{"id":4562,"date":"2025-12-16T10:06:38","date_gmt":"2025-12-16T01:06:38","guid":{"rendered":"https:\/\/readtrends.com\/ko\/ra-microplastics-synovial-fluid\/"},"modified":"2025-12-16T10:06:38","modified_gmt":"2025-12-16T01:06:38","slug":"ra-microplastics-synovial-fluid","status":"publish","type":"post","link":"https:\/\/readtrends.com\/ko\/ra-microplastics-synovial-fluid\/","title":{"rendered":"\ub958\ub9c8\ud2f0\uc2a4\uad00\uc808\uc5fc \ud65c\uc561\uc11c \ud3f4\ub9ac\uc2a4\ud2f0\ub80c \ubbf8\uc138\ud50c\ub77c\uc2a4\ud2f1 \ud655\uc778\u2026\uc5fc\uc99d\u00b7\uad00\uc808\ud30c\uad34 \uc720\ubc1c \uaddc\uba85"},"content":{"rendered":"<article>\n<h2>\ud575\uc2ec \uc694\uc57d<\/h2>\n<p>\ucd5c\uadfc \uc5f0\uad6c\uc5d0\uc11c \ub958\ub9c8\ud2f0\uc2a4\uad00\uc808\uc5fc(RA) \ud658\uc790\uc758 \ud65c\uc561(synovial fluid)\uc5d0\uc11c \ud3f4\ub9ac\uc2a4\ud2f0\ub80c \uae30\ubc18 \ubbf8\uc138\ud50c\ub77c\uc2a4\ud2f1(PS-MPs)\uc774 \uac80\ucd9c\ub410\uc73c\uba70, \uc2e4\ud5d8 \uacb0\uacfc \uc774 \uc785\uc790\ub4e4\uc774 \ud65c\ub9c9 \uc12c\uc720\uc544\uc138\ud3ec\ub97c \uc790\uadf9\ud574 \uc5fc\uc99d \uc2e0\ud638(NF-\u03baB\u00b7MAPK)\ub97c \ud65c\uc131\ud654\ud558\uace0 MMP \uc720\ubc1c\uc744 \ud1b5\ud574 \uad00\uc808 \uc190\uc0c1\uc744 \ucd09\uc9c4\ud55c\ub2e4\uace0 \ubcf4\uace0\ub410\ub2e4. \uc5f0\uad6c\ub294 \uc778\uccb4 \uc0d8\ud50c \ubd84\uc11d(Py-GC\/MS\/MS), in vitro \uc138\ud3ec\uc2e4\ud5d8, in vivo \uc774\uc2dd(xenograft) \ubaa8\ub378\uc744 \ud1b5\ud574 \uc77c\uad00\ub41c \uc720\ud574\uc131\uc744 \ud655\uc778\ud588\ub2e4. \uc774\ubc88 \uacb0\uacfc\ub294 \ud658\uacbd\uc131 \ubbf8\uc138\ud50c\ub77c\uc2a4\ud2f1\uc774 \ub9cc\uc131 \uad00\uc808\uc5fc\uc758 \uad6d\uc18c \uc5fc\uc99d\uacfc \ubcd1\ub9ac\uc801 \uc545\ud654\uc5d0 \uae30\uc5ec\ud560 \uac00\ub2a5\uc131\uc744 \uc2dc\uc0ac\ud55c\ub2e4.<\/p>\n<h2>\ud575\uc2ec \uc0ac\uc2e4<\/h2>\n<ul>\n<li>\uc5f0\uad6c\ub294 \ub958\ub9c8\ud2f0\uc2a4\uad00\uc808\uc5fc \ud658\uc790\uc758 \ud65c\uc561\uc5d0\uc11c \ud3f4\ub9ac\uc2a4\ud2f0\ub80c \ubbf8\uc138\ud50c\ub77c\uc2a4\ud2f1(PS-MPs)\uc744 \uac80\ucd9c\ud588\uc73c\uba70, \uac80\ucd9c\ubc95\uc73c\ub85c Py-GC\/MS\/MS\uac00 \uc0ac\uc6a9\ub410\ub2e4.<\/li>\n<li>in vitro\uc5d0\uc11c \uc9c1\uacbd \uc57d 5\u03bcm \uc218\uc900\uc758 PS-MPs\uac00 RA \ud658\uc790 \uc720\ub798 \ud65c\ub9c9 \uc12c\uc720\uc544\uc138\ud3ec(RA-FLS)\uc758 NF-\u03baB\uc640 MAPK \uc2e0\ud638\ub97c \ud65c\uc131\ud654\ud588\ub2e4.<\/li>\n<li>\uc774 \uc2e0\ud638 \ud65c\uc131\ud654\ub294 IL-6, IL-8 \ub4f1 \uc5fc\uc99d\uc131 \uc0ac\uc774\ud1a0\uce74\uc778\uacfc MMP3\u00b7MMP9 \ubc1c\ud604 \uc99d\uac00\ub85c \uc774\uc5b4\uc838 \uc870\uc9c1 \ubd84\ud574\ub97c \ucd09\uc9c4\ud588\ub2e4.<\/li>\n<li>in vivo xenograft \ubaa8\ub378\uc5d0\uc11c PS-MPs \ub178\ucd9c\uc740 \uc774\uc2dd\ub41c RA-FLS\uc758 \uc5fc\uc99d\ubc18\uc751\uacfc \uc870\uc9c1 \ud30c\uad34\ub97c \uc545\ud654\uc2dc\ud0a4\ub294 \uac83\uc73c\ub85c \uad00\ucc30\ub410\ub2e4.<\/li>\n<li>\uc5f0\uad6c \uacb0\uacfc\ub294 PS-MPs\uc758 \uc9c1\uc811\uc801 \uba74\uc5ed\ub3c5\uc131(immunotoxicology) \uac00\ub2a5\uc131\uacfc \uad00\uc808 \uc870\uc9c1 \ub0b4 \uc7a5\uae30 \uccb4\ub958\uac00 \uc9c8\ud658 \uc545\ud654\uc5d0 \uae30\uc5ec\ud560 \uc218 \uc788\uc74c\uc744 \uc81c\uc2dc\ud55c\ub2e4.<\/li>\n<\/ul>\n<h2>\uc0ac\uac74 \ubc30\uacbd<\/h2>\n<p>\ubbf8\uc138\ud50c\ub77c\uc2a4\ud2f1\uc740 \ub300\uae30\u00b7\uc218\uacc4\u00b7\uc2dd\ud488\uc744 \ud1b5\ud574 \uc778\uac04 \ub178\ucd9c\uc774 \ube48\ubc88\ud574\uc9c0\uba70 \uc804\uc2e0\uc801\u00b7\uad6d\uc18c\uc801 \uac74\uac15\uc601\ud5a5 \uc6b0\ub824\uac00 \ucee4\uc84c\ub2e4. \ud2b9\ud788 \ud3f4\ub9ac\uc2a4\ud2f0\ub80c \uacc4\uc5f4 \uc785\uc790\ub294 \uc0dd\ud65c\uc6a9\ud488\u00b7\ud3ec\uc7a5\uc7ac\uc5d0\uc11c \ud754\ud788 \uc720\ub798\ud574 \ud658\uacbd \uc911\uc5d0\uc11c \ub110\ub9ac \ubd84\ud3ec\ud55c\ub2e4. \uacfc\uac70\uc5d0\ub294 \ud638\ud761\uae30\u00b7\uc18c\ud654\uae30 \uacbd\ub85c\ub85c \uc778\ud55c \uc804\uc2e0 \ub3c5\uc131\u00b7\uc5fc\uc99d \uc5f0\uad6c\uac00 \uc8fc\ub85c \uc774\ub904\uc84c\uc9c0\ub9cc, \uad00\uc808\uac15\uacfc \uac19\uc740 \ud3d0\uc1c4\ub41c \uccb4\uac15 \ub0b4 \uc874\uc7ac\uc640 \uc601\ud5a5\uc5d0 \ub300\ud55c \uc5f0\uad6c\ub294 \ubd80\uc871\ud588\ub2e4.<\/p>\n<p>\ub958\ub9c8\ud2f0\uc2a4\uad00\uc808\uc5fc\uc740 \uba74\uc5ed\ub9e4\uac1c \ub9cc\uc131\uc5fc\uc99d \uc9c8\ud658\uc73c\ub85c \ud65c\ub9c9\uc758 \uacfc\ub3c4\ud55c \uc5fc\uc99d\uacfc \ub9e4\ud2b8\ub9ad\uc2a4 \ubd84\ud574 \ud6a8\uc18c\uc758 \ud65c\uc131\ud654\uac00 \uad00\uc808\ud30c\uad34\ub97c \ucd08\ub798\ud55c\ub2e4. \uc678\ubd80 \ubb3c\uc9c8\uc774 \ud65c\ub9c9 \ubbf8\uc138\ud658\uacbd\uc5d0 \ub4e4\uc5b4\uac00\uba74 \uad6d\uc18c \uc5fc\uc99d\uc99d\ud3ed\uacfc \uba74\uc5ed\uc138\ud3ec\u00b7\uc12c\uc720\uc544\uc138\ud3ec\uc758 \ubcd1\uc801 \ud65c\uc131\ud654\ub97c \ucd09\ubc1c\ud560 \uc218 \uc788\ub2e4\ub294 \uac00\uc124\uc774 \uc788\uc5c8\uace0, \uc774\ubc88 \uc5f0\uad6c\ub294 \uadf8 \uac00\uc124\uc744 \uc2e4\ud5d8\uc801\uc73c\ub85c \ud3c9\uac00\ud55c \uacb0\uacfc\ub85c \ubcfc \uc218 \uc788\ub2e4.<\/p>\n<h2>\uc8fc\uc694 \uc0ac\uac74<\/h2>\n<p>\uc5f0\uad6c\ud300\uc740 RA \ud658\uc790\uc758 \ud65c\uc561 \uc0d8\ud50c\uc744 \uc218\uc9d1\ud574 Py-GC\/MS\/MS \ubd84\uc11d\uc744 \ud1b5\ud574 \ud3f4\ub9ac\uc2a4\ud2f0\ub80c \uc131\ubd84\uc758 \ubbf8\uc138\ud50c\ub77c\uc2a4\ud2f1\uc744 \ud655\uc778\ud588\ub2e4. \ubd84\uc11d\ubc95\uc740 \uc0d8\ud50c\uc758 \uc720\uae30\uc131\u00b7\ubb34\uae30\uc131 \ubb3c\uc9c8 \ubd84\ud574 \ud6c4 \ud3f4\ub9ac\uba38 \ud2b9\uc774 \ud30c\ud3b8\uc744 \ub3d9\uc815\ud558\ub294 \uc808\ucc28\ub97c \ud3ec\ud568\ud55c\ub2e4. \uc5f0\uad6c\uc5d0 \uc0ac\uc6a9\ub41c PS-MPs\uc758 \ud3c9\uade0 \uc9c1\uacbd\uc740 \uc57d 5\u03bcm\ub85c \ubcf4\uace0\ub410\ub2e4.<\/p>\n<p>\uc138\ud3ec\uc2e4\ud5d8\uc5d0\uc11c\ub294 \uc778\uac04 \uc720\ub798 RA-FLS\ub97c PS-MPs\uc5d0 \ub178\ucd9c\uc2dc\ud0a8 \uacb0\uacfc NF-\u03baB\uc640 MAPK \uacc4\uc5f4 \uc778\uc0b0\ud654\uac00 \uc99d\uac00\ud588\uace0, \uc774\ub85c \uc778\ud574 IL-6\u00b7IL-8 \ubd84\ube44\uac00 \uc720\uc758\ud558\uac8c \uc0c1\uc2b9\ud588\ub2e4. \ub3d9\uc2dc\uc5d0 MMP3\u00b7MMP9 \ub4f1 \uae30\uc9c8\ubd84\ud574\ud6a8\uc18c\uc758 \ubc1c\ud604\uc774 \ub298\uc5b4\ub098 \uc138\ud3ec\uc678\uae30\uc9c8 \ubd84\ud574 \uc720\ubc1c \uc2e0\ud638\uac00 \uad00\ucc30\ub410\ub2e4.<\/p>\n<p>\ub3d9\ubb3c\ubaa8\ub378(\uc774\uc2dd \uae30\ubc18 xenograft)\uc5d0\uc11c\ub294 PS-MPs \ucc98\ub9ac\uad70\uc5d0\uc11c \uc774\uc2dd\ub41c \uc778\uccb4 \uc138\ud3ec \uc8fc\ubcc0 \uc870\uc9c1\uc758 \uc5fc\uc99d\uc9c0\ud45c\uc640 \uc870\uc9c1\ud30c\uad34\uac00 \ub300\uc870\uad70\ubcf4\ub2e4 \uc545\ud654\ub410\ub2e4. \uc5f0\uad6c\uc9c4\uc740 PS-MPs\uac00 \ud65c\ub9c9 \ub0b4\uc5d0\uc11c \uad6d\uc18c \uc5fc\uc99d \ub9c8\uc774\ud06c\ub85c\ud658\uacbd\uc744 \ud615\uc131\ud574 \uad00\uc808 \ud30c\uad34\ub97c \ucd09\uc9c4\ud560 \uac00\ub2a5\uc131\uc744 \uc81c\uae30\ud588\ub2e4.<\/p>\n<h2>\ubd84\uc11d \ubc0f \uc758\ubbf8<\/h2>\n<p>\uccab\uc9f8, \ud65c\uc561\uc5d0\uc11c\uc758 PS-MPs \uac80\ucd9c\uc740 \ubbf8\uc138\ud50c\ub77c\uc2a4\ud2f1\uc774 \uc804\uc2e0 \uc21c\ud658\uc744 \ud1b5\ud574 \ud3d0\uc1c4\ub41c \uad00\uc808\uac15\uc5d0 \ub3c4\ub2ec\ud558\uac70\ub098 \uad6d\uc18c\uc801\uc73c\ub85c \uc720\uc785\ub420 \uc218 \uc788\uc74c\uc744 \uc758\ubbf8\ud55c\ub2e4. \uc774\ub294 \uae30\uc874\uc758 \uc804\uc2e0 \ub3c5\uc131 \uc5f0\uad6c\ub97c \ub118\uc5b4 \uad6d\uc18c \uae30\uad00 \ud2b9\uc774\uc801 \ubcd1\ud0dc\uc0dd\ub9ac \uae30\uc804\uc744 \uc7ac\uac80\ud1a0\ud558\uac8c \ub9cc\ub4e0\ub2e4. \ub2e4\ub9cc \uc0d8\ud50c \uc218\uc640 \ud658\uc790 \ud2b9\uc131(\ubcd1\uae30\u00b7\uce58\ub8cc\ub825)\uc5d0 \ub530\ub978 \ubcc0\ub3d9\uc131\uc740 \ucd94\uac00 \ud655\uc778\uc774 \ud544\uc694\ud558\ub2e4.<\/p>\n<p>\ub458\uc9f8, NF-\u03baB\u00b7MAPK \uacbd\ub85c \ud65c\uc131\ud654\uc640 MMP \uc720\ub3c4\uc758 \uc5f0\uacb0 \uace0\ub9ac\ub294 \ub958\ub9c8\ud2f0\uc2a4\uad00\uc808\uc5fc\uc758 \ubcd1\ub9ac\uae30\uc804\uacfc \uc9c1\uc811 \ub9de\ub2ff\ub294\ub2e4. \uc678\ubd80 \ubbf8\uc138\uc785\uc790\uac00 \ud65c\ub9c9 \uc12c\uc720\uc544\uc138\ud3ec\uc758 \uc5fc\uc99d \ubc18\uc751\uc744 \uc99d\ud3ed\ud558\uba74 \uae30\uc874 \uba74\uc5ed\ubc18\uc751\uacfc \uc0c1\ud638\uc791\uc6a9\ud574 \uc9c8\ud658 \uc9c4\ud589\uc744 \uac00\uc18d\ud560 \uc218 \uc788\ub2e4. \uc774\ub294 \uce58\ub8cc \ud45c\uc801 \ubc0f \uc608\ubc29 \uc804\ub7b5\uc744 \uc7ac\uace0\ud558\uac8c \ud558\ub294 \uc2dc\uc0ac\uc810\uc744 \uc81c\uacf5\ud55c\ub2e4.<\/p>\n<p>\uc14b\uc9f8, \uacf5\uc911\ubcf4\uac74\uc801 \uad00\uc810\uc5d0\uc11c \uc0dd\ud65c\ud658\uacbd\u00b7\uc2dd\ud488\u00b7\uc758\ub8cc\uc6a9\ud488\uc73c\ub85c\ubd80\ud130\uc758 \ubbf8\uc138\ud50c\ub77c\uc2a4\ud2f1 \ub178\ucd9c \uc800\uac10 \ud544\uc694\uc131\uc774 \uc81c\uae30\ub41c\ub2e4. \ud2b9\ud788 \ucde8\uc57d\uad70(\ub9cc\uc131\uc5fc\uc99d\uc9c8\ud658\uc790, \uace0\ub178\ucd9c \uc9c1\uc5c5\uad70)\uc5d0 \ub300\ud55c \uad00\ub9ac\u00b7\ubaa8\ub2c8\ud130\ub9c1\uacfc \uad00\ub828 \uaddc\uc81c\u00b7\uae30\uc900 \ub9c8\ub828\uc758 \uadfc\uac70\ub85c \ud65c\uc6a9\ub420 \uc218 \uc788\ub2e4.<\/p>\n<h2>\ube44\uad50 \ubc0f \ub370\uc774\ud130<\/h2>\n<figure>\n<table>\n<thead>\n<tr>\n<th>\uc5f0\uad6c \uc720\ud615<\/th>\n<th>\ubaa8\ub378<\/th>\n<th>\ud575\uc2ec \uacb0\uacfc<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\uc778\uccb4 \uac80\ucd9c<\/td>\n<td>\ub958\ub9c8\ud2f0\uc2a4\uad00\uc808\uc5fc \ud658\uc790 \ud65c\uc561<\/td>\n<td>Py-GC\/MS\/MS\ub85c PS-MPs \ub3d9\uc815<\/td>\n<\/tr>\n<tr>\n<td>In vitro<\/td>\n<td>RA-FLS(\ud65c\ub9c9 \uc12c\uc720\uc544\uc138\ud3ec)<\/td>\n<td>NF-\u03baB\/MAPK \ud65c\uc131\ud654\u00b7IL-6\/IL-8\u00b7MMP \uc99d\ub300<\/td>\n<\/tr>\n<tr>\n<td>In vivo<\/td>\n<td>xenograft \uc774\uc2dd\ubaa8\ub378<\/td>\n<td>PS-MPs \ub178\ucd9c \uc2dc \uc5fc\uc99d\u00b7\uc870\uc9c1\ud30c\uad34 \uc545\ud654<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n<p>\uc704 \ud45c\ub294 \uc5f0\uad6c\uc758 \uc138 \ucd95(\uac80\ucd9c\u00b7\uc138\ud3ec\uc2e4\ud5d8\u00b7\ub3d9\ubb3c\ubaa8\ub378)\uc5d0\uc11c \uc77c\uad00\ub41c \uc720\ud574\uc131 \uc9d5\ud6c4\uac00 \uad00\ucc30\ub410\uc74c\uc744 \uc694\uc57d\ud55c\ub2e4. \ub2e4\ub9cc \uc778\uccb4 \ub0b4 \ub18d\ub3c4\u00b7\uc7a5\uae30 \uccb4\ub958 \uc5ec\ubd80\u00b7\uc785\uc790 \ud45c\uba74\ud2b9\uc131 \ub4f1\uc740 \ucd94\uac00 \ub370\uc774\ud130\uac00 \ud544\uc694\ud558\ub2e4.<\/p>\n<h2>\ubc18\uc751 \ubc0f \uc778\uc6a9<\/h2>\n<p>\uc5f0\uad6c \ubc1c\ud45c \uc9c1\ud6c4 \uc5f0\uad6c\uc9c4\uc740 \uc5f0\uad6c\uc758 \uc758\uc758\ub97c \uc9e7\uac8c \uc124\uba85\ud558\uba70 \ud5a5\ud6c4 \uc5ed\ud559\uc801 \uc5f0\uacc4 \uc5f0\uad6c\uc758 \ud544\uc694\uc131\uc744 \uac15\uc870\ud588\ub2e4.<\/p>\n<blockquote>\n<p>\ud65c\uc561\uc5d0\uc11c \ubbf8\uc138\ud50c\ub77c\uc2a4\ud2f1\uc744 \ub3d9\uc815\ud55c \uc774\ubc88 \uacb0\uacfc\ub294 \ud658\uacbd\uc785\uc790\uac00 \uad00\uc808\uc5fc \ubcd1\ud0dc\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5\uc744 \uc7ac\ud3c9\uac00\ud560 \uacc4\uae30\ub97c \uc81c\uacf5\ud569\ub2c8\ub2e4.<\/p>\n<p><cite>\uc5f0\uad6c\ud300(\ud559\uc220 \ubc1c\ud45c)<\/cite><\/p><\/blockquote>\n<p>\ud55c \ub958\ub9c8\ud2f0\uc2a4\ub0b4\uacfc \uc804\ubb38\uac00\ub294 \uc784\uc0c1\uc801 \ud568\uc758\ub97c \uc2e0\uc911\ud788 \ud3c9\uac00\ud574\uc57c \ud55c\ub2e4\uace0 \ub9d0\ud588\ub2e4. \uadf8\ub294 \uc138\ud3ec\u00b7\ub3d9\ubb3c \ub370\uc774\ud130\ub294 \uacbd\uace0 \uc2e0\ud638\uc9c0\ub9cc \uc778\uacfc\uad00\uacc4 \ud655\ub9bd\uc5d0\ub294 \ub300\uaddc\ubaa8 \uc784\uc0c1\uc5ed\ud559 \uc5f0\uad6c\uac00 \ud544\uc694\ud558\ub2e4\uace0 \ub367\ubd99\uc600\ub2e4.<\/p>\n<blockquote>\n<p>\uc138\ud3ec\uc640 \ub3d9\ubb3c \ubaa8\ub378\uc740 \uae30\uc804 \uc99d\uba85\uc744 \ub3d5\uc9c0\ub9cc, \ud658\uc790 \uc218\uc900\uc5d0\uc11c \ub178\ucd9c\uacfc \uc9c8\ud658 \uc545\ud654\uc758 \uc9c1\uc811 \uc5f0\uacb0\uc744 \ud655\uc778\ud558\ub824\uba74 \ucd94\uac00 \uc5f0\uad6c\uac00 \ud544\uc694\ud569\ub2c8\ub2e4.<\/p>\n<p><cite>\ub958\ub9c8\ud2f0\uc2a4\ub0b4\uacfc \uc804\ubb38\uc758(\uc758\ud559\uacc4)<\/cite><\/p><\/blockquote>\n<p>\ud658\uacbd\ubcf4\uac74 \ubd84\uc57c\uc758 \ud55c \ub2e8\uccb4\ub294 \uc0dd\ud65c\ud658\uacbd\uc5d0\uc11c\uc758 \ubbf8\uc138\ud50c\ub77c\uc2a4\ud2f1 \uad00\ub9ac \uac15\ud654\ub97c \ucd09\uad6c\ud588\ub2e4. \ub2e8\uccb4\ub294 \ucde8\uc57d \ud658\uc790 \ubcf4\ud638\ub97c \uc704\ud574 \ub178\ucd9c \uc800\uac10 \uc815\ucc45\uc744 \uc81c\uc548\ud560 \uac83\uc744 \uc694\uad6c\ud588\ub2e4.<\/p>\n<blockquote>\n<p>\uc774\ubc88 \uc5f0\uad6c\ub294 \ubbf8\uc138\ud50c\ub77c\uc2a4\ud2f1\uc758 \uac74\uac15\uc601\ud5a5 \ubc94\uc704\ub97c \ud655\uc7a5\ud574 \ubcf4\uc5ec\uc8fc\ubbc0\ub85c, \uc608\ubc29\uc801 \uaddc\uc81c\uc640 \ubaa8\ub2c8\ud130\ub9c1\uc774 \ud544\uc694\ud569\ub2c8\ub2e4.<\/p>\n<p><cite>\ud658\uacbd\ub2e8\uccb4(\uc2dc\ubbfc\ub2e8\uccb4)<\/cite><\/p><\/blockquote>\n<aside>\n<details>\n<summary>\uc6a9\uc5b4\/\ubc29\ubc95\ub860<\/summary>\n<p>Py-GC\/MS\/MS(Pyrolysis-Gas Chromatography tandem Mass Spectrometry)\ub294 \uc2dc\ub8cc\ub97c \uc5f4\ubd84\ud574\ud574 \uc0dd\uc131\ub41c \ubd84\ud574 \uc0b0\ubb3c\uc744 \uac00\uc2a4\ud06c\ub85c\ub9c8\ud1a0\uadf8\ub798\ud53c\ub85c \ubd84\ub9ac\ud55c \ub4a4 \uc9c8\ub7c9\ubd84\uc11d\uc73c\ub85c \ud3f4\ub9ac\uba38 \uc885\ub958\ub97c \ub3d9\uc815\ud558\ub294 \ubc29\ubc95\uc774\ub2e4. NF-\u03baB\uc640 MAPK\ub294 \uc5fc\uc99d\u00b7\uc138\ud3ec\uc0dd\uc874 \uad00\ub828 \uc8fc\uc694 \uc2e0\ud638\uc804\ub2ec \uacbd\ub85c\ub85c, \ud65c\uc131\ud654\ub418\uba74 \uc5fc\uc99d\uc131 \uc0ac\uc774\ud1a0\uce74\uc778\uacfc \ubd84\ud574\ud6a8\uc18c \ubc1c\ud604\uc744 \uc720\ub3c4\ud55c\ub2e4. RA-FLS\ub294 \ub958\ub9c8\ud2f0\uc2a4\uad00\uc808\uc5fc \ud65c\ub9c9\uc5d0\uc11c \ubcd1\ub9ac\uc801 \uc5ed\ud560\uc744 \ud558\ub294 \uc12c\uc720\uc544\uc138\ud3ec\ub85c, \uc5fc\uc99d\uacfc \uae30\uc9c8\ud30c\uad34\ub97c \ub9e4\uac1c\ud55c\ub2e4.<\/p>\n<\/details>\n<\/aside>\n<h2>\ubd88\ud655\uc2e4\ud55c \ubd80\ubd84 (Unconfirmed)<\/h2>\n<ul>\n<li>\ud65c\uc561\uc5d0\uc11c \uac80\ucd9c\ub41c PS-MPs\uc758 \ucd9c\ucc98(\uc804\uc2e0\uc801 \uc720\uc785 vs \uad00\uc808\uac15 \uad6d\uc18c \uc720\uc785)\ub294 \uc544\uc9c1 \ud655\uc815\ub418\uc9c0 \uc54a\uc558\ub2e4.<\/li>\n<li>\ud658\uc790\ub4e4\uc5d0\uc11c \uad00\ucc30\ub41c \ubbf8\uc138\ud50c\ub77c\uc2a4\ud2f1 \ub18d\ub3c4\uc640 \uc9c8\ud658 \uc911\uc99d\ub3c4 \uac04\uc758 \uc9c1\uc811\uc801 \uc0c1\uad00\uad00\uacc4\ub294 \ub300\uaddc\ubaa8 \uc5ed\ud559\uc790\ub8cc\ub85c \uac80\uc99d\ub418\uc5b4\uc57c \ud55c\ub2e4.<\/li>\n<li>\uc7a5\uae30\uac04 \uc800\ub18d\ub3c4 \ub178\ucd9c\uc774 \uc778\uccb4 \uad00\uc808 \uae30\ub2a5\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5\uacfc \ud68c\ubcf5 \uac00\ub2a5\uc131\uc5d0 \ub300\ud55c \uc790\ub8cc\ub294 \uc81c\ud55c\uc801\uc774\ub2e4.<\/li>\n<\/ul>\n<h2>\ucd1d\ud3c9<\/h2>\n<p>\uc774\ubc88 \uc5f0\uad6c\ub294 \ubbf8\uc138\ud50c\ub77c\uc2a4\ud2f1\uc774 \ub2e8\uc21c\ud55c \ud658\uacbd\uc624\uc5fc \ubb3c\uc9c8\uc744 \ub118\uc5b4 \ub9cc\uc131\uc5fc\uc99d \uc9c8\ud658\uc758 \ubcd1\ub9ac\uc801 \ud658\uacbd\uc744 \ubcc0\ud654\uc2dc\ud0ac \uac00\ub2a5\uc131\uc744 \uc81c\uc2dc\ud588\ub2e4. \uac80\ucd9c\u00b7\uae30\uc804\u00b7\ub3d9\ubb3c\ubaa8\ub378\uc5d0\uc11c \uc77c\uad00\ub41c \uc9d5\ud6c4\uac00 \ud655\uc778\ub41c \uc810\uc740 \uc8fc\ubaa9\ud560 \ub9cc\ud558\uc9c0\ub9cc, \uc778\uacfc\uad00\uacc4\uc758 \ud655\uc815\uacfc \uc784\uc0c1\uc801 \uc758\ubbf8 \uaddc\uba85\uc744 \uc704\ud574\uc11c\ub294 \ub300\uaddc\ubaa8 \ud658\uc790 \uae30\ubc18 \uc5f0\uad6c\uc640 \uc7a5\uae30 \uad00\ucc30\uc774 \ud544\uc694\ud558\ub2e4.<\/p>\n<p>\uc815\ucc45\uc801\uc73c\ub85c\ub294 \ubbf8\uc138\ud50c\ub77c\uc2a4\ud2f1 \ub178\ucd9c \uc800\uac10\uacfc \ucde8\uc57d\uad70 \ubcf4\ud638\ub97c \uc704\ud55c \uc870\uce58\uac00 \uac80\ud1a0\ub420 \ud544\uc694\uac00 \uc788\ub2e4. \uc758\ub8cc\uacc4\ub294 \ud5a5\ud6c4 \uc5f0\uad6c \uacb0\uacfc\ub97c \ubc14\ud0d5\uc73c\ub85c \ud658\uc790 \uc0c1\ub2f4\uacfc \uc608\ubc29 \uad8c\uace0\ub97c \ubcf4\uc644\ud574\uc57c \ud560 \uac83\uc774\ub2e4.<\/p>\n<h2>\ucd9c\ucc98<\/h2>\n<ul>\n<li><a href=\"https:\/\/news.nate.com\/view\/20251216n07860\" target=\"_blank\" rel=\"noopener\">\ub124\uc774\ud2b8 \ub274\uc2a4(\uc5b8\ub860)<\/a><\/li>\n<li><a href=\"https:\/\/www.journals.elsevier.com\/journal-of-hazardous-materials\" target=\"_blank\" rel=\"noopener\">Journal of Hazardous Materials(\ud559\uc220\uc9c0)<\/a><\/li>\n<\/ul>\n<\/article>\n","protected":false},"excerpt":{"rendered":"<p>\ud575\uc2ec \uc694\uc57d \ucd5c\uadfc \uc5f0\uad6c\uc5d0\uc11c \ub958\ub9c8\ud2f0\uc2a4\uad00\uc808\uc5fc(RA) \ud658\uc790\uc758 \ud65c\uc561(synovial fluid)\uc5d0\uc11c \ud3f4\ub9ac\uc2a4\ud2f0\ub80c \uae30\ubc18 \ubbf8\uc138\ud50c\ub77c\uc2a4\ud2f1(PS-MPs)\uc774 \uac80\ucd9c\ub410\uc73c\uba70, \uc2e4\ud5d8 \uacb0\uacfc \uc774 \uc785\uc790\ub4e4\uc774 \ud65c\ub9c9 \uc12c\uc720\uc544\uc138\ud3ec\ub97c \uc790\uadf9\ud574 \uc5fc\uc99d \uc2e0\ud638(NF-\u03baB\u00b7MAPK)\ub97c \ud65c\uc131\ud654\ud558\uace0 MMP \uc720\ubc1c\uc744 \ud1b5\ud574 \uad00\uc808 \uc190\uc0c1\uc744 \ucd09\uc9c4\ud55c\ub2e4\uace0 \ubcf4\uace0\ub410\ub2e4. \uc5f0\uad6c\ub294 \uc778\uccb4 \uc0d8\ud50c \ubd84\uc11d(Py-GC\/MS\/MS), in vitro \uc138\ud3ec\uc2e4\ud5d8, in vivo \uc774\uc2dd(xenograft) \ubaa8\ub378\uc744 \ud1b5\ud574 \uc77c\uad00\ub41c \uc720\ud574\uc131\uc744 \ud655\uc778\ud588\ub2e4. \uc774\ubc88 \uacb0\uacfc\ub294 \ud658\uacbd\uc131 \ubbf8\uc138\ud50c\ub77c\uc2a4\ud2f1\uc774 \ub9cc\uc131 \uad00\uc808\uc5fc\uc758 \uad6d\uc18c \uc5fc\uc99d\uacfc \ubcd1\ub9ac\uc801 \uc545\ud654\uc5d0 \uae30\uc5ec\ud560 &#8230; <a title=\"\ub958\ub9c8\ud2f0\uc2a4\uad00\uc808\uc5fc \ud65c\uc561\uc11c \ud3f4\ub9ac\uc2a4\ud2f0\ub80c \ubbf8\uc138\ud50c\ub77c\uc2a4\ud2f1 \ud655\uc778\u2026\uc5fc\uc99d\u00b7\uad00\uc808\ud30c\uad34 \uc720\ubc1c \uaddc\uba85\" class=\"read-more\" href=\"https:\/\/readtrends.com\/ko\/ra-microplastics-synovial-fluid\/\" aria-label=\"\ub958\ub9c8\ud2f0\uc2a4\uad00\uc808\uc5fc \ud65c\uc561\uc11c \ud3f4\ub9ac\uc2a4\ud2f0\ub80c \ubbf8\uc138\ud50c\ub77c\uc2a4\ud2f1 \ud655\uc778\u2026\uc5fc\uc99d\u00b7\uad00\uc808\ud30c\uad34 \uc720\ubc1c \uaddc\uba85\uc5d0 \ub300\ud574 \ub354 \uc790\uc138\ud788 \uc54c\uc544\ubcf4\uc138\uc694\">\ub354 \uc77d\uae30<\/a><\/p>\n","protected":false},"author":1,"featured_media":4557,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"rank_math_title":"\ub958\ub9c8\ud2f0\uc2a4\uad00\uc808\uc5fc \ud65c\uc561\uc11c \ubbf8\uc138\ud50c\ub77c\uc2a4\ud2f1 \uac80\ucd9c\u00b7\uc720\ud574\uc131 \uaddc\uba85 - \ub274\uc2a4\uc778\uc0ac\uc774\ud2b8","rank_math_description":"\ub958\ub9c8\ud2f0\uc2a4\uad00\uc808\uc5fc \ud658\uc790 \ud65c\uc561\uc5d0\uc11c \ud3f4\ub9ac\uc2a4\ud2f0\ub80c \ubbf8\uc138\ud50c\ub77c\uc2a4\ud2f1\uc774 \ud655\uc778\ub418\uace0, \uc138\ud3ec\u00b7\ub3d9\ubb3c\uc2e4\ud5d8\uc5d0\uc11c \uc5fc\uc99d\u00b7\uad00\uc808\ud30c\uad34 \uc720\ubc1c\uc774 \uc785\uc99d\ub410\uc2b5\ub2c8\ub2e4. \uc5f0\uad6c\uc758 \uc758\ubbf8\uc640 \ud5a5\ud6c4 \uacfc\uc81c\ub97c \uc815\ub9ac\ud569\ub2c8\ub2e4.","rank_math_focus_keyword":"\ub958\ub9c8\ud2f0\uc2a4\uad00\uc808\uc5fc,\ubbf8\uc138\ud50c\ub77c\uc2a4\ud2f1,\ud65c\uc561,\ud3f4\ub9ac\uc2a4\ud2f0\ub80c,\uc5fc\uc99d","footnotes":""},"categories":[2],"tags":[],"class_list":["post-4562","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-top-stories"],"_links":{"self":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/posts\/4562","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/comments?post=4562"}],"version-history":[{"count":0,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/posts\/4562\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/media\/4557"}],"wp:attachment":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/media?parent=4562"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/categories?post=4562"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/tags?post=4562"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}