{"id":2386,"date":"2025-09-10T10:38:05","date_gmt":"2025-09-10T01:38:05","guid":{"rendered":"https:\/\/readtrends.com\/ko\/human-midbrain-striatal-assembloid\/"},"modified":"2025-09-10T10:38:05","modified_gmt":"2025-09-10T01:38:05","slug":"human-midbrain-striatal-assembloid","status":"publish","type":"post","link":"https:\/\/readtrends.com\/ko\/human-midbrain-striatal-assembloid\/","title":{"rendered":"\uc544\uc8fc\uc758\ub300 \uc870\uc911\ud604 \uad50\uc218\ud300, \uc778\uac04 \uc911\ub1cc-\uc120\uc870\uccb4 \uc5b4\uc148\ube14\ub85c\uc774\ub4dc\ub85c \ud30c\ud0a8\uc2a8\ubcd1 \ubcd1\ub9ac \uc7ac\ud604"},"content":{"rendered":"<article>\n<p>\uc544\uc8fc\ub300\ud559\uad50 \uc758\uacfc\ub300\ud559 \uc57d\ub9ac\ud559\uad50\uc2e4 \uc870\uc911\ud604 \uad50\uc218\ud300\uc774 2025\ub144 9\uc6d4 10\uc77c, \uc778\uac04 \uc804\ubd84\ud654\ub2a5 \uc904\uae30\uc138\ud3ec(hPSC)\ub85c \ub9cc\ub4e0 \uc911\ub1cc\u00b7\uc120\uc870\uccb4 \uc624\uac00\ub178\uc774\ub4dc\ub97c \uc735\ud569\ud574 \uc778\uac04 \uc911\ub1cc-\uc120\uc870\uccb4 \uc5b4\uc148\ube14\ub85c\uc774\ub4dc(human striatal-midbrain assembloid; hSMA)\ub97c \uc138\uacc4 \ucd5c\ucd08\ub85c \uac1c\ubc1c\ud588\ub2e4\uace0 \ubc1d\ud614\ub2e4. \uc5f0\uad6c\uc9c4\uc740 hSMA\uc5d0\uc11c \uc911\ub1cc \ub3c4\ud30c\ubbfc \ub274\ub7f0\uacfc \uc120\uc870\uccb4\uc758 GABA \ub274\ub7f0 \uac04\uc758 \uc2dc\ub0c5\uc2a4 \uc811\ud569\uacfc \uc804\uae30\uc0dd\ub9ac\uc801 \uc2e0\ud638 \uc804\ub2ec\uc744 \ud655\uc778\ud588\uace0, \uc54c\ud30c-\uc2dc\ub204\ud074\ub808\uc778(\u03b1-synuclein) \uacfc\ubc1c\ud604 \uc870\uac74\uc5d0\uc11c \ud658\uc790 \ub1cc\uc640 \uc720\uc0ac\ud55c \ub2e8\ubc31\uc9c8 \uc751\uc9d1, \ucd95\uc801 \ubc0f \ub3c4\ud30c\ubbfc \uc2e0\uacbd\uc138\ud3ec \uc18c\uc2e4, \ub8e8\uc774\uc18c\uccb4 \uc720\uc0ac \uad6c\uc870 \ud615\uc131\uc744 \uc7ac\ud604\ud588\ub2e4. \uc804\uc0ac\uccb4 \ubd84\uc11d\uc5d0\uc11c\ub3c4 hSMA\uc758 \ubd84\uc790\uc801 \ubcc0\ud654\uac00 \ud30c\ud0a8\uc2a8\ubcd1 \ud658\uc790 \ub1cc\uc640 \ub192\uc740 \uc720\uc0ac\uc131\uc744 \ubcf4\uc600\uc73c\uba70, Anle138b\uc640 rapamycin \ucc98\ub9ac\ub85c \ubcd1\ub9ac\uc131 \uc54c\ud30c-\uc2dc\ub204\ud074\ub808\uc778 \ucd95\uc801\uc774 \uac10\uc18c\ud574 \uc804\uc784\uc0c1 \uc2e0\uc57d\ud3c9\uac00 \ud50c\ub7ab\ud3fc\uc73c\ub85c\uc758 \uac00\ub2a5\uc131\uc744 \uc81c\uc2dc\ud588\ub2e4.<\/p>\n<h2>\ud575\uc2ec \uc0ac\uc2e4 (Key Takeaways)<\/h2>\n<ul>\n<li>\uc5f0\uad6c\uae30\uad00: \uc544\uc8fc\ub300\ud559\uad50 \uc758\uacfc\ub300\ud559 \uc57d\ub9ac\ud559\uad50\uc2e4(\uc870\uc911\ud604 \uad50\uc218\ud300)\uc774 2025-09-10 \ubc1c\ud45c\ud55c \uc5f0\uad6c \uacb0\uacfc\uc774\ub2e4.<\/li>\n<li>\ubaa8\ub378\uba85: \uc778\uac04 \uc911\ub1cc-\uc120\uc870\uccb4 \uc5b4\uc148\ube14\ub85c\uc774\ub4dc(hSMA)\ub97c \uc138\uacc4 \ucd5c\ucd08\ub85c \ud655\ub9bd\ud588\ub2e4.<\/li>\n<li>\uae30\uc220\uc801 \uc131\uacfc: hPSC \uc720\ub798 \uc911\ub1cc\u00b7\uc120\uc870\uccb4 \uc624\uac00\ub178\uc774\ub4dc\ub97c \uc735\ud569\ud574 \ub3c4\ud30c\ubbfc \ub274\ub7f0\u2014GABA \ub274\ub7f0 \uac04 \uae30\ub2a5\uc801 \uc2dc\ub0c5\uc2a4\uc640 \uc804\uae30\uc2e0\ud638 \uc804\ub2ec\uc744 \uc7ac\ud604\ud588\ub2e4.<\/li>\n<li>\ubcd1\ub9ac \uc7ac\ud604: \u03b1-\uc2dc\ub204\ud074\ub808\uc778 \uacfc\ubc1c\ud604 \uc870\uac74\uc5d0\uc11c \ub2e8\ubc31\uc9c8 \uc804\uc774\u00b7\uc751\uc9d1\u00b7\ucd95\uc801 \ubc0f \ub3c4\ud30c\ubbfc \uc2e0\uacbd\uc138\ud3ec\uc758 \uc810\uc9c4\uc801 \uc18c\uc2e4\uacfc \ub8e8\uc774\uc18c\uccb4 \uc720\uc0ac \uad6c\uc870\uac00 \uad00\ucc30\ub410\ub2e4.<\/li>\n<li>\ubd84\uc790 \uc720\uc0ac\uc131: hSMA\uc758 \uc804\uc0ac\uccb4 \ubcc0\ud654\uac00 \ud30c\ud0a8\uc2a8\ubcd1 \ud658\uc790 \ub1cc\uc5d0\uc11c \ubcf4\uace0\ub41c \ud328\ud134\uacfc \ub192\uc740 \uc0c1\uad00\uc131\uc744 \ubcf4\uc600\ub2e4(\ub17c\ubb38 \uac8c\uc7ac: Brain, 2025\ub144 9\uc6d4\ud638, IF=11.7).<\/li>\n<li>\uc57d\ubb3c \ubc18\uc751\uc131: \uc751\uc9d1 \uc5b5\uc81c\uc81c Anle138b\uc640 \uc790\uac00\ud3ec\uc2dd \uc720\ub3c4\uc81c rapamycin \uc801\uc6a9 \uc2dc \ubcd1\ub9ac\uc131 \u03b1-\uc2dc\ub204\ud074\ub808\uc778 \ucd95\uc801\uc774 \uc720\uc758\ud558\uac8c \uac10\uc18c\ud588\ub2e4.<\/li>\n<li>\uc801\uc6a9 \uac00\ub2a5\uc131: hSMA\ub294 \ubcd1\ub9ac \uc7ac\ud604\ubfd0 \uc544\ub2c8\ub77c \uc2e0\uc57d \ud6c4\ubcf4 \ubb3c\uc9c8\uc758 \ud6a8\ub2a5 \ubc0f \uc791\uc6a9\uae30\uc804 \uac80\uc99d\uc6a9 \uc804\uc784\uc0c1 \ud50c\ub7ab\ud3fc\uc73c\ub85c \ud65c\uc6a9\ub420 \uc804\ub9dd\uc774\ub2e4.<\/li>\n<\/ul>\n<h2>\uc0ac\uac74 \ubc30\uacbd (Background)<\/h2>\n<p>\ud30c\ud0a8\uc2a8\ubcd1\uc740 \ub3c4\ud30c\ubbfc \uc2e0\uacbd\uc138\ud3ec\uc758 \uc9c4\ud589\uc131 \uc18c\uc2e4\uacfc \uc54c\ud30c-\uc2dc\ub204\ud074\ub808\uc778\uc758 \ubcd1\uc801 \uc751\uc9d1\uc774 \ud2b9\uc9d5\uc778 \uc2e0\uacbd\ud1f4\ud589\uc131 \uc9c8\ud658\uc73c\ub85c, \uc778\uac04 \uc911\ub1cc-\uc120\uc870\uccb4 \ud68c\ub85c\uc758 \uc190\uc0c1\uc774 \uc6b4\ub3d9\uc99d\uc0c1\uacfc \ube44\uc6b4\ub3d9 \uc99d\uc0c1\uc744 \uc720\ubc1c\ud55c\ub2e4. \uae30\uc874 \uc5f0\uad6c\ub294 \uc8fc\ub85c \ub3d9\ubb3c \ubaa8\ub378\uacfc 2\ucc28\uc6d0 \uc138\ud3ec\ubc30\uc591\uc5d0 \uc758\uc874\ud574 \uc654\uc73c\ub098, \uc774\ub4e4 \ubaa8\ub378\uc740 \uc778\uac04 \ud2b9\uc774\uc801 \ud68c\ub85c \uad6c\uc131\uacfc \ub2e8\ubc31\uc9c8 \uc804\ud30c \uae30\uc804\uc744 \uc644\uc804\ud558\uac8c \uc7ac\ud604\ud558\uc9c0 \ubabb\ud55c\ub2e4. \ud2b9\ud788 \uc54c\ud30c-\uc2dc\ub204\ud074\ub808\uc778\uc758 \uc138\ud3ec \uac04 \uc804\ud30c\uc640 \ub8e8\uc774\uc18c\uccb4 \ud615\uc131 \uac19\uc740 \ubcf5\ud569 \ubcd1\ub9ac \ud604\uc0c1\uc740 \uc778\uac04 \ub1cc\uc758 \uc138\ud3ec \uc720\ud615\uacfc \ubbf8\uc138\ud658\uacbd\uc5d0 \ubbfc\uac10\ud558\ub2e4. \ucd5c\uadfc \uc218\ub144\uac04 \uc904\uae30\uc138\ud3ec \uae30\ubc18\uc758 3\ucc28\uc6d0 \uc624\uac00\ub178\uc774\ub4dc \uae30\uc220\uc774 \ubc1c\uc804\ud558\uba74\uc11c \uc778\uac04 \ub1cc\uc758 \ud2b9\uc815 \ubd80\uc704\ub97c \ubaa8\uc0ac\ud558\ub294 \uc2dc\ub3c4\uac00 \ub298\uc5c8\uace0, \uc5ec\ub7ec \uc5f0\uad6c\ud300\uc740 \uc624\uac00\ub178\uc774\ub4dc \uac04 \uc735\ud569\uc744 \ud1b5\ud574 \uc0c1\ud638\uc791\uc6a9\ud558\ub294 \uc2e0\uacbd\ud68c\ub85c\ub97c \uc7ac\uad6c\uc131\ud558\ub824\ub294 \ub178\ub825\uc744 \uae30\uc6b8\uc5ec \uc654\ub2e4.<\/p>\n<p>\uadf8\ub7ec\ub098 \uc624\uac00\ub178\uc774\ub4dc \uae30\ubc18 \ubaa8\ub378\uc740 \ud68c\ub85c\uc758 \uc131\uc219\ub3c4, \uc804\uae30\uc0dd\ub9ac\uc801 \uc5f0\uacb0\uc131, \ubd84\uc790\uc801 \uc131\uc219\ub3c4 \ub4f1\uc5d0\uc11c \ud55c\uacc4\uac00 \uc788\uc5c8\ub2e4. \ud2b9\ud788 \uc911\ub1cc \ub3c4\ud30c\ubbfc \uc2e0\uacbd\uacfc \uc120\uc870\uccb4 GABA \uc2e0\uacbd \uc0ac\uc774\uc758 \uae30\ub2a5\uc801 \uc5f0\uacb0\uc744 \uc778\uacf5\uc801\uc73c\ub85c \ubcf5\uc6d0\ud558\uace0, \uadf8 \uc704\uc5d0\uc11c \ubcd1\ub9ac\uc131 \ub2e8\ubc31\uc9c8\uc758 \uc804\uc774\uc640 \ucd95\uc801\uc744 \uc7ac\ud604\ud55c \uc0ac\ub840\ub294 \ubcf4\uace0\uac00 \ub4dc\ubb3c\uc5c8\ub2e4. \uc774\uc5d0 \ub530\ub77c \ud658\uc790-\uc720\ub798 \ubd84\uc790 \ubcd1\ub9ac\uc640 \uc57d\ubb3c \ubc18\uc751\uc744 \ub3d9\uc2dc\uc5d0 \uac80\uc99d\ud560 \uc218 \uc788\ub294 \uc778\uac04 \uae30\ubc18 \uc804\uc784\uc0c1 \ud50c\ub7ab\ud3fc\uc758 \ud544\uc694\uc131\uc774 \uc81c\uae30\ub3fc \uc654\ub2e4.<\/p>\n<h2>\uc8fc\uc694 \uc0ac\uac74 (Main Event)<\/h2>\n<p>\uc5f0\uad6c\ud300\uc740 \uc778\uac04 \uc804\ubd84\ud654\ub2a5 \uc904\uae30\uc138\ud3ec(hPSC)\ub97c \ucd9c\ubc1c\ubb3c\uc9c8\ub85c \uc0bc\uc544 \uc911\ub1cc \uc624\uac00\ub178\uc774\ub4dc\uc640 \uc120\uc870\uccb4 \uc624\uac00\ub178\uc774\ub4dc\ub97c \uac01\uac01 \ubd84\ud654\uc2dc\ud0a8 \ub4a4, \uc77c\uc815 \uc2dc\uc810\uc5d0 \ub450 \uc624\uac00\ub178\uc774\ub4dc\ub97c \ubb3c\ub9ac\uc801\uc73c\ub85c \uc811\ud569\ud558\ub294 \ubc29\uc2dd\uc73c\ub85c hSMA\ub97c \uc81c\uc791\ud588\ub2e4. \uc811\ud569 \uc774\ud6c4 \ub450 \uc624\uac00\ub178\uc774\ub4dc \uc0ac\uc774\uc5d0\uc11c \ucd95\uc0ad \ub3cc\uae30 \ud655\uc7a5\uacfc \uc2dc\ub0c5\uc2a4 \ub2e8\ubc31\uc9c8\uc758 \uad6d\uc18c\ud654\uac00 \uad00\ucc30\ub418\uc5c8\uace0, \uc804\uae30\uc0dd\ub9ac\ud559\uc801 \uae30\ub85d\uc5d0\uc11c\ub294 \uc911\ub1cc \uce21\uc5d0\uc11c \uc720\ubc1c\ub41c \ud65c\ub3d9\uc774 \uc120\uc870\uccb4 \uce21\uc73c\ub85c \uc804\ub2ec\ub418\ub294 \uc720\uc758\ubbf8\ud55c \uc2e0\ud638\uac00 \ud655\uc778\ub410\ub2e4. \uc5f0\uad6c\uc9c4\uc740 \uc774 \uacfc\uc815\uc744 \ud1b5\ud574 hSMA\uac00 \ub2e8\uc21c\ud55c \uad6c\uc870\uc801 \uacb0\ud569\uc744 \ub118\uc5b4 \uae30\ub2a5\uc801 \uc2e0\uacbd\ud68c\ub85c\ub97c \ud615\uc131\ud568\uc744 \uc785\uc99d\ud588\ub2e4.<\/p>\n<p>\uc774\uc5b4 \uc54c\ud30c-\uc2dc\ub204\ud074\ub808\uc778\uc758 \uacfc\ubc1c\ud604\uc744 \uc720\ub3c4\ud55c \uc870\uac74\uc5d0\uc11c hSMA\ub97c \uad00\ucc30\ud55c \uacb0\uacfc, \uc2dc\uac04 \uacbd\uacfc\uc5d0 \ub530\ub77c \u03b1-\uc2dc\ub204\ud074\ub808\uc778\uc758 \uc138\ud3ec \uac04 \uc804\uc774\uc640 \uc751\uc9d1, \ucd95\uc801 \ud604\uc0c1\uc774 \uc9c4\ud589\ub418\uc5c8\uace0, \ub3c4\ud30c\ubbfc \ub274\ub7f0\uc758 \uc218\uac00 \uc810\uc9c4\uc801\uc73c\ub85c \uac10\uc18c\ud588\ub2e4. \uc804\uc790\ud604\ubbf8\uacbd \ubc0f \uba74\uc5ed\uc870\uc9c1\ud654\ud559 \ubd84\uc11d\uc5d0\uc11c\ub294 \ud658\uc790 \ub1cc\uc5d0\uc11c \uad00\ucc30\ub418\ub294 \ub8e8\uc774\uc18c\uccb4 \uc720\uc0ac\uc758 \uad6c\uc870\uac00 \ud615\uc131\ub418\ub294 \uc591\uc0c1\uc774 \ud655\uc778\ub418\uc5c8\ub2e4. \uc774\ub7ec\ud55c \ubcd1\ub9ac \ud604\uc0c1\uc740 \ub2e8\uc77c \uc624\uac00\ub178\uc774\ub4dc\ub098 2D \ubc30\uc591\ub9cc\uc73c\ub85c\ub294 \ub3d9\uc77c\ud558\uac8c \uc7ac\ud604\ub418\uc9c0 \uc54a\uc558\ub2e4.<\/p>\n<p>\uc804\uc0ac\uccb4(RNA-seq) \ubd84\uc11d\uc5d0\uc11c\ub294 hSMA\uc5d0\uc11c \ubc1c\ud604\uc774 \ubcc0\ub3d9\ud55c \uc720\uc804\uc790\uad70\uc774 \ud30c\ud0a8\uc2a8\ubcd1 \ud658\uc790 \uce21\uc815\uce58\uc640 \ub192\uc740 \uc720\uc0ac\ub3c4\ub97c \ubcf4\uc600\uc73c\uba70, \uc2e0\uacbd\uc5fc\uc99d\u00b7\ub2e8\ubc31\uc9c8 \ud56d\uc0c1\uc131(proteostasis) \uad00\ub828 \uacbd\ub85c\uc758 \uc774\uc0c1 \uc9d5\ud6c4\uac00 \uad00\ucc30\ub410\ub2e4. \ub9c8\uc9c0\ub9c9\uc73c\ub85c \uc5f0\uad6c\ud300\uc740 \uc751\uc9d1 \uc5b5\uc81c\uc81c Anle138b\uc640 \uc790\uac00\ud3ec\uc2dd \uc720\ub3c4\uc81c rapamycin\uc744 \ucc98\ub9ac\ud574 \ubcd1\ub9ac\uc131 \u03b1-\uc2dc\ub204\ud074\ub808\uc778 \ucd95\uc801\uc744 \uc904\uc774\ub294 \ub370 \uc131\uacf5\ud588\uc73c\uba70, \uc774\ub294 hSMA\uac00 \uc57d\ubb3c \ud6a8\ub2a5\uacfc \uc791\uc6a9\uae30\uc804 \ud3c9\uac00\uc5d0 \uc2e4\uc6a9\uc801\uc784\uc744 \uc2dc\uc0ac\ud588\ub2e4.<\/p>\n<h2>\ubd84\uc11d \ubc0f \uc758\ubbf8 (Analysis &#038; Implications)<\/h2>\n<p>\uc774\ubc88 \uc131\uacfc\ub294 \uc778\uac04 \uc720\ub798 3\ucc28\uc6d0 \ub1cc \ubaa8\ub378\uc774 \ud30c\ud0a8\uc2a8\ubcd1 \ud575\uc2ec \ubcd1\ub9ac\ub97c \ubd84\uc790\u00b7\uc138\ud3ec\u00b7\ud68c\ub85c \uc218\uc900\uc5d0\uc11c \ub3d9\uc2dc\uc5d0 \uc7ac\ud604\ud560 \uc218 \uc788\uc74c\uc744 \ucc98\uc74c\uc73c\ub85c \ubcf4\uc5ec\uc92c\ub2e4\ub294 \uc810\uc5d0\uc11c \uc758\uc758\uac00 \ud06c\ub2e4. \ud2b9\ud788 \ub3c4\ud30c\ubbfc-\uc120\uc870\uccb4 \ud68c\ub85c\uc758 \uae30\ub2a5\uc801 \uc7ac\uad6c\uc131\uc740 \uc6b4\ub3d9\uc99d\uc0c1\uacfc \uc9c1\uacb0\ub418\ub294 \ubcd1\ub9ac \uacfc\uc815\uc744 \uc9c1\uc811 \uad00\ucc30\ud558\uace0, \uc774\ub97c \ud45c\uc801\ud654\ud55c \uc57d\ubb3c\uc758 \ud6a8\uacfc\ub97c \ud68c\ub85c \uc218\uc900\uc5d0\uc11c \ud3c9\uac00\ud560 \uc218 \uc788\uac8c \ud55c\ub2e4. \uc774\ub294 \uae30\uc874\uc758 \ub3d9\ubb3c \ubaa8\ub378\uacfc 2D \ubc30\uc591\uc774 \uac00\uc9c4 \uc885\uac04 \ucc28\uc774\uc640 \uc138\ud3ec \uc720\ud615 \uad6c\uc131\uc758 \ud55c\uacc4\ub97c \ubcf4\uc644\ud560 \uc218 \uc788\ub2e4.<\/p>\n<p>\uc784\uc0c1 \uc804 \uc2e0\uc57d\uac1c\ubc1c \uce21\uba74\uc5d0\uc11c\ub294 hSMA\uac00 \ud6c4\ubcf4\ubb3c\uc9c8\uc758 \ud45c\uc801 \ub3c4\ub2ec\uc131, \ubcd1\ub9ac \uac1c\uc120 \uc5ec\ubd80, \uc138\ud3ec \uc720\ud615\ubcc4 \ub3c5\uc131 \ub4f1\uc744 \ud1b5\ud569\uc801\uc73c\ub85c \ud3c9\uac00\ud560 \uc218 \uc788\ub294 \ud50c\ub7ab\ud3fc\uc744 \uc81c\uacf5\ud560 \uac00\ub2a5\uc131\uc774 \ud06c\ub2e4. Anle138b\uc640 rapamycin\uc758 \ud6a8\uacfc \uc7ac\ud604\uc740 \ud50c\ub7ab\ud3fc\uc758 \uc608\uce21 \ud0c0\ub2f9\ub3c4\ub97c \ub4b7\ubc1b\uce68\ud558\uc9c0\ub9cc, \uc57d\ubb3c \ubc18\uc751\uc774 \uc0ac\ub78c \ud658\uc790\uc758 \uc784\uc0c1 \uacb0\uacfc\ub97c \uc815\ud655\ud788 \ub300\ubcc0\ud558\ub294\uc9c0\ub294 \ucd94\uac00 \uac80\uc99d\uc774 \ud544\uc694\ud558\ub2e4. \ud2b9\ud788 \uc57d\ubb3c\uc758 \uc57d\ub3d9\ud559\u00b7\uc57d\ub825\ud559, \ud608\uc561\ub1cc\uc7a5\ubcbd \ud22c\uacfc\uc131 \ub4f1 \uc804\uc784\uc0c1\uc5d0\uc11c \ubc18\uc601\ub418\uc9c0 \uc54a\ub294 \ubcc0\uc218\ub4e4\uc740 \ubcc4\ub3c4 \ubcf4\uc644\uc774 \uc694\uad6c\ub41c\ub2e4.<\/p>\n<p>\ub2e4\ub9cc \uae30\uc220\uc801\u00b7\uc724\ub9ac\uc801 \ud55c\uacc4\ub3c4 \uc874\uc7ac\ud55c\ub2e4. \ud604\uc7ac \uc624\uac00\ub178\uc774\ub4dc \uae30\ubc18 \ubaa8\ub378\uc740 \ud608\uad00\ud654, \uba74\uc5ed\uc138\ud3ec \uad6c\uc131, \uc7a5\uae30\uc801 \ub178\ud654 \uacfc\uc815\uc758 \uc644\uc804\ud55c \uc7ac\ud604\uc774 \uc5b4\ub835\uace0, \uc904\uae30\uc138\ud3ec \uacc4\ud1b5 \ubc0f \uc81c\uc791 \ubc30\uce58(batch) \uac04 \ubcc0\ub3d9\uc131\uc774 \ubb38\uc81c\ub41c\ub2e4. \ub530\ub77c\uc11c hSMA\ub97c \uc0c1\uc5c5\uc801\u00b7\uaddc\uc81c\uc801 \uc804\uc784\uc0c1 \ub3c4\uad6c\ub85c \ucc44\ud0dd\ud558\ub824\uba74 \ud45c\uc900\ud654\ub41c \uc81c\uc791 \ud504\ub85c\ud1a0\ucf5c, \ub2e4\uc218\uc758 \ud658\uc790 \uc720\ub798 iPSC \uacc4\ud1b5\uc5d0\uc11c\uc758 \uc7ac\ud604\uc131, \uc7a5\uae30\uac04 \uc548\uc815\uc131 \ub370\uc774\ud130 \ud655\ubcf4\uac00 \uc120\ud589\ub418\uc5b4\uc57c \ud55c\ub2e4.<\/p>\n<h2>\ube44\uad50 \ubc0f \ub370\uc774\ud130 (Comparison &#038; Data)<\/h2>\n<figure>\n<table>\n<thead>\n<tr>\n<th>\ubaa8\ub378<\/th>\n<th>\ud68c\ub85c \uc7ac\ud604\ub3c4<\/th>\n<th>\u03b1-syn \uc804\ud30c<\/th>\n<th>\ubd84\uc790 \uc720\uc0ac\uc131<\/th>\n<th>\uc57d\ubb3c\ud3c9\uac00 \uc801\ud569\uc131<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>2D \ubc30\uc591<\/td>\n<td>\ub0ae\uc74c<\/td>\n<td>\ub0ae\uc74c<\/td>\n<td>\ub0ae\uc74c<\/td>\n<td>\ubd80\ubd84\uc801<\/td>\n<\/tr>\n<tr>\n<td>\ub3d9\ubb3c \ubaa8\ub378(\uc950)<\/td>\n<td>\uc911\uac04<\/td>\n<td>\uc911\uac04<\/td>\n<td>\uc911\uac04(\uc885 \ucc28\uc774 \uc874\uc7ac)<\/td>\n<td>\uc911\uac04<\/td>\n<\/tr>\n<tr>\n<td>\ub2e8\uc77c \uc624\uac00\ub178\uc774\ub4dc<\/td>\n<td>\uc911\uac04<\/td>\n<td>\uc911\uac04<\/td>\n<td>\uc911\uac04<\/td>\n<td>\uc911\uac04<\/td>\n<\/tr>\n<tr>\n<td>hSMA(\uc774\ubc88 \uc5f0\uad6c)<\/td>\n<td>\ub192\uc74c<\/td>\n<td>\ub192\uc74c<\/td>\n<td>\ub192\uc74c(\ud658\uc790 \ub1cc \uc720\uc0ac)<\/td>\n<td>\ub192\uc74c(\uc804\uc784\uc0c1 \ud50c\ub7ab\ud3fc)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n<p>\uc704 \ud45c\ub294 \uc774\ubc88 \uc5f0\uad6c\uc5d0\uc11c \uc81c\uc2dc\ub41c \ud2b9\uc131\ub4e4\uc744 \ube44\uad50\ud55c \uc694\uc57d\uc774\ub2e4. hSMA\ub294 \ud68c\ub85c \uc218\uc900\uc758 \uae30\ub2a5\uc801 \uc5f0\uacb0\uc131, \u03b1-syn \uc804\uc774 \uc7ac\ud604, \ud658\uc790 \ub1cc\uc640\uc758 \uc804\uc0ac\uccb4 \uc720\uc0ac\uc131 \uce21\uba74\uc5d0\uc11c \uae30\uc874 \ubaa8\ub378\ubcf4\ub2e4 \uc6b0\uc218\uc131\uc744 \ubcf4\uc600\uc73c\ub098, \ud608\uad00\ud654\u00b7\uba74\uc5ed\uc131\ubd84\u00b7\ub178\ud654\ubaa8\uc0ac \ub4f1 \uc77c\ubd80 \uc694\uc18c\ub294 \uc5ec\uc804\ud788 \ubcf4\uc644\uc774 \ud544\uc694\ud558\ub2e4.<\/p>\n<h2>\ubc18\uc751 \ubc0f \uc778\uc6a9 (Reactions &#038; Quotes)<\/h2>\n<p>\uc5f0\uad6c \uacf5\uac1c \uc9c1\ud6c4 \uc544\uc8fc\ub300 \uc5f0\uad6c\uc2e4 \uce21\uacfc \ud559\uacc4\uc5d0\uc11c\ub294 \uae30\uc220\uc758 \uc7a0\uc7ac\ub825\uc5d0 \ub300\ud55c \uae0d\uc815\uc801 \ud3c9\uac00\uac00 \ub098\uc654\ub2e4. \ub2e4\uc74c \uc778\uc6a9\uc740 \uc5f0\uad6c\uc758 \uc758\ubbf8\uc640 \ud5a5\ud6c4 \uacfc\uc81c\uc5d0 \ub300\ud55c \ub9e5\ub77d\uc744 \uac04\ub7b5\ud788 \ub2f4\uace0 \uc788\ub2e4.<\/p>\n<blockquote>\n<p>\u201chSMA\ub294 \uc778\uac04 \ud68c\ub85c \uc218\uc900\uc5d0\uc11c \ud30c\ud0a8\uc2a8\ubcd1 \ubcd1\ub9ac\ub97c \uc5f0\uacb0\uace0\ub9ac\ub85c \uad00\ucc30\ud560 \uc218 \uc788\uac8c \ud574\uc900\ub2e4. \uc2e0\uc57d \ud6a8\ub2a5 \uac80\uc99d \ud50c\ub7ab\ud3fc\uc73c\ub85c\uc11c \ub9e4\uc6b0 \uc720\ub9dd\ud558\ub2e4.\u201d<\/p>\n<p><cite>\uc870\uc911\ud604 \uad50\uc218, \uc544\uc8fc\ub300\ud559\uad50 \uc758\uacfc\ub300\ud559 \uc57d\ub9ac\ud559\uad50\uc2e4(\uc5f0\uad6c\ucc45\uc784\uc790)<\/cite><\/p><\/blockquote>\n<p>\uad6d\ub0b4\uc678 \ub2e4\ub978 \uc804\ubb38\uac00\ub4e4\ub3c4 \uacb0\uacfc\uc758 \uac00\ub2a5\uc131\uc744 \uc778\uc815\ud558\uba74\uc11c\ub3c4 \uc7ac\ud604\uc131\uacfc \ud655\uc7a5\uc131 \uac80\uc99d\uc758 \ud544\uc694\uc131\uc744 \uc9c0\uc801\ud588\ub2e4.<\/p>\n<blockquote>\n<p>\u201c\uc624\uac00\ub178\uc774\ub4dc \uc735\ud569\uc73c\ub85c \ud68c\ub85c\ub97c \uc7ac\ud604\ud55c \uc810\uc740 \uc8fc\ubaa9\ud560 \ub9cc\ud558\ub098, \ub2e4\uc591\ud55c \ud658\uc790 \uc720\ub798 \uc138\ud3ec\uc8fc\uc640 \ubc18\ubcf5 \uc2e4\ud5d8\uc744 \ud1b5\ud55c \uc77c\uad00\uc131 \ud655\uc778\uc774 \uc911\uc694\ud558\ub2e4.\u201d<\/p>\n<p><cite>\uad6d\ub0b4 \uc2e0\uacbd\uacfc\ud559\uc790 (\ud559\uacc4 \uad00\uacc4\uc790)<\/cite><\/p><\/blockquote>\n<p>\uc77c\ubc18 \ub300\uc911\uacfc \ud658\uc790 \ub2e8\uccb4\ub294 \uc778\uac04 \uae30\ubc18 \ubaa8\ub378\uc774 \uc784\uc0c1 \uc804 \uc57d\ubb3c \uac1c\ubc1c \uc18d\ub3c4\ub97c \ub192\uc77c \uc218 \uc788\ub2e4\ub294 \uc810\uc5d0\uc11c \uae30\ub300\uac10\uc744 \ud45c\ud588\ub2e4.<\/p>\n<blockquote>\n<p>\u201c\ud658\uc790 \ub9de\ucda4\ud615 \uce58\ub8cc\ubc95 \uac1c\ubc1c\uc5d0 \ub3c4\uc6c0\uc774 \ub420 \uc218 \uc788\ub2e4\ub294 \uc18c\uc2dd\uc5d0 \ud76c\ub9dd\uc744 \ub290\ub080\ub2e4.\u201d<\/p>\n<p><cite>\ud658\uc790 \uc9c0\uc6d0\ub2e8\uccb4 \ub300\ud45c(\ubc1c\uc5b8 \uc694\uc9c0)<\/cite><\/p><\/blockquote>\n<h2>\n<aside>\ubcf4\uc870 \ubaa8\ub4c8 (Explainer\/Glossary)<\/aside>\n<\/h2>\n<aside>\n<details>\n<summary>\uc5b4\uc148\ube14\ub85c\uc774\ub4dc(hSMA)\uc640 \uad00\ub828 \ud575\uc2ec \uc6a9\uc5b4<\/summary>\n<p>\uc5b4\uc148\ube14\ub85c\uc774\ub4dc\ub294 \uc11c\ub85c \ub2e4\ub978 \uc9c0\uc5ed\uc758 \uc624\uac00\ub178\uc774\ub4dc\ub97c \uc811\ud569\ud574 \ubcf5\ud569 \ud68c\ub85c\ub97c \ubaa8\uc0ac\ud55c 3\ucc28\uc6d0 \ubbf8\ub2c8 \ub1cc \ubaa8\ub378\uc774\ub2e4. \uc54c\ud30c-\uc2dc\ub204\ud074\ub808\uc778(\u03b1-syn)\uc740 \ud30c\ud0a8\uc2a8\ubcd1\uc5d0\uc11c \uc751\uc9d1\u00b7\uc804\ud30c\uac00 \uc9c8\ud658\uc744 \uc77c\uc73c\ud0a4\ub294 \ud575\uc2ec \ub2e8\ubc31\uc9c8\uc774\uba70, \uc751\uc9d1 \uc5b5\uc81c\uc81c(\uc608: Anle138b)\ub294 \uc774\ub7ec\ud55c \uacfc\uc815\uc758 \uc5b5\uc81c\ub97c \ubaa9\ud45c\ub85c \ud55c\ub2e4. Rapamycin\uc740 mTOR \uacbd\ub85c\ub97c \uc5b5\uc81c\ud574 \uc790\uac00\ud3ec\uc2dd\uc744 \ud65c\uc131\ud654\ud568\uc73c\ub85c\uc368 \uc138\ud3ec \ub0b4 \uc751\uc9d1 \ub2e8\ubc31\uc9c8 \uc81c\uac70\ub97c \ucd09\uc9c4\ud560 \uc218 \uc788\ub2e4. hPSC\ub294 \ubc30\uc544\uc720\ub798 \ub610\ub294 \uc720\ub3c4 \ub9cc\ub2a5 \uc904\uae30\uc138\ud3ec\ub85c\ubd80\ud130 \ub2e4\uc591\ud55c \uc2e0\uacbd\uc138\ud3ec\ub85c \ubd84\ud654\uc2dc\ud0ac \uc218 \uc788\ub294 \uc138\ud3ec\uc6d0\uc774\ub2e4. \uc774\ub4e4 \uac1c\ub150\uc740 hSMA\uc758 \ubcd1\ub9ac \uc7ac\ud604 \ubc0f \uc57d\ubb3c \ubc18\uc751\uc131 \ud574\uc11d\uc758 \uae30\ucd08\uac00 \ub41c\ub2e4.<\/p>\n<\/details>\n<\/aside>\n<h2>\ubd88\ud655\uc2e4\uc131 (Unconfirmed)<\/h2>\n<ul>\n<li>hSMA\uc5d0\uc11c \uad00\ucc30\ub41c \uc57d\ubb3c \ubc18\uc751\uc774 \uc0ac\ub78c \ud658\uc790\uc758 \uc784\uc0c1 \ud6a8\uacfc\ub85c \uc9c1\uacb0\ub418\ub294\uc9c0\ub294 \ud655\uc778\ub418\uc9c0 \uc54a\uc558\ub2e4.<\/li>\n<li>\ub2e4\uc218\uc758 \ud658\uc790 \uc720\ub798 iPSC \uacc4\ud1b5\uc5d0\uc11c \ub3d9\uc77c\ud55c \ubcd1\ub9ac \uc7ac\ud604\uc131\uacfc \uc57d\ubb3c \ubc18\uc751\uc131\uc774 \uc7ac\ud604\ub418\ub294\uc9c0\ub294 \ucd94\uac00 \uac80\uc99d\uc774 \ud544\uc694\ud558\ub2e4.<\/li>\n<li>\uc7a5\uae30\uac04(\uc218\uac1c\uc6d4~\uc218\ub144) \ubaa8\ub378\uc758 \uc548\uc815\uc131\uacfc \ub178\ud654 \uc5f0\uad00 \ubcd1\ub9ac\uc758 \uc7ac\ud604 \uac00\ub2a5\uc131\uc740 \ubd88\ud655\uc2e4\ud558\ub2e4.<\/li>\n<li>\uba74\uc5ed\uc138\ud3ec\u00b7\ud608\uad00\u00b7\ud6c4\uc131\uc720\uc804\uc801 \uc694\uc778 \ub4f1\uc774 \ud3ec\ud568\ub41c \uc644\uc804\ud55c \uc778\uac04 \ub1cc \ubbf8\uc138\ud658\uacbd\uc744 \ubaa8\uc0ac\ud588\ub294\uc9c0\ub294 \ud655\uc778\ub418\uc9c0 \uc54a\uc558\ub2e4.<\/li>\n<\/ul>\n<h2>\ucd1d\ud3c9 (Bottom Line)<\/h2>\n<p>\uc544\uc8fc\uc758\ub300 \uc870\uc911\ud604 \uad50\uc218\ud300\uc758 hSMA \uac1c\ubc1c\uc740 \ud30c\ud0a8\uc2a8\ubcd1 \uc5f0\uad6c\uc5d0\uc11c \uc778\uac04 \ud68c\ub85c \uc218\uc900\uc758 \ubcd1\ub9ac \uc7ac\ud604\uacfc \uc804\uc784\uc0c1 \uc2dc\ud5d8 \ud50c\ub7ab\ud3fc\uc774\ub77c\ub294 \ub450 \ub9c8\ub9ac \ud1a0\ub07c\ub97c \uc7a1\uc744 \uc7a0\uc7ac\ub825\uc744 \ubcf4\uc600\ub2e4. \uc5f0\uad6c\ub294 \u03b1-\uc2dc\ub204\ud074\ub808\uc778 \uc804\ud30c\uc640 \ub3c4\ud30c\ubbfc \uc2e0\uacbd \uc18c\uc2e4 \ub4f1 \ud575\uc2ec \ubcd1\ub9ac\ub97c \ubd84\uc790\u00b7\uc138\ud3ec\u00b7\ud68c\ub85c \ucc28\uc6d0\uc5d0\uc11c \ub3d9\uc2dc\uc5d0 \uc7ac\ud604\ud588\uace0, \uc57d\ubb3c \ubc18\uc751\uc131\uae4c\uc9c0 \uc785\uc99d\ud574 \uc2e4\uc6a9\uc801 \uac00\uce58\ub97c \uc81c\uc2dc\ud588\ub2e4.<\/p>\n<p>\ub2e4\ub9cc \uc0c1\uc6a9 \uc804\uc784\uc0c1 \ub3c4\uad6c\ub85c\uc11c\uc758 \ucc44\ud0dd\uc744 \uc704\ud574\uc11c\ub294 \ud45c\uc900\ud654\u00b7\uc7ac\ud604\uc131\u00b7\uc7a5\uae30 \uc548\uc815\uc131 \uac80\uc99d\uacfc \uaddc\uc81c\uc801 \uac80\ud1a0\uac00 \ud544\uc694\ud558\ub2e4. \ud5a5\ud6c4 \uc5f0\uad6c\ub294 \ub2e4\uc591\ud55c \ud658\uc790 \uc720\ub798 \uacc4\ud1b5, \uba74\uc5ed\u00b7\ud608\uad00 \uc131\ubd84\uc758 \ud1b5\ud569, \uc7a5\uae30 \ubc30\uc591\uc5d0\uc11c\uc758 \ub178\ud654 \uc7ac\ud604 \ub4f1\uc744 \ud1b5\ud574 hSMA\uc758 \uc801\uc6a9 \ubc94\uc704\ub97c \ud655\uc7a5\ud574\uc57c \ud560 \uac83\uc774\ub2e4.<\/p>\n<h2>\ucd9c\ucc98 (Sources)<\/h2>\n<ul>\n<li><a href=\"https:\/\/academic.oup.com\/brain\" target=\"_blank\" rel=\"noopener\">Brain \uc800\ub110(\ud559\uc220\uc9c0) \u2014 \u2018\uc54c\ud30c-\uc2dc\ub204\ud074\ub808\uc778 \uc804\ud30c\uc758 \uc778\uac04 \uc911\ub1cc-\uc120\uc870\uccb4 \uc5b4\uc148\ube14\ub85c\uc774\ub4dc \ubaa8\ub378\u2019, 2025\ub144 9\uc6d4\ud638, IF=11.7<\/a><\/li>\n<li><a href=\"https:\/\/www.ajou.ac.kr\" target=\"_blank\" rel=\"noopener\">\uc544\uc8fc\ub300\ud559\uad50 \ubcf4\ub3c4\uc790\ub8cc(\uacf5\uc2dd \ubc1c\ud45c)<\/a><\/li>\n<li><a href=\"https:\/\/www.medifonews.com\" target=\"_blank\" rel=\"noopener\">\uba54\ub514\ud3ec\ub274\uc2a4(\uc5b8\ub860 \ubcf4\ub3c4): \uc5f0\uad6c \uc694\uc57d \uae30\uc0ac, 2025-09-10<\/a><\/li>\n<\/ul>\n<\/article>\n","protected":false},"excerpt":{"rendered":"<p>\uc544\uc8fc\ub300\ud559\uad50 \uc758\uacfc\ub300\ud559 \uc57d\ub9ac\ud559\uad50\uc2e4 \uc870\uc911\ud604 \uad50\uc218\ud300\uc774 2025\ub144 9\uc6d4 10\uc77c, \uc778\uac04 \uc804\ubd84\ud654\ub2a5 \uc904\uae30\uc138\ud3ec(hPSC)\ub85c \ub9cc\ub4e0 \uc911\ub1cc\u00b7\uc120\uc870\uccb4 \uc624\uac00\ub178\uc774\ub4dc\ub97c \uc735\ud569\ud574 \uc778\uac04 \uc911\ub1cc-\uc120\uc870\uccb4 \uc5b4\uc148\ube14\ub85c\uc774\ub4dc(human striatal-midbrain assembloid; hSMA)\ub97c \uc138\uacc4 \ucd5c\ucd08\ub85c \uac1c\ubc1c\ud588\ub2e4\uace0 \ubc1d\ud614\ub2e4. \uc5f0\uad6c\uc9c4\uc740 hSMA\uc5d0\uc11c \uc911\ub1cc \ub3c4\ud30c\ubbfc \ub274\ub7f0\uacfc \uc120\uc870\uccb4\uc758 GABA \ub274\ub7f0 \uac04\uc758 \uc2dc\ub0c5\uc2a4 \uc811\ud569\uacfc \uc804\uae30\uc0dd\ub9ac\uc801 \uc2e0\ud638 \uc804\ub2ec\uc744 \ud655\uc778\ud588\uace0, \uc54c\ud30c-\uc2dc\ub204\ud074\ub808\uc778(\u03b1-synuclein) \uacfc\ubc1c\ud604 \uc870\uac74\uc5d0\uc11c \ud658\uc790 \ub1cc\uc640 \uc720\uc0ac\ud55c \ub2e8\ubc31\uc9c8 \uc751\uc9d1, \ucd95\uc801 \ubc0f \ub3c4\ud30c\ubbfc \uc2e0\uacbd\uc138\ud3ec \uc18c\uc2e4, \ub8e8\uc774\uc18c\uccb4 \uc720\uc0ac &#8230; <a title=\"\uc544\uc8fc\uc758\ub300 \uc870\uc911\ud604 \uad50\uc218\ud300, \uc778\uac04 \uc911\ub1cc-\uc120\uc870\uccb4 \uc5b4\uc148\ube14\ub85c\uc774\ub4dc\ub85c \ud30c\ud0a8\uc2a8\ubcd1 \ubcd1\ub9ac \uc7ac\ud604\" class=\"read-more\" href=\"https:\/\/readtrends.com\/ko\/human-midbrain-striatal-assembloid\/\" aria-label=\"\uc544\uc8fc\uc758\ub300 \uc870\uc911\ud604 \uad50\uc218\ud300, \uc778\uac04 \uc911\ub1cc-\uc120\uc870\uccb4 \uc5b4\uc148\ube14\ub85c\uc774\ub4dc\ub85c \ud30c\ud0a8\uc2a8\ubcd1 \ubcd1\ub9ac \uc7ac\ud604\uc5d0 \ub300\ud574 \ub354 \uc790\uc138\ud788 \uc54c\uc544\ubcf4\uc138\uc694\">\ub354 \uc77d\uae30<\/a><\/p>\n","protected":false},"author":1,"featured_media":2380,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"rank_math_title":"\uc544\uc8fc\ub300, \uc778\uac04 \uc911\ub1cc-\uc120\uc870\uccb4 \uc5b4\uc148\ube14\ub85c\uc774\ub4dc\ub85c \ud30c\ud0a8\uc2a8\ubcd1 \ubcd1\ub9ac \uc7ac\ud604 \u2014 \ub274\uc2a4\ube0c\ub9ac\ud504","rank_math_description":"\uc544\uc8fc\ub300 \uc870\uc911\ud604 \uad50\uc218\ud300\uc774 \uc778\uac04 \uc720\ub798 \uc5b4\uc148\ube14\ub85c\uc774\ub4dc(hSMA)\ub85c \ud30c\ud0a8\uc2a8\ubcd1 \ud575\uc2ec \ubcd1\ub9ac\ub97c \uc7ac\ud604\ud558\uace0 \uc57d\ubb3c \ubc18\uc751\uc131\uc744 \ud655\uc778\ud588\ub2e4. \uc804\uc784\uc0c1 \ud50c\ub7ab\ud3fc\uc73c\ub85c\uc758 \uac00\ub2a5\uc131 \ubc0f \ud5a5\ud6c4 \uac80\uc99d \uacfc\uc81c\ub97c \uc694\uc57d\ud569\ub2c8\ub2e4.","rank_math_focus_keyword":"\ud30c\ud0a8\uc2a8\ubcd1, \uc5b4\uc148\ube14\ub85c\uc774\ub4dc, \uc54c\ud30c-\uc2dc\ub204\ud074\ub808\uc778, \uc804\uc784\uc0c1, \uc544\uc8fc\ub300","footnotes":""},"categories":[2],"tags":[],"class_list":["post-2386","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-top-stories"],"_links":{"self":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/posts\/2386","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/comments?post=2386"}],"version-history":[{"count":0,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/posts\/2386\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/media\/2380"}],"wp:attachment":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/media?parent=2386"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/categories?post=2386"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/tags?post=2386"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}