{"id":3644,"date":"2025-11-25T19:07:33","date_gmt":"2025-11-25T10:07:33","guid":{"rendered":"https:\/\/readtrends.com\/ko\/cml-abl1-resistance-prime-editing\/"},"modified":"2025-11-25T19:07:33","modified_gmt":"2025-11-25T10:07:33","slug":"cml-abl1-resistance-prime-editing","status":"publish","type":"post","link":"https:\/\/readtrends.com\/ko\/cml-abl1-resistance-prime-editing\/","title":{"rendered":"\ub9cc\uc131\uace8\uc218\uc131\ubc31\ud608\ubcd1 \ud56d\uc554\uc81c \ud6a8\uacfc\u00b7\ub0b4\uc131 \uc608\uce21\u2026\u2018\ub9de\ucda4\uce58\ub8cc\u2019 \uc131\ud07c &#8211; \ub18d\ubbfc\uc2e0\ubb38"},"content":{"rendered":"<article>\n<p>\ud575\uc2ec \uc694\uc57d: \uc5f0\uc138\ub300\ud559\uad50 \uc758\ub300 \uc5f0\uad6c\ud300\uc774 \ud504\ub77c\uc784 \ud3b8\uc9d1 \uae30\uc220\ub85c \ub9cc\uc131\uace8\uc218\uc131\ubc31\ud608\ubcd1(CML) \uc138\ud3ec\uc5d0\uc11c ABL1 \uc720\uc804\uc790\uc758 \ub2e8\uc77c \uc544\ubbf8\ub178\uc0b0 \ubcc0\uc774 98%(1954\/1998)\ub97c \uad6c\ud604\ud574 1\uc138\ub300\ubd80\ud130 4\uc138\ub300 \ud56d\uc554\uc81c 5\uc885\uc5d0 \ub300\ud55c \ub0b4\uc131 \ud328\ud134\uc744 \ubd84\uc11d\ud588\ub2e4. \uc5f0\uad6c\ub294 361\uc30d\uc758 \uc2e0\uaddc \uc57d\ubb3c \ub0b4\uc131 \ubcc0\uc774\ub97c \uaddc\uba85\ud588\uace0, \ub2e4\ub978 \uc138\ud3ec\uc8fc\uc640 \uc0dd\uc950 \ubaa8\ub378\uc5d0\uc11c \uc7ac\ud604\ub418\uc5b4 \uc77c\uad00\uc131\uc744 \ubcf4\uc600\ub2e4. \uc774\ubc88 \uacb0\uacfc\ub294 \ud658\uc790 \uc720\uc804\uc790 \ubcc0\uc774\uc5d0 \uadfc\uac70\ud55c \uc57d\uc81c \uc120\ud0dd, \uc989 \ub9de\ucda4\ud615 \uce58\ub8cc \uc804\ub7b5 \uc124\uacc4\uc5d0 \uc720\uc6a9\ud55c \uadfc\uac70\ub97c \uc81c\uacf5\ud560 \uac83\uc73c\ub85c \uae30\ub300\ub41c\ub2e4.<\/p>\n<ul>\n<li>\ubd84\uc11d \ubc94\uc704: ABL1 \uc720\uc804\uc790\uc758 \uac00\ub2a5\ud55c \ub2e8\uc77c \uc544\ubbf8\ub178\uc0b0 \ubcc0\uc774 1,998\uc885 \uac00\uc6b4\ub370 1,954\uc885(98%)\ub97c \ud504\ub77c\uc784 \ud3b8\uc9d1\uc73c\ub85c \uc81c\uc791\ud558\uc5ec \ud3c9\uac00\ud588\ub2e4.<\/li>\n<li>\uc2dc\ud5d8 \uc57d\ubb3c: \uc774\ub9c8\ud2f0\ub2d9(imatinib), \ub2d0\ub85c\ud2f0\ub2d9(nilotinib), \ubcf4\uc218\ud2f0\ub2d9(bosutinib), \ud3ec\ub098\ud2f0\ub2d9(ponatinib), \uc560\uc2dc\ubbf8\ub2d9(asciminib) \ub4f1 5\uc885\uc758 1~4\uc138\ub300 \uc57d\ubb3c\uc5d0 \ub300\ud574 \ub0b4\uc131 \uc815\ub3c4\ub97c \uce21\uc815\ud588\ub2e4.<\/li>\n<li>\uc2e0\uaddc \ubc1c\uacac: \uc774\uc804\uc5d0 \ubcf4\uace0\ub418\uc9c0 \uc54a\uc558\ub358 361\uc30d\uc758 \uc57d\ubb3c \ub0b4\uc131 \ubcc0\uc774 \ud328\ud134\uc744 \uc0c8\ub85c \uaddc\uba85\ud588\ub2e4.<\/li>\n<li>\uc7ac\ud604\uc131: K562 \uc138\ud3ec\uc8fc\uc5d0\uc11c \ud655\ubcf4\ud55c \uacb0\uacfc\ub97c KCL22 \uc138\ud3ec\uc8fc \ubc0f \uc0dd\uc950 \ubaa8\ub378\uc5d0\uc11c \uc7ac\uac80\uc99d\ud574 \uc77c\uad00\ub41c \ub0b4\uc131 \uc591\uc0c1\uc744 \ud655\uc778\ud588\ub2e4.<\/li>\n<li>\ud559\uc220\uc801 \uc131\uacfc: \uc5f0\uad6c \uacb0\uacfc\ub294 \uad6d\uc81c\ud559\uc220\uc9c0 Nature Biomedical Engineering(IF 26.7)\uc5d0 \uac8c\uc7ac\ub410\ub2e4(\ubc1c\ud45c\uc77c \uae30\uc900 25\uc77c \uacf5\uac1c \ubc1c\ud45c).<\/li>\n<\/ul>\n<h2>\uc0ac\uac74 \ubc30\uacbd<\/h2>\n<p>\ub9cc\uc131\uace8\uc218\uc131\ubc31\ud608\ubcd1(CML)\uc740 BCR\u2013ABL1 \uc735\ud569 \uc720\uc804\uc790\uac00 \uc0dd\uc131\ud558\ub294 \ube44\uc815\uc0c1\uc801 ABL1 \ud2f0\ub85c\uc2e0\ud0a4\ub098\uc81c\uc758 \uc9c0\uc18d\uc801 \ud65c\uc131\ud654\ub85c \ubc1c\uc0dd\ud558\ub294 \ub300\ud45c\uc801 \ud608\uc561\uc554\uc774\ub2e4. \uc774 \uc9c8\ud658\uc740 \ud45c\uc801\uce58\ub8cc\uc81c\uc758 \ubc1c\ub2ec\ub85c \ub9ce\uc740 \ud658\uc790\uc5d0\uc11c \uc7a5\uae30 \uad00\ud574\uac00 \uac00\ub2a5\ud574\uc84c\uc9c0\ub9cc, \uce58\ub8cc\uac00 \uc624\ub798 \uc9c0\uc18d\ub420\uc218\ub85d ABL1 \uc720\uc804\uc790\uc5d0 \ubcc0\uc774\uac00 \ucd95\uc801\ub418\uc5b4 \uc57d\ubb3c \ub0b4\uc131\uc774 \uc0dd\uae30\ub294 \ubb38\uc81c\uac00 \ubc18\ubcf5\ub418\uc5b4 \uc654\ub2e4. \uc784\uc0c1\uc5d0\uc11c\ub294 \ud2b9\uc815 \ubcc0\uc774\uac00 \uc5b4\ub5a4 \uc57d\ubb3c\uc5d0 \ub300\ud574 \ubbfc\uac10\ud558\uac70\ub098 \ub0b4\uc131\uc744 \ubcf4\uc774\ub294\uc9c0\uc5d0 \ub300\ud55c \ud3ec\uad04\uc801 \ub370\uc774\ud130\uac00 \ubd80\uc871\ud574 \uc57d\uc81c \uc120\ud0dd\uc5d0 \ud55c\uacc4\uac00 \uc788\uc5c8\ub2e4. \ucd5c\uadfc \uba87 \ub144\uac04 \uc720\uc804\uc790 \ud3b8\uc9d1 \uae30\uc220\uc774 \uc815\uad50\ud574\uc9c0\uba74\uc11c, \ubaa8\ub4e0 \uac00\ub2a5\ud55c \ubcc0\uc774\ub97c \uccb4\uacc4\uc801\uc73c\ub85c \ub9cc\ub4e4\uace0 \uc57d\ubb3c \ubc18\uc751\uc744 \ube44\uad50\ud558\ub294 \ubc29\uc2dd\uc774 \ud604\uc2e4\ud654\ub418\uace0 \uc788\ub2e4.<\/p>\n<p>\ud504\ub77c\uc784 \ud3b8\uc9d1\uc740 \uae30\uc874\uc758 \uc720\uc804\uc790 \ud3b8\uc9d1 \uae30\ubc95\ubcf4\ub2e4 \ud45c\uc801 \ubcc0\uc774\ub97c \uc815\ubc00\ud558\uac8c \ub3c4\uc785\ud560 \uc218 \uc788\uc5b4 \ub2e8\uc77c \uc544\ubbf8\ub178\uc0b0 \uce58\ud658\uc744 \ub300\uaddc\ubaa8\ub85c \uc0dd\uc131\u00b7\ud3c9\uac00\ud558\ub294 \ub370 \uc801\ud569\ud558\ub2e4. \uc5f0\uad6c\uc9c4\uc740 \uc774\ub7ec\ud55c \uae30\uc220\uc801 \ubc30\uacbd\uc744 \ubc14\ud0d5\uc73c\ub85c \uc784\uc0c1\uc5d0\uc11c \uad00\ucc30\ub418\ub294 \ubcc0\uc774\ub294 \ubb3c\ub860 \uc544\uc9c1 \ubcf4\uace0\ub418\uc9c0 \uc54a\uc740 \ubcc0\uc774\uae4c\uc9c0 \ud3ec\ud568\ud574 \ud56d\uc554\uc81c \ub0b4\uc131 \uc2a4\ud399\ud2b8\ub7fc\uc744 \uc804\ubc18\uc801\uc73c\ub85c \uad6c\ucd95\ud558\ub824\ub294 \ubaa9\ud45c\ub97c \uc138\uc6e0\ub2e4. \uc774\ud574\ub2f9\uc0ac\uc790\ub85c\ub294 \uc5f0\uad6c\ub97c \uc218\ud589\ud55c \uc5f0\uc138\uc758\ub300\uc640 \uc784\uc0c1 \uc801\uc6a9\uc744 \uace0\ub824\ud558\ub294 \ud608\uc561\uc885\uc591\ub0b4\uacfc, \ud658\uc790 \uce58\ub8cc\uc744 \ub2f4\ub2f9\ud558\ub294 \ubcd1\uc6d0\ub4e4\uc774 \uc788\ub2e4. \ub610\ud55c \uc81c\uc57d\uc0ac\ub4e4\uc740 \uc2e0\uc57d \uac1c\ubc1c \ubc0f \uc801\uc751\uc99d \ud655\ub300\uc5d0 \ubcf8 \uc5f0\uad6c \uacb0\uacfc\ub97c \ud65c\uc6a9\ud560 \uc218 \uc788\ub2e4.<\/p>\n<h2>\uc8fc\uc694 \uc0ac\uac74<\/h2>\n<p>\uc5f0\uad6c\ud300\uc740 \uba3c\uc800 K562 \uc138\ud3ec\uc8fc\ub97c \uc774\uc6a9\ud574 ABL1\uc758 1,954\uac1c \ub2e8\uc77c \uc544\ubbf8\ub178\uc0b0 \ubcc0\uc774\ub97c \ud504\ub77c\uc784 \ud3b8\uc9d1\uc73c\ub85c \uc21c\ucc28\uc801\uc73c\ub85c \ub3c4\uc785\ud588\ub2e4. \uc774\ud6c4 5\uc885\uc758 \ud45c\uc801\ud56d\uc554\uc81c \uac01\uac01\uc5d0 \ub300\ud574 \uc138\ud3ec \uc99d\uc2dd \uc5b5\uc81c\uc640 \uc0dd\uc874\uc131 \ubcc0\ud654\ub97c \uc815\ub7c9\ud654\ud574 \uc57d\ubb3c\ubcc4 \ub0b4\uc131 \uc9c0\ub3c4\ub97c \uc791\uc131\ud588\ub2e4. \ubd84\uc11d \uacfc\uc815\uc5d0\uc11c \uae30\uc874 \ubb38\ud5cc\uc5d0 \ubcf4\uace0\ub418\uc9c0 \uc54a\uc740 \ubcc0\uc774\ub4e4\uc774 \ub2e4\uc218 \ubc1c\uacac\ub418\uc5c8\uace0, \uadf8\uc911 361\uac1c \uc870\ud569\uc740 \ud2b9\uc815 \uc57d\ubb3c\uc5d0 \ub300\ud55c \ub0b4\uc131 \ub610\ub294 \ub2e4\uc911 \ub0b4\uc131 \ud328\ud134\uc73c\ub85c \uc0c8\ub85c \uc815\uc758\ub410\ub2e4.<\/p>\n<p>\uc5f0\uad6c\uc9c4\uc740 \uac19\uc740 \uc808\ucc28\ub97c KCL22 \uc138\ud3ec\uc8fc\uc640 \uc0dd\uccb4 \ub0b4 \uc0dd\uc950 \ubaa8\ub378\ub85c \ud655\uc7a5\ud574 \uc8fc\uc694 \uacb0\uacfc\ub97c \uad50\ucc28\uac80\uc99d\ud588\ub2e4. \uc138\ud3ec\uc8fc \uac04\u00b7\ubaa8\ub378 \uac04 \uacb0\uacfc\ub294 \ub300\uccb4\ub85c \uc77c\uce58\ud588\uc73c\uba70, \uc77c\ubd80 \ubcc0\uc774\ub294 \uc138\ud3ec\uc8fc \ud2b9\uc774\uc131\uc744 \ubcf4\uc774\ub294 \uacbd\ud5a5\uc774 \uad00\ucc30\ub410\ub2e4. \uc5f0\uad6c\ud300\uc740 \uc774 \uacb0\uacfc\ub97c \ubc14\ud0d5\uc73c\ub85c \uc784\uc0c1 \uc720\uc804\uccb4 \uac80\uc0ac\uc5d0\uc11c \uad00\ucc30\ub418\ub294 \ubcc0\uc774\uc5d0 \ub300\ud574 \uc5b4\ub5a4 \uc57d\uc81c\ub97c \uc6b0\uc120 \uace0\ub824\ud574\uc57c \ud558\ub294\uc9c0\uc5d0 \ub300\ud55c \uac00\uc774\ub4dc\ub77c\uc778 \ucd08\uc548\uc744 \uc81c\uc2dc\ud560 \uc218 \uc788\uac8c \ub410\ub2e4.<\/p>\n<p>\uc5f0\uad6c \ucc45\uc784\uc790\uc778 \uae40\ud615\ubc94 \uad50\uc218\ub294 \uc5f0\uad6c\uc758 \uc2e4\ubb34\uc801 \uc758\uc758\ub97c \uac15\uc870\ud588\ub2e4. \uc5f0\uad6c \uacb0\uacfc\uac00 \uc784\uc0c1 \uc758\uc0ac\ub4e4\uc5d0\uac8c \ud658\uc790 \uc720\uc804\uc790 \ubcc0\uc774\uc5d0 \ub530\ub978 \uc57d\uc81c \uc120\ud0dd\uc758 \uacfc\ud559\uc801 \uadfc\uac70\ub97c \uc81c\uacf5\ud560 \uc218 \uc788\ub2e4\ub294 \uc810\uc5d0\uc11c, \ud5a5\ud6c4 \uc720\uc804\uccb4 \uae30\ubc18 \ub9de\ucda4\uce58\ub8cc(precision medicine) \uad6c\ud604\uc5d0 \uae30\uc5ec\ud560 \uac83\uc73c\ub85c \uae30\ub300\ub41c\ub2e4\uace0 \ubc1d\ud614\ub2e4. \ub610\ud55c \uc77c\ubd80 \ubc1c\uacac\ub41c \ubcc0\uc774\ub294 \uae30\uc874 \uce58\ub8cc \uc9c0\uce68\uc5d0 \ud3ec\ud568\ub418\uc9c0 \uc54a\uc544 \uc784\uc0c1 \ub370\uc774\ud130\ubca0\uc774\uc2a4 \uc5c5\ub370\uc774\ud2b8\uc758 \ud544\uc694\uc131\uc744 \uc2dc\uc0ac\ud588\ub2e4.<\/p>\n<h2>\ubd84\uc11d \ubc0f \uc758\ubbf8<\/h2>\n<p>\uccab\uc9f8, \uc774\ubc88 \uc5f0\uad6c\ub294 ABL1 \ubcc0\uc774-\uc57d\ubb3c \ubc18\uc751 \uac04 \uc804\uc218(\u5168\u6578) \uc218\uc900\uc758 \ub9e4\ud551(mapping)\uc744 \ubaa9\ud45c\ub85c \ud588\ub2e4\ub294 \uc810\uc5d0\uc11c \uc758\uc758\uac00 \ud06c\ub2e4. \uae30\uc874\uc5d0\ub294 \uc784\uc0c1\uc5d0\uc11c \uad00\ucc30\ub41c \uc77c\ubd80 \ubcc0\uc774\uc5d0 \ub300\ud574 \uac1c\ubcc4 \uc0ac\ub840 \uc5f0\uad6c\ub098 \uc18c\uaddc\ubaa8 \uc5f0\uad6c\uac00 \uc788\uc5c8\uc9c0\ub9cc, \ubcc0\uc774 \uc2a4\ud399\ud2b8\ub7fc\uc744 \uccb4\uacc4\uc801\uc73c\ub85c \ube44\uad50\ud55c \uc5f0\uad6c\ub294 \ub4dc\ubb3c\uc5c8\ub2e4. \uc804\uc218 \ubd84\uc11d\uc740 \ub4dc\ubb38 \ubcc0\uc774\ub3c4 \uc784\uc0c1\uc801 \uc758\ubbf8\ub97c \uac00\uc9c8 \uc218 \uc788\uc74c\uc744 \ubcf4\uc5ec\uc8fc\uba70, \ud76c\uc18c \ubcc0\uc774\uc5d0 \ub300\ud55c \uc784\uc0c1\uc801 \ud310\ub2e8 \uadfc\uac70\ub97c \ubcf4\uac15\ud55c\ub2e4.<\/p>\n<p>\ub458\uc9f8, \uc784\uc0c1 \uc801\uc6a9 \uce21\uba74\uc5d0\uc11c \uc774 \ub370\uc774\ud130\ubca0\uc774\uc2a4\ub294 \ud658\uc790\ubcc4 \uc57d\uc81c \uc120\ud0dd\uc758 \uadfc\uac70\uac00 \ub420 \uc218 \uc788\ub2e4. \uc608\ucee8\ub300 \ud2b9\uc815 \ubcc0\uc774\uac00 \uc788\uc73c\uba74 A \uc57d\uc81c \ub300\uc2e0 B \uc57d\uc81c\ub97c \uc6b0\uc120 \uace0\ub824\ud558\uac70\ub098, \ub2e4\uc911 \ub0b4\uc131\uc774 \uad00\ucc30\ub418\ub294 \uacbd\uc6b0 \ubcd1\uc6a9\uc694\ubc95\u00b7\ucc28\uc138\ub300 \uc57d\ubb3c\ub85c\uc758 \uc804\ud658\uc744 \uc2e0\uc18d\ud788 \uac80\ud1a0\ud560 \uc218 \uc788\ub2e4. \ub2e4\ub9cc \uc2e4\ud5d8\uc2e4 \ubaa8\ub378 \uacb0\uacfc\uac00 \ubaa8\ub4e0 \uc784\uc0c1 \uc0c1\ud669\uc5d0 \uadf8\ub300\ub85c \uc801\uc6a9\ub418\ub294 \uac83\uc740 \uc544\ub2c8\ubbc0\ub85c \uc784\uc0c1\uc2dc\ud5d8\uc774\ub098 \uc2e4\uc81c \ud658\uc790 \ucf54\ud638\ud2b8\uc5d0\uc11c\uc758 \ucd94\uac00 \uac80\uc99d\uc774 \ud544\uc694\ud558\ub2e4.<\/p>\n<p>\uc14b\uc9f8, \uc81c\uc57d\uc0b0\uc5c5\uacfc \uaddc\uc81c \uce21\uba74\uc5d0\uc11c\ub3c4 \ud65c\uc6a9 \uac00\uce58\uac00 \ud06c\ub2e4. \uc2e0\uc57d \uac1c\ubc1c\uc5d0\uc11c\ub294 \ub0b4\uc131 \ubc1c\uc0dd \uae30\uc804 \uc774\ud574\uac00 \ube44\uc6a9 \ud6a8\uc728\uc801\uc778 \ud6c4\ubcf4\ubb3c\uc9c8 \uc124\uacc4\uc5d0 \uae30\uc5ec\ud560 \uc218 \uc788\uc73c\uba70, \uaddc\uc81c\uae30\uad00\uc740 \ubcc0\uc774\ubcc4 \ubc18\uc751 \ub370\uc774\ud130\ub97c \uadfc\uac70\ub85c \ud2b9\ud5c8\u00b7\uc801\uc751\uc99d \uc2ec\uc0ac\uc640 \uce58\ub8cc\uc9c0\uce68 \uac31\uc2e0\uc744 \uac80\ud1a0\ud560 \uc218 \uc788\ub2e4. \uad6d\uc81c\uc801\uc73c\ub85c\ub3c4 CML \uce58\ub8cc\uc758 \ud45c\uc900\uc744 \ub2e8\uacc4\uc801\uc73c\ub85c \uc7ac\uc124\uacc4\ud560 \uc218 \uc788\ub294 \uadfc\uac70\ub85c \uc791\uc6a9\ud560 \uac00\ub2a5\uc131\uc774 \uc788\ub2e4.<\/p>\n<h2>\ube44\uad50 \ubc0f \ub370\uc774\ud130<\/h2>\n<figure>\n<table>\n<thead>\n<tr>\n<th>\ud56d\ubaa9<\/th>\n<th>\uc218\uce58<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\ubd84\uc11d\ub41c \ub2e8\uc77c \uc544\ubbf8\ub178\uc0b0 \ubcc0\uc774<\/td>\n<td>1,954\/1,998 (98%)<\/td>\n<\/tr>\n<tr>\n<td>\ud3c9\uac00\ud55c \ud56d\uc554\uc81c \uc218<\/td>\n<td>5\uc885(\uc774\ub9c8\ud2f0\ub2d9\u00b7\ub2d0\ub85c\ud2f0\ub2d9\u00b7\ubcf4\uc218\ud2f0\ub2d9\u00b7\ud3ec\ub098\ud2f0\ub2d9\u00b7\uc560\uc2dc\ubbf8\ub2d9)<\/td>\n<\/tr>\n<tr>\n<td>\uc2e0\uaddc \ub0b4\uc131 \uc30d<\/td>\n<td>361\uc30d<\/td>\n<\/tr>\n<\/tbody>\n<\/table><figcaption>ABL1 \ubcc0\uc774 \uc804\uc218 \ubd84\uc11d \uacb0\uacfc \uc694\uc57d(\uc5f0\uad6c\ud300 \uc790\uccb4 \uc9d1\uacc4)<\/figcaption><\/figure>\n<p>\uc704 \ud45c\ub294 \uc5f0\uad6c\ud300\uc774 \ubcf4\uace0\ud55c \ud575\uc2ec \uc218\uce58\ub97c \uc694\uc57d\ud55c \uac83\uc774\ub2e4. \uacfc\uac70 \uc5f0\uad6c\ub4e4\uc740 \uc77c\ubd80 \ubcc0\uc774\uc5d0 \ub300\ud55c \uc57d\ubb3c \ubc18\uc751\ub9cc\uc744 \ubcf4\uace0\ud55c \uacbd\uc6b0\uac00 \ub9ce\uc544 \uc804\uccb4 \uc2a4\ud399\ud2b8\ub7fc\uacfc \ube44\uad50\uac00 \uc5b4\ub824\uc6e0\ub2e4. \uc774\ubc88 \ub370\uc774\ud130\ub294 \ud45c\uc900 \uce58\ub8cc\uc81c 5\uc885\uc744 \ub3d9\uc77c\ud55c \uc2dc\uc2a4\ud15c\uc5d0\uc11c \ube44\uad50\ud588\ub2e4\ub294 \uc810\uc5d0\uc11c \uc9c1\uad00\uc801 \ube44\uad50\uac00 \uac00\ub2a5\ud558\ub2e4. \ub2e4\ub9cc \uc138\ud3ec\uc8fc\u00b7\ub3d9\ubb3c\ubaa8\ub378\uc758 \ud55c\uacc4\uc640 \uc784\uc0c1\uc801 \uc774\uc2dd \uac00\ub2a5\uc131\uc740 \ubcc4\ub3c4\uc758 \ubcf4\uc815\uacfc \uac80\uc99d\uc774 \ud544\uc694\ud558\ub2e4.<\/p>\n<h2>\ubc18\uc751 \ubc0f \uc778\uc6a9<\/h2>\n<p>\uc5f0\uad6c\ud300\uc758 \uacf5\uc2dd \uc124\uba85\uc740 \uc774\ubc88 \ubd84\uc11d\uc774 \uc784\uc0c1\uc801 \uc758\uc0ac\uacb0\uc815\uc5d0 \uc9c1\uc811\uc801\uc73c\ub85c \uae30\uc5ec\ud560 \uc218 \uc788\ub294 \ub370\uc774\ud130\ub97c \uc81c\uacf5\ud55c\ub2e4\uace0 \ubc1d\ud78c \uc810\uc774\ub2e4. \uc5f0\uad6c\uc790\uc758 \ucf54\uba58\ud2b8\ub294 \uc5f0\uad6c\uc758 \ubaa9\uc801\uacfc \ud55c\uacc4\ub97c \ub3d9\uc2dc\uc5d0 \uc124\uba85\ud558\uba70 \uc2e4\uc81c \uc801\uc6a9\uc744 \uc704\ud574\uc11c\ub294 \ucd94\uac00 \uc784\uc0c1\uc5f0\uad6c\uac00 \ud544\uc694\ud568\uc744 \uac15\uc870\ud588\ub2e4.<\/p>\n<blockquote>\n<p>\uc774\ubc88 \uc5f0\uad6c\ub97c \ud1b5\ud574 ABL1 \uc720\uc804\uc790 \ubcc0\uc774 \uc804\ubc18\uc5d0 \ub300\ud55c \ud56d\uc554\uc81c \ub0b4\uc131 \uc815\ubcf4\ub97c \ud655\uc778\ud560 \uc218 \uc788\uc5c8\ub2e4. \ud658\uc790 \uac1c\ubcc4\uc758 \uc720\uc804\uc790 \ubcc0\uc774 \uc815\ubcf4\uac00 \uc784\uc0c1\uc801 \uc57d\uc81c \uc120\ud0dd\uc5d0 \ud65c\uc6a9\ub420 \uac00\ub2a5\uc131\uc774 \ucee4\uc84c\ub2e4.<\/p>\n<p><cite>\uae40\ud615\ubc94 \uad50\uc218\u00b7\uc5f0\uc138\ub300\ud559\uad50 \uc758\uacfc\ub300\ud559(\uc5f0\uad6c\ucc45\uc784\uc790)<\/cite><\/p><\/blockquote>\n<p>\ud559\uacc4\uc640 \uc784\uc0c1 \ud604\uc7a5\uc5d0\uc11c\ub294 \uc774\ubc88 \uacb0\uacfc\ub97c \ud658\uc601\ud558\uba74\uc11c\ub3c4, \ubaa8\ub378 \uc2dc\uc2a4\ud15c\uacfc \uc2e4\uc81c \ud658\uc790\uac04 \ucc28\uc774\ub97c \uc881\ud788\uae30 \uc704\ud55c \ucd94\uac00 \uc5f0\uad6c\ub97c \uc8fc\ubb38\ud558\ub294 \ubaa9\uc18c\ub9ac\ub3c4 \uc788\ub2e4. \uacf5\uc2e0\ub825 \uc788\ub294 \ub2e4\uae30\uad00 \uc784\uc0c1 \uac80\uc99d\uc774 \ud544\uc694\ud558\ub2e4\ub294 \uc9c0\uc801\uc774 \ub098\uc628\ub2e4.<\/p>\n<blockquote>\n<p>\uc804\uc784\uc0c1 \ubaa8\ub378\uc5d0\uc11c\uc758 \uacb0\uacfc\ub294 \uc720\uc758\ubbf8\ud558\uc9c0\ub9cc, \ud658\uc790 \ucf54\ud638\ud2b8 \uae30\ubc18\uc758 \uc784\uc0c1 \uac80\uc99d\uc744 \ud1b5\ud574 \uc2e4\ud6a8\uc131\uc744 \ud655\uc778\ud574\uc57c \ud55c\ub2e4.<\/p>\n<p><cite>\uad6d\ub0b4 \ud608\uc561\uc885\uc591\ud559 \uc804\ubb38\uac00(\uc775\uba85)<\/cite><\/p><\/blockquote>\n<p>\ud658\uc790\ub2e8\uccb4 \ub4f1 \ud604\uc7a5\uc758 \ubc18\uc751\uc740 \uc989\uac01\uc801 \uc784\uc0c1 \uc801\uc6a9\uc744 \uae30\ub300\ud558\ub294 \ub3d9\uc2dc\uc5d0 \uc548\uc804\uc131\uacfc \uc811\uadfc\uc131 \ubb38\uc81c\uc5d0 \ub300\ud55c \uc6b0\ub824\ub97c \uc81c\uae30\ud558\uace0 \uc788\ub2e4. \ub370\uc774\ud130\uac00 \uc2e4\uc81c \uc9c4\ub8cc \uc9c0\uce68\uc5d0 \ubc18\uc601\ub418\uae30\uae4c\uc9c0\ub294 \uc808\ucc28\uc640 \uc2dc\uac04\uc774 \ud544\uc694\ud558\ub2e4\ub294 \uc810\uc744 \uc778\uc9c0\ud558\uace0 \uc788\ub2e4.<\/p>\n<blockquote>\n<p>\ub9de\ucda4\ud615 \uce58\ub8cc\uc758 \uac00\ub2a5\uc131\uc740 \ud658\uc790\uc5d0\uac8c \ud070 \ud76c\ub9dd\uc774\uc9c0\ub9cc, \ubcf4\ud5d8 \uc801\uc6a9\uacfc \uce58\ub8cc \uc811\uadfc\uc131 \ubb38\uc81c\ub3c4 \ud568\uaed8 \uac80\ud1a0\ub418\uc5b4\uc57c \ud55c\ub2e4.<\/p>\n<p><cite>\ud658\uc790\ub2e8\uccb4 \uad00\uacc4\uc790<\/cite><\/p><\/blockquote>\n<aside>\n<details>\n<summary>\uc6a9\uc5b4\/\ubc29\ubc95\ub860<\/summary>\n<p>\ud504\ub77c\uc784 \ud3b8\uc9d1(prime editing)\uc740 \ud45c\uc801 DNA \uc11c\uc5f4\uc5d0 \uc815\ud655\ud55c \uc5fc\uae30 \uce58\ud658, \uc0bd\uc785 \ub610\ub294 \uacb0\uc190\uc744 \uc720\ub3c4\ud560 \uc218 \uc788\ub294 \ucd5c\uc2e0 \uc720\uc804\uc790 \ud3b8\uc9d1 \uae30\ubc95\uc774\ub2e4. BCR\u2013ABL1\uc740 \ub9cc\uc131\uace8\uc218\uc131\ubc31\ud608\ubcd1\uc758 \ud575\uc2ec \ubcd1\uc778 \uc720\uc804\uc790\ub85c, BCR \uc720\uc804\uc790\uc640 ABL1 \uc720\uc804\uc790\uac00 \uc735\ud569\ud574 \uc0dd\uc131\ub418\ub294 \uc9c0\uc18d\uc801 \ud2f0\ub85c\uc2e0\ud0a4\ub098\uc81c \ud65c\uc131\ud654\uac00 \uc554\uc138\ud3ec \uc99d\uc2dd\uc744 \ucd09\uc9c4\ud55c\ub2e4. \uc774\ubc88 \uc5f0\uad6c\ub294 ABL1\uc758 \ub2e8\uc77c \uc544\ubbf8\ub178\uc0b0 \ubcc0\uc774 \uac01\uac01\uc774 \ud45c\uc801\ud56d\uc554\uc81c\uc5d0 \uc5b4\ub5a4 \uc601\ud5a5\uc744 \uc8fc\ub294\uc9c0\ub97c \uc138\ud3ec\u00b7\ub3d9\ubb3c \ubaa8\ub378\uc5d0\uc11c \uccb4\uacc4\uc801\uc73c\ub85c \ud3c9\uac00\ud55c \uc810\uc774 \ud575\uc2ec\uc774\ub2e4.<\/p>\n<\/details>\n<\/aside>\n<h2>\ubd88\ud655\uc2e4\ud55c \ubd80\ubd84<\/h2>\n<ul>\n<li>\uc784\uc0c1 \uc801\uc6a9 \uac00\ub2a5\uc131: \uc138\ud3ec\uc8fc\uc640 \ub3d9\ubb3c\ubaa8\ub378\uc5d0\uc11c \ud655\uc778\ub41c \ub0b4\uc131 \ud328\ud134\uc774 \ubaa8\ub4e0 \ud658\uc790\uc5d0\uc11c \ub3d9\uc77c\ud558\uac8c \ub098\ud0c0\ub0a0\uc9c0 \uc5ec\ubd80\ub294 \ucd94\uac00 \uc784\uc0c1\uc5f0\uad6c\uac00 \ud544\uc694\ud558\ub2e4.<\/li>\n<li>\ud76c\uc18c \ubcc0\uc774\uc758 \uc784\uc0c1\uc801 \uc758\ubbf8: \ub4dc\ubb38 \ubcc0\uc774\uc5d0 \ub300\ud574\uc120 \ud45c\ubcf8 \uc218 \ubd80\uc871\uc73c\ub85c \ud6a8\uacfc \ud06c\uae30(\uc784\uc0c1\uc801 \uc720\uc758\uc131)\ub97c \ud655\uc815\ud558\uae30 \uc5b4\ub835\ub2e4.<\/li>\n<li>\uc7a5\uae30\uc801 \ub0b4\uc131 \ub3d9\ud559: \uce58\ub8cc \uc7a5\uae30\ud654\uc5d0 \ub530\ub978 \ubcc0\uc774 \ucd95\uc801\uacfc \uce58\ub8cc \ubc18\uc751\uc758 \uc2dc\uac04\uc801 \ubcc0\ud654\ub294 \ubcf8 \uc5f0\uad6c\ub9cc\uc73c\ub85c\ub294 \ucda9\ubd84\ud788 \uc124\uba85\ub418\uc9c0 \uc54a\ub294\ub2e4.<\/li>\n<\/ul>\n<h2>\ucd1d\ud3c9<\/h2>\n<p>\uc774\ubc88 \uc5f0\uad6c\ub294 ABL1 \uc720\uc804\uc790 \ubcc0\uc774\uc640 \ud45c\uc801\ud56d\uc554\uc81c \ubc18\uc751 \uac04 \uad00\uacc4\ub97c \ub300\uaddc\ubaa8\ub85c \uaddc\uba85\ud588\ub2e4\ub294 \uc810\uc5d0\uc11c CML \uce58\ub8cc \uc5f0\uad6c\uc5d0 \uc911\uc694\ud55c \uc774\uc815\ud45c\ub97c \uc81c\uc2dc\ud55c\ub2e4. \ud2b9\ud788 361\uc30d\uc758 \uc2e0\uaddc \ub0b4\uc131 \ubcc0\uc774 \ubc1c\uacac\uacfc \uc57d\ubb3c\ubcc4 \ub0b4\uc131 \uc2a4\ud399\ud2b8\ub7fc \ub3c4\ucd9c\uc740 \uc784\uc0c1 \uc758\uc0ac\uacb0\uc815\uacfc \uc2e0\uc57d \uac1c\ubc1c\uc5d0 \uc2e4\uc9c8\uc801 \uadfc\uac70\ub97c \uc81c\uacf5\ud560 \uc218 \uc788\ub2e4.<\/p>\n<p>\ub2e4\ub9cc \uc2e4\ud5d8 \uacb0\uacfc\ub97c \uace7\ubc14\ub85c \ud658\uc790 \uc9c4\ub8cc\uc5d0 \uc801\uc6a9\ud558\uae30\ubcf4\ub2e4\ub294, \ub2e4\uae30\uad00 \uc784\uc0c1 \ub370\uc774\ud130\uc640\uc758 \uad50\ucc28\uac80\uc99d \ubc0f \ubcf4\uac74\uccb4\uacc4\uc758 \uc900\ube44\uac00 \ubcd1\ud589\ub3fc\uc57c \ud55c\ub2e4. \ud5a5\ud6c4 \uc5f0\uad6c\ub294 \uc784\uc0c1 \ucf54\ud638\ud2b8 \uae30\ubc18\uc758 \uac80\uc99d, \ubcc0\uc774\ubcc4 \uc608\ud6c4\uc640\uc758 \uc5f0\uad00\uc131 \ubd84\uc11d, \ubcf4\ud5d8\u00b7\uc815\ucc45\uc801 \uc218\uc6a9\uc131 \uac80\ud1a0\ub97c \ud1b5\ud574 \uc2e4\uc6a9\uc801 \ub9de\ucda4\uc758\ub8cc\ub85c \uc804\ud658\ud558\ub294 \uacfc\uc815\uc774 \ud544\uc694\ud558\ub2e4.<\/p>\n<h2>\ucd9c\ucc98<\/h2>\n<ul>\n<li><a href=\"https:\/\/www.nongmin.com\/article\/20251125500505\" target=\"_blank\" rel=\"noopener\">\ub18d\ubbfc\uc2e0\ubb38 \uae30\uc0ac<\/a> (\uc5b8\ub860 \ubcf4\ub3c4)<\/li>\n<li><a href=\"https:\/\/www.nature.com\/natbiomedeng\/\" target=\"_blank\" rel=\"noopener\">Nature Biomedical Engineering<\/a> (\ud559\uc220\uc9c0, \uac8c\uc7ac\uc9c0 \uc548\ub0b4)<\/li>\n<\/ul>\n<\/article>\n","protected":false},"excerpt":{"rendered":"<p>\ud575\uc2ec \uc694\uc57d: \uc5f0\uc138\ub300\ud559\uad50 \uc758\ub300 \uc5f0\uad6c\ud300\uc774 \ud504\ub77c\uc784 \ud3b8\uc9d1 \uae30\uc220\ub85c \ub9cc\uc131\uace8\uc218\uc131\ubc31\ud608\ubcd1(CML) \uc138\ud3ec\uc5d0\uc11c ABL1 \uc720\uc804\uc790\uc758 \ub2e8\uc77c \uc544\ubbf8\ub178\uc0b0 \ubcc0\uc774 98%(1954\/1998)\ub97c \uad6c\ud604\ud574 1\uc138\ub300\ubd80\ud130 4\uc138\ub300 \ud56d\uc554\uc81c 5\uc885\uc5d0 \ub300\ud55c \ub0b4\uc131 \ud328\ud134\uc744 \ubd84\uc11d\ud588\ub2e4. \uc5f0\uad6c\ub294 361\uc30d\uc758 \uc2e0\uaddc \uc57d\ubb3c \ub0b4\uc131 \ubcc0\uc774\ub97c \uaddc\uba85\ud588\uace0, \ub2e4\ub978 \uc138\ud3ec\uc8fc\uc640 \uc0dd\uc950 \ubaa8\ub378\uc5d0\uc11c \uc7ac\ud604\ub418\uc5b4 \uc77c\uad00\uc131\uc744 \ubcf4\uc600\ub2e4. \uc774\ubc88 \uacb0\uacfc\ub294 \ud658\uc790 \uc720\uc804\uc790 \ubcc0\uc774\uc5d0 \uadfc\uac70\ud55c \uc57d\uc81c \uc120\ud0dd, \uc989 \ub9de\ucda4\ud615 \uce58\ub8cc \uc804\ub7b5 \uc124\uacc4\uc5d0 \uc720\uc6a9\ud55c \uadfc\uac70\ub97c \uc81c\uacf5\ud560 &#8230; <a title=\"\ub9cc\uc131\uace8\uc218\uc131\ubc31\ud608\ubcd1 \ud56d\uc554\uc81c \ud6a8\uacfc\u00b7\ub0b4\uc131 \uc608\uce21\u2026\u2018\ub9de\ucda4\uce58\ub8cc\u2019 \uc131\ud07c &#8211; \ub18d\ubbfc\uc2e0\ubb38\" class=\"read-more\" href=\"https:\/\/readtrends.com\/ko\/cml-abl1-resistance-prime-editing\/\" aria-label=\"\ub9cc\uc131\uace8\uc218\uc131\ubc31\ud608\ubcd1 \ud56d\uc554\uc81c \ud6a8\uacfc\u00b7\ub0b4\uc131 \uc608\uce21\u2026\u2018\ub9de\ucda4\uce58\ub8cc\u2019 \uc131\ud07c &#8211; \ub18d\ubbfc\uc2e0\ubb38\uc5d0 \ub300\ud574 \ub354 \uc790\uc138\ud788 \uc54c\uc544\ubcf4\uc138\uc694\">\ub354 \uc77d\uae30<\/a><\/p>\n","protected":false},"author":1,"featured_media":3642,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"rank_math_title":"\ub9cc\uc131\uace8\uc218\uc131\ubc31\ud608\ubcd1 ABL1 \ubcc0\uc774\uc758 \uc57d\ubb3c \ub0b4\uc131 \uc9c0\ub3c4\ud654\ub85c \ub9de\ucda4\uce58\ub8cc \uac00\ub2a5\uc131 - \ub18d\ubbfc\uc2e0\ubb38","rank_math_description":"\uc5f0\uc138\ub300 \uc5f0\uad6c\ud300\uc774 \ud504\ub77c\uc784 \ud3b8\uc9d1\uc73c\ub85c ABL1 \ubcc0\uc774 1,954\uc885\uc744 \ubd84\uc11d\ud574 361\uc30d\uc758 \uc2e0\uaddc \uc57d\ubb3c \ub0b4\uc131 \ud328\ud134\uc744 \uaddc\uba85\ud588\ub2e4. \ub370\uc774\ud130\ub294 \ud658\uc790\ubcc4 \ub9de\ucda4\ud615 \uc57d\uc81c \uc120\ud0dd \uadfc\uac70\ub85c \ud65c\uc6a9\ub420 \uc804\ub9dd\uc774\ub2e4.","rank_math_focus_keyword":"\ub9cc\uc131\uace8\uc218\uc131\ubc31\ud608\ubcd1,ABL1,\ud504\ub77c\uc784\ud3b8\uc9d1,\uc57d\ubb3c\ub0b4\uc131,\ub9de\ucda4\uce58\ub8cc","footnotes":""},"categories":[2],"tags":[],"class_list":["post-3644","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-top-stories"],"_links":{"self":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/posts\/3644","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/comments?post=3644"}],"version-history":[{"count":0,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/posts\/3644\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/media\/3642"}],"wp:attachment":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/media?parent=3644"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/categories?post=3644"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/tags?post=3644"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}