{"id":3028,"date":"2025-11-14T10:09:01","date_gmt":"2025-11-14T01:09:01","guid":{"rendered":"https:\/\/readtrends.com\/ko\/trd-genetic-clues-nordic\/"},"modified":"2025-11-14T10:09:01","modified_gmt":"2025-11-14T01:09:01","slug":"trd-genetic-clues-nordic","status":"publish","type":"post","link":"https:\/\/readtrends.com\/ko\/trd-genetic-clues-nordic\/","title":{"rendered":"\ud56d\uc6b0\uc6b8\uc81c \uc548 \ub4e3\ub294 \u2018\ub09c\uce58\uc131 \uc6b0\uc6b8\uc99d\u2019, \uc720\uc804\uc790\uc5d0\uc11c \ub2e8\uc11c \ucc3e\uc558\ub2e4 &#8211; \ubc14\uc774\uc624\ud0c0\uc784\uc988"},"content":{"rendered":"<article>\n<p>\ud575\uc2ec \uc694\uc57d: 2025\ub144 6\uc6d4 26\uc77c \uac8c\uc7ac\ub41c \uad6d\uc81c\ud559\uc220\uc9c0 Molecular Psychiatry \ub17c\ubb38\uc5d0\uc11c \uc2a4\uc6e8\ub374 \uce74\ub864\ub9b0\uc2a4\uce74\uc5f0\uad6c\uc18c\u00b7\uc608\ud14c\ubcf4\ub9ac\ub300, \ud540\ub780\ub4dc FinnGen, \uc5d0\uc2a4\ud1a0\ub2c8\uc544 \ubc14\uc774\uc624\ubc45\ud06c \ub4f1 \ubd81\uc720\ub7fd \uc5f0\uad6c\uc9c4\uc740 \uc57d 80\ub9cc \uba85\uc758 \uc720\uc804\uccb4\uc640 \uc9c4\ub8cc\uae30\ub85d\uc744 \ubd84\uc11d\ud574 \ud56d\uc6b0\uc6b8\uc81c\uc5d0 \ubc18\uc751\ud558\uc9c0 \uc54a\ub294 \ub09c\uce58\uc131 \uc6b0\uc6b8\uc99d(TRD)\uc758 \uc720\uc804\uc801 \ud2b9\uc9d5\uc744 \uc81c\uc2dc\ud588\ub2e4. \uc5f0\uad6c\ub294 TRD\uac00 \uc77c\ubc18 \uc8fc\uc694\uc6b0\uc6b8\uc7a5\uc560(MDD)\uc640 \uac15\ud55c \uc720\uc804\uc801 \uacb9\uce68\uc744 \ubcf4\uc774\uba74\uc11c\ub3c4 \uc591\uadf9\uc131 \uc7a5\uc560\uc640 \uc870\ud604\ubcd1\uacfc\uc758 \uc720\uc804\uc801 \uad00\ub828\uc131\uc774 \ub354 \ub192\uac8c \ub098\ud0c0\ub0ac\uace0(rg\u22480.86, 0.57), \ud76c\uadc0 \ubcf5\uc81c\uc218 \ubcc0\uc774(CNV)\uc758 \uacb0\uc2e4\ub3c4 \ub354 \uc790\uc8fc \uad00\ucc30\ub41c\ub2e4\uace0 \ubcf4\uace0\ud588\ub2e4. \uc5f0\uad6c\uc9c4\uc740 \uc774\ub7ec\ud55c \uacb0\uacfc\uac00 \ub09c\uce58\uc131 \uc6b0\uc6b8\uc99d\uc744 \uc815\ubc00\uc758\ud559 \uad00\uc810\uc5d0\uc11c \uc7ac\ubd84\ub958\ud558\uace0 \ub9de\ucda4 \uce58\ub8cc\ub85c \uc5f0\uacb0\ud560 \ub2e8\uc11c\ub97c \uc81c\uacf5\ud560 \uc218 \uc788\ub2e4\uace0 \ud3c9\uac00\ud588\ub2e4.<\/p>\n<h2>\ud575\uc2ec \uc0ac\uc2e4<\/h2>\n<ul>\n<li>\ubd84\uc11d \uaddc\ubaa8: \ubd81\uc720\ub7fd 3\uac1c\uad6d \ucf54\ud638\ud2b8\uc758 \uc720\uc804\uccb4 \ubc0f \uc804\uc790\uc758\ubb34\uae30\ub85d\uc744 \ud1b5\ud569\ud574 \uc57d 80\ub9cc \uba85 \uaddc\ubaa8\ub97c \ubd84\uc11d\ud588\ub2e4.<\/li>\n<li>\ud559\uc220 \uac8c\uc7ac: \uacb0\uacfc\ub294 2025\ub144 6\uc6d4 26\uc77c Molecular Psychiatry \uc628\ub77c\uc778\ud310\uc5d0 \uac8c\uc7ac(DOI: 10.1038\/s41380-025-03084-z)\ub418\uc5c8\ub2e4.<\/li>\n<li>\uc720\uc804 \uc0c1\uad00: \ub09c\uce58\uc131 \uc6b0\uc6b8\uc99d(TRD)\uc740 \uc77c\ubc18 \uc6b0\uc6b8\uc99d(MDD)\uacfc \ub192\uc740 \uc720\uc804\uc801 \uacb9\uce68(rg \u2248 0.90)\uc744 \ubcf4\uc600\uc73c\ub098, \uc591\uadf9\uc131 \uc7a5\uc560\uc640\uc758 rg \u2248 0.86, \uc870\ud604\ubcd1\uacfc\uc758 rg \u2248 0.57\ub85c MDD\ubcf4\ub2e4 \uc911\uc99d \uc815\uc2e0\uc9c8\ud658\uacfc \ub354 \uac15\ud55c \uc5f0\uacb0\uc744 \ubcf4\uc600\ub2e4.<\/li>\n<li>CNV \uacb0\uacfc: TRD \ud658\uc790\ub294 \uc804\uccb4 CNV \uacb0\uc2e4 \uc218\uc640 \uae38\uc774\uac00 \uc720\uc758\ud558\uac8c \ub9ce\uc558\uace0, \uc2e0\uacbd\ubc1c\ub2ec\u00b7\uc870\ud604\ubcd1 \uad00\ub828 54\uc885\uc758 CNV\uc5d0 \ub300\ud574 \uc57d 1.7\u20132.9\ubc30\uc758 \ub354 \ub192\uc740 \ubcf4\uc720 \ube48\ub3c4\ub97c \ubcf4\uc600\ub2e4.<\/li>\n<li>\ubd84\uc11d \ubc29\ubc95: \ub2e8\uc77c\uc5fc\uae30\ub2e4\ud615\uc131(SNP) \uae30\ubc18 GWAS \ube44\uad50\uc640 \ud76c\uadc0 \ubcf5\uc81c\uc218 \ubcc0\uc774(CNV) \ubd84\uc11d\uc744 \ubcd1\ud589\ud574 \ub2e4\uc911 \uc720\uc804\uc801 \uc9c0\ud45c\ub97c \ud3c9\uac00\ud588\ub2e4.<\/li>\n<li>\uc784\uc0c1\uc801 \ud568\uc758: \uc5f0\uad6c\uc9c4\uc740 TRD \uc77c\ubd80\uac00 \uc2dc\uac04\uc774 \uc9c0\ub098 \uc591\uadf9\uc131 \uc7a5\uc560\ub85c \uc7ac\ubd84\ub958\ub418\uac70\ub098 \uc815\uc2e0\ubcd1\uc801 \uc99d\uc0c1\uc744 \ub3d9\ubc18\ud558\ub294 \uc784\uc0c1 \uad00\ucc30\uacfc \uc720\uc804 \uacb0\uacfc\uac00 \uc77c\uce58\ud55c\ub2e4\uace0 \ud574\uc11d\ud588\ub2e4.<\/li>\n<\/ul>\n<h2>\uc0ac\uac74 \ubc30\uacbd<\/h2>\n<p>\ub09c\uce58\uc131 \uc6b0\uc6b8\uc99d(TRD)\uc740 \ud56d\uc6b0\uc6b8\uc81c\ub97c \uc5ec\ub7ec \ucc28\ub840 \ubcc0\uacbd\ud558\uac70\ub098 \uc6a9\ub7c9\uc744 \ub192\uc5ec\ub3c4 \uad00\ud574\uc5d0 \uc774\ub974\uc9c0 \ubabb\ud55c \uc8fc\uc694\uc6b0\uc6b8\uc7a5\uc560 \ud658\uc790 \uc9d1\ub2e8\uc744 \uc9c0\uce6d\ud55c\ub2e4. \uc77c\ubc18\uc801\uc73c\ub85c \uc8fc\uc694\uc6b0\uc6b8\uc7a5\uc560 \ud658\uc790\uc758 \uc57d 2\/3\uac00 \uccab \uce58\ub8cc\ub85c \uc644\uc804 \uad00\ud574\uc5d0 \ub3c4\ub2ec\ud558\uc9c0 \ubabb\ud558\uba70, \uc774 \uc911 \uc77c\ubd80\uac00 \ubc18\ubcf5\ub41c \uce58\ub8cc \uc2e4\ud328\ub85c TRD\ub85c \uc9c4\ud589\ud55c\ub2e4. TRD\ub294 \uc7ac\uc785\uc6d0\u00b7\uc790\uc0b4 \uc704\ud5d8\u00b7\uc870\uae30 \uc0ac\ub9dd\ub960\uc774 \ub354 \ub192\uace0 \uc758\ub8cc\u00b7\uc0ac\ud68c\uc801 \ube44\uc6a9 \ubd80\ub2f4\uc774 \ucee4 \uc804\uae30\uacbd\ub828\uc694\ubc95(ECT) \ub4f1 \uac15\ub3c4 \ub192\uc740 \uce58\ub8cc\uac00 \ud22c\uc785\ub418\ub294 \uacbd\uc6b0\uac00 \ub9ce\ub2e4. \uc815\uc2e0\uc9c8\ud658 \uc5f0\uad6c\ub294 \uc720\uc804\uccb4\u00b7\uc815\ubc00\uc758\ud559 \ubd84\uc57c\uc5d0\uc11c \ub2e4\ub978 \uc9c8\ud658\ubcf4\ub2e4 \uc801\uc6a9\uc774 \ub354\ub518 \ud3b8\uc774\uc5c8\uc73c\ub098, \ub300\uaddc\ubaa8 \ucf54\ud638\ud2b8\uc640 \ud1b5\ud569 \ub370\uc774\ud130\ubca0\uc774\uc2a4\uc758 \ub4f1\uc7a5\uc73c\ub85c \uc0c8\ub85c\uc6b4 \uc720\uc804\uc801 \ubd84\ub958 \uac00\ub2a5\uc131\uc774 \ub300\ub450\ub410\ub2e4.<\/p>\n<p>\ubd81\uc720\ub7fd\uc740 \ube44\uad50\uc801 \ud3ec\uad04\uc801 \uc804\uad6d\ub4f1\ub85d\uacfc \ubc14\uc774\uc624\ubc45\ud06c\ub97c \ud1b5\ud574 \ub300\uaddc\ubaa8 \uc5f0\uacc4 \uc5f0\uad6c\uac00 \uac00\ub2a5\ud55c \ud658\uacbd\uc744 \uac16\ucd94\uace0 \uc788\ub2e4. \uc774\ubc88 \uc5f0\uad6c\ub294 \uc2a4\uc6e8\ub374\u00b7\ud540\ub780\ub4dc\u00b7\uc5d0\uc2a4\ud1a0\ub2c8\uc544\uc758 \uc804\uc790\uc758\ubb34\uae30\ub85d\uacfc \uc720\uc804\uccb4 \ub370\uc774\ud130\ub97c \uacb0\ud569\ud574 TRD\uc758 \uc720\uc804\uc801 \uc2e0\ud638\ub97c \uac80\ucd9c\ud558\ub294 \ub370 \uc801\ud569\ud55c \ud45c\ubcf8\uc744 \ud655\ubcf4\ud588\ub2e4. \uacfc\uac70 \uc5f0\uad6c\ub4e4\uc740 \uc8fc\ub85c MDD \uc804\uccb4\ub97c \ub300\uc0c1\uc73c\ub85c \ud588\uc9c0\ub9cc, \uc774\ubc88\ucc98\ub7fc \uce58\ub8cc \ubc18\uc751 \uae30\ubc18 \ud558\uc704\uad70\uc744 \ub300\uaddc\ubaa8\ub85c \uaddc\uc815\ud574 \ubd84\uc11d\ud55c \uc5f0\uad6c\ub294 \ub4dc\ubb3c\ub2e4. \ub530\ub77c\uc11c \uc774\ubc88 \uacb0\uacfc\ub294 \uc784\uc0c1\uc801 \uc774\uc9c8\uc131\uc774 \uc720\uc804 \uc2e0\ud638 \ud574\uc11d\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5\uc744 \uc9c1\uc811\uc801\uc73c\ub85c \ubcf4\uc5ec\uc900\ub2e4.<\/p>\n<h2>\uc8fc\uc694 \uc0ac\uac74<\/h2>\n<p>\uc5f0\uad6c\uc9c4\uc740 \uba3c\uc800 \uce58\ub8cc\ubc18\uc751 \uc815\ubcf4\ub97c \ubc14\ud0d5\uc73c\ub85c TRD\uc640 \ube44\ub09c\uce58\uc131 MDD, \uadf8\ub9ac\uace0 \ub300\uc870\uad70(\ubb34\uc99d\uc0c1\u00b7\uac74\uac15\uc778)\uc744 \uc815\uc758\ud588\ub2e4. \uc774\ud6c4 \uae30\uc874 \uc815\uc2e0\uc9c8\ud658 GWAS \uacb0\uacfc\uc640 \ube44\uad50\ud574 \uc720\uc804\uc801 \uc0c1\uad00(rg)\uc744 \uacc4\uc0b0\ud588\uace0, TRD\uac00 \uc591\uadf9\uc131 \uc7a5\uc560\u00b7\uc870\ud604\ubcd1\uacfc\uc758 \uc720\uc804\uc801 \uacb9\uce68\uc774 \uc0c1\ub300\uc801\uc73c\ub85c \ud06c\ub2e4\ub294 \ud328\ud134\uc744 \ud655\uc778\ud588\ub2e4. \uc774 \uacfc\uc815\uc5d0\uc11c TRD\uc640 MDD \uac04\uc758 rg\ub294 \uc57d 0.90\uc73c\ub85c \ub9e4\uc6b0 \ub192\uc558\uc9c0\ub9cc, \uc591\uadf9\uc131 \uc7a5\uc560\uc640\uc758 rg \u2248 0.86\uc740 TRD\uac00 \ub2e8\uc21c\ud55c MDD\uc758 \uc911\uc99d \ud615\ud0dc\ub9cc\uc774 \uc544\ub2d8\uc744 \uc2dc\uc0ac\ud588\ub2e4.<\/p>\n<p>\ub610\ud55c SNP \uae30\ubc18 \ub2e4\ud615\uc131 \uc2e0\ud638 \uc678\uc5d0 \ud76c\uadc0 \ubcf5\uc81c\uc218 \ubcc0\uc774(CNV)\ub97c \uc870\uc0ac\ud55c \uacb0\uacfc, TRD \uc9d1\ub2e8\uc5d0\uc11c \uc804\uccb4 \uacb0\uc2e4(deletion) \uc218\uc640 \ucd1d \uae38\uc774\uac00 \ud1b5\uacc4\uc801\uc73c\ub85c \uc720\uc758\ud558\uac8c \uc99d\uac00\ud588\ub2e4. \uc5f0\uad6c\uc9c4\uc740 \ud2b9\ud788 \uc2e0\uacbd\ubc1c\ub2ec\uc7a5\uc560\u00b7\uc870\ud604\ubcd1\uacfc \uc5f0\uad00 \uc788\ub294 54\uc885\uc758 CNV\ub97c \ud45c\uc801 \ubd84\uc11d\ud55c \uacb0\uacfc TRD \ud658\uc790\uac00 \ud574\ub2f9 CNV\ub97c \ub354 \uc790\uc8fc \ubcf4\uc720\ud55c\ub2e4\uace0 \ubcf4\uace0\ud588\ub2e4. \uc774\ub7ec\ud55c CNV \uc99d\uac00\ub294 \ub1cc\ubc1c\ub2ec\u00b7\uc778\uc9c0\uae30\ub2a5\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\ub294 \uad6c\uc870\uc801 \uc720\uc804\ubcc0\uc774\uac00 TRD \ucde8\uc57d\uc131\uc5d0 \uae30\uc5ec\ud560 \uac00\ub2a5\uc131\uc744 \ub4b7\ubc1b\uce68\ud55c\ub2e4.<\/p>\n<p>\uc5f0\uad6c\uc9c4\uc740 \uacb0\uacfc \ud574\uc11d\uc5d0\uc11c \uacfc\ub300\uc77c\ubc18\ud654\ub97c \uacbd\uacc4\ud558\uba70, \uc720\uc804\uc801 \uc5f0\uad00\uc131\uc774 \uace7\ubc14\ub85c \uac1c\ubcc4 \ud658\uc790\uc758 \uc57d\ubb3c\ubc18\uc751\uc744 \uc608\uce21\ud558\ub294 \ub3c4\uad6c\uac00 \ub418\uc9c0\ub294 \uc54a\ub294\ub2e4\uace0 \ubc1d\ud614\ub2e4. \ub300\uc2e0 \uc9d1\ub2e8 \uc218\uc900\uc758 \uc720\uc804 \ud328\ud134\uc774 \uc784\uc0c1 \ud558\uc704\uc720\ud615\uc744 \ubd84\ub958\ud558\uace0, \ud5a5\ud6c4 \ud45c\uc801 \uce58\ub8cc \uac1c\ubc1c\uc758 \ub2e8\uc11c\ub97c \uc81c\uacf5\ud560 \uc218 \uc788\ub2e4\uace0 \uc81c\uc548\ud588\ub2e4.<\/p>\n<h2>\ubd84\uc11d \ubc0f \uc758\ubbf8<\/h2>\n<p>\uccab\uc9f8, TRD\uac00 \uc591\uadf9\uc131 \uc7a5\uc560\u00b7\uc870\ud604\ubcd1\uacfc \ub354 \ub192\uc740 \uc720\uc804\uc801 \uad00\ub828\uc131\uc744 \ubcf4\uc778\ub2e4\ub294 \uc0ac\uc2e4\uc740 \uce58\ub8cc \ubc18\uc751 \uc2e4\ud328\ub97c \ub2e8\uc21c\ud55c \uc57d\ubb3c \uc120\ud0dd \uc624\ub958\ub098 \ud658\uacbd\uc801 \uc694\uc778\uc73c\ub85c\ub9cc \uc124\uba85\ud558\uae30 \uc5b4\ub835\ub2e4\ub294 \uc810\uc744 \uac15\uc870\ud55c\ub2e4. \uc774\ub294 \uc77c\ubd80 \ud658\uc790\uc5d0\uc11c \uc57d\ubb3c \ubc18\uc751 \uc2e4\ud328\uac00 \uc720\uc804\uc801\u00b7\ubc1c\ub2ec\uc801 \uae30\uc800\ub97c \ubc18\uc601\ud560 \uc218 \uc788\uc74c\uc744 \uc2dc\uc0ac\ud55c\ub2e4. \uc784\uc0c1\uc801\uc73c\ub85c\ub294 \ucd08\uae30 \uc9c4\ub2e8 \uc2dc \uc870\uae30 \ud45c\uc9c0\uc790(markers)\ub97c \ucc3e\uc544 \uce58\ub8cc \uc804\ub7b5\uc744 \ub2e4\ub974\uac8c \uc124\uacc4\ud558\ub294 \uadfc\uac70\ub97c \uc81c\uacf5\ud560 \uc218 \uc788\ub2e4.<\/p>\n<p>\ub458\uc9f8, CNV\uc640 \uac19\uc740 \ud76c\uadc0 \uad6c\uc870 \ubcc0\uc774\uc758 \uc99d\uac00\ub294 \ub1cc\ubc1c\ub2ec \uad00\ub828 \uc0dd\ubb3c\ud559\uc801 \uacbd\ub85c\uac00 TRD\uc5d0 \uad00\uc5ec\ud560 \uac00\ub2a5\uc131\uc744 \ubcf4\uc5ec\uc900\ub2e4. \uc2e0\uacbd\ubc1c\ub2ec \uad00\ub828 CNV\ub294 \ub300\uac1c \ub192\uc740 \uc601\ud5a5\ub825\uc744 \uac00\uc9c4 \ubcc0\uc774\ub85c \uc54c\ub824\uc838 \uc788\uc5b4, \uac1c\ubcc4 \ud658\uc790 \uc218\uc900\uc5d0\uc11c\ub294 \uce58\ub8cc\ubc95 \uc120\ud0dd\uc774\ub098 \uc608\ud6c4 \ud3c9\uac00\uc5d0 \uc911\uc694\ud55c \uc815\ubcf4\uac00 \ub420 \uc218 \uc788\ub2e4. \ub2e4\ub9cc \ud604\uc7ac\ub85c\uc11c\ub294 \ud45c\uc900 \uc9c4\ub8cc\uc5d0 CNV \uac80\uc0ac\ub97c \uad11\ubc94\uc704\ud558\uac8c \ub3c4\uc785\ud560 \uadfc\uac70\ub294 \uc544\uc9c1 \ubd80\uc871\ud558\ub2e4.<\/p>\n<p>\uc14b\uc9f8, \uc5f0\uad6c\uc758 \uc0b0\uc5c5\uc801\u00b7\uc784\uc0c1\uc801 \uc758\ubbf8\ub294 \uc815\ubc00\uc758\ud559\uc801 \uc811\uadfc\uc744 \ud1b5\ud574 TRD \ud658\uc790\uc5d0\uac8c ECT \uac19\uc740 \ub9d0\ub2e8 \uce58\ub8cc\ub85c \uac00\uae30 \uc804 \ub354 \uc801\ud569\ud55c \uc911\uac04 \uce58\ub8cc \uc635\uc158\uc744 \uc81c\uc2dc\ud560 \uac00\ub2a5\uc131\uc774\ub2e4. \uc81c\uc57d\u00b7\ubc14\uc774\uc624 \uc0b0\uc5c5 \uad00\uc810\uc5d0\uc11c\ub294 TRD\ub97c \ud45c\uc801\ud558\ub294 \uc57d\ubb3c \uac1c\ubc1c\uc758 \uc6b0\uc120\uc21c\uc704 \uc124\uc815\uacfc \ud658\uc790\uce35 \uc138\ubd84\ud654(stratification)\uc5d0 \uc774\ubc88 \uacb0\uacfc\uac00 \uae30\uc5ec\ud560 \uc218 \uc788\ub2e4. \uadf8\ub7ec\ub098 \uc2e4\uc81c \uc784\uc0c1 \uc801\uc6a9\uc744 \uc704\ud574\uc11c\ub294 \uc608\uce21\ubaa8\ub378\uc758 \ubbfc\uac10\ub3c4\u00b7\ud2b9\uc774\ub3c4, \ube44\uc6a9-\ud3b8\uc775 \ubd84\uc11d \ub4f1 \ucd94\uac00 \uac80\uc99d\uc774 \ud544\uc694\ud558\ub2e4.<\/p>\n<h2>\ube44\uad50 \ubc0f \ub370\uc774\ud130<\/h2>\n<figure>\n<table>\n<thead>\n<tr>\n<th>\ube44\uad50 \ud56d\ubaa9<\/th>\n<th>\uc218\uce58<\/th>\n<th>\uc758\ubbf8<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\ubd84\uc11d \ud45c\ubcf8<\/td>\n<td>\uc57d 800,000\uba85<\/td>\n<td>\ubd81\uc720\ub7fd \uc804\uc790\uc758\ubb34\uae30\ub85d\u00b7\uc720\uc804\uccb4 \ud1b5\ud569<\/td>\n<\/tr>\n<tr>\n<td>TRD vs MDD rg<\/td>\n<td>\u2248 0.90<\/td>\n<td>\uac15\ud55c \uc720\uc804\uc801 \uacb9\uce68<\/td>\n<\/tr>\n<tr>\n<td>TRD vs \uc591\uadf9\uc131 \uc7a5\uc560 rg<\/td>\n<td>\u2248 0.86<\/td>\n<td>MDD\ubcf4\ub2e4 \ub192\uc740 \uc5f0\uad00\uc131<\/td>\n<\/tr>\n<tr>\n<td>TRD vs \uc870\ud604\ubcd1 rg<\/td>\n<td>\u2248 0.57<\/td>\n<td>\uc911\ub4f1\ub3c4 \uc5f0\uad00\uc131<\/td>\n<\/tr>\n<tr>\n<td>\uc2e0\uacbd\uc815\uc2e0 CNV \ubcf4\uc720 \uc704\ud5d8\ub3c4<\/td>\n<td>\uc57d 1.7\u20132.9\ubc30<\/td>\n<td>TRD\uc5d0\uc11c \ub192\uc740 \ube48\ub3c4<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n<p>\uc774 \ud45c\ub294 \ub17c\ubb38\uc758 \ud575\uc2ec \uc218\uce58\ub97c \uc694\uc57d\ud55c \uac83\uc774\ub2e4. \ub300\uaddc\ubaa8 \ud45c\ubcf8\uacfc \ub2e4\uc911\uc720\uc804\uc9c0\ud45c \ub3d9\uc2dc \ubd84\uc11d\uc740 \uacb0\uacfc\uc758 \uc2e0\ub8b0\ub3c4\ub97c \ub192\uc5ec\uc8fc\uc9c0\ub9cc, \ud45c\ubcf8 \ub300\ubd80\ubd84\uc774 \ubd81\uc720\ub7fd \uc720\ub798\ub77c\ub294 \uc810\uc740 \uacb0\uacfc\uc758 \ubcf4\ud3b8\uc131(generalizability)\uc744 \uc81c\ud55c\ud560 \uc218 \uc788\ub2e4.<\/p>\n<h2>\ubc18\uc751 \ubc0f \uc778\uc6a9<\/h2>\n<p>\uc5f0\uad6c\uc9c4\uc740 \ub17c\ubb38\uc5d0\uc11c TRD\uc758 \uc720\uc804\uc801 \uad6c\uc870\ub97c \ud655\uc778\ud55c \uc758\ubbf8\ub97c \uc2e0\uc911\ud788 \uc124\uba85\ud588\ub2e4.<\/p>\n<blockquote>\n<p>&#8220;\ub09c\uce58\uc131 \uc6b0\uc6b8\uc99d\uc740 \ubd84\uba85\ud55c \uc720\uc804\uc801 \uad6c\uc870\ub97c \uac00\uc9c0\uace0 \uc788\uc73c\uba70, \ud2b9\ud788 \ub2e4\ub978 \uc911\uc99d \uc815\uc2e0\uc9c8\ud658 \ubc0f \uc778\uc9c0 \uae30\ub2a5\uacfc \uae4a\uac8c \uc5f0\uacb0\ub418\uc5b4 \uc788\ub2e4.&#8221;<\/p>\n<p><cite>\uc5f0\uad6c\uc9c4(\uce74\ub864\ub9b0\uc2a4\uce74\uc5f0\uad6c\uc18c\u00b7\uc608\ud14c\ubcf4\ub9ac\ub300\u00b7FinnGen \ub4f1, \uacf5\uc2dd \ubc1c\ud45c)<\/cite><\/p><\/blockquote>\n<p>\ub610\ud55c \uc5f0\uad6c\ud300\uc740 \ud5a5\ud6c4 \uc5f0\uad6c \ubc29\ud5a5\uc5d0 \ub300\ud574 \ub2e4\uc74c\uacfc \uac19\uc774 \ub367\ubd99\uc600\ub2e4.<\/p>\n<blockquote>\n<p>&#8220;\uc6b0\ub9ac\ub294 \uc544\uc9c1 \uc2dc\uc791 \ub2e8\uacc4\uc5d0 \uc788\ub2e4. \ub354 \ub9ce\uc740 \ud658\uc790\uc640 \ub2e4\uc591\ud55c \uc778\uc885\uc744 \ud3ec\ud568\ud55c \ub370\uc774\ud130\uac00 \ucd95\uc801\ub420\uc218\ub85d \uc784\uc0c1\uc801 \uc120\ud0dd\uc9c0\ub97c \ub113\ud790 \uc218 \uc788\uc744 \uac83\uc774\ub77c \ubbff\ub294\ub2e4.&#8221;<\/p>\n<p><cite>\uc5f0\uad6c\uc9c4(\uacf5\uc2dd \ub17c\ud3c9)<\/cite><\/p><\/blockquote>\n<p>\uc784\uc0c1 \ud604\uc7a5\uc758 \ubc18\uc751\uc740 \uc870\uc2ec\uc2a4\ub7ec\uc6b4 \uae30\ub300\ub97c \ubcf4\uc600\ub2e4. \ud55c \uc784\uc0c1\uac00\ub294 TRD\uc758 \uc720\uc804\uc801 \uc5f0\uacb0\uc774 \uc9c4\ub2e8 \ubc0f \uce58\ub8cc \uc804\ub7b5 \uc7ac\uc124\uacc4\uc5d0 \uc2e4\uc9c8\uc801 \ub2e8\uc11c\ub97c \uc904 \uc218 \uc788\ub2e4\uace0 \ud3c9\uac00\ud558\uba74\uc11c\ub3c4, \uc784\uc0c1 \uc801\uc6a9 \uc804 \ucd94\uac00 \uac80\uc99d\uc744 \uc694\uad6c\ud588\ub2e4.<\/p>\n<blockquote>\n<p>&#8220;\uc774\ubc88 \uc5f0\uad6c\ub294 \uc784\uc0c1\uc801 \uad00\ucc30\uc744 \uc720\uc804\ud559\uc801\uc73c\ub85c \ub4b7\ubc1b\uce68\ud558\uc9c0\ub9cc, \uac1c\ubcc4 \ud658\uc790 \uc9c4\ub8cc\uc5d0 \uc801\uc6a9\ud558\ub824\uba74 \uc608\uce21\ub825 \uac80\uc99d\uacfc \uc784\uc0c1\uc2dc\ud5d8\uc774 \ud544\uc694\ud558\ub2e4.&#8221;<\/p>\n<p><cite>\uc784\uc0c1 \uc815\uc2e0\uac74\uac15 \uc804\ubb38\uac00(\ubcd1\uc6d0\u00b7\uc784\uc0c1 \ubd84\uc57c)<\/cite><\/p><\/blockquote>\n<h2>\n<aside>\n<details>\n<summary>\uc6a9\uc5b4\/\ubc29\ubc95\ub860<\/summary>\n<p>GWAS(Genome-Wide Association Study)\ub294 \uc218\uc2ed\ub9cc~\uc218\ubc31\ub9cc \uac1c\uc758 \uc720\uc804\uccb4 \ud45c\uc9c0\uc790(SNP)\ub97c \ube44\uad50\ud574 \uc9c8\ud658\uacfc \uc5f0\uad00\ub41c \uc720\uc804 \uc2e0\ud638\ub97c \ucc3e\ub294 \ubc29\ubc95\uc774\ub2e4. CNV(Copy Number Variant)\ub294 \uc5fc\uc0c9\uccb4\uc758 \uc77c\ubd80\uac00 \uacb0\uc2e4\ub418\uac70\ub098 \uc911\ubcf5\ub418\ub294 \uad6c\uc870\uc801 \ubcc0\uc774\ub85c, \ub4dc\ubb3c\uc9c0\ub9cc \uc601\ud5a5\ub825\uc774 \ud070 \uacbd\uc6b0\uac00 \uc788\ub2e4. \uc720\uc804 \uc0c1\uad00(rg)\uc740 \uc11c\ub85c \ub2e4\ub978 \uc9c8\ud658 \uac04\uc5d0 \uacf5\ud1b5\uc73c\ub85c \uc791\uc6a9\ud558\ub294 \uc720\uc804\uc801 \uc694\uc778\uc758 \ube44\uc728\uc744 \ub098\ud0c0\ub0b4\uba70, 0~1 \uc0ac\uc774 \uac12\uc73c\ub85c \ud45c\ud604\ub41c\ub2e4. \ubcf8 \uc5f0\uad6c\ub294 SNP \uae30\ubc18 \ub2e4\ud615\uc131\uacfc \ud76c\uadc0 CNV\ub97c \ub3d9\uc2dc\uc5d0 \ubd84\uc11d\ud574 \uc9d1\ub2e8 \uc218\uc900\uc758 \uc720\uc804\uc801 \ud328\ud134\uc744 \ud3c9\uac00\ud588\ub2e4. \ub2e4\ub9cc \uc720\uc804 \uc0c1\uad00\uc740 \uc778\uacfc\uad00\uacc4\ub97c \uc99d\uba85\ud558\uc9c0 \uc54a\uc73c\uba70, \ud658\uacbd\u00b7\uc9c4\ub2e8\uc801 \uc774\uc9c8\uc131\uc758 \uc601\ud5a5\uc744 \ubc1b\uc744 \uc218 \uc788\ub2e4.<\/p>\n<\/details>\n<\/aside>\n<\/h2>\n<h2>\ubd88\ud655\uc2e4\ud55c \ubd80\ubd84<\/h2>\n<ul>\n<li>\uc784\uc0c1 \uc608\uce21\ub825: \ud604\uc7ac\uc758 \uc720\uc804\uc801 \ud45c\uc9c0\uc790\uac00 \uac1c\ubcc4 \ud658\uc790\uc758 \uc57d\ubb3c\ubc18\uc751\uc744 \uc608\uce21\ud560 \uc218 \uc788\ub294\uc9c0 \uc5ec\ubd80\ub294 \ucd94\uac00 \uc5f0\uad6c\uac00 \ud544\uc694\ud558\ub2e4.<\/li>\n<li>\uc778\uc885\uc801 \uc77c\ubc18\ud654: \ubd84\uc11d \ud45c\ubcf8\uc774 \ubd81\uc720\ub7fd \uc911\uc2ec\uc774\uc5b4\uc11c \ube44\uc720\ub7fd\uacc4 \uc778\uad6c\uc5d0 \ub300\ud55c \uc801\uc6a9 \uac00\ub2a5\uc131\uc740 \ud655\uc778\ub418\uc9c0 \uc54a\uc558\ub2e4.<\/li>\n<li>\uc778\uacfc\uc131 \ud574\uc11d: \uc720\uc804\uc801 \uc5f0\uad00\uc131\uc740 \uae30\uc804(\uc778\uacfc\uc131)\uc744 \uc9c1\uc811 \uc99d\uba85\ud558\uc9c0 \uc54a\uc73c\uba70, \ud658\uacbd \uc694\uc778\uacfc\uc758 \uc0c1\ud638\uc791\uc6a9\uc740 \ubd88\ud655\uc2e4\ud558\ub2e4.<\/li>\n<\/ul>\n<h2>\ucd1d\ud3c9<\/h2>\n<p>\uc774\ubc88 \ub300\uaddc\ubaa8 \uc5f0\uad6c\ub294 \ub09c\uce58\uc131 \uc6b0\uc6b8\uc99d\uc774 \ub2e8\uc21c\ud55c \uce58\ub8cc \uc2e4\ud328 \uc9d1\ub2e8\uc774 \uc544\ub2c8\ub77c \uc720\uc804\uc801\u00b7\ubc1c\ub2ec\uc801 \ud2b9\uc131\uc744 \uac00\uc9c4 \ud558\ub098\uc758 \uc2a4\ud399\ud2b8\ub7fc\uc73c\ub85c \uc774\ud574\ub420 \uadfc\uac70\ub97c \uc81c\uc2dc\ud588\ub2e4. \ud2b9\ud788 \uc591\uadf9\uc131 \uc7a5\uc560 \ubc0f \uc870\ud604\ubcd1\uacfc\uc758 \uc0c1\ub300\uc801 \uc720\uc804\uc801 \uadfc\uc811\uc131\uc740 \uc784\uc0c1\uc801 \uc7ac\ubd84\ub958\uc640 \uce58\ub8cc \uc804\ub7b5\uc758 \ucc28\ubcc4\ud654 \ud544\uc694\uc131\uc744 \ubd80\uac01\uc2dc\ud0a8\ub2e4.<\/p>\n<p>\ud5a5\ud6c4 \uacfc\uc81c\ub294 \uc774\ub7ec\ud55c \uc9d1\ub2e8 \uc218\uc900\uc758 \uc720\uc804 \uc2e0\ud638\ub97c \uc784\uc0c1\uc5d0\uc11c \ud65c\uc6a9 \uac00\ub2a5\ud55c \uc608\uce21\u00b7\uce58\ub8cc \uc54c\uace0\ub9ac\uc998\uc73c\ub85c \uc804\ud658\ud558\ub294 \uac83\uc774\ub2e4. \ub354 \ub9ce\uc740 \uc778\uad6c\uc9d1\ub2e8\uacfc \ub2e4\uce35(\uc720\uc804\uccb4\u00b7\uc804\uc0ac\uccb4\u00b7\uc784\uc0c1) \ub370\uc774\ud130\uc758 \ud1b5\ud569\uc774 \uc774\ub8e8\uc5b4\uc9c8 \ub54c TRD \ud658\uc790\uc5d0\uac8c ECT \uc774\uc804\uc758 \uc2e4\uc9c8\uc801 \ub300\uc548\uc774 \ub9c8\ub828\ub420 \uac00\ub2a5\uc131\uc774 \ucee4\uc9c4\ub2e4.<\/p>\n<h2>\ucd9c\ucc98<\/h2>\n<ul>\n<li><a href=\"https:\/\/doi.org\/10.1038\/s41380-025-03084-z\" target=\"_blank\" rel=\"noopener\">Molecular Psychiatry (\ud559\uc220\uc9c0, \ub17c\ubb38 DOI)<\/a><\/li>\n<li><a href=\"https:\/\/www.biotimes.co.kr\/news\/articleView.html?idxno=25318\" target=\"_blank\" rel=\"noopener\">\ubc14\uc774\uc624\ud0c0\uc784\uc988 \uae30\uc0ac (\uc5b8\ub860 \ubcf4\ub3c4)<\/a><\/li>\n<li><a href=\"https:\/\/www.finngen.fi\/\" target=\"_blank\" rel=\"noopener\">FinnGen (\uacf5\uc2dd \uc5f0\uad6c \ucf54\ud638\ud2b8)<\/a><\/li>\n<\/ul>\n<\/article>\n","protected":false},"excerpt":{"rendered":"<p>\ud575\uc2ec \uc694\uc57d: 2025\ub144 6\uc6d4 26\uc77c \uac8c\uc7ac\ub41c \uad6d\uc81c\ud559\uc220\uc9c0 Molecular Psychiatry \ub17c\ubb38\uc5d0\uc11c \uc2a4\uc6e8\ub374 \uce74\ub864\ub9b0\uc2a4\uce74\uc5f0\uad6c\uc18c\u00b7\uc608\ud14c\ubcf4\ub9ac\ub300, \ud540\ub780\ub4dc FinnGen, \uc5d0\uc2a4\ud1a0\ub2c8\uc544 \ubc14\uc774\uc624\ubc45\ud06c \ub4f1 \ubd81\uc720\ub7fd \uc5f0\uad6c\uc9c4\uc740 \uc57d 80\ub9cc \uba85\uc758 \uc720\uc804\uccb4\uc640 \uc9c4\ub8cc\uae30\ub85d\uc744 \ubd84\uc11d\ud574 \ud56d\uc6b0\uc6b8\uc81c\uc5d0 \ubc18\uc751\ud558\uc9c0 \uc54a\ub294 \ub09c\uce58\uc131 \uc6b0\uc6b8\uc99d(TRD)\uc758 \uc720\uc804\uc801 \ud2b9\uc9d5\uc744 \uc81c\uc2dc\ud588\ub2e4. \uc5f0\uad6c\ub294 TRD\uac00 \uc77c\ubc18 \uc8fc\uc694\uc6b0\uc6b8\uc7a5\uc560(MDD)\uc640 \uac15\ud55c \uc720\uc804\uc801 \uacb9\uce68\uc744 \ubcf4\uc774\uba74\uc11c\ub3c4 \uc591\uadf9\uc131 \uc7a5\uc560\uc640 \uc870\ud604\ubcd1\uacfc\uc758 \uc720\uc804\uc801 \uad00\ub828\uc131\uc774 \ub354 \ub192\uac8c \ub098\ud0c0\ub0ac\uace0(rg\u22480.86, 0.57), \ud76c\uadc0 \ubcf5\uc81c\uc218 \ubcc0\uc774(CNV)\uc758 \uacb0\uc2e4\ub3c4 \ub354 &#8230; <a title=\"\ud56d\uc6b0\uc6b8\uc81c \uc548 \ub4e3\ub294 \u2018\ub09c\uce58\uc131 \uc6b0\uc6b8\uc99d\u2019, \uc720\uc804\uc790\uc5d0\uc11c \ub2e8\uc11c \ucc3e\uc558\ub2e4 &#8211; \ubc14\uc774\uc624\ud0c0\uc784\uc988\" class=\"read-more\" href=\"https:\/\/readtrends.com\/ko\/trd-genetic-clues-nordic\/\" aria-label=\"\ud56d\uc6b0\uc6b8\uc81c \uc548 \ub4e3\ub294 \u2018\ub09c\uce58\uc131 \uc6b0\uc6b8\uc99d\u2019, \uc720\uc804\uc790\uc5d0\uc11c \ub2e8\uc11c \ucc3e\uc558\ub2e4 &#8211; \ubc14\uc774\uc624\ud0c0\uc784\uc988\uc5d0 \ub300\ud574 \ub354 \uc790\uc138\ud788 \uc54c\uc544\ubcf4\uc138\uc694\">\ub354 \uc77d\uae30<\/a><\/p>\n","protected":false},"author":1,"featured_media":3025,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"rank_math_title":"\ud56d\uc6b0\uc6b8\uc81c \ub4e3\uc9c0 \uc54a\ub294 \ub09c\uce58\uc131 \uc6b0\uc6b8\uc99d\uc758 \uc720\uc804\uc801 \ub2e8\uc11c \u2014 \ubc14\uc774\uc624\ud0c0\uc784\uc988","rank_math_description":"\ubd81\uc720\ub7fd 3\uac1c\uad6d \uc57d 80\ub9cc \uba85 \uc720\uc804\uccb4\u00b7\uc758\ubb34\uae30\ub85d \ubd84\uc11d\uc73c\ub85c \ub09c\uce58\uc131 \uc6b0\uc6b8\uc99d(TRD)\uc774 \uc591\uadf9\uc131\u00b7\uc870\ud604\ubcd1\uacfc \uc720\uc804\uc801\uc73c\ub85c \ub354 \uac00\uae5d\uace0 \ud76c\uadc0 CNV\uac00 \ub354 \ub9ce\ub2e4\ub294 \uacb0\uacfc\uac00 \uc81c\uc2dc\ub410\ub2e4. \uc815\ubc00\uc758\ud559 \uad00\uc810\uc758 \ud568\uc758\ub97c \uc815\ub9ac\ud588\ub2e4.","rank_math_focus_keyword":"\ub09c\uce58\uc131\uc6b0\uc6b8\uc99d,\uc720\uc804\uc790,CNV,GWAS,\ubd81\uc720\ub7fd,\uc815\ubc00\uc758\ud559","footnotes":""},"categories":[2],"tags":[],"class_list":["post-3028","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-top-stories"],"_links":{"self":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/posts\/3028","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/comments?post=3028"}],"version-history":[{"count":0,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/posts\/3028\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/media\/3025"}],"wp:attachment":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/media?parent=3028"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/categories?post=3028"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/tags?post=3028"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}