uc11c \ud070 \uc758\ubbf8\uac00 \uc788\ub2e4.&#8221;<\/p>\n<p><cite>\uc784\ubbf8\ud76c \uad50\uc218, KAIST \ud654\ud559\uacfc(\uc5f0\uad6c\ucc45\uc784\uc790)<\/cite><\/p><\/blockquote>\n<blockquote>\n<p>&#8220;\ub3d9\ubb3c\uc2e4\ud5d8\uc5d0\uc11c \uc804\uad6c\uc57d\ubb3c\uc774 BBB\ub97c \ud1b5\uacfc\ud574 \ub1cc\uc5d0\uc11c \ud65c\uc131\ud654\ub418\ub294 \uac83\uc744 \ud655\uc778\ud588\uc73c\uba70, \uc778\uc9c0 \uae30\ub2a5 \uac1c\uc120\uae4c\uc9c0 \ud655\uc778\ub41c \uc810\uc774 \uace0\ubb34\uc801\uc774\ub2e4.&#8221;<\/p>\n<p><cite>\uc774\uc9c0\ubbfc \ubc15\uc0ac\uacfc\uc815(\uacf5\ub3d9 \uc81c1\uc800\uc790)<\/cite><\/p><\/blockquote>\n<blockquote>\n<p>&#8220;\uc804\uad6c\uc57d\ubb3c \ubc29\uc2dd\uc740 \uc548\uc804\uc131 \ud504\ub85c\ud30c\uc77c\uc744 \uac1c\uc120\ud560 \uc218 \uc788\ub294 \uc7a0\uc7ac\ub825\uc774 \uc788\uc73c\ub098, \uc778\uac04 \ub300\uc0c1 \uc784\uc0c1\uc5d0\uc11c\uc758 \uc57d\ub3d9\ud559\u00b7\uc548\uc804\uc131 \uac80\uc99d\uc774 \ud544\uc694\ud558\ub2e4.&#8221;<\/p>\n<p><cite>\uc5f0\uad6c\ud300 \ubc1c\ud45c \uc694\uc57d(\uc5f0\uad6c\uc9c4\uc758 \uacf5\ud1b5 \ud3c9\uac00)<\/cite><\/p><\/blockquote>\n<h2>\n<aside>\n<details>\n<summary>\uc6a9\uc5b4\/\ubc29\ubc95\ub860<\/summary>\n<p>\uc804\uad6c\uc57d\ubb3c(prodrug)\uc740 \ud22c\uc5ec \uc2dc\uc5d0\ub294 \ube44\ud65c\uc131 \uc0c1\ud0dc\ub85c \uc874\uc7ac\ud558\ub2e4\uac00 \uc870\uc9c1 \ud2b9\uc774\uc801 \ud658\uacbd(\ud6a8\uc18c, pH, \uc0b0\ud654\ud658\uc6d0 \uc870\uac74 \ub4f1)\uc5d0 \uc758\ud574 \ud65c\uc131\ud615 \uc57d\ubb3c\ub85c \uc804\ud658\ub418\ub294 \uc758\uc57d\ud488 \uc124\uacc4 \ubc29\uc2dd\uc774\ub2e4. \ubcf8 \uc5f0\uad6c\uc5d0\uc11c\ub294 \uacfc\uc0b0\ud654\uc218\uc18c(H\u2082O\u2082)\ub97c \ud654\ud559\uc801 \ud2b8\ub9ac\uac70\ub85c \uc774\uc6a9\ud574 \uc54c\uce20\ud558\uc774\uba38 \ubcd1\ubcc0\uc5d0\uc11c\ub9cc \ud65c\uc131\ud654\ub418\ub294 \uc2dc\uc2a4\ud15c\uc744 \uad6c\ud604\ud588\ub2e4. BBB(\ud608\uc561-\ub1cc\uc7a5\ubcbd)\ub294 \ud608\uc561\uacfc \ub1cc\uc870\uc9c1 \uc0ac\uc774\uc758 \uc120\ud0dd\uc801 \uc7a5\ubcbd\uc73c\ub85c \uc57d\ubb3c\uc758 \ub1cc \ub3c4\ub2ec\uc744 \uc81c\ud55c\ud558\ub294 \uc8fc\uc694 \uc7a5\uc560\ubb3c\uc774\uba70, \ubcf8 \uc5f0\uad6c\ub294 \uc804\uad6c\uc57d\ubb3c\uc774 BBB\ub97c \ud1b5\uacfc\ud55c \ub4a4 \ub1cc \ub0b4\uc5d0\uc11c \ud65c\uc131\ud654\ub428\uc744 \ud655\uc778\ud588\ub2e4.<\/p>\n<\/details>\n<\/aside>\n<\/h2>\n<h2>\ubd88\ud655\uc2e4\ud55c \ubd80\ubd84<\/h2>\n<ul>\n<li>\uc784\uc0c1 \uc804\uc784\uc0c1(\ub3d9\ubb3c) \uacb0\uacfc\uac00 \uc778\uac04 \uc784\uc0c1 \ud6a8\ub2a5\u00b7\uc548\uc804\uc131\uc73c\ub85c \uc774\uc5b4\uc9c8\uc9c0\ub294 \uc544\uc9c1 \ud655\uc778\ub418\uc9c0 \uc54a\uc558\ub2e4.<\/li>\n<li>BE-1\u00b7BE-2\uc758 \uc7a5\uae30 \ub3c5\uc131 \ud504\ub85c\ud30c\uc77c\uacfc \ub300\uc0ac \uacbd\ub85c\uc5d0 \ub300\ud55c \uc0c1\uc138 \ub370\uc774\ud130\ub294 \uacf5\uac1c\ub41c \ubc94\uc704\uc5d0\uc11c \uc81c\ud55c\uc801\uc774\ub2e4.<\/li>\n<li>\uc5b4\ub5a4 \ubcd1\uae30(\ucd08\uae30\u00b7\uc911\ub4f1\ub3c4\u00b7\ub9d0\uae30)\uc758 \ud658\uc790\uc5d0 \uac00\uc7a5 \uc801\ud569\ud55c\uc9c0, \uadf8\ub9ac\uace0 \ub3d9\ubc18 \uc9c8\ud658\uc774 \uc788\ub294 \ud658\uc790\uad70\uc5d0\uc11c\uc758 \uc791\uc6a9\uc131\uc740 \ucd94\uac00 \uac80\uc99d\uc774 \ud544\uc694\ud558\ub2e4.<\/li>\n<\/ul>\n<h2>\ucd1d\ud3c9<\/h2>\n<p>\uc774\ubc88 KAIST \uc5f0\uad6c\ub294 \uacfc\uc0b0\ud654\uc218\uc18c\ub77c\ub294 \ubcd1\ub9ac\ud559\uc801 \ud45c\uc9c0\ub97c \uc57d\ubb3c \ud65c\uc131\ud654\uc758 \uc2e0\ud638\ub85c \uc804\ud658\ud55c \uc810\uc5d0\uc11c \uac1c\ub150\uc801 \uc804\ud658\uc744 \uc774\ub918\ub2e4. \uc804\uad6c\uc57d\ubb3c \uc124\uacc4\ub294 \uce58\ub8cc\uc758 \uc120\ud0dd\uc131\uc744 \ub192\uc774\uace0 \uc815\uc0c1 \uc870\uc9c1\uc5d0 \ub300\ud55c \ubd80\uc791\uc6a9\uc744 \uc904\uc77c \uc218 \uc788\ub294 \uc7a5\uc810\uc744 \uac16\ub294\ub2e4. \ub3d9\ubb3c\ubaa8\ub378 \uc218\uc900\uc5d0\uc11c\uc758 \uc778\uc9c0\uae30\ub2a5 \uac1c\uc120\uacfc \uc544\ubc00\ub85c\uc774\ub4dc \ucd95\uc801 \uac10\uc18c\ub294 \uc804\uc784\uc0c1 \ub2e8\uacc4\uc5d0\uc11c \uc758\ubbf8 \uc788\ub294 \uc131\uacfc\ub85c \ud3c9\uac00\ub41c\ub2e4.<\/p>\n<p>\uadf8\ub7ec\ub098 \ub3d9\ubb3c\uc2e4\ud5d8 \uc131\uacf5\uc774 \uace7\ubc14\ub85c \uc784\uc0c1 \uc131\uacf5\uc73c\ub85c \uc9c1\uacb0\ub418\uc9c0\ub294 \uc54a\ub294\ub2e4. \ud5a5\ud6c4 \uacfc\uc81c\ub294 \uc0ac\ub78c\uc5d0\uc11c\uc758 \uc57d\ub3d9\ud559\u00b7\ub3c5\uc131 \ud3c9\uac00, \uc801\uc815 \uc6a9\ubc95 \ud655\ubcf4, \uadf8\ub9ac\uace0 \ub2e4\uc591\ud55c \ubcd1\uae30\u00b7\ud658\uc790\uad70\uc5d0\uc11c\uc758 \ud6a8\ub2a5 \uac80\uc99d\uc774\ub2e4. \uadf8\ub7fc\uc5d0\ub3c4 \ubd88\uad6c\ud558\uace0 \uc774\ubc88 \uc5f0\uad6c\ub294 \uc54c\uce20\ud558\uc774\uba38\ub97c \ud3ec\ud568\ud55c \ud1f4\ud589\uc131 \ub1cc\uc9c8\ud658\uc758 \uce58\ub8cc \ud328\ub7ec\ub2e4\uc784\uc744 \ud655\uc7a5\ud560 \uc218 \uc788\ub294 \uc0c8\ub85c\uc6b4 \ud50c\ub7ab\ud3fc\uc744 \uc81c\uc2dc\ud588\ub2e4\ub294 \uc810\uc5d0\uc11c \uc8fc\ubaa9\ud560 \ub9cc\ud558\ub2e4.<\/p>\n<h2>\ucd9c\ucc98<\/h2>\n<ul>\n<li><a href=\"http:\/\/www.e-patentnews.com\/14944\" target=\"_blank\" rel=\"noopener\">\ud2b9\ud5c8\ub274\uc2a4(\uc5b8\ub860 \ubcf4\ub3c4)<\/a> \u2014 \uc5f0\uad6c \ubc1c\ud45c \ubcf4\ub3c4<\/li>\n<li><a href=\"https:\/\/onlinelibrary.wiley.com\/journal\/16130028\" target=\"_blank\" rel=\"noopener\">Small (\ud559\uc220\uc9c0)<\/a> \u2014 \ud559\uc220 \ub17c\ubb38 \uac8c\uc7ac(2026\ub144 5\uc6d4 31\uc77c \uc628\ub77c\uc778)<\/li>\n<\/ul>\n<\/article>\n","protected":false},"excerpt":{"rendered":"<p>\ud575\uc2ec \uc694\uc57d KAIST \ud654\ud559\uacfc \uc784\ubbf8\ud76c \uad50\uc218 \uc5f0\uad6c\ud300\uc774 \uc54c\uce20\ud558\uc774\uba38\ubcd1 \ud658\uc790\uc758 \ub1cc\uc5d0\uc11c \uacfc\ub3c4\ud558\uac8c \uc0dd\uc131\ub418\ub294 \uacfc\uc0b0\ud654\uc218\uc18c(H\u2082O\u2082)\ub97c \uc774\uc6a9\ud574 \ubcd1\ub4e0 \ubd80\uc704\uc5d0\uc11c\ub9cc \ud65c\uc131\ud654\ub418\ub294 \uc804\uad6c\uc57d\ubb3c(prodrug)\uc744 \uac1c\ubc1c\ud588\ub2e4. \uc5f0\uad6c\ud300\uc774 \ub9cc\ub4e0 \uc804\uad6c\uc57d\ubb3c(BE-1, BE-2)\uc740 \uc815\uc0c1 \ub1cc\uc5d0\uc11c\ub294 \uac70\uc758 \ubc18\uc751\ud558\uc9c0 \uc54a\ub2e4\uac00 H\u2082O\u2082\ub97c \ub9cc\ub098 \ud65c\uc131\ud615(AP-1, AP-2)\uc73c\ub85c \uc804\ud658\ub418\uba70, \ub3d9\ubb3c\uc2e4\ud5d8\uc5d0\uc11c \ud608\uc561-\ub1cc\uc7a5\ubcbd(BBB) \ud1b5\uacfc\uc640 \uc778\uc9c0\uae30\ub2a5 \ud68c\ubcf5 \ud6a8\uacfc\ub97c \ud655\uc778\ud588\ub2e4. \uc774\ubc88 \uc131\uacfc\ub294 \uacfc\uc0b0\ud654\uc218\uc18c\ub97c \uc81c\uac70 \ub300\uc0c1\uc5d0\uc11c &#8216;\uce58\ub8cc \uc2a4\uc704\uce58&#8217;\ub85c \uc804\ud658\ud55c \uc5ed\ubc1c\uc0c1\uc774\ub77c\ub294 \uc810\uc5d0\uc11c \ucc28\uc138\ub300 \uc54c\uce20\ud558\uc774\uba38 \uce58\ub8cc \uc804\ub7b5\uc758 \uac00\ub2a5\uc131\uc744 &#8230; <a title=\"\uce58\ub9e4\ub97c \uc77c\uc73c\ud0a4\ub358 \ubb3c\uc9c8\uc774 \uc57d\uc774 \ub410\ub2e4\u2026KAIST, \ubcd1\ub4e0 \ub1cc\uc5d0\uc11c\ub9cc \uc791\ub3d9\ud558\ub294 &#8216;\uc2a4\ub9c8\ud2b8 \uce58\ub8cc\uc81c&#8217; \uac1c\ubc1c\" class=\"read-more\" href=\"https:\/\/readtrends.com\/ko\/kaist-smart-prodrug\/\" aria-label=\"\uce58\ub9e4\ub97c \uc77c\uc73c\ud0a4\ub358 \ubb3c\uc9c8\uc774 \uc57d\uc774 \ub410\ub2e4\u2026KAIST, \ubcd1\ub4e0 \ub1cc\uc5d0\uc11c\ub9cc \uc791\ub3d9\ud558\ub294 &#8216;\uc2a4\ub9c8\ud2b8 \uce58\ub8cc\uc81c&#8217; \uac1c\ubc1c\uc5d0 \ub300\ud574 \ub354 \uc790\uc138\ud788 \uc54c\uc544\ubcf4\uc138\uc694\">\ub354 \uc77d\uae30<\/a><\/p>\n","protected":false},"author":1,"featured_media":12788,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"rank_math_title":"\uce58\ub9e4 \uc720\ubc1c\ubb3c\uc9c8\uc744 \uce58\ub8cc \uc2e0\ud638\ub85c\u2026KAIST '\uc2a4\ub9c8\ud2b8 \uc804\uad6c\uc57d\ubb3c' \uac1c\ubc1c | \ud2b9\ud5c8\ub274\uc2a4","rank_math_description":"KAIST \uc5f0\uad6c\uc9c4\uc774 \uacfc\uc0b0\ud654\uc218\uc18c(H\u2082O\u2082)\ub97c \ud65c\uc131\ud654 \uc2e0\ud638\ub85c \uc0bc\ub294 \uc804\uad6c\uc57d\ubb3c BE-1\u00b7BE-2\ub97c \uac1c\ubc1c\ud588\ub2e4. \ub3d9\ubb3c\uc2e4\ud5d8\uc5d0\uc11c BBB \ud1b5\uacfc\uc640 \uc778\uc9c0\uae30\ub2a5 \uac1c\uc120\uc744 \ud655\uc778\ud55c \ucc28\uc138\ub300 \uc54c\uce20\ud558\uc774\uba38 \uce58\ub8cc \uc804\ub7b5\uc785\ub2c8\ub2e4.","rank_math_focus_keyword":"\uc54c\uce20\ud558\uc774\uba38,\uc804\uad6c\uc57d\ubb3c,\uacfc\uc0b0\ud654\uc218\uc18c,KAIST,\ud65c\uc131\uc0b0\uc18c","footnotes":""},"categories":[2],"tags":[],"class_list":["post-12789","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-top-stories"],"_links":{"self":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/posts\/12789","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/comments?post=12789"}],"version-history":[{"count":0,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/posts\/12789\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/media\/12788"}],"wp:attachment":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/media?parent=12789"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/categories?post=12789"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/tags?post=12789"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}