{"id":4077,"date":"2025-12-03T12:06:31","date_gmt":"2025-12-03T03:06:31","guid":{"rendered":"https:\/\/readtrends.com\/ko\/plasma-ev-map\/"},"modified":"2025-12-03T12:06:31","modified_gmt":"2025-12-03T03:06:31","slug":"plasma-ev-map","status":"publish","type":"post","link":"https:\/\/readtrends.com\/ko\/plasma-ev-map\/","title":{"rendered":"\ud638\uc8fc \uc5f0\uad6c\uc9c4, \uc0ac\ub78c \ud608\uc561 \uc18d \uc5d1\uc18c\uc880 \ub2e8\ubc31\uc9c8\u00b7\uc9c0\uc9c8 \uc9c0\ub3c4 \ub300\uaddc\ubaa8 \uaddc\uba85"},"content":{"rendered":"<article>\n<h2>\ud575\uc2ec \uc694\uc57d<\/h2>\n<p>\ud638\uc8fc Baker Heart and Diabetes Institute\uc640 \uba5c\ubc84\ub978\ub300, \ub77c\ud2b8\ub85c\ube0c\ub300 \uacf5\ub3d9\uc5f0\uad6c\uc9c4\uc740 2025\ub144 11\uc6d4 28\uc77c\uc790 Nature Cell Biology(doi:10.1038\/s41556-025-01795-7)\uc5d0 \uc0ac\ub78c \ud608\uc7a5(plasma)\uc5d0\uc11c \uc21c\ud658\ud558\ub294 \uc18c\ud615 \uc138\ud3ec\uc678\uc18c\ud3ec(extracellular vesicles, EV)\uc758 \ub2e8\ubc31\uc9c8\uacfc \uc9c0\uc9c8 \uad6c\uc131\uc744 \ub300\uaddc\ubaa8 \ub2e4\uc911\uc624\ubbf9\uc2a4 \ubd84\uc11d\uc73c\ub85c \uaddc\uba85\ud55c \uc5f0\uad6c\ub97c \ubc1c\ud45c\ud588\ub2e4. \uc5f0\uad6c\ud300\uc740 140\uba85 \uc774\uc0c1\uc758 \uac74\uac15\ud55c \uc131\uc778 \ud608\uc7a5 \uc0d8\ud50c\uc744 \uace0\ud574\uc0c1\ub3c4 \ubc00\ub3c4 \uad6c\ubc30 \ubd84\ud68d\ubc95\uc73c\ub85c \ubd84\ub9ac\ud55c \ub4a4 \uc9c8\ub7c9\ubd84\uc11d \uae30\ubc18 \ub2e8\ubc31\uc9c8\uccb4\u00b7\uc9c0\uc9c8\uccb4 \ubd84\uc11d\uc744 \uc9c4\ud589\ud574 EV\uc5d0\uc11c \uacf5\ud1b5\uc73c\ub85c \uad00\ucc30\ub418\ub294 \ud575\uc2ec\uc131\ubd84\uc744 \ucd94\ub838\ub2e4. \uadf8 \uacb0\uacfc \ucd1d 4,500\uc5ec \uc885\uc758 \ub2e8\ubc31\uc9c8\uacfc 829\uc885\uc758 \uc9c0\uc9c8 \ud504\ub85c\ud30c\uc77c\uc744 \ud655\ubcf4\ud588\uace0, \uc774 \uac00\uc6b4\ub370 182\uac1c \ub2e8\ubc31\uc9c8\uacfc 52\uac1c \uc9c0\uc9c8\uc744 \u2018\ud575\uc2ec EV \ub9c8\ucee4\u2019\ub85c \uc81c\uc2dc\ud588\ub2e4. \uc5f0\uad6c \uacb0\uacfc\ub294 EVMap\uc774\ub77c\ub294 \uc6f9 \uc778\ud130\ud398\uc774\uc2a4\ub85c \uacf5\uac1c\ub3fc \uc804 \uc138\uacc4 \uc5f0\uad6c\uc790\ub4e4\uc774 \ub370\uc774\ud130\ub97c \uc9c1\uc811 \ud655\uc778\ud560 \uc218 \uc788\uac8c \ub410\ub2e4.<\/p>\n<h2>\ud575\uc2ec \uc0ac\uc2e4<\/h2>\n<ul>\n<li>\uc5f0\uad6c \uc0d8\ud50c: \uac74\uac15\ud55c \uc131\uc778 140\uba85 \uc774\uc0c1\uc73c\ub85c\ubd80\ud130 \ucc44\ucde8\ud55c \ud608\uc7a5(plasma)\uc744 \ubd84\uc11d\ud588\ub2e4.<\/li>\n<li>\ucd1d \uc2dd\ubcc4\ubd84\uc790: \uc9c8\ub7c9\ubd84\uc11d\uc73c\ub85c \ub2e8\ubc31\uc9c8 \uc57d 4,500\uc885\uacfc \uc9c0\uc9c8 829\uc885\uc744 \uc815\ub7c9 \ud504\ub85c\ud30c\uc77c\ub9c1\ud588\ub2e4.<\/li>\n<li>\ud575\uc2ec \ub9c8\ucee4: 182\uac1c \ub2e8\ubc31\uc9c8\uacfc 52\uac1c \uc9c0\uc9c8\uc744 EV\uc758 \uacf5\ud1b5 \ucf54\uc5b4(hallmark features)\ub85c \uc120\ubcc4\ud588\ub2e4.<\/li>\n<li>\ub300\ud45c \uc131\ubd84: ADAM10, STEAP3, STX7 \uac19\uc740 \ub9c9\ub2e8\ubc31\uc9c8\uacfc PS, PIPs, Hex2Cer, PA \uacc4\uc5f4 \uc9c0\uc9c8\uc774 \ud3ec\ud568\ub410\ub2e4.<\/li>\n<li>\ud2b9\uc774 \ub9c8\ucee4 \ud6c4\ubcf4: ADAM10\uacfc \uc9c0\uc9c8 PS(36:1)\uc740 EV \ubd84\ud68d\uc5d0\uc11c \uc9c0\uc18d\uc801 \uace0\ubc1c\ud604\uc744 \ubcf4\uc600\uace0 \ube44-EV \ubd84\ud68d\uc5d0\uc11c\ub294 \ub0ae\uac8c \uad00\ucc30\ub410\ub2e4.<\/li>\n<li>\ubc29\ubc95\ub860: \uace0\ud574\uc0c1\ub3c4 \ubc00\ub3c4 \uad6c\ubc30 \ubd84\ud68d\ubc95\uc73c\ub85c EV\uc640 \ube44-EV \ubd84\ud68d\uc744 \ubd84\ub9ac\ud55c \ub4a4, \ub2e8\ubc31\uc9c8\uccb4\u00b7\uc9c0\uc9c8\uccb4 \ub2e4\uc911\uc624\ubbf9\uc2a4\ub85c \ube44\uad50\ud588\ub2e4.<\/li>\n<li>\ub370\uc774\ud130 \uacf5\uac1c: \uc5f0\uad6c \uacb0\uacfc\uc640 \ubd84\uc11d \ub3c4\uad6c\ub294 \uc6f9 \uae30\ubc18 \uc778\ud130\ub799\ud2f0\ube0c \ud50c\ub7ab\ud3fc &#8216;EVMap&#8217;\uc73c\ub85c \uacf5\uac1c\ub410\ub2e4.<\/li>\n<\/ul>\n<h2>\uc0ac\uac74 \ubc30\uacbd<\/h2>\n<p>\uc138\ud3ec\uc678\uc18c\ud3ec(EV)\ub294 \uc9c0\ub984 30~1,000nm \uc218\uc900\uc758 \uc9c0\uc9c8\ub9c9 \uc18c\ud3ec\ub85c, \ub2e8\ubc31\uc9c8\u00b7\uc9c0\uc9c8\u00b7\ud575\uc0b0\u00b7\ub300\uc0ac\uc0b0\ubb3c\uc744 \ub2f4\uc544 \uc138\ud3ec \uac04 \uc2e0\ud638\ub97c \uc804\ub2ec\ud55c\ub2e4. \ud608\uc7a5 EV\ub294 \uc804\uc2e0 \uac01 \uc7a5\uae30\uc5d0\uc11c \uc720\ub798\ud55c \uc18c\ud3ec\ub4e4\uc774 \uc11e\uc5ec \uc788\uc5b4 \ud658\uc790\uc758 \uc804\ubc18\uc801 \uc0dd\ub9ac\u00b7\ubcd1\ub9ac \uc0c1\ud0dc\ub97c \ubc18\uc601\ud558\ub294 \uc21c\ud658 \ubc14\uc774\uc624\ub9c8\ucee4\ub85c \uc8fc\ubaa9\ubc1b\uc544 \uc654\ub2e4. \uadf8\ub7ec\ub098 \ud608\uc7a5\uc5d0\ub294 \uc9c0\ub2e8\ubc31(lipoprotein), \uba74\uc5ed\ub2e8\ubc31\uc9c8(\ud56d\uccb4, \ubcf4\uccb4) \ub4f1 \ube44-EV \uc785\uc790\uac00 EV\ubcf4\ub2e4 \ud6e8\uc52c \ub9ce\uc740 \ube44\uc728\ub85c \uc874\uc7ac\ud574 EV\ub9cc\uc744 \uc815\ud655\ud788 \ubd84\ub9ac\u00b7\ubd84\uc11d\ud558\ub294 \uac83\uc774 \uae30\uc220\uc801 \ub09c\uc81c\ub85c \uc9c0\uc801\ub410\ub2e4. \uc774 \ub54c\ubb38\uc5d0 \uc9c0\uae08\uae4c\uc9c0 \ud608\uc7a5 EV \uad00\ub828 \ub370\uc774\ud130\ub294 \uc0d8\ud50c \ucc98\ub9ac\ubc95\uacfc \ubd84\uc11d \ud50c\ub7ab\ud3fc\uc5d0 \ub530\ub77c \uacb0\uacfc\uac00 \ubd84\uc0b0\ub418\uace0, \uc77c\uad00\ub41c \u2018\ud45c\uc900 \ub808\ud37c\ub7f0\uc2a4\u2019\uc758 \ubd80\uc7ac\uac00 \uc5f0\uad6c\u00b7\uc784\uc0c1 \uc751\uc6a9\uc744 \uac00\ub85c\ub9c9\uc544 \uc654\ub2e4.<\/p>\n<p>\ucd5c\uadfc \ub4e4\uc5b4 \uace0\ud574\uc0c1\ub3c4 \ubd84\ud68d\ubc95\uacfc \uc815\ubc00 \uc9c8\ub7c9\ubd84\uc11d \uae30\uc220\uc774 \ubc1c\uc804\ud558\uba74\uc11c \ud608\uc7a5 \ub0b4 \uc18c\ud615 \uc785\uc790\uad70\uc744 \ubcf4\ub2e4 \uc138\ubc00\ud558\uac8c \ub098\ub204\uace0 \uac01 \ubd84\ud68d\uc758 \ubd84\uc790\uad6c\uc131 \ucc28\uc774\ub97c \ube44\uad50\ud560 \uc218 \uc788\uac8c \ub410\ub2e4. \ub2e4\uc911\uc624\ubbf9\uc2a4 \uc811\uadfc\ubc95\uc740 \ub2e8\ubc31\uc9c8\uccb4\uc640 \uc9c0\uc9c8\uccb4 \uc815\ubcf4\ub97c \uacb0\ud569\ud574 EV\uc758 \uad6c\uc870\uc801\u00b7\uae30\ub2a5\uc801 \ud2b9\uc9d5\uc744 \ub354 \uc644\uc804\ud558\uac8c \ud3ec\ucc29\ud55c\ub2e4. \uc5f0\uad6c\uc9c4\uc740 \uc774\ub7ec\ud55c \uae30\uc220\uc801 \uc9c4\ubcf4\ub97c \ubc14\ud0d5\uc73c\ub85c \ub2e4\uc218\uc758 \uac74\uac15\uc778 \uc0d8\ud50c\uc5d0\uc11c \uc77c\uad00\ub418\uac8c \uad00\ucc30\ub418\ub294 \ubd84\uc790\ub4e4\uc744 \u2018\uacf5\ud1b5 \uace8\uaca9\u2019\uc73c\ub85c \uaddc\uc815\ud574 \ud45c\uc900\ud654 \uac00\ub2a5\uc131\uc744 \ud0c0\uc9c4\ud588\ub2e4.<\/p>\n<h2>\uc8fc\uc694 \uc0ac\uac74<\/h2>\n<p>\uc5f0\uad6c\uc9c4\uc740 \uc6b0\uc120 \ud608\uc7a5 \uc0d8\ud50c\uc744 \ucd08\uace0\uc21c\ub3c4 \ubc00\ub3c4 \uad6c\ubc30 \ubd84\ud68d\ubc95\uc73c\ub85c \uc5ec\ub7ec \ubd84\ud68d\uc73c\ub85c \ub098\ub208 \ub4a4, EV\uac00 \ud48d\ubd80\ud55c \ubd84\ud68d\uacfc \ube44-EV \ubd84\ud68d\uc744 \ubd84\ub9ac\ud588\ub2e4. \uac01 \ubd84\ud68d\uc5d0 \ub300\ud574 \uc9c8\ub7c9\ubd84\uc11d \uae30\ubc18\uc758 \ub2e8\ubc31\uc9c8\uccb4 \ubc0f \uc9c0\uc9c8\uccb4 \ubd84\uc11d\uc744 \ubcd1\ud589\ud574 \uc815\ub7c9 \ud504\ub85c\ud30c\uc77c\uc744 \ub9cc\ub4e4\uc5c8\ub2e4. \uc774 \uacfc\uc815\uc744 \ud1b5\ud574 \ub2e8\uc77c \uc0d8\ud50c\uc5d0\uc11c EV \uad00\ub828 \ubd84\uc790\uc640 \ube44-EV \uc131\ubd84\uc744 \uc9c1\uc811 \ube44\uad50\ud560 \uc218 \uc788\uac8c \ub410\ub2e4.<\/p>\n<p>\ub2e4\uc74c\uc73c\ub85c 140\uba85 \uc774\uc0c1\uc758 \uae30\uc5ec\uc790 \uc0d8\ud50c\uc744 \ud1b5\ud569 \ubd84\uc11d\ud574 \uc0ac\ub78c \ud608\uc7a5 \uc804\ubc18\uc5d0\uc11c \ubc18\ubcf5\uc801\uc73c\ub85c \ub098\ud0c0\ub098\ub294 \ubd84\uc790\ub4e4\uc744 \ucd94\ub824\ub0c8\ub2e4. \uadf8 \uacb0\uacfc ADAM10, STEAP3, STX7 \ub4f1 \ub9c9 \uad00\ub828 \ub2e8\ubc31\uc9c8\uacfc PS(\ud3ec\uc2a4\ud30c\ud2f0\ub51c\uc138\ub9b0), PIPs(\ud3ec\uc2a4\ud30c\ud2f0\ub51c\uc774\ub178\uc2dc\ud1a8 \uc778\uc0b0\ud654 \uc9c0\uc9c8), Hex2Cer(\uae00\ub9ac\ucf54\uc2e4\uc138\ub77c\ub9c8\uc774\ub4dc \uacc4\uc5f4), PA(\ud3ec\uc2a4\ud30c\ud2f0\ub51c\uc0b0) \ub4f1 \uc9c0\uc9c8\uc774 EV\uc758 \ud2b9\uc9d5\uc801 \uad6c\uc131\uc694\uc18c\ub85c \uaddc\uba85\ub410\ub2e4. \ud2b9\ud788 ADAM10\uacfc PS(36:1)\uc740 EV \ubd84\ud68d\uc5d0\uc11c \uc77c\uad00\ub418\uac8c \ub192\uc740 \uc2e0\ud638\ub97c \ubcf4\uc774\uba70 \ube44-EV \ubd84\ud68d\uc5d0\uc11c\ub294 \ub0ae\uc740 \ub300\ube44\ub97c \ub098\ud0c0\ub0c8\ub2e4.<\/p>\n<p>\uc5f0\uad6c\uc9c4\uc740 \uc120\ubcc4\ub41c 182\uac1c \ub2e8\ubc31\uc9c8 \ubc0f 52\uac1c \uc9c0\uc9c8\uc744 EV\uc758 \u2018\ud575\uc2ec \ub9c8\ucee4\u2019\ub85c \uc81c\uc2dc\ud558\uba74\uc11c, \uc774\ub4e4 \uc911 \uc77c\ubd80\ub294 ELISA \uae30\ubc18 \uc9c4\ub2e8\ubc95\uc774\ub098 \uc18c\uc218\uc758 \ud0c0\uae43\uc744 \ub300\uc0c1\uc73c\ub85c \ud55c \uc9c8\ub7c9\ubd84\uc11d \ud328\ub110\ub85c \uc804\ud658 \uac00\ub2a5\ud558\ub2e4\uace0 \uc124\uba85\ud588\ub2e4. \ub610\ud55c EVMap \ud50c\ub7ab\ud3fc\uc744 \ud1b5\ud574 \uac1c\ubcc4 \ubd84\uc790\ubcc4 \ud48d\ubd80\ub3c4, \ubd84\ud68d\ubcc4 \ubd84\ud3ec, \uc5f0\uad00 \uacbd\ub85c \ub4f1\uc744 \uc2dc\uac01\uc801\uc73c\ub85c \uc81c\uacf5\ud574 \uc5f0\uad6c\uc790\uac00 \uc9c1\uc811 \ub370\uc774\ud130\ub97c \ud0d0\uc0c9\ud558\ub3c4\ub85d \ud588\ub2e4.<\/p>\n<h2>\ubd84\uc11d \ubc0f \uc758\ubbf8<\/h2>\n<p>\uc774\ubc88 \uc5f0\uad6c\uc758 \uac00\uc7a5 \uc911\uc694\ud55c \uc758\ubbf8\ub294 \ud608\uc7a5 EV\uc758 \ubd84\uc790\uc801 \uacf5\ud1b5\ubd84\ubaa8\ub97c \ub300\uaddc\ubaa8 \uac74\uac15\uc778 \uc9d1\ub2e8\uc5d0\uc11c \uaddc\uba85\ud574 \u2018\ud45c\uc900 \ub808\ud37c\ub7f0\uc2a4\u2019\ub97c \uc81c\uc548\ud588\ub2e4\ub294 \uc810\uc774\ub2e4. \uc784\uc0c1 \uc5f0\uad6c\uc640 \uc0b0\uc5c5 \uc751\uc6a9\uc5d0\uc11c \uc77c\uad00\ub41c \uae30\uc900\uc774 \uc5c6\uc73c\uba74 \ubc14\uc774\uc624\ub9c8\ucee4 \uac1c\ubc1c\uc774\ub098 \ud488\uc9c8\uad00\ub9ac(QC) \uc9c0\ud45c \uc124\uc815\uc774 \uc5b4\ub835\uae30 \ub54c\ubb38\uc5d0, \uacf5\ud1b5 \ub9c8\ucee4 \ubaa9\ub85d\uc740 \uc784\uc0c1\uc2dc\ud5d8 \uc124\uacc4\uc640 \uaddc\uc81c \uc81c\ucd9c \uc790\ub8cc\uc5d0\uc11c \uc720\uc6a9\ud558\uac8c \ud65c\uc6a9\ub420 \uc218 \uc788\ub2e4.<\/p>\n<p>ADAM10\uacfc PS(36:1)\ucc98\ub7fc EV\uc5d0 \ud2b9\uc774\uc801\uc778 \ub9c8\ucee4\ub294 \uc9c4\ub2e8\ud0a4\ud2b8 \uac1c\ubc1c, \uc815\uc81c\u00b7\ub18d\ucd95 \uacf5\uc815\uc758 QC \ud56d\ubaa9, EV \uae30\ubc18 \uce58\ub8cc\uc81c\uc758 \ud2b9\uc131\ud654 \uc9c0\ud45c\ub85c \ucc44\ud0dd\ub420 \uac00\ub2a5\uc131\uc774 \ud06c\ub2e4. \ub2e4\ub9cc \uc774\ubc88 \uacb0\uacfc\ub294 \ud608\uc7a5 \ub0b4 \uc804\uccb4 EV\ub97c \ubc8c\ud06c(bulk)\ub85c \ubd84\uc11d\ud55c \uacb0\uacfc\ub77c\ub294 \uc810\uc744 \uba85\ud655\ud788 \ud574\uc57c \ud55c\ub2e4. \ub2e4\uc591\ud55c \ud06c\uae30\u00b7\uae30\uc6d0\u00b7\uae30\ub2a5\uc744 \uac00\uc9c4 \ud558\uc704 \uc9d1\ub2e8\ubcc4 \ud2b9\uc774\uc131\uc740 \ubcc4\ub3c4 \ubd84\ub958\u00b7\ubd84\uc11d \uae30\uc220\uc774 \ubcf4\uc644\ub420 \ub54c \ub354 \uc815\uad50\ud558\uac8c \uaddc\uc815\ub420 \uac83\uc774\ub2e4.<\/p>\n<p>\uad6d\ub0b4\uc678\uc5d0\uc11c EV\ub97c \uc784\uc0c1 \ubc14\uc774\uc624\ub9c8\ucee4\ub85c \uc0c1\uc6a9\ud654\ud558\ub824\ub294 \uc2dc\ub3c4\uac00 \uc99d\uac00\ud558\ub294 \uac00\uc6b4\ub370, \uacf5\uac1c\ub41c \ub370\uc774\ud130\ubca0\uc774\uc2a4\ub294 \uc5f0\uad6c\uc7ac\ud604\uc131(reproducibility)\uacfc \ud45c\uc900\ud654(standardization)\ub97c \ucd09\uc9c4\ud560 \uc7a0\uc7ac\ub825\uc774 \uc788\ub2e4. \ub2e4\ub9cc \ud45c\uc900 \ub808\ud37c\ub7f0\uc2a4\uac00 \uace7\ubc14\ub85c \ubcd1\ub9ac \ud2b9\uc774\uc801 \ubc14\uc774\uc624\ub9c8\ucee4\ub97c \uc758\ubbf8\ud558\uc9c0\ub294 \uc54a\uc73c\ubbc0\ub85c, \uc9c8\ud658\ubcc4\u00b7\uc7a5\uae30\ubcc4 \ud2b9\uc774 EV \uc11c\uba85\uc744 \uaddc\uba85\ud558\uae30 \uc704\ud55c \ud6c4\uc18d \uc5f0\uad6c\uac00 \ud544\uc694\ud558\ub2e4.<\/p>\n<h2>\ube44\uad50 \ubc0f \ub370\uc774\ud130<\/h2>\n<figure><figcaption>\uc5f0\uad6c \uc694\uc57d \uc218\uce58<\/figcaption><table>\n<thead>\n<tr>\n<th>\ud56d\ubaa9<\/th>\n<th>\uc218\uce58<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\ubd84\uc11d \ub300\uc0c1 \uc778\uc6d0<\/td>\n<td>140\uba85 \uc774\uc0c1<\/td>\n<\/tr>\n<tr>\n<td>\uc2dd\ubcc4 \ub2e8\ubc31\uc9c8<\/td>\n<td>\uc57d 4,500\uc885<\/td>\n<\/tr>\n<tr>\n<td>\uc2dd\ubcc4 \uc9c0\uc9c8<\/td>\n<td>829\uc885<\/td>\n<\/tr>\n<tr>\n<td>\ud575\uc2ec \ub2e8\ubc31\uc9c8<\/td>\n<td>182\uac1c<\/td>\n<\/tr>\n<tr>\n<td>\ud575\uc2ec \uc9c0\uc9c8<\/td>\n<td>52\uac1c<\/td>\n<\/tr>\n<tr>\n<td>\ud559\uc220\uc9c0\u00b7\ucd9c\ud310\uc77c<\/td>\n<td>Nature Cell Biology\u00b72025-11-28<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n<p>\ud45c\ub294 \uc5f0\uad6c\uc5d0\uc11c \ubcf4\uace0\ud55c \uc8fc\uc694 \uc815\ub7c9 \uc218\uce58\ub97c \uc694\uc57d\ud55c \uac83\uc774\ub2e4. \ub300\uaddc\ubaa8 \uc0d8\ud50c \uae30\ubc18\uc758 \ubc8c\ud06c \ubd84\uc11d\uc774\ub77c\ub294 \uc810\uc5d0\uc11c \uac12\uc740 \u2018\ud608\uc7a5 \uc804\uccb4\uc758 \uacf5\ud1b5\uc801 \uad6c\uc131\u2019\uc744 \ubc18\uc601\ud55c\ub2e4. \uacfc\uac70 \uc18c\uaddc\ubaa8 \ubcf4\uace0\ub4e4\uacfc \ube44\uad50\ud558\uba74, \uc774\ubc88 \uc5f0\uad6c\ub294 \ud45c\ubcf8 \uc218\uc640 \uc2dd\ubcc4 \ubd84\uc790 \uc218 \ub450 \ucd95\uc5d0\uc11c \ud655\uc7a5\ub418\uc5c8\ub2e4. \uadf8\ub7ec\ub098 \ud558\uc704 EV \uc544\ud615(subpopulation)\ubcc4 \ucc28\uc774\ub294 \ubcc4\ub3c4 \ud45c\uc900\ud654\ub41c \ubd84\ub9ac\u00b7\ubd84\uc11d \ud50c\ub7ab\ud3fc\uc5d0\uc11c \ucd94\uac00\ub85c \ud655\uc778\ud574\uc57c \ud55c\ub2e4.<\/p>\n<h2>\ubc18\uc751 \ubc0f \uc778\uc6a9<\/h2>\n<p>\uc5f0\uad6c \uad50\uc2e0\uc800\uc790\uc778 \uadf8\ub9ac\ub2dd \uad50\uc218\ub294 \uc5f0\uad6c\uc758 \uc758\uc758\ub97c \uc124\uba85\ud558\uba70 \ud5a5\ud6c4 \uc801\uc6a9 \uac00\ub2a5\uc131\uc744 \uac15\uc870\ud588\ub2e4. \uadf8\ub294 \uc774\ubc88 \uc791\uc5c5\uc774 \ud608\uc7a5 EV\ub97c \uc9c8\ubcd1 \uc9c4\ub2e8\u00b7\ubaa8\ub2c8\ud130\ub9c1\uc5d0 \ud65c\uc6a9\ud558\ub294 \ub370 \ud544\uc694\ud55c \uae30\ucd08 \ucc38\uc870\ub97c \uc81c\uacf5\ud55c\ub2e4\uace0 \ub9d0\ud588\ub2e4.<\/p>\n<blockquote>\n<p>\uc774\uc81c \ud608\uc911\uc758 \uc791\uc740 \uc18c\ud3ec\ub4e4\uc744 \ub2e8\uc21c\ud55c \uc794\uc5ec\ubb3c\uc774 \uc544\ub2c8\ub77c \uc6b0\ub9ac\uac00 \uc77d\uc744 \uc218 \uc788\ub294 &#8216;\ubd84\uc790 \ub9ac\ud3ec\ud2b8&#8217;\ub85c \ud574\uc11d\ud560 \uc218 \uc788\uac8c \ub410\ub2e4.<\/p>\n<p><cite>\uadf8\ub9ac\ub2dd \uad50\uc218, Baker Heart and Diabetes Institute(\uad50\uc2e0\uc800\uc790)<\/cite><\/p><\/blockquote>\n<p>\uba5c\ubc84\ub978\ub300\uc640 \ub77c\ud2b8\ub85c\ube0c\ub300\uc5d0 \uc18c\uc18d\ub41c \uacf5\ub3d9\uc5f0\uad6c\uc790\ub4e4\uc740 \ub370\uc774\ud130\ubca0\uc774\uc2a4 \uacf5\uac1c\uac00 \uc5f0\uad6c\uc790 \ucee4\ubba4\ub2c8\ud2f0\uc758 \ud611\uc5c5\uc744 \ucd09\uc9c4\ud560 \uac83\uc73c\ub85c \uae30\ub300\ud55c\ub2e4\uace0 \ubc1d\ud614\ub2e4. \uc774\ub4e4\uc740 \ub3c4\uad6c\ub97c \ud1b5\ud574 \ub2e4\ub978 \uc5f0\uad6c\uc790\uac00 \uc790\uc2e0\uc758 \uc0d8\ud50c \uacb0\uacfc\ub97c \ube44\uad50\u00b7\uac80\uc99d\ud560 \uc218 \uc788\ub2e4\uace0 \ub367\ubd99\uc600\ub2e4.<\/p>\n<blockquote>\n<p>EVMap\uc744 \ud1b5\ud574 \ub204\uad6c\ub098 \ud2b9\uc815 \ub2e8\ubc31\uc9c8\u00b7\uc9c0\uc9c8\uc758 \ubd84\ud3ec\uc640 \uc5f0\uad00 \uacbd\ub85c\ub97c \uc9c1\uc811 \ud655\uc778\ud560 \uc218 \uc788\ub2e4.<\/p>\n<p><cite>\uacf5\ub3d9\uc5f0\uad6c\ud300 \ubc1c\ud45c, \uba5c\ubc84\ub978\ub300\u00b7\ub77c\ud2b8\ub85c\ube0c\ub300(\uc5f0\uad6c\uc9c4)<\/cite><\/p><\/blockquote>\n<p>\ub3c5\ub9bd\uc801\uc778 EV \ubd84\uc57c \uc804\ubb38\uac00\ub4e4\uc740 \uc774\ubc88 \uc131\uacfc\ub97c \ud658\uc601\ud558\uba74\uc11c\ub3c4, \uc9c8\ud658 \ud2b9\uc774\uc801 \ubc14\uc774\uc624\ub9c8\ucee4\ub85c \uc804\ud658\ud558\ub824\uba74 \ucd94\uac00 \uac80\uc99d\uc774 \ud544\uc694\ud558\ub2e4\uace0 \ud3c9\uac00\ud588\ub2e4. \ud2b9\ud788 EV \ud558\uc704\uc9d1\ub2e8 \ubd84\ub9ac\uc640 \ud45c\uc900\ud654\ub41c \uc804\ucc98\ub9ac\ubc95 \ud655\ub9bd\uc744 \ud6c4\uc18d \uacfc\uc81c\ub85c \uc81c\uc2dc\ud588\ub2e4.<\/p>\n<blockquote>\n<p>\uacf5\ud1b5 \ub9c8\ucee4\ub294 \uadc0\uc911\ud55c \uae30\uc900\uc744 \uc81c\uacf5\ud558\uc9c0\ub9cc, \uc784\uc0c1\uc801 \uac80\uc99d\uacfc \ud558\uc704\uc9d1\ub2e8 \ubd84\ud574\ub2a5\uc740 \uc55e\uc73c\ub85c\uc758 \uacfc\uc81c\ub2e4.<\/p>\n<p><cite>\ub3c5\ub9bd \uc804\ubb38\uac00(\uad6d\uc81c EV \uc5f0\uad6c\uc790)<\/cite><\/p><\/blockquote>\n<h2>\n<aside>\n<details>\n<summary>\uc6a9\uc5b4\/\ubc29\ubc95\ub860<\/summary>\n<p>\uc138\ud3ec\uc678\uc18c\ud3ec(EV)\ub294 \uc138\ud3ec\uac00 \ubd84\ube44\ud558\ub294 \uc9c0\uc9c8\ub9c9 \uc18c\ud3ec\ub85c, \ud06c\uae30\uc640 \uae30\uc6d0\uc5d0 \ub530\ub77c \ub2e4\uc591\ud55c \uc544\ud615\uc774 \uc874\uc7ac\ud55c\ub2e4. \ub2e4\uc911\uc624\ubbf9\uc2a4(multi-omics)\ub294 \ub2e8\ubc31\uc9c8\uccb4(proteomics)\uc640 \uc9c0\uc9c8\uccb4(lipidomics) \ub4f1 \uc5ec\ub7ec \ubd84\uc790\uce35\uc744 \ub3d9\uc2dc\uc5d0 \ubd84\uc11d\ud574 \ubcf5\ud569\uc801 \uc0dd\ubb3c\ud559\uc801 \ud2b9\uc131\uc744 \ud30c\uc545\ud558\ub294 \uc811\uadfc\ubc95\uc774\ub2e4. \ubc00\ub3c4 \uad6c\ubc30 \ubd84\ud68d\ubc95(density gradient fractionation)\uc740 \uc785\uc790\uc758 \ubc00\ub3c4 \ucc28\uc774\ub97c \uc774\uc6a9\ud574 EV\uc640 \ube44-EV \uc785\uc790\ub97c \ubd84\ub9ac\ud558\ub294 \ubc29\ubc95\uc73c\ub85c, \uace0\ud574\uc0c1\ub3c4 \ubd84\ud68d\uc740 \uc21c\ub3c4 \ub192\uc740 EV \ud68c\uc218\ub97c \ub3d5\ub294\ub2e4. \uc9c8\ub7c9\ubd84\uc11d\ubc95(MS)\uc740 \ub2e8\ubc31\uc9c8\u00b7\uc9c0\uc9c8\uc758 \ud654\ud559\uc801 \ud2b9\uc131\uacfc \uc0c1\ub300\ub7c9\uc744 \uc815\ub7c9\ud654\ud574 \ubd84\uc790 \ud504\ub85c\ud30c\uc77c\uc744 \uc0dd\uc131\ud55c\ub2e4. EVMap\uc740 \uc774\ub7ec\ud55c \uc815\ub7c9 \ub370\uc774\ud130\ub97c \uc2dc\uac01\ud654\u00b7\uac80\uc0c9 \uac00\ub2a5\ud55c \ud615\ud0dc\ub85c \uc81c\uacf5\ud558\ub294 \uc6f9 \uae30\ubc18 \ub3c4\uad6c\ub2e4.<\/p>\n<\/details>\n<\/aside>\n<\/h2>\n<h2>\ubd88\ud655\uc2e4\ud55c \ubd80\ubd84<\/h2>\n<ul>\n<li>\ud558\uc704\uc9d1\ub2e8 \ud2b9\uc774\uc131: \uc774\ubc88 \uc5f0\uad6c\ub294 \ud608\uc7a5 \uc804\uccb4 EV\uc758 \ubc8c\ud06c \ubd84\uc11d\uc73c\ub85c, \ud2b9\uc815 \uc7a5\uae30 \uc720\ub798 EV\ub098 \ud06c\uae30\ubcc4 \uc544\ud615\uc758 \ud2b9\uc774\uc131\uc740 \ucd94\uac00 \ud655\uc778\uc774 \ud544\uc694\ud558\ub2e4.<\/li>\n<li>\uc784\uc0c1\uc801 \uc720\ud6a8\uc131: ADAM10\u00b7PS(36:1) \ub4f1 \ud6c4\ubcf4 \ub9c8\ucee4\ub97c \uc2e4\uc81c \uc9c8\ud658 \uc9c4\ub2e8\uc5d0 \uc801\uc6a9\ud558\ub824\uba74 \ud658\uc790 \uc9d1\ub2e8\uc5d0\uc11c\uc758 \ubbfc\uac10\ub3c4\u00b7\ud2b9\uc774\ub3c4 \uac80\uc99d\uc774 \uc694\uad6c\ub41c\ub2e4.<\/li>\n<li>\uc804\ucc98\ub9ac \ud45c\uc900\ud654: \ub2e4\ub978 \uc5f0\uad6c\uc2e4\u00b7\ud50c\ub7ab\ud3fc\uc5d0\uc11c \ub3d9\uc77c\ud55c \ub9c8\ucee4 \ud504\ub85c\ud30c\uc77c\uc744 \uc7ac\ud604\ud558\ub824\uba74 \uc0d8\ud50c \ucc98\ub9ac\uc640 \ubd84\ud68d\ubc95 \ud45c\uc900\ud654\uac00 \ud544\uc218\uc801\uc774\ub2e4.<\/li>\n<\/ul>\n<h2>\ucd1d\ud3c9<\/h2>\n<p>\uc774\ubc88 \uc5f0\uad6c\ub294 \uc0ac\ub78c \ud608\uc7a5 EV\uc758 \ub2e8\ubc31\uc9c8\u00b7\uc9c0\uc9c8 \uad6c\uc131\uc5d0 \ub300\ud55c \ub300\uaddc\ubaa8\uc801\uc774\uace0 \uccb4\uacc4\uc801\uc778 \uc9c0\ub3c4\ub97c \ucc98\uc74c\uc73c\ub85c \uc81c\uc2dc\ud588\ub2e4\ub294 \uc810\uc5d0\uc11c \ud559\uacc4\u00b7\uc0b0\uc5c5\uacc4\uc5d0 \uc911\uc694\ud55c \uae30\uc900\uc810\uc744 \uc81c\uacf5\ud55c\ub2e4. \uacf5\uac1c\ub41c 182\uac1c \ub2e8\ubc31\uc9c8\uacfc 52\uac1c \uc9c0\uc9c8 \ubaa9\ub85d\uc740 \ud45c\uc900 \ub808\ud37c\ub7f0\uc2a4\ub85c\uc11c \uc5f0\uad6c\uac04 \uc7ac\ud604\uc131 \ud655\ubcf4\uc640 \uc784\uc0c1\uc2dc\ud5d8 \uc124\uacc4\uc5d0 \ub3c4\uc6c0\uc744 \uc904 \uc218 \uc788\ub2e4. \ub2e4\ub9cc \uacb0\uacfc\uac00 \ud608\uc7a5 \uc804\uccb4\ub97c \ub300\uc0c1\uc73c\ub85c \ud55c \ubc8c\ud06c \ud504\ub85c\ud30c\uc77c\uc784\uc744 \uac10\uc548\ud558\uba74, \uc9c8\ud658 \ud2b9\uc774\uc801 \ubc14\uc774\uc624\ub9c8\ucee4 \ub3c4\ucd9c\uacfc \uce58\ub8cc\uc81c \uac1c\ubc1c\uc744 \uc704\ud574\uc120 \ud558\uc704\uc9d1\ub2e8 \ubd84\ub958\u00b7\uac80\uc99d \uc5f0\uad6c\uac00 \ub4a4\ub530\ub77c\uc57c \ud55c\ub2e4.<\/p>\n<p>\uc5f0\uad6c\uc9c4\uc774 \uacf5\uac1c\ud55c EVMap \ud50c\ub7ab\ud3fc\uc740 \uc804 \uc138\uacc4 \uc5f0\uad6c\uc790\uac00 \ub370\uc774\ud130\ub97c \uc9c1\uc811 \uc870\ud68c\ud558\uace0 \uc790\uc2e0\uc758 \uacb0\uacfc\uc640 \ube44\uad50\ud560 \uc218 \uc788\uac8c \ud574, EV \uc5f0\uad6c\uc758 \ud22c\uba85\uc131\uacfc \ud611\uc5c5\uc744 \ucd09\uc9c4\ud560 \uc804\ub9dd\uc774\ub2e4. \ud5a5\ud6c4\uc5d0\ub294 \uc9c8\ud658\ubcc4 \ud658\uc790 \ub370\uc774\ud130, \uae30\uc220 \uac04 \uad50\ucc28\uac80\uc99d, \uaddc\uc81c\uae30\uad00\uacfc\uc758 \ud611\uc5c5\uc744 \ud1b5\ud55c \ud45c\uc900\ud654 \uc791\uc5c5\uc774 \ubcd1\ud589\ub420 \ub54c \uc784\uc0c1\uc801\u00b7\uc0c1\uc5c5\uc801 \ud30c\uae09\ud6a8\uacfc\uac00 \ubcf8\uaca9\ud654\ub420 \uac83\uc774\ub2e4.<\/p>\n<h2>\ucd9c\ucc98<\/h2>\n<ul>\n<li><a href=\"http:\/\/www.biotimes.co.kr\/news\/articleView.html?idxno=25700\" target=\"_blank\" rel=\"noopener\">\ubc14\uc774\uc624\ud0c0\uc784\uc988 \uae30\uc0ac(\uc5b8\ub860)<\/a><\/li>\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41556-025-01795-7\" target=\"_blank\" rel=\"noopener\">Nature Cell Biology \ub17c\ubb38(\ud559\uc220\u00b7\uc6d0\ubb38, DOI:10.1038\/s41556-025-01795-7)<\/a><\/li>\n<li><a href=\"https:\/\/www.baker.edu.au\" target=\"_blank\" rel=\"noopener\">Baker Heart and Diabetes Institute(\uae30\uad00\u00b7\uc5f0\uad6c\ubc1c\ud45c)<\/a><\/li>\n<\/ul>\n<\/article>\n","protected":false},"excerpt":{"rendered":"<p>\ud575\uc2ec \uc694\uc57d \ud638\uc8fc Baker Heart and Diabetes Institute\uc640 \uba5c\ubc84\ub978\ub300, \ub77c\ud2b8\ub85c\ube0c\ub300 \uacf5\ub3d9\uc5f0\uad6c\uc9c4\uc740 2025\ub144 11\uc6d4 28\uc77c\uc790 Nature Cell Biology(doi:10.1038\/s41556-025-01795-7)\uc5d0 \uc0ac\ub78c \ud608\uc7a5(plasma)\uc5d0\uc11c \uc21c\ud658\ud558\ub294 \uc18c\ud615 \uc138\ud3ec\uc678\uc18c\ud3ec(extracellular vesicles, EV)\uc758 \ub2e8\ubc31\uc9c8\uacfc \uc9c0\uc9c8 \uad6c\uc131\uc744 \ub300\uaddc\ubaa8 \ub2e4\uc911\uc624\ubbf9\uc2a4 \ubd84\uc11d\uc73c\ub85c \uaddc\uba85\ud55c \uc5f0\uad6c\ub97c \ubc1c\ud45c\ud588\ub2e4. \uc5f0\uad6c\ud300\uc740 140\uba85 \uc774\uc0c1\uc758 \uac74\uac15\ud55c \uc131\uc778 \ud608\uc7a5 \uc0d8\ud50c\uc744 \uace0\ud574\uc0c1\ub3c4 \ubc00\ub3c4 \uad6c\ubc30 \ubd84\ud68d\ubc95\uc73c\ub85c \ubd84\ub9ac\ud55c \ub4a4 \uc9c8\ub7c9\ubd84\uc11d \uae30\ubc18 \ub2e8\ubc31\uc9c8\uccb4\u00b7\uc9c0\uc9c8\uccb4 \ubd84\uc11d\uc744 \uc9c4\ud589\ud574 EV\uc5d0\uc11c \uacf5\ud1b5\uc73c\ub85c \uad00\ucc30\ub418\ub294 \ud575\uc2ec\uc131\ubd84\uc744 &#8230; <a title=\"\ud638\uc8fc \uc5f0\uad6c\uc9c4, \uc0ac\ub78c \ud608\uc561 \uc18d \uc5d1\uc18c\uc880 \ub2e8\ubc31\uc9c8\u00b7\uc9c0\uc9c8 \uc9c0\ub3c4 \ub300\uaddc\ubaa8 \uaddc\uba85\" class=\"read-more\" href=\"https:\/\/readtrends.com\/ko\/plasma-ev-map\/\" aria-label=\"\ud638\uc8fc \uc5f0\uad6c\uc9c4, \uc0ac\ub78c \ud608\uc561 \uc18d \uc5d1\uc18c\uc880 \ub2e8\ubc31\uc9c8\u00b7\uc9c0\uc9c8 \uc9c0\ub3c4 \ub300\uaddc\ubaa8 \uaddc\uba85\uc5d0 \ub300\ud574 \ub354 \uc790\uc138\ud788 \uc54c\uc544\ubcf4\uc138\uc694\">\ub354 \uc77d\uae30<\/a><\/p>\n","protected":false},"author":1,"featured_media":4071,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"rank_math_title":"\ud638\uc8fc \uc5f0\uad6c\uc9c4, \ud608\uc7a5 \uc5d1\uc18c\uc880 \ub2e8\ubc31\uc9c8\u00b7\uc9c0\uc9c8 \uc9c0\ub3c4 \uacf5\uac1c \u2014 \ubc14\uc774\uc624\ud0c0\uc784\uc988","rank_math_description":"\ud638\uc8fc \uacf5\ub3d9\uc5f0\uad6c\uc9c4\uc774 140\uba85 \uc774\uc0c1 \uc0d8\ud50c\uc758 \ub2e4\uc911\uc624\ubbf9\uc2a4 \ubd84\uc11d\uc73c\ub85c \ud608\uc7a5 EV\uc758 \ub2e8\ubc31\uc9c8 4,500\uc885\u00b7\uc9c0\uc9c8 829\uc885\uc744 \uaddc\uba85\ud558\uace0 182\uac1c \ub2e8\ubc31\uc9c8\u00b752\uac1c \uc9c0\uc9c8\uc758 \ud575\uc2ec \ub9c8\ucee4\uc640 EVMap\uc744 \uacf5\uac1c\ud588\uc2b5\ub2c8\ub2e4.","rank_math_focus_keyword":"\ud608\uc7a5EV, \uc5d1\uc18c\uc880, ADAM10, PS(36:1), EVMap","footnotes":""},"categories":[2],"tags":[],"class_list":["post-4077","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-top-stories"],"_links":{"self":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/posts\/4077","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/comments?post=4077"}],"version-history":[{"count":0,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/posts\/4077\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/media\/4071"}],"wp:attachment":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/media?parent=4077"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/categories?post=4077"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/tags?post=4077"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}