{"id":4753,"date":"2025-12-18T07:07:43","date_gmt":"2025-12-17T22:07:43","guid":{"rendered":"https:\/\/readtrends.com\/ko\/mrna-tcell-rejuvenation\/"},"modified":"2025-12-18T07:07:43","modified_gmt":"2025-12-17T22:07:43","slug":"mrna-tcell-rejuvenation","status":"publish","type":"post","link":"https:\/\/readtrends.com\/ko\/mrna-tcell-rejuvenation\/","title":{"rendered":"[100\uc138 \uacfc\ud559] \ucf54\ub85c\ub098 \ubc31\uc2e0 \uae30\uc220\ub85c \ud68c\ucd98\u2026T\uc138\ud3ec \ub298\ub824 \uba74\uc5ed\ub825 \ud68c\ubcf5 &#8211; \ub124\uc774\ud2b8"},"content":{"rendered":"<article>\n<p>\ud575\uc2ec \uc694\uc57d: \ucd5c\uadfc \ubc1c\ud45c\ub41c 2025\ub144 Nature \ub17c\ubb38\uc740 \ucf54\ub85c\ub09819 \ubc31\uc2e0\uc5d0 \uc4f0\uc778 mRNA \uc804\ub2ec \uae30\uc220\uc744 \uc751\uc6a9\ud574 \ub178\ud654\ub85c \uac10\uc18c\ud55c T\uc138\ud3ec(\ud2b9\ud788 na\u00efve T\uc138\ud3ec)\ub97c \ud68c\ubcf5\uc2dc\ud0ac \uc218 \uc788\ub2e4\ub294 \uc5f0\uad6c \uacb0\uacfc\ub97c \uc81c\uc2dc\ud588\ub2e4. MIT \uc5f0\uad6c\ud300(Feng Zhang \ub4f1)\uc740 FLT3L, IL-7, DLL1 \ub4f1\uc744 \ud45c\uc801\uc73c\ub85c \ud558\ub294 mRNA \uc870\ud569\uc744 \ub3d9\ubb3c\uc2e4\ud5d8 \ubc0f \uc138\ud3ec\uc2e4\ud5d8\uc5d0\uc11c \ud22c\uc5ec\ud574 \ud2b9\uc815 \uc2e4\ud5d8\uc5d0\uc11c \ucd5c\ub300 18\ubc30\uae4c\uc9c0 na\u00efve T\uc138\ud3ec\uac00 \uc99d\uac00\ud588\ub2e4\uace0 \ubcf4\uace0\ud588\ub2e4. \uc5f0\uad6c\uc9c4\uc740 \uc774 \uc811\uadfc\ubc95\uc774 \ub178\uc778\uce35\uc758 \uba74\uc5ed \ubc18\uc751\uc744 \ud68c\ubcf5\uc2dc\ucf1c \ubc31\uc2e0 \ud6a8\ub2a5\uc744 \ub192\uc77c \uc7a0\uc7ac\ub825\uc774 \uc788\ub2e4\uace0 \ud3c9\uac00\ud588\uc73c\ub098, \uc778\uccb4 \uc784\uc0c1 \uc801\uc751\uacfc \uc7a5\uae30 \uc548\uc804\uc131\uc740 \ucd94\uac00 \ud655\uc778\uc774 \ud544\uc694\ud558\ub2e4\uace0 \ubc1d\ud614\ub2e4.<\/p>\n<h2>\ud575\uc2ec \uc0ac\uc2e4<\/h2>\n<ul>\n<li>\uc5f0\uad6c \ubc1c\ud45c: 2025\ub144 Nature \ub17c\ubb38(doi: https:\/\/doi.org\/10.1038\/s41586-025-09873-4)\uc5d0 \uacb0\uacfc \uac8c\uc7ac\ub428(\ud559\uacc4 \ub17c\ubb38).<\/li>\n<li>\uc5f0\uad6c\ud300: MIT \uc18c\uc18d \uc5f0\uad6c\uc9c4\uc774 \uc8fc\ub3c4\ud588\uc73c\uba70, \uc800\uc790\ub85c Feng Zhang \ub4f1\uc774 \ud3ec\ud568\ub428(\ud559\uacc4, \uc5f0\uad6c\ucc45\uc784\uc790 \ud45c\uae30).<\/li>\n<li>\uae30\uc220: mRNA \uc804\ub2ec \ud50c\ub7ab\ud3fc\uc744 \uc774\uc6a9\ud574 \uba74\uc5ed\uc870\uc808 \uc778\uc790(\uc608: FLT3L, IL-7, DLL1) \ubc1c\ud604\uc744 \uc720\ub3c4\ud568(\ubd84\uc790\ud45c\uc801 \uba85\uc2dc).<\/li>\n<li>\ud6a8\uacfc: \ubcf4\uace0\uc11c\uc5d0\uc11c \uc77c\ubd80 \uc2e4\ud5d8 \uc870\uac74 \ud558\uc5d0 na\u00efve T\uc138\ud3ec \uc218\uac00 \ucd5c\ub300 18\ubc30 \uc99d\uac00\ud55c \uad00\ucc30\uc774 \uc788\uc5c8\uc74c(\ub17c\ubb38 \uc218\uce58 \ubcf4\uc874).<\/li>\n<li>\uc2e4\ud5d8 \ub300\uc0c1: \uc8fc\ub85c \ub3d9\ubb3c\ubaa8\ub378 \ubc0f \uc778\uac04 \uc720\ub798 \uc138\ud3ec \uc2e4\ud5d8\uc744 \ubcd1\ud589\ud588\ub2e4\uace0 \uae30\uc220\ub428(\ub17c\ubb38 \uae30\uc220 \uae30\ubc18).<\/li>\n<li>\ubaa9\ud45c: \ub178\ud654\ub85c \uac10\uc18c\ud55c T\uc138\ud3ec \ud480 \ubcf5\uc6d0\uacfc \ubc31\uc2e0\u00b7\uac10\uc5fc \ub300\uc751\ub825 \ud68c\ubcf5\uc744 \ubaa9\ud45c\ub85c \ud568(\uc5f0\uad6c \ubaa9\uc801).<\/li>\n<li>\uc548\uc804\uc131\u00b7\uc784\uc0c1: \uc5f0\uad6c\ub294 \uc804\uc784\uc0c1 \ub2e8\uacc4\uc5d0 \ud574\ub2f9\ud558\uba70, \uc778\uccb4 \uc801\uc6a9\uacfc \uc7a5\uae30 \uc548\uc804\uc131\uc740 \ucd94\uac00 \uc5f0\uad6c \ud544\uc694(\uc5f0\uad6c\uc790\uac00 \ubc1d\ud798).<\/li>\n<\/ul>\n<h2>\uc0ac\uac74 \ubc30\uacbd<\/h2>\n<p>\ub178\ud654\uc5d0 \ub530\ub978 \uba74\uc5ed\uccb4\uacc4 \uc57d\ud654, \uc18c\uc704 \uba74\uc5ed\ub178\ud654(immunosenescence)\ub294 \uace0\ub839\uc790\uc5d0\uc11c \ubc31\uc2e0 \ubc18\uc751 \uc800\ud558\uc640 \uac10\uc5fc \uc704\ud5d8 \uc99d\uac00\uc758 \uc911\uc694\ud55c \uc6d0\uc778\uc774\ub2e4. \ud2b9\ud788 na\u00efve T\uc138\ud3ec \ud480\uc758 \uac10\uc18c\ub294 \uc0c8\ub85c\uc6b4 \ubcd1\uc6d0\uccb4\uc5d0 \ub300\ud55c \ucd08\uae30 \uc801\uc751 \uba74\uc5ed \ub2a5\ub825\uc744 \uc57d\ud654\uc2dc\ucf1c \uc911\uc99d\ud654 \uac00\ub2a5\uc131\uc744 \ub192\uc778\ub2e4. \ucf54\ub85c\ub09819 \ud32c\ub370\ubbf9 \uc774\ud6c4 mRNA \ubc31\uc2e0 \ud50c\ub7ab\ud3fc\uc740 \ube60\ub978 \uc124\uacc4\u00b7\ub300\ub7c9 \uc0dd\uc0b0 \ub2a5\ub825\uc73c\ub85c \uc8fc\ubaa9\ubc1b\uc558\uace0, \uac19\uc740 \uc804\ub2ec \uae30\uc220\uc744 \uba74\uc5ed\uc7ac\uc0dd(immunorestoration) \ubaa9\uc801\uc73c\ub85c \uc751\uc6a9\ud558\ub824\ub294 \uc5f0\uad6c\uac00 \ud65c\ubc1c\ud574\uc84c\ub2e4. \uc774\ubc88 \uc5f0\uad6c\ub294 \uadf8\ub7ec\ud55c \ud750\ub984\uc758 \uc5f0\uc7a5\uc120\uc5d0\uc11c mRNA\uac00 \ub2e8\uc21c \ud56d\uc6d0 \ub3c4\uc785\uc744 \ub118\uc5b4 \uba74\uc5ed\uc870\uc808 \uc778\uc790 \ubc1c\ud604\uc744 \ud1b5\ud574 \u2018T\uc138\ud3ec \ud480\u2019 \uc790\uccb4\ub97c \ub298\ub9ac\ub294 \uc804\ub7b5\uc744 \uc2e4\ud5d8\uc801\uc73c\ub85c \ud0d0\uc0c9\ud588\ub2e4.<\/p>\n<p>\uacfc\uac70\uc5d0\ub3c4 IL-7 \ub4f1 \uc0ac\uc774\ud1a0\uce74\uc778\uc774\ub098 \uc131\uc7a5\uc778\uc790\ub97c \uc774\uc6a9\ud55c T\uc138\ud3ec \uc7ac\uc0dd \uc2dc\ub3c4\ub294 \uc788\uc5b4 \uc654\uc73c\ub098 \uc804\ub2ec \ubc29\uc2dd\u00b7\uc9c0\uc18d\uc131\u00b7\ubd80\uc791\uc6a9 \ubb38\uc81c\uac00 \ub0a8\uc544 \uc788\uc5c8\ub2e4. mRNA \uae30\uc220\uc740 \ud45c\uc801 \ub2e8\ubc31\uc9c8\uc744 \uc77c\uc2dc\uc801\uc73c\ub85c \uc0dd\uc0b0\uc2dc\ud0a4\ub418 \uc720\uc804\uc790\ub85c\uc758 \ud1b5\ud569 \uc5c6\uc774 \ubd84\ud574\ub41c\ub2e4\ub294 \uc810\uc5d0\uc11c \uc720\ub9ac\ud558\ub2e4\uace0 \ud3c9\uac00\ub41c\ub2e4. \ub2e4\ub9cc mRNA\uc758 \uc804\ub2ec \ud6a8\uc728, \ubc1c\ud604 \uc591\uc0c1\uacfc \uc9c0\uc18d\uc2dc\uac04, \uba74\uc5ed\uacfc\ubbfc\uc131(\uacfc\ub3c4\ud55c \uc5fc\uc99d \uc720\ubc1c) \uac00\ub2a5\uc131 \ub4f1\uc740 \uac01\uac01 \ubcc4\ub3c4 \uc548\uc804\uc131 \uac80\ud1a0 \ub300\uc0c1\uc774\ub2e4. \uc5f0\uad6c\ud300\uc740 \uc774\ub7ec\ud55c \uc7a5\ub2e8\uc810\uc744 \uace0\ub824\ud574 \ud2b9\uc815 \uc778\uc790\ub4e4\uc758 \uc870\ud569\uacfc \ud22c\uc5ec\ubc95\uc744 \uc124\uacc4\ud588\ub2e4\uace0 \ubcf4\uace0\ud588\ub2e4.<\/p>\n<h2>\uc8fc\uc694 \uc0ac\uac74<\/h2>\n<p>\uc5f0\uad6c\uc9c4\uc740 mRNA\ub97c \ud1b5\ud574 FLT3L, IL-7, DLL1 \ub4f1 \ubcf5\uc218\uc758 \uba74\uc5ed\uc790\uadf9 \uc778\uc790\ub97c \ubc1c\ud604\uc2dc\ucf1c \ud749\uc120 \ubc0f \ub9d0\ucd08\uc5d0\uc11c T\uc138\ud3ec \uc804\uad6c\uccb4\uc758 \uc99d\uc2dd\uacfc \ubd84\ud654 \uc720\ub3c4\ub97c \uc2dc\ub3c4\ud588\ub2e4. \ub17c\ubb38\uc5d0 \ub530\ub974\uba74 \ub3d9\ubb3c\uc2e4\ud5d8\uacfc ex vivo \uc778\uac04 \uc138\ud3ec\uc2e4\ud5d8\uc5d0\uc11c na\u00efve T\uc138\ud3ec \ube44\uc728\uacfc \ucd1d \uc218\uac00 \uc720\uc758\ud558\uac8c \uc99d\uac00\ud588\uace0, \uc77c\ubd80 \uc870\uac74\uc5d0\uc11c\ub294 \ucd5c\ub300 18\ubc30 \uc99d\uac00\uac00 \uad00\ucc30\ub418\uc5c8\ub2e4. \uc5f0\uad6c\ub294 \ub610\ud55c \uc99d\uac00\ud55c T\uc138\ud3ec\uac00 \ud56d\uc6d0 \ubc18\uc751\uc131\uc744 \ud68c\ubcf5\ud574 \ubc31\uc2e0 \ud56d\uc6d0\uc5d0 \ub300\ud55c \ubc18\uc751\uc131\uc774 \ud5a5\uc0c1\ub418\ub294 \uc9d5\ud6c4\ub97c \ubcf4\uc600\ub2e4\uace0 \ubcf4\uace0\ud588\ub2e4.<\/p>\n<p>\uc5f0\uad6c\ud300\uc740 \uc2e4\ud5d8 \uacfc\uc815\uc5d0\uc11c mRNA\uc758 \ud22c\uc5ec \ud69f\uc218\u00b7\uc6a9\ub7c9\u00b7\uc9c0\uc9c8\ub098\ub178\uc785\uc790(LNP) \uc804\ub2ec\uccb4 \ub4f1 \uc81c\ud615 \ubcc0\uc218\ub97c \uc870\uc815\ud574 \ucd5c\uc801 \uc870\uac74\uc744 \ud0d0\uc0c9\ud588\ub2e4. \ubcf4\uace0\uc11c\ub294 \ud2b9\uc815 \uc5f0\ub839 \ub610\ub294 \uae30\uc800\uc9c8\ud658\uc744 \uac00\uc9c4 \uc778\uac04 \ucc38\uac00\uc790 \ub300\uc0c1\uc758 \uc784\uc0c1\uc2dc\ud5d8 \uacb0\uacfc\uac00 \uc544\ub2c8\ub77c \uc804\uc784\uc0c1 \uadfc\uac70\uc784\uc744 \uba85\ud655\ud788 \ud588\ub2e4. \uc5f0\uad6c\uc9c4\uc740 \ub17c\ubb38 \ubcf8\ubb38\uacfc \ubcf4\ucda9\uc790\ub8cc\uc5d0\uc11c \uc2e4\ud5d8\ubcc4 \uc218\uce58\uc640 \ud1b5\uacc4\ucc98\ub9ac \uacb0\uacfc\ub97c \uc81c\uc2dc\ud574 \uc7ac\ud604 \uac00\ub2a5\uc131\uc744 \ub192\uc774\ub824 \ud588\ub2e4.<\/p>\n<p>\ud55c\ud3b8 \uc5f0\uad6c \uacb0\uacfc\ub294 \uc989\uac01\uc801\uc778 \uce58\ub8cc\uc801 \uc801\uc6a9\uc744 \uc758\ubbf8\ud558\uc9c0 \uc54a\ub294\ub2e4. \ub17c\ubb38 \uc800\uc790\ub4e4\uc740 \uc548\uc804\uc131 \uac80\uc99d, \uc801\uc815 \uc6a9\ub7c9 \uc124\uc815, \ub9cc\uc131 \ud22c\uc5ec \uc2dc \uc704\ud5d8\uc131 \ud3c9\uac00 \ub4f1 \ud6c4\uc18d \uc5f0\uad6c\uac00 \ud544\uc218\uc801\uc774\ub77c\ub294 \uc810\uc744 \uac15\uc870\ud588\ub2e4. \uaddc\uc81c\u00b7\uc724\ub9ac\uc801 \uac80\ud1a0\uc640 \ub354\ubd88\uc5b4 \ub300\uaddc\ubaa8 \uc778\uccb4\uc2dc\ud5d8\uc774 \uc120\ud589\ub418\uc5b4\uc57c \uc0c1\uc6a9\ud654 \uac00\ub2a5\uc131\uc744 \ud3c9\uac00\ud560 \uc218 \uc788\ub2e4.<\/p>\n<h2>\ubd84\uc11d \ubc0f \uc758\ubbf8<\/h2>\n<p>\uccab\uc9f8, \uae30\uc220\uc801 \uad00\uc810\uc5d0\uc11c mRNA\ub97c \ub2e8\ubc31\uc9c8 \ubc1c\ud604 \ub3c4\uad6c\ub85c \ud65c\uc6a9\ud574 \uba74\uc5ed\uc870\uc808 \uc778\uc790\ub97c \ud45c\uc801\ud654\ud55c \uc811\uadfc\uc740 \uae30\uc874 \ub2e8\ubc31\uc9c8 \uc8fc\uc0ac\ub098 \uc720\uc804\uc790 \uce58\ub8cc\uc640 \ub2e4\ub978 \uc7a5\uc810\uc744 \uc81c\uacf5\ud55c\ub2e4. mRNA\ub294 \uc124\uacc4 \uc720\uc5f0\uc131, \uc0dd\uc0b0 \uc18d\ub3c4, \uc720\uc804\uc790 \ud1b5\ud569 \uc704\ud5d8 \ubd80\uc7ac \ub4f1\uc758 \uc7a5\uc810\uc774 \uc788\uc5b4 \uc804\uc784\uc0c1 \ub2e8\uacc4\uc5d0\uc11c \ub9e4\ub825\uc801\uc774\ub2e4. \uadf8\ub7ec\ub098 \ub2e8\uae30 \ubc1c\ud604\uc774\ub77c\ub294 \ud2b9\uc131 \ub54c\ubb38\uc5d0 \ubc18\ubcf5 \ud22c\uc5ec\uac00 \ud544\uc694\ud560 \uc218 \uc788\uc73c\uba70, \uc774\ub85c \uc778\ud55c \uba74\uc5ed\uc6d0\uc131 \ubc0f \ubd80\uc791\uc6a9 \uac00\ub2a5\uc131\uc740 \uba74\ubc00\ud788 \uac80\ud1a0\ud574\uc57c \ud55c\ub2e4.<\/p>\n<p>\ub458\uc9f8, \uc0ac\ud68c\u00b7\uc784\uc0c1\uc801 \uc758\ubbf8\ub294 \uace0\ub839\uce35 \ubc31\uc2e0 \ud6a8\uacfc \ud5a5\uc0c1\uacfc \uac10\uc5fc\uc131 \uc9c8\ud658\uc5d0 \ub300\ud55c \uc9d1\ub2e8 \ucde8\uc57d\uc131 \uac10\uc18c \uac00\ub2a5\uc131\uc774\ub2e4. \ub9cc\uc57d \uc778\uac04\uc5d0\uc11c \uc548\uc804\ud558\uac8c na\u00efve T\uc138\ud3ec \ud480\uc744 \ud68c\ubcf5\uc2dc\ud0ac \uc218 \uc788\ub2e4\uba74, \ub178\uc778\uc5d0\uc11c\uc758 \uc2e0\uaddc \ubcd1\uc6d0\uccb4 \ub300\uc751\ub825\uacfc \ubc31\uc2e0 \ud6a8\uc728\uc744 \uac1c\uc120\ud560 \uc218 \uc788\ub2e4. \uc774\ub294 \uc778\uad6c \uace0\ub839\ud654\uac00 \uc9c4\ud589 \uc911\uc778 \uad6d\uac00\ub4e4\uc758 \uacf5\uc911\ubcf4\uac74 \ubd80\ub2f4\uc744 \uc904\uc77c \uc218 \uc788\ub294 \uc7a0\uc7ac\uc801 \uc218\ub2e8\uc774\ub2e4.<\/p>\n<p>\uc14b\uc9f8, \ud604\uc2e4\uc801 \uc81c\uc57d\ub3c4 \ud06c\ub2e4. \uc784\uc0c1 \uc801\uc6a9\uc744 \uc704\ud574\uc11c\ub294 \uc7a5\uae30 \uc548\uc804\uc131 \ub370\uc774\ud130\uc640 \ud45c\uc900\ud654\ub41c \ud22c\uc5ec \ud504\ub85c\ud1a0\ucf5c\uc774 \ud544\uc694\ud558\ub2e4. \uaddc\uc81c \ub2f9\uad6d\uc740 mRNA\uac00 \uc77c\uc2dc\uc801 \ub2e8\ubc31\uc9c8 \ubc1c\ud604\uc744 \uc720\ub3c4\ud55c\ub2e4\uace0 \ud574\ub3c4 \uba74\uc5ed\uacc4 \uc870\uc791\uc5d0 \ub530\ub978 \uc608\uc0c1\uce58 \ubabb\ud55c \uacb0\uacfc\ub97c \uc6b0\ub824\ud560 \uac83\uc774\ub2e4. \uacbd\uc81c\uc801 \uce21\uba74\uc5d0\uc11c\ub294 \ub300\uaddc\ubaa8 \uc608\ubc29 \ubaa9\uc801\uc758 \ud22c\uc5ec\uac00 \ube44\uc6a9-\ud6a8\uacfc \uce21\uba74\uc5d0\uc11c \ud0c0\ub2f9\ud55c\uc9c0\ub3c4 \uac80\uc99d\ud574\uc57c \ud55c\ub2e4.<\/p>\n<h2>\ube44\uad50 \ubc0f \ub370\uc774\ud130<\/h2>\n<figure>\n<table>\n<thead>\n<tr>\n<th>\ud56d\ubaa9<\/th>\n<th>\uc5f0\uad6c \ubcf4\uace0\uce58<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\ucd5c\ub300 na\u00efve T\uc138\ud3ec \uc99d\uac00\uc728<\/td>\n<td>\uc5f0\uad6c \uc77c\ubd80 \uc870\uac74\uc5d0\uc11c \ucd5c\ub300 18\ubc30 \uc99d\uac00(\ub17c\ubb38 \uc218\uce58)<\/td>\n<\/tr>\n<tr>\n<td>\uc8fc\uc694 \ud45c\uc801 \uc778\uc790<\/td>\n<td>FLT3L, IL-7, DLL1(\uba85\uc2dc\ub428)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n<p>\uc704 \ud45c\ub294 \ub17c\ubb38\uc5d0\uc11c \uc81c\uc2dc\ub41c \uc8fc\uc694 \uc218\uce58\u00b7\ud45c\uc801\uc744 \uc694\uc57d\ud55c \uac83\uc774\ub2e4. \ub17c\ubb38\uc740 \uc2e4\ud5d8\ubcc4\ub85c \uc99d\uac00\uc728\uc774 \ub2ec\ub790\uc74c\uc744 \ubcf4\ucda9\uc790\ub8cc\uc5d0 \uc81c\uc2dc\ud558\uace0 \uc788\uc5b4 \ub2e8\uc77c \uac12\uc73c\ub85c \uc77c\ubc18\ud654\ud558\uae30\ub294 \uc5b4\ub835\ub2e4. \ub610\ud55c \ub3d9\ubb3c\ubaa8\ub378\uacfc \uc778\uac04 \uc720\ub798 \uc138\ud3ec \uac04\uc758 \ubc18\uc751 \ucc28\uc774\ub3c4 \uc874\uc7ac\ud558\ubbc0\ub85c \ud45c\uc758 \uc218\uce58\ub294 \ub9e5\ub77d\uc5d0 \ub530\ub77c \ud574\uc11d\ud574\uc57c \ud55c\ub2e4.<\/p>\n<h2>\ubc18\uc751 \ubc0f \uc778\uc6a9<\/h2>\n<p>\ub2e4\uc74c\uc740 \uc5f0\uad6c \ubc1c\ud45c\uc5d0 \ub300\ud55c \uc8fc\uc694 \ubc18\uc751\uacfc \ub9e5\ub77d \uc694\uc57d\uc774\ub2e4.<\/p>\n<blockquote>\n<p>&#8220;\uc774\ubc88 \uc5f0\uad6c\ub294 mRNA \ud50c\ub7ab\ud3fc\uc744 \uba74\uc5ed\uc7ac\uc0dd \ubaa9\uc801\uc73c\ub85c \ud655\uc7a5\ud560 \uc218 \uc788\uc74c\uc744 \ubcf4\uc5ec\uc900\ub2e4. \uadf8\ub7ec\ub098 \uc778\uccb4 \uc801\uc6a9 \uc804 \uad11\ubc94\uc704\ud55c \uc548\uc804\uc131 \uac80\ud1a0\uac00 \ud544\uc694\ud558\ub2e4.&#8221;<\/p>\n<p><cite>MIT \uc5f0\uad6c\ud300(\uc5f0\uad6c\uc9c4 \ubc1c\ud45c \uc694\uc57d)<\/cite><\/p><\/blockquote>\n<p>\uc704 \uc778\uc6a9\uc740 \uc5f0\uad6c\uc9c4\uc774 \ub17c\ubb38\uacfc \uae30\uc790\uc790\ub8cc\uc5d0\uc11c \ubc18\ubcf5\ud574 \ubc1d\ud78c \uc785\uc7a5\uc744 \uc694\uc57d\ud55c \uac83\uc774\ub2e4. \uc5f0\uad6c\uc9c4\uc740 \uae0d\uc815\uc801 \uac00\ub2a5\uc131\uacfc \ud568\uaed8 \uc784\uc0c1 \uc804 \uac80\uc99d\uc758 \ud544\uc694\uc131\uc744 \ubd84\uba85\ud788 \ud588\ub2e4.<\/p>\n<blockquote>\n<p>&#8220;\uc804\uc784\uc0c1 \uacb0\uacfc\ub294 \ud76c\ub9dd\uc801\uc774\uc9c0\ub9cc, \uace0\ub839\uce35\uc5d0\uc11c\uc758 \uc7a5\uae30 \ud6a8\uacfc\uc640 \ubd80\uc791\uc6a9\uc740 \uc544\uc9c1 \ud655\uc778\ub418\uc9c0 \uc54a\uc558\ub2e4.&#8221;<\/p>\n<p><cite>\ub3c5\ub9bd \uba74\uc5ed\ud559 \uc804\ubb38\uac00(\ud559\uacc4 \uacac\ud574)<\/cite><\/p><\/blockquote>\n<p>\ud55c \uc804\ubb38\uac00\ub294 \ubcf8 \uc5f0\uad6c\uc758 \ud601\uc2e0\uc131\uc744 \uc778\uc815\ud558\uba74\uc11c\ub3c4, \uaddc\ubaa8\uac00 \ud070 \uc778\uccb4\uc5f0\uad6c\uc640 \uc7a5\uae30 \ucd94\uc801\uc870\uc0ac\uac00 \ud544\uc694\ud558\ub2e4\uace0 \uc9c0\uc801\ud588\ub2e4. \uc774\ub294 \uc758\ud559\uc801\u00b7\uc724\ub9ac\uc801 \uae30\uc900\uc744 \ucda9\uc871\uc2dc\ud0a4\uae30 \uc704\ud55c \ud1b5\uc0c1\uc801\uc778 \uc694\uad6c\uc0ac\ud56d\uc774\ub2e4.<\/p>\n<h2>\n<aside>\n<details>\n<summary>\uc6a9\uc5b4\/\ubc29\ubc95\ub860<\/summary>\n<p>mRNA\ub294 \uba54\uc2e0\uc800\ub9ac\ubcf4\ud575\uc0b0\uc73c\ub85c, \uc138\ud3ec \ub0b4\uc5d0\uc11c \ud2b9\uc815 \ub2e8\ubc31\uc9c8\uc744 \uc77c\uc2dc\uc801\uc73c\ub85c \ud569\uc131\ud558\ub3c4\ub85d \uc815\ubcf4\ub97c \uc804\ub2ec\ud55c\ub2e4. FLT3L\uc740 \uc870\ud608 \ubc0f \uba74\uc5ed\uc804\uad6c\uc138\ud3ec\uc758 \uc99d\uc2dd\uc744 \uc790\uadf9\ud558\ub294 \uc778\uc790\uc774\uba70, IL-7\uc740 T\uc138\ud3ec \uc0dd\uc874\uacfc \uc99d\uc2dd\uc5d0 \uae30\uc5ec\ud558\ub294 \uc0ac\uc774\ud1a0\uce74\uc778\uc774\ub2e4. DLL1\uc740 \uc138\ud3ec \uac04 \uc2e0\ud638\uc804\ub2ec\uc744 \ud1b5\ud574 \ud749\uc120 \ubd84\ud654 \ub4f1 \ud608\uad6c\ubd84\ud654\uc5d0 \uc601\ud5a5\uc744 \uc8fc\ub294 \ubd84\uc790\ub85c \uc54c\ub824\uc838 \uc788\ub2e4. \uc5f0\uad6c\uc5d0\uc11c\ub294 mRNA\ub97c \uc9c0\uc9c8\ub098\ub178\uc785\uc790(LNP) \ub4f1 \uc804\ub2ec\uccb4\ub85c \ud3ec\uc7a5\ud574 \ud45c\uc801 \uc870\uc9c1\uc5d0 \uc804\ub2ec\ud558\uace0, \uc77c\uc2dc\uc801 \ub2e8\ubc31\uc9c8 \ubc1c\ud604\uc744 \uc720\ub3c4\ud574 \uc804\uad6c\uc138\ud3ec \ud480\uc744 \ud655\uc7a5\ud558\ub294 \ubc29\uc2dd\uc73c\ub85c \uc124\uacc4\ub418\uc5c8\ub2e4. \uc774 \uc811\uadfc\uc740 \uc720\uc804\uc790 \ud1b5\ud569 \uc704\ud5d8\uc774 \ub0ae\uc9c0\ub9cc \ubc18\ubcf5 \ud22c\uc5ec\ub85c \uc778\ud55c \uba74\uc5ed\ubc18\uc751 \uc720\ubc1c \uac00\ub2a5\uc131\uc740 \ub0a8\uc544 \uc788\ub2e4.<\/p>\n<\/details>\n<\/aside>\n<\/h2>\n<h2>\ubd88\ud655\uc2e4\ud55c \ubd80\ubd84<\/h2>\n<ul>\n<li>\uc778\uccb4 \uc784\uc0c1\uc5d0\uc11c \uc2e4\uc81c\ub85c \ub3d9\uc77c\ud55c \uc218\uc900(\uc608: 18\ubc30)\uc758 na\u00efve T\uc138\ud3ec \uc99d\uac00\uac00 \uc7ac\ud604\ub418\ub294\uc9c0\ub294 \ud655\uc778\ub418\uc9c0 \uc54a\uc558\ub2e4.<\/li>\n<li>\uc7a5\uae30 \uc548\uc804\uc131(\uba74\uc5ed\uacfc\ubbfc\uc131, \uc790\uac00\uba74\uc5ed \uc720\ubc1c \ub4f1)\uc5d0 \uad00\ud55c \ub370\uc774\ud130\ub294 \uc544\uc9c1 \ubd80\uc871\ud558\ub2e4.<\/li>\n<li>\uc5b4\ub5a4 \uc5f0\ub839\ub300\u00b7\uae30\uc800\uc9c8\ud658\uad70\uc5d0\uc11c \uac00\uc7a5 \ud6a8\uacfc\uc801\uc774\uace0 \uc548\uc804\ud55c\uc9c0\uc5d0 \ub300\ud55c \uc138\ubd80 \uae30\uc900\uc740 \ubbf8\ud655\uc815\uc774\ub2e4.<\/li>\n<li>\ub300\uaddc\ubaa8 \uc608\ubc29\uc801 \ud22c\uc5ec \uc2dc\uc758 \ube44\uc6a9\ud6a8\uacfc\uc131\u00b7\uacf5\uc911\ubcf4\uac74\uc801 \uc774\ub4dd\uc740 \ucd94\uac00 \ubd84\uc11d\uc774 \ud544\uc694\ud558\ub2e4.<\/li>\n<\/ul>\n<h2>\ucd1d\ud3c9<\/h2>\n<p>\uc774\ubc88 \uc5f0\uad6c\ub294 mRNA \ud50c\ub7ab\ud3fc\uc744 \uba74\uc5ed\uc7ac\uc0dd \ubd84\uc57c\ub85c \ud655\uc7a5\ud55c \uc7a0\uc7ac\uc131\uc744 \ubcf4\uc5ec\uc900 \uc911\uc694\ud55c \uc804\uc784\uc0c1 \uacb0\uacfc\ub2e4. \ud2b9\ud788 FLT3L\u00b7IL-7\u00b7DLL1 \ub4f1 \ud45c\uc801 \uc870\ud569\uc744 \ud1b5\ud574 na\u00efve T\uc138\ud3ec \ud480\uc744 \uc99d\ub300\uc2dc\ud0ac \uc218 \uc788\ub2e4\ub294 \uc810\uc740 \uace0\ub839\uce35 \ubc31\uc2e0 \ubc18\uc751 \uac1c\uc120 \uac00\ub2a5\uc131\uc744 \uc2dc\uc0ac\ud55c\ub2e4. \uadf8\ub7ec\ub098 \ud604\uc7ac \uc99d\uac70\ub294 \uc8fc\ub85c \uc804\uc784\uc0c1\uacfc \uc138\ud3ec\uc2e4\ud5d8\uc5d0 \uae30\ubc18\ud558\uba70, \uc778\uccb4 \uc801\uc6a9\uc744 \uc704\ud55c \uc548\uc804\uc131\u00b7\uc720\ud6a8\uc131 \uac80\uc99d\uacfc \uaddc\uc81c \uc808\ucc28\uac00 \ub0a8\uc544 \uc788\ub2e4.<\/p>\n<p>\uacb0\ub860\uc801\uc73c\ub85c \uc774\ubc88 \uc5f0\uad6c\ub294 \uae30\ucd08\u00b7\uc804\uc784\uc0c1 \ub2e8\uacc4\uc5d0\uc11c \uc758\ubbf8 \uc788\ub294 \uc9c4\uc804\uc73c\ub85c \ud3c9\uac00\ub418\uc9c0\ub9cc, \uc2e4\uc81c \uc784\uc0c1 \ub3c4\uc785\uae4c\uc9c0\ub294 \uc5ec\ub7ec \ub2e8\uacc4\uc758 \uac80\uc99d\uc774 \ud544\uc694\ud558\ub2e4. \ub3c5\uc790\ub294 \ub17c\ubb38\uc758 \uc218\uce58\uc640 \uc5f0\uad6c \uc870\uac74\uc744 \uad6c\uccb4\uc801\uc73c\ub85c \ud655\uc778\ud558\uace0, \ud5a5\ud6c4 \uc778\uccb4\uc2dc\ud5d8 \uacb0\uacfc\uc640 \uaddc\uc81c \ub2f9\uad6d\uc758 \ud3c9\uac00\ub97c \uc8fc\uc758 \uae4a\uac8c \uc9c0\ucf1c\ubcfc \ud544\uc694\uac00 \uc788\ub2e4.<\/p>\n<h2>\ucd9c\ucc98<\/h2>\n<ul>\n<li><a href=\"https:\/\/doi.org\/10.1038\/s41586-025-09873-4\" target=\"_blank\" rel=\"noopener\">Nature (\ud559\uacc4, \uc6d0\ubb38 \ub17c\ubb38 DOI)<\/a><\/li>\n<li><a href=\"https:\/\/news.nate.com\/view\/20251218n02841\" target=\"_blank\" rel=\"noopener\">Nate (\uc5b8\ub860 \ubcf4\ub3c4: \uc6d0\ubb38 \uae30\uc0ac)<\/a><\/li>\n<li><a href=\"https:\/\/www.chosun.com\" target=\"_blank\" rel=\"noopener\">ChosunBiz (\uc5b8\ub860 \ubcf4\ub3c4 \ubc0f \ucde8\uc7ac\uc790\ub8cc)<\/a><\/li>\n<\/ul>\n<\/article>\n","protected":false},"excerpt":{"rendered":"<p>\ud575\uc2ec \uc694\uc57d: \ucd5c\uadfc \ubc1c\ud45c\ub41c 2025\ub144 Nature \ub17c\ubb38\uc740 \ucf54\ub85c\ub09819 \ubc31\uc2e0\uc5d0 \uc4f0\uc778 mRNA \uc804\ub2ec \uae30\uc220\uc744 \uc751\uc6a9\ud574 \ub178\ud654\ub85c \uac10\uc18c\ud55c T\uc138\ud3ec(\ud2b9\ud788 na\u00efve T\uc138\ud3ec)\ub97c \ud68c\ubcf5\uc2dc\ud0ac \uc218 \uc788\ub2e4\ub294 \uc5f0\uad6c \uacb0\uacfc\ub97c \uc81c\uc2dc\ud588\ub2e4. MIT \uc5f0\uad6c\ud300(Feng Zhang \ub4f1)\uc740 FLT3L, IL-7, DLL1 \ub4f1\uc744 \ud45c\uc801\uc73c\ub85c \ud558\ub294 mRNA \uc870\ud569\uc744 \ub3d9\ubb3c\uc2e4\ud5d8 \ubc0f \uc138\ud3ec\uc2e4\ud5d8\uc5d0\uc11c \ud22c\uc5ec\ud574 \ud2b9\uc815 \uc2e4\ud5d8\uc5d0\uc11c \ucd5c\ub300 18\ubc30\uae4c\uc9c0 na\u00efve T\uc138\ud3ec\uac00 \uc99d\uac00\ud588\ub2e4\uace0 \ubcf4\uace0\ud588\ub2e4. \uc5f0\uad6c\uc9c4\uc740 \uc774 \uc811\uadfc\ubc95\uc774 \ub178\uc778\uce35\uc758 \uba74\uc5ed \ubc18\uc751\uc744 &#8230; <a title=\"[100\uc138 \uacfc\ud559] \ucf54\ub85c\ub098 \ubc31\uc2e0 \uae30\uc220\ub85c \ud68c\ucd98\u2026T\uc138\ud3ec \ub298\ub824 \uba74\uc5ed\ub825 \ud68c\ubcf5 &#8211; \ub124\uc774\ud2b8\" class=\"read-more\" href=\"https:\/\/readtrends.com\/ko\/mrna-tcell-rejuvenation\/\" aria-label=\"[100\uc138 \uacfc\ud559] \ucf54\ub85c\ub098 \ubc31\uc2e0 \uae30\uc220\ub85c \ud68c\ucd98\u2026T\uc138\ud3ec \ub298\ub824 \uba74\uc5ed\ub825 \ud68c\ubcf5 &#8211; \ub124\uc774\ud2b8\uc5d0 \ub300\ud574 \ub354 \uc790\uc138\ud788 \uc54c\uc544\ubcf4\uc138\uc694\">\ub354 \uc77d\uae30<\/a><\/p>\n","protected":false},"author":1,"featured_media":4745,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"rank_math_title":"\ucf54\ub85c\ub098 mRNA\ub85c T\uc138\ud3ec \ud68c\ubcf5\u2026\uba74\uc5ed \ud68c\ucd98 \uc5f0\uad6c \uacb0\uacfc - \ub124\uc774\ud2b8","rank_math_description":"2025\ub144 Nature \ub17c\ubb38\uc740 \ucf54\ub85c\ub098 \ubc31\uc2e0 mRNA \uae30\uc220\ub85c \ub178\ud654\ub85c \uac10\uc18c\ud55c na\u00efve T\uc138\ud3ec\ub97c \ud68c\ubcf5\uc2dc\ud0ac \uac00\ub2a5\uc131\uc744 \uc81c\uc2dc\ud55c\ub2e4. MIT \uc5f0\uad6c\uc9c4\uc740 FLT3L\u00b7IL-7\u00b7DLL1 mRNA \uc870\ud569\uc73c\ub85c \uc77c\ubd80 \uc2e4\ud5d8\uc5d0\uc11c \ucd5c\ub300 18\ubc30 \uc99d\uac00\ub97c \ubcf4\uace0\ud588\uc73c\ub098, \uc778\uccb4 \uc801\uc6a9\uacfc \uc548\uc804\uc131\uc740 \ucd94\uac00 \uac80\uc99d\uc774 \ud544\uc694\ud558\ub2e4.","rank_math_focus_keyword":"mRNA,T\uc138\ud3ec,\uba74\uc5ed\ud68c\ubcf5,\ucf54\ub85c\ub098\ubc31\uc2e0,\ud68c\ucd98","footnotes":""},"categories":[2],"tags":[],"class_list":["post-4753","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-top-stories"],"_links":{"self":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/posts\/4753","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/comments?post=4753"}],"version-history":[{"count":0,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/posts\/4753\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/media\/4745"}],"wp:attachment":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/media?parent=4753"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/categories?post=4753"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/tags?post=4753"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}