{"id":2776,"date":"2025-11-07T12:05:37","date_gmt":"2025-11-07T03:05:37","guid":{"rendered":"https:\/\/readtrends.com\/ko\/sorl1-apcdd1-alzheimers-korea\/"},"modified":"2025-11-07T12:05:37","modified_gmt":"2025-11-07T03:05:37","slug":"sorl1-apcdd1-alzheimers-korea","status":"publish","type":"post","link":"https:\/\/readtrends.com\/ko\/sorl1-apcdd1-alzheimers-korea\/","title":{"rendered":"\uad6d\ub0b4 \uc5f0\uad6c\uc9c4, \uc54c\uce20\ud558\uc774\uba38\ubcd1\uc758 \ubc1c\ubcd1 \uad00\ub828 \uc720\uc804\uc790 \ub300\uac70 \uaddc\uba85 \ubc0f \ub204\uc801 \ud6a8\uacfc \ubaa8\ub378 \uc81c\uc2dc &#8211; \ubc14\uc774\uc624\ud0c0\uc784\uc988"},"content":{"rendered":"<article>\n<h2>\ud575\uc2ec \uc694\uc57d<\/h2>\n<p>\uc9c8\ubcd1\uad00\ub9ac\uccad \uad6d\ub9bd\ubcf4\uac74\uc5f0\uad6c\uc6d0 \uc8fc\ub3c4 BRIDGE \uc0ac\uc5c5\uc758 \ud55c\uad6d\ud615 \uce58\ub9e4 \ucf54\ud638\ud2b8(BRIDGE-LLOD)\ub97c \ud65c\uc6a9\ud55c \ud1b5\ud569 \ubd84\uc11d\uc5d0\uc11c SORL1, APCDD1, DRC7 \ub4f1 \uc2e0\uaddc \uc720\uc804\uc790\uac00 \uc54c\uce20\ud558\uc774\uba38\ubcd1\uacfc \uc720\uc758\ud558\uac8c \uc5f0\uad00\ub41c \uac83\uc73c\ub85c \ubc1d\ud600\uc84c\ub2e4. \uc5f0\uad6c\ub294 \uc544\ubc00\ub85c\uc774\ub4dc PET \uc601\uc0c1\uacfc \uc804\uc7a5 \uc720\uc804\uccb4(WGS\/GWAS)\ub97c \uc5f0\uacb0\ud574 \ub3d9\uc544\uc2dc\uc544\u00b7\uc720\ub7fd \ub2e4\uc778\uc885 \uba54\ud0c0\ubd84\uc11d\uc744 \uc218\ud589\ud588\uace0, SORL1 \ubcc0\uc774(rs76490923)\uac00 \ub3d9\uc544\uc2dc\uc544\uc5d0\uc11c \ud2b9\ud788 \uac15\ud55c \uc2e0\ud638(p=3.09\u00d710\u207b\u00b9\u00b9)\ub97c \ubcf4\uc600\ub2e4. \uc5f0\uad6c\uc9c4\uc740 APOE \u03b54, \ub2e4\uc720\uc804\uc790 \ubd80\ub2f4(polygenic risk), \uad6c\uc870\uc801 \ubcc0\uc774\uc758 \ub204\uc801 \ud6a8\uacfc\uac00 \uc778\uc9c0\uc800\ud558\uc640 \uc544\ubc00\ub85c\uc774\ub4dc \ucd95\uc801\uc744 \ud568\uaed8 \ucd09\uc9c4\ud55c\ub2e4\ub294 \uc815\ub7c9\uc801 \ubaa8\ub378\uc744 \uc81c\uc2dc\ud588\ub2e4. \uacb0\uacfc\ub294 2025\ub144 4\uc6d4 2\uc77c\uacfc 5\uc6d4 26\uc77c\uc790 Nature Communications 2\ud3b8\uc73c\ub85c \uac8c\uc7ac\ub410\ub2e4.<\/p>\n<h2>\ud575\uc2ec \uc0ac\uc2e4<\/h2>\n<ul>\n<li>\uc5f0\uad6c \uc790\ub8cc: BRIDGE-LLOD \ud55c\uad6d\uc778 \ucf54\ud638\ud2b8 \uae30\ubc18\uc73c\ub85c \uc544\ubc00\ub85c\uc774\ub4dc PET \uc601\uc0c1\u00b7\uc784\uc0c1\u00b7\uc720\uc804\uccb4 \ub370\uc774\ud130\ub97c \ud1b5\ud569 \ubd84\uc11d\ud588\ub2e4.<\/li>\n<li>\ub17c\ubb38 \uac8c\uc7ac: Nature Communications\uc5d0 \ub450 \ud3b8 \uac8c\uc7ac(2025-04-02, 2025-05-26).<\/li>\n<li>1\ucc28 GWAS \ud45c\ubcf8: \ub3d9\uc544\uc2dc\uc544(EAS) 3,387\uba85, \ubcf5\uc81c\ud45c\ubcf8 753\uba85, \uc720\ub7fd(EUR) \ub370\uc774\ud130 11,816\uba85 \ud3ec\ud568\ud55c \ub2e4\uc778\uc885 \uba54\ud0c0\ubd84\uc11d \uc218\ud589.<\/li>\n<li>SORL1 \uc2e0\ud638: \ubcc0\uc774 rs76490923\uac00 \uc544\ubc00\ub85c\uc774\ub4dc \ucd95\uc801\uacfc \uc720\uc758\ud55c \uc5f0\uad00\uc744 \ubcf4\uc600\uace0 \uba54\ud0c0\ubd84\uc11d p=3.09\u00d710\u207b\u00b9\u00b9\ub97c \uae30\ub85d\ud568.<\/li>\n<li>WGS \ubd84\uc11d: \ud55c\uad6d\uc778 1,559\uba85 \ub300\uc0c1 \uace0\uc2ec\ub3c4 \uc804\uc7a5\uc720\uc804\uccb4\ub85c \ud76c\uadc0 \ubcc0\uc774\u00b7\uad6c\uc870\uc801 \ubcc0\uc774(STR \ud655\uc7a5, \ubcf5\uc81c \ub4f1)\ub97c \ud0d0\uc0c9\ud574 APCDD1 \ub4f1 \uc2e0\uaddc \uc88c\uc704 \uc81c\uc2dc.<\/li>\n<li>\ub204\uc801 \ud6a8\uacfc \ubaa8\ub378: APOE \u03b54 \ubcf4\uc720 \uc5ec\ubd80, \ub2e4\uc720\uc804\uc790 \ubd80\ub2f4, \uad6c\uc870\uc801 \ubcc0\uc774\uc758 \uc0c1\ud638\uc791\uc6a9\uc774 \uc778\uc9c0 \uc800\ud558 \uc18d\ub3c4\u00b7\uc544\ubc00\ub85c\uc774\ub4dc \uc218\uce58 \uc0c1\uc2b9\uc5d0 \uae30\uc5ec\ud568\uc744 \uc815\ub7c9\ud654.<\/li>\n<li>\uc784\uc0c1\uc801 \ud568\uc758: PET \uae30\ubc18 \ubcd1\ub9ac \uc9c0\ud45c\ub97c \ud65c\uc6a9\ud55c \uc608\uce21\uc73c\ub85c \uc870\uae30 \uc704\ud5d8\ub3c4 \uc0b0\uc815\uacfc \ub9de\ucda4 \uce58\ub8cc \ud45c\uc801 \ubc1c\uad74\uc5d0 \uae30\ucd08\ub97c \uc81c\uacf5.<\/li>\n<\/ul>\n<h2>\uc0ac\uac74 \ubc30\uacbd<\/h2>\n<p>\uc54c\uce20\ud558\uc774\uba38\ubcd1\uc740 \uc804 \uc138\uacc4\uc801\uc73c\ub85c 5,700\ub9cc \uba85 \uc774\uc0c1\uc774 \uacaa\ub294 \ud1f4\ud589\uc131 \uc2e0\uacbd\uc9c8\ud658\uc73c\ub85c, \uc720\uc804 \uc694\uc778\uc774 \ubc1c\ubcd1 \uc704\ud5d8\uc758 \uc57d 60~80%\ub97c \ucc28\uc9c0\ud55c\ub2e4\uace0 \uc54c\ub824\uc838 \uc788\ub2e4. \ud558\uc9c0\ub9cc \uae30\uc874 \ub300\uaddc\ubaa8 GWAS \ub300\ubd80\ubd84\uc774 \uc720\ub7fd\uc778 \uc911\uc2ec\uc73c\ub85c \uc218\ud589\ub3fc \ub3d9\uc544\uc2dc\uc544\uc5d0\uc11c \ube48\ubc88\ud55c \ubcc0\uc774\ub098 \uc778\uc885 \ud2b9\uc774 \uc2e0\ud638\ub97c \ud3ec\ucc29\ud558\uae30 \uc5b4\ub835\ub2e4\ub294 \ud55c\uacc4\uac00 \uc788\uc5c8\ub2e4. \ub610\ud55c \ub9ce\uc740 \uc5f0\uad6c\uac00 \uc784\uc0c1 \uc9c4\ub2e8 \uae30\uc900\uc5d0 \uc758\uc874\ud574 \ubca0\ud0c0 \uc544\ubc00\ub85c\uc774\ub4dc \ub4f1 \uc9c1\uc811\uc801 \ubcd1\ub9ac \uc9c0\ud45c\ub97c \ubc18\uc601\ud558\uc9c0 \ubabb\ud588\uae30 \ub54c\ubb38\uc5d0 \uc720\uc804-\ubcd1\ub9ac \uc5f0\uacb0\uc131\uc774 \uc57d\ud558\uac8c \ub4dc\ub7ec\ub098\uae30\ub3c4 \ud588\ub2e4.<\/p>\n<p>BRIDGE-LLOD \ucf54\ud638\ud2b8\ub294 \uc815\uc0c1\uad70, \uacbd\ub3c4\uc778\uc9c0\uc7a5\uc560(MCI), \uce58\ub9e4 \ud658\uc790\ub97c \uc7a5\uae30\uac04 \ucd94\uc801\ud558\uba70 \uc784\uc0c1\u00b7\uc601\uc0c1\u00b7\uc720\uc804\uccb4 \ub370\uc774\ud130\ub97c \ud45c\uc900\ud654\ud574 \ucd95\uc801\ud55c \uad6d\ub0b4 \ub300\uaddc\ubaa8 \uc790\uc6d0\uc774\ub2e4. \uad6d\uac00 \ucc28\uc6d0\uc758 \uccb4\uacc4\uc801 \ucf54\ud638\ud2b8\uc640 \uace0\ud488\uc9c8 PET \uc601\uc0c1, \uc804\uc7a5 \uc720\uc804\uccb4\uc758 \uacb0\ud569\uc740 \ub3d9\uc544\uc2dc\uc544 \ud2b9\uc774 \uc2e0\ud638\ub97c \ubc1c\uad74\ud558\uace0 \ud76c\uadc0\u00b7\uad6c\uc870\uc801 \ubcc0\uc774\uae4c\uc9c0 \ud0d0\uc9c0\ud558\ub294 \ub370 \uacb0\uc815\uc801 \uc5ed\ud560\uc744 \ud588\ub2e4.<\/p>\n<h2>\uc8fc\uc694 \uc0ac\uac74<\/h2>\n<p>\uccab \ubc88\uc9f8 \ub17c\ubb38\uc740 \ub3d9\uc544\uc2dc\uc544 3,387\uba85\uc744 \ud3ec\ud568\ud55c 1\ub2e8\uacc4 GWAS\uc640 753\uba85 \ub3c5\ub9bd \ubcf5\uc81c\ud45c\ubcf8, \ucd94\uac00\uc801\uc73c\ub85c \uc720\ub7fd 11,816\uba85\uc744 \ud569\uce5c \ub2e4\uc778\uc885 \uba54\ud0c0\ubd84\uc11d\uc744 \ud1b5\ud574 APOE, CR1, FERMT2\uc640 \ub354\ubd88\uc5b4 SORL1 \ubcc0\uc774\uac00 \uc544\ubc00\ub85c\uc774\ub4dc \ucd95\uc801\uacfc \uac15\ud558\uac8c \uc5f0\uad00\ub428\uc744 \ubcf4\uace0\ud588\ub2e4. \ud2b9\ud788 SORL1\uc740 \ub3d9\uc544\uc2dc\uc544\uc5d0\uc11c \ub192\uc740 \ub300\ub9bd\uc720\uc804\uc790 \ube48\ub3c4\ub97c \ubcf4\uc600\uace0, \uba54\ud0c0\ubd84\uc11d\uc5d0\uc11c \uac15\ud55c \ud1b5\uacc4\uc801 \uc720\uc758\uc131\uc744 \ub098\ud0c0\ub0c8\ub2e4.<\/p>\n<p>\uc5f0\uad6c\uc9c4\uc740 SORL1\uc774 APP(\uc544\ubc00\ub85c\uc774\ub4dc \uc804\uad6c\uccb4 \ub2e8\ubc31\uc9c8)\uc758 \uc138\ud3ec \ub0b4 \uc218\uc1a1\uacfc \ubd84\ud574\ub97c \uc870\uc808\ud574 \ubca0\ud0c0 \uc544\ubc00\ub85c\uc774\ub4dc \uc0dd\uc131\uc744 \uc5b5\uc81c\ud558\ub294 \uc0dd\ub9ac\uc801 \uc5ed\ud560\uc744 \uac00\uc9c4\ub2e4\ub294 \uc810\uc744 \uadfc\uac70\ub85c, \ud574\ub2f9 \uc720\uc804\uc790\uc758 \ubcc0\uc774\uc640 \uc2e4\uc81c PET\uc5d0\uc11c \uad00\ucc30\ub418\ub294 \uc544\ubc00\ub85c\uc774\ub4dc \ucd95\uc801 \ucc28\uc774\ub97c \uc5f0\uacb0\ud588\ub2e4. APOE \u03b54 \ubcf4\uc720\uc790\ub77c\ub3c4 SORL1\uc758 \ubcf4\ud638 \ubcc0\uc774\ub97c \uac00\uc9c4 \uacbd\uc6b0 \uc544\ubc00\ub85c\uc774\ub4dc \ucd95\uc801 \uc704\ud5d8\uc774 43~56% \ub0ae\uc544\uc9c0\ub294 \uc644\ud654 \ud6a8\uacfc\ub97c \ud655\uc778\ud588\ub2e4.<\/p>\n<p>\ub450 \ubc88\uc9f8 \ub17c\ubb38\uc740 \uac19\uc740 \ucf54\ud638\ud2b8\uc758 1,559\uba85\uc744 \ub300\uc0c1\uc73c\ub85c \uace0\uc2ec\ub3c4 WGS\ub97c \uc218\ud589\ud574 \ud76c\uadc0 \ube44\ubd80\ud638\ud654 \ubcc0\uc774\uc640 \uad6c\uc870\uc801 \ubcc0\uc774\uae4c\uc9c0 \ud3ec\uad04\uc801\uc73c\ub85c \uac80\uc0c9\ud588\ub2e4. \uc774 \ubd84\uc11d\uc5d0\uc11c APCDD1\uc744 \uc0c8\ub85c\uc6b4 \uacf5\ud1b5 \ubcc0\uc774 \uc88c\uc704\ub85c \uc81c\uc2dc\ud588\uace0, \ud765\ubd84\uc131 \uc2e0\uacbd\uc138\ud3ec\uc5d0\uc11c \uc791\ub3d9\ud558\ub294 \uc870\uc808 \uc694\uc18c\uc758 \ud76c\uadc0 \ubcc0\uc774\uac00 \uc778\uc9c0\uc800\ud558\uc640 \uc5f0\uad00\ub428\uc744 \ubc1d\ud600\ub0c8\ub2e4. \ub610\ud55c STR \ud655\uc7a5 \ub4f1 \uad6c\uc870\uc801 \ubcc0\uc774\uac00 \uc54c\uce20\ud558\uc774\uba38 \uc704\ud5d8 \uc99d\uac00\uc640 \uc5f0\uacc4\ub418\ub294 \uc2e0\ud638\ub97c \ubcf4\uc600\ub2e4.<\/p>\n<h2>\ubd84\uc11d \ubc0f \uc758\ubbf8<\/h2>\n<p>\uc774\ubc88 \uc5f0\uad6c\ub294 \uc720\uc804 \uc2e0\ud638 \ub2e8\uc77c \uc88c\uc704\uc758 \uc720\ud6a8\uc131 \uc785\uc99d\uc744 \ub118\uc5b4, \uc11c\ub85c \ub2e4\ub978 \uc720\ud615\uc758 \uc720\uc804\uc801 \uc694\uc18c\uac00 \ud569\uccd0\uc838 \ubc1c\ubcd1\uc5d0 \uc774\ub974\ub294 &#8216;\uc784\uacc4\uac12&#8217; \uac1c\ub150\uc744 \uc2e4\uc99d\uc801\uc73c\ub85c \uc81c\uc2dc\ud588\ub2e4. APOE \u03b54 \uac19\uc740 \uace0\uc704\ud5d8 \ubcc0\uc774\ubfd0 \uc544\ub2c8\ub77c \ub2e4\uc218\uc758 \uc18c\ud6a8\uacfc \ubcc0\uc774, \ud76c\uadc0\u00b7\uad6c\uc870\uc801 \ubcc0\uc774\uac00 \ub204\uc801\ub420 \ub54c \ubcd1\ub9ac\uc801 \uc544\ubc00\ub85c\uc774\ub4dc \ucd95\uc801\uacfc \uc778\uc9c0\uc800\ud558 \uc18d\ub3c4\ub97c \ud06c\uac8c \ub192\uc77c \uc218 \uc788\uc74c\uc744 \uc815\ub7c9\ud654\ud588\ub2e4. \uc774\ub294 \uc784\uc0c1\uc5d0\uc11c \ub2e8\uc77c \uc720\uc804\uc790 \uac80\uc0ac\ub85c\ub294 \ud3ec\ucc29\ud558\uae30 \uc5b4\ub824\uc6b4 \uac1c\uc778\ubcc4 \ucd1d\uccb4\uc801 \uc704\ud5d8\ub3c4\ub97c \uc0b0\ucd9c\ud560 \ud544\uc694\uac00 \uc788\uc74c\uc744 \uc758\ubbf8\ud55c\ub2e4.<\/p>\n<p>\uc784\uc0c1 \uc801\uc6a9 \uad00\uc810\uc5d0\uc11c PET \uae30\ubc18 \ubcd1\ub9ac \uc9c0\ud45c\ub97c \ud3ec\ud568\ud558\uba74 \ud5a5\ud6c4 \uc218\ub144 \ub0b4 \uc544\ubc00\ub85c\uc774\ub4dc \ucd95\uc801 \ucd94\uc774\uc640 \uc778\uc9c0\uc800\ud558 \uac00\ub2a5\uc131\uc744 \ub354 \uc815\ubc00\ud558\uac8c \uc608\uce21\ud560 \uc218 \uc788\ub2e4. \ub610\ud55c SORL1\ucc98\ub7fc APP \ucc98\ub9ac \uacbd\ub85c\uc5d0 \uad00\uc5ec\ud558\ub294 \uc720\uc804\uc790\ub97c \ud45c\uc801\uc73c\ub85c \ud558\ub294 \uce58\ub8cc \uc804\ub7b5\uc740 \uc57d\ubb3c \ud45c\uc801\ud654(targeting)\uc640 \ubcd1\uc6a9\uc694\ubc95 \uc124\uacc4\uc5d0\uc11c \uc2e4\uc9c8\uc801 \uadfc\uac70\ub97c \uc81c\uacf5\ud55c\ub2e4. \uc608\ucee8\ub300 SORL1 \uae30\ub2a5\uc744 \ubcf4\uac15\ud558\ub294 \uce58\ub8cc\uac00 APOE \u03b54 \uad00\ub828 \uc704\ud5d8\uc744 \uc77c\ubd80 \uc0c1\uc1c4\ud560 \uc218 \uc788\ub2e4\ub294 \uc99d\uac70\ub294 \uc57d\ubb3c \uc7ac\ucc3d\ucd9c \ub610\ub294 \uc2e0\uc57d \uac1c\ubc1c\uc758 \uc6b0\uc120\uc21c\uc704\ub97c \uc7ac\uc815\ub9bd\ud558\uac8c \ud55c\ub2e4.<\/p>\n<p>\ub354\ubd88\uc5b4 \ub3d9\uc544\uc2dc\uc544 \ud2b9\uc774 \uc2e0\ud638\uc640 \uc778\uc885 \uacf5\ud1b5 \uc2e0\ud638\ub97c \ub3d9\uc2dc\uc5d0 \uac80\ucd9c\ud55c \ub2e4\uc778\uc885 \uba54\ud0c0\ubd84\uc11d\uc740 \uad6d\ub0b4\uc5d0\uc11c \uac1c\ubc1c\ub41c \uc9c4\ub2e8\u00b7\uc608\ubc29\ubc95\uc758 \ud574\uc678 \ud655\uc7a5\uc131\ub3c4 \ub192\uc778\ub2e4\ub294 \uc810\uc5d0\uc11c \uae30\uc220 \uc0c1\uc6a9\ud654\u00b7\uae00\ub85c\ubc8c\ud654 \uad00\uc810\uc758 \uc911\uc694\uc131\uc774 \ud06c\ub2e4. \ub2e8, \uc720\uc804\uccb4-\uc601\uc0c1 \ud1b5\ud569 \ub370\uc774\ud130\ub294 \ub300\uaddc\ubaa8\u00b7\uc7a5\uae30 \ucd94\uc801 \uc778\ud504\ub77c\uac00 \uc804\uc81c\ub418\uc5b4\uc57c \uc7ac\ud604 \uac00\ub2a5\ud558\ub2e4\ub294 \ud604\uc2e4\uc801 \uc870\uac74\uc744 \ud568\uaed8 \uace0\ub824\ud574\uc57c \ud55c\ub2e4.<\/p>\n<h2>\ube44\uad50 \ubc0f \ub370\uc774\ud130<\/h2>\n<figure>\n<table>\n<thead>\n<tr>\n<th>\ubd84\uc11d \uc720\ud615<\/th>\n<th>\ud45c\ubcf8 \uc218<\/th>\n<th>\uc8fc\uc694 \ub370\uc774\ud130<\/th>\n<th>\ud575\uc2ec \uacb0\uacfc<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>GWAS(\ub3d9\uc544\uc2dc\uc544)<\/td>\n<td>3,387<\/td>\n<td>\uc544\ubc00\ub85c\uc774\ub4dc PET, \uc784\uc0c1, GWAS<\/td>\n<td>SORL1(rs76490923) \uc720\uc758(p=3.09\u00d710\u207b\u00b9\u00b9)<\/td>\n<\/tr>\n<tr>\n<td>\ubcf5\uc81c \ud45c\ubcf8<\/td>\n<td>753<\/td>\n<td>\ub3d9\uc77c \ucf54\ud638\ud2b8 \ub3c5\ub9bd \ud45c\ubcf8<\/td>\n<td>GWAS \uc2e0\ud638 \ubcf5\uc81c<\/td>\n<\/tr>\n<tr>\n<td>\ub2e4\uc778\uc885 \uba54\ud0c0\ubd84\uc11d<\/td>\n<td>EUR 11,816 \ucd94\uac00<\/td>\n<td>\ub2e4\uc778\uc885 \ud1b5\ud569<\/td>\n<td>\ub3d9\uc544\uc2dc\uc544\u00b7\uc720\ub7fd \uacf5\ud1b5\/\ud2b9\uc774 \uc2e0\ud638 \ud655\uc778<\/td>\n<\/tr>\n<tr>\n<td>WGS<\/td>\n<td>1,559<\/td>\n<td>\uc804\uc7a5\uc720\uc804\uccb4 \uc5fc\uae30\uc11c\uc5f4<\/td>\n<td>APCDD1, \ud76c\uadc0\u00b7\uad6c\uc870\uc801 \ubcc0\uc774 \uc2e0\ud638 \ud0d0\uc0c9<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n<p>\uc704 \ud45c\ub294 \uc5f0\uad6c\uc5d0 \uc0ac\uc6a9\ub41c \uc8fc\uc694 \ud45c\ubcf8 \uad6c\uc131\uacfc \ud575\uc2ec \uacb0\uacfc\ub97c \uc694\uc57d\ud55c \uac83\uc774\ub2e4. \ud45c\ubcf8 \uaddc\ubaa8\uc640 \ub370\uc774\ud130 \ud0c0\uc785(\uc601\uc0c1+\uc720\uc804\uccb4)\uc758 \uacb0\ud569\uc774 \uc774\ubc88 \ubc1c\uacac\uc758 \uc2e0\ub8b0\ub3c4\ub97c \ub192\uc600\ub2e4\ub294 \uc810\uc744 \ubcf4\uc5ec\uc900\ub2e4. \ud2b9\ud788 WGS\ub294 \ud76c\uadc0\u00b7\uad6c\uc870\uc801 \ubcc0\uc774\ub97c \ud3ec\ucc29\ud560 \uc218 \uc788\uc5b4 GWAS \ub2e8\ub3c5 \ubd84\uc11d\uc758 \ud55c\uacc4\ub97c \ubcf4\uc644\ud588\ub2e4.<\/p>\n<h2>\ubc18\uc751 \ubc0f \uc778\uc6a9<\/h2>\n<p>\uc5f0\uad6c \ucc45\uc784\uc790\ub97c \ud3ec\ud568\ud55c \uc5f0\uad6c\uc9c4\uc740 \uc774\ubc88 \ud1b5\ud569 \ubd84\uc11d\uc774 &#8216;\uc784\uc0c1 \ubcd1\ub9ac&#8217;\uc640 &#8216;\uc720\uc804\uccb4 \uc2e0\ud638&#8217;\ub97c \uc9c1\uc811 \uc5f0\uacb0\ud588\ub2e4\ub294 \uc810\uc5d0\uc11c \uc758\uc758\uac00 \ud06c\ub2e4\uace0 \uc124\uba85\ud588\ub2e4. \uc774\ub4e4\uc740 SORL1 \uac19\uc740 \ubcf4\ud638\u00b7\uc704\ud5d8 \uc2e0\ud638\ub97c \uac1c\uc778\ubcc4\ub85c \ud1b5\ud569\ud574 \ub204\uc801 \uc704\ud5d8\uc744 \uacc4\uc0b0\ud558\uba74 \uc870\uae30 \uc608\uce21\uacfc \ub9de\ucda4 \uce58\ub8cc\uc758 \uc815\ud655\ub3c4\uac00 \ud06c\uac8c \ub192\uc544\uc9c8 \uac83\uc774\ub77c\uace0 \ubc1d\ud614\ub2e4.<\/p>\n<blockquote>\n<p>&#8220;PET\ub85c \ud655\uc778\ub41c \uc544\ubc00\ub85c\uc774\ub4dc\uc640 \uc720\uc804\uccb4\ub97c \ud55c \ucd95\uc5d0\uc11c \ubd84\uc11d\ud574 \uc54c\uce20\ud558\uc774\uba38\uc758 \uc0dd\ubb3c\ud559\uc801 \uae30\uc804\uc744 \uc0ac\ub78c \ub370\uc774\ud130\ub85c \ud655\uc778\ud588\ub2e4.&#8221;<\/p>\n<p><cite>\uc11c\uc0c1\uc6d0 \uad50\uc218(\uc0bc\uc131\uc11c\uc6b8\ubcd1\uc6d0, \uacf5\ub3d9\uc5f0\uad6c\ucc45\uc784)<\/cite><\/p><\/blockquote>\n<p>\ubcf4\uac74\ub2f9\uad6d\uc740 \uad6d\uac00 \uc8fc\ub3c4 \ucf54\ud638\ud2b8\uc640 \ub370\uc774\ud130 \uc778\ud504\ub77c\uc758 \uc911\uc694\uc131\uc744 \uc7ac\ucc28 \uac15\uc870\ud558\uba70 \uc7a5\uae30 \ucd94\uc801 \uc5f0\uad6c\uc758 \uc9c0\uc18d\uc801 \uc9c0\uc6d0 \uc758\uc9c0\ub97c \ubc1d\ud614\ub2e4. \uc774\ub294 \ud5a5\ud6c4 \ub300\uaddc\ubaa8 \ub370\uc774\ud130 \uae30\ubc18 \uc815\ubc00\uc758\ub8cc \ud655\uc0b0\uc5d0 \ub300\ud55c \uc815\ucc45\uc801 \uc2e0\ud638\ub85c \uc77d\ud78c\ub2e4.<\/p>\n<blockquote>\n<p>&#8220;\uad6d\uac00 \ucf54\ud638\ud2b8\uc640 \ub370\uc774\ud130 \uc778\ud504\ub77c\uac00 \uad6d\ubbfc \uac74\uac15 \ubb38\uc81c \ud574\uacb0\uc5d0 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud588\uc74c\uc744 \ubcf4\uc5ec\uc900\ub2e4. \uc9c0\uc18d \uc9c0\uc6d0\ud558\uaca0\ub2e4.&#8221;<\/p>\n<p><cite>\uc784\uc2b9\uad00 \uc9c8\ubcd1\uad00\ub9ac\uccad\uc7a5(\uacf5\uc2dd \ubc1c\uc5b8)<\/cite><\/p><\/blockquote>\n<h2>\n<aside>\n<details>\n<summary>\uc6a9\uc5b4\/\ubc29\ubc95\ub860<\/summary>\n<p>PET(\uc591\uc804\uc790\ubc29\ucd9c\ub2e8\uce35\ucd2c\uc601)\uc740 \ub1cc \ub0b4 \ubca0\ud0c0 \uc544\ubc00\ub85c\uc774\ub4dc \ucd95\uc801\uc744 \uc601\uc0c1\uc73c\ub85c \uc815\ub7c9\ud654\ud558\ub294 \ubc29\ubc95\uc774\ub2e4. GWAS\ub294 \uc218\ucc9c~\uc218\ub9cc \uba85\uc758 \ud45c\ubcf8\uc5d0\uc11c \uacf5\ud1b5 \uc720\uc804 \ubcc0\uc774\uc640 \uc9c8\ubcd1 \uc5f0\uad00\uc744 \ucc3e\ub294 \ubc18\uba74, WGS\ub294 \uac1c\uc778\uc758 \uc804\uc7a5 \uc720\uc804\uccb4\ub97c \ud574\ub3c5\ud574 \ud76c\uadc0 \ubcc0\uc774\ub098 \uad6c\uc870\uc801 \ubcc0\uc774\uae4c\uc9c0 \ud3ec\ucc29\ud55c\ub2e4. APOE \u03b54\ub294 \uc54c\ub824\uc9c4 \uace0\uc704\ud5d8 \ub300\ub9bd\uc720\uc804\uc790\ub85c \uc54c\uce20\ud558\uc774\uba38 \ubc1c\ubcd1 \uc704\ud5d8\uc744 \ub192\uc774\uba70, SORL1\uc740 APP \ub2e8\ubc31\uc9c8\uc758 \uc138\ud3ec \ub0b4 \uc774\ub3d9\u00b7\ubd84\ud574\uc5d0 \uad00\uc5ec\ud574 \ubca0\ud0c0 \uc544\ubc00\ub85c\uc774\ub4dc \uc0dd\uc131\uc5d0 \uc601\ud5a5\uc744 \uc900\ub2e4. \ub2e4\uc720\uc804\uc790 \ubd80\ub2f4(polygenic risk)\uc740 \uc5ec\ub7ec \uc18c\ud6a8\uacfc \ubcc0\uc774\ub97c \ud569\uccd0 \uac1c\uc778\ubcc4 \uc720\uc804\uc801 \uc704\ud5d8\uc744 \uc218\uce58\ud654\ud55c \uac1c\ub150\uc774\ub2e4.<\/p>\n<\/details>\n<\/aside>\n<\/h2>\n<h2>\ubd88\ud655\uc2e4\ud55c \ubd80\ubd84<\/h2>\n<ul>\n<li>\ube44\uad50\uc801 \uc791\uc740 \ud45c\ubcf8\uc5d0\uc11c \uad00\ucc30\ub41c \uc77c\ubd80 \ud76c\uadc0\u00b7\uad6c\uc870\uc801 \ubcc0\uc774\uc758 \ud6a8\uacfc \ud06c\uae30\uc640 \uc7ac\ud604\uc131\uc740 \ucd94\uac00 \ud45c\ubcf8\uc5d0\uc11c \ud655\uc778\uc774 \ud544\uc694\ud558\ub2e4.<\/li>\n<li>\ud55c\uad6d\uc778 \ucf54\ud638\ud2b8\uc5d0\uc11c \ud655\uc778\ub41c \ub3d9\uc544\uc2dc\uc544 \ud2b9\uc774 \uc2e0\ud638\uac00 \ub2e4\ub978 \uc544\uc2dc\uc544\uad8c(\uc608: \uc911\uad6d\u00b7\uc77c\ubcf8) \uc804\uccb4\uc5d0 \ub3d9\uc77c\ud558\uac8c \uc801\uc6a9\ub418\ub294\uc9c0\ub294 \uc544\uc9c1 \ubd88\ud655\uc2e4\ud558\ub2e4.<\/li>\n<li>\uc720\uc804\uc801 \ub204\uc801 \uc704\ud5d8 \ubaa8\ub378\uc758 \uc784\uc0c1 \uc801\uc6a9(\uc608: \uc2a4\ud06c\ub9ac\ub2dd \uad8c\uace0 \uae30\uc900\ud654, \ubcf4\ud5d8\u00b7\uc9c4\ub8cc \uccb4\uacc4 \ubc18\uc601)\uc740 \uc815\ucc45\uc801\u00b7\uc724\ub9ac\uc801 \ub17c\uc758\uc640 \ucd94\uac00 \uac80\uc99d\uc774 \uc694\uad6c\ub41c\ub2e4.<\/li>\n<\/ul>\n<h2>\ucd1d\ud3c9<\/h2>\n<p>\uc774\ubc88 \uc5f0\uad6c\ub294 \uace0\ud488\uc9c8 \ud55c\uad6d\uc778 \ucf54\ud638\ud2b8\uc640 PET\u00b7\uc720\uc804\uccb4 \ud1b5\ud569 \ubd84\uc11d\uc73c\ub85c \ub3d9\uc544\uc2dc\uc544\uc5d0\uc11c \ud2b9\ud788 \ub3c4\ub4dc\ub77c\uc9c0\ub294 \uc720\uc804 \uc2e0\ud638\ub97c \uaddc\uba85\ud558\uace0, \ub2e4\uc911 \uc720\uc804 \uc694\uc778\uc758 \ub204\uc801\uc774 \uc2e4\uc81c \ubcd1\ub9ac\uc640 \uc778\uc9c0\uc800\ud558\uc5d0 \uc5b4\ub5bb\uac8c \uc5f0\uacb0\ub418\ub294\uc9c0 \uc815\ub7c9\uc801\uc73c\ub85c \uc81c\uc2dc\ud588\ub2e4. SORL1\uc758 \ubcf4\ud638 \ud6a8\uacfc\uc640 APCDD1 \ub4f1 \uc2e0\uaddc \uc88c\uc704\uc758 \ubc1c\uad74\uc740 \ubcd1\ud0dc\uc0dd\ub9ac \uae30\ubc18 \ud45c\uc801 \ubc1c\uad74\uacfc \uc815\ubc00 \uc704\ud5d8 \uc608\uce21\uc758 \uadfc\uac70\ub97c \ud655\uc7a5\ud55c\ub2e4.<\/p>\n<p>\ud5a5\ud6c4 \uc5f0\uad6c\ub294 \ud45c\uc900\ud654\ub41c \ub2e4\uad6d\uac00 \ucf54\ud638\ud2b8\uc640 \ucd94\uac00 \ubc14\uc774\uc624\ub9c8\ucee4(\ud0c0\uc6b0, \uc5fc\uc99d \uc9c0\ud45c), \uc0dd\ud65c\uc2b5\uad00\u00b7\ud608\uc561 \ud45c\uc9c0\uc790\u00b7\ub514\uc9c0\ud138 \uc778\uc9c0 \uc9c0\ud45c\ub97c \uacb0\ud569\ud574 \uc608\uce21\ub825\uc744 \ub192\uc774\ub294 \ubc29\ud5a5\uc73c\ub85c \uc9c4\ud589\ub420 \ud544\uc694\uac00 \uc788\ub2e4. \uc784\uc0c1\uc801\u00b7\uc815\ucc45\uc801 \uc801\uc6a9\uc744 \uc704\ud574\uc11c\ub294 \ub300\uaddc\ubaa8 \uc7ac\ud604\uc5f0\uad6c\uc640 \uc724\ub9ac\u00b7\uc0ac\ud68c\uc801 \ub17c\uc758\uac00 \ubcd1\ud589\ub418\uc5b4\uc57c \ud55c\ub2e4.<\/p>\n<h2>\ucd9c\ucc98<\/h2>\n<ul>\n<li><a href=\"http:\/\/www.biotimes.co.kr\/news\/articleView.html?idxno=25175\" target=\"_blank\" rel=\"noopener\">\ubc14\uc774\uc624\ud0c0\uc784\uc988(\uc5b8\ub860)<\/a><\/li>\n<li><a href=\"https:\/\/doi.org\/10.1038\/s41467-025-57751-4\" target=\"_blank\" rel=\"noopener\">Nature Communications (\ud559\uc220\uc9c0, 2025-04-02 DOI:10.1038\/s41467-025-57751-4)<\/a><\/li>\n<li><a href=\"https:\/\/doi.org\/10.1038\/s41467-025-59949-y\" target=\"_blank\" rel=\"noopener\">Nature Communications (\ud559\uc220\uc9c0, 2025-05-26 DOI:10.1038\/s41467-025-59949-y)<\/a><\/li>\n<\/ul>\n<\/article>\n","protected":false},"excerpt":{"rendered":"<p>\ud575\uc2ec \uc694\uc57d \uc9c8\ubcd1\uad00\ub9ac\uccad \uad6d\ub9bd\ubcf4\uac74\uc5f0\uad6c\uc6d0 \uc8fc\ub3c4 BRIDGE \uc0ac\uc5c5\uc758 \ud55c\uad6d\ud615 \uce58\ub9e4 \ucf54\ud638\ud2b8(BRIDGE-LLOD)\ub97c \ud65c\uc6a9\ud55c \ud1b5\ud569 \ubd84\uc11d\uc5d0\uc11c SORL1, APCDD1, DRC7 \ub4f1 \uc2e0\uaddc \uc720\uc804\uc790\uac00 \uc54c\uce20\ud558\uc774\uba38\ubcd1\uacfc \uc720\uc758\ud558\uac8c \uc5f0\uad00\ub41c \uac83\uc73c\ub85c \ubc1d\ud600\uc84c\ub2e4. \uc5f0\uad6c\ub294 \uc544\ubc00\ub85c\uc774\ub4dc PET \uc601\uc0c1\uacfc \uc804\uc7a5 \uc720\uc804\uccb4(WGS\/GWAS)\ub97c \uc5f0\uacb0\ud574 \ub3d9\uc544\uc2dc\uc544\u00b7\uc720\ub7fd \ub2e4\uc778\uc885 \uba54\ud0c0\ubd84\uc11d\uc744 \uc218\ud589\ud588\uace0, SORL1 \ubcc0\uc774(rs76490923)\uac00 \ub3d9\uc544\uc2dc\uc544\uc5d0\uc11c \ud2b9\ud788 \uac15\ud55c \uc2e0\ud638(p=3.09\u00d710\u207b\u00b9\u00b9)\ub97c \ubcf4\uc600\ub2e4. \uc5f0\uad6c\uc9c4\uc740 APOE \u03b54, \ub2e4\uc720\uc804\uc790 \ubd80\ub2f4(polygenic risk), \uad6c\uc870\uc801 \ubcc0\uc774\uc758 \ub204\uc801 \ud6a8\uacfc\uac00 \uc778\uc9c0\uc800\ud558\uc640 \uc544\ubc00\ub85c\uc774\ub4dc \ucd95\uc801\uc744 &#8230; <a title=\"\uad6d\ub0b4 \uc5f0\uad6c\uc9c4, \uc54c\uce20\ud558\uc774\uba38\ubcd1\uc758 \ubc1c\ubcd1 \uad00\ub828 \uc720\uc804\uc790 \ub300\uac70 \uaddc\uba85 \ubc0f \ub204\uc801 \ud6a8\uacfc \ubaa8\ub378 \uc81c\uc2dc &#8211; \ubc14\uc774\uc624\ud0c0\uc784\uc988\" class=\"read-more\" href=\"https:\/\/readtrends.com\/ko\/sorl1-apcdd1-alzheimers-korea\/\" aria-label=\"\uad6d\ub0b4 \uc5f0\uad6c\uc9c4, \uc54c\uce20\ud558\uc774\uba38\ubcd1\uc758 \ubc1c\ubcd1 \uad00\ub828 \uc720\uc804\uc790 \ub300\uac70 \uaddc\uba85 \ubc0f \ub204\uc801 \ud6a8\uacfc \ubaa8\ub378 \uc81c\uc2dc &#8211; \ubc14\uc774\uc624\ud0c0\uc784\uc988\uc5d0 \ub300\ud574 \ub354 \uc790\uc138\ud788 \uc54c\uc544\ubcf4\uc138\uc694\">\ub354 \uc77d\uae30<\/a><\/p>\n","protected":false},"author":1,"featured_media":2770,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"rank_math_title":"\ud55c\uad6d\uc778 \ucf54\ud638\ud2b8\ub85c \uaddc\uba85\ud55c \uc54c\uce20\ud558\uc774\uba38 \uc720\uc804\uc790\u00b7\ub204\uc801\uc704\ud5d8 \ubaa8\ub378 \ubc1c\ud45c - \ubc14\uc774\uc624\ud0c0\uc784\uc988","rank_math_description":"BRIDGE-LLOD \ucf54\ud638\ud2b8\uc758 PET \uc601\uc0c1\u00b7\uc804\uc7a5\uc720\uc804\uccb4 \ud1b5\ud569 \uc5f0\uad6c\uc5d0\uc11c SORL1\u00b7APCDD1 \ub4f1 \uc2e0\uaddc \uc720\uc804\uc790\uc640 \uc720\uc804 \uc2e0\ud638\uc758 \ub204\uc801 \ud6a8\uacfc\uac00 \uc54c\uce20\ud558\uc774\uba38 \ubc1c\ubcd1\uc5d0 \uae30\uc5ec\ud568\uc744 \ubcf4\uace0\ud588\ub2e4. \ub9de\ucda4\uc608\uce21\uacfc \uce58\ub8cc \ud45c\uc801 \uac00\ub2a5\uc131 \uc81c\uc2dc.","rank_math_focus_keyword":"SORL1,APCDD1,\uc54c\uce20\ud558\uc774\uba38,\ub204\uc801\ud6a8\uacfc,\ud55c\uad6d\uc778\ucf54\ud638\ud2b8","footnotes":""},"categories":[2],"tags":[],"class_list":["post-2776","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-top-stories"],"_links":{"self":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/posts\/2776","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/comments?post=2776"}],"version-history":[{"count":0,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/posts\/2776\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/media\/2770"}],"wp:attachment":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/media?parent=2776"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/categories?post=2776"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/tags?post=2776"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}