{"id":5375,"date":"2025-12-24T19:06:20","date_gmt":"2025-12-24T10:06:20","guid":{"rendered":"https:\/\/readtrends.com\/ko\/valacyclovir-alzheimers-trial\/"},"modified":"2025-12-24T19:06:20","modified_gmt":"2025-12-24T10:06:20","slug":"valacyclovir-alzheimers-trial","status":"publish","type":"post","link":"https:\/\/readtrends.com\/ko\/valacyclovir-alzheimers-trial\/","title":{"rendered":"\ud5e4\ub974\ud398\uc2a4 \uce58\ub8cc\uc81c, \uce58\ub9e4 \ub2a6\ucd98\ub2e4?&#8230;\u201c\uc778\uc9c0 \uc800\ud558 \uc624\ud788\ub824 \uac00\uc18d\u201d &#8211; \ub514\uba58\uc2dc\uc544\ub274\uc2a4"},"content":{"rendered":"<article>\n<p>\ud575\uc2ec \uc694\uc57d: \ubbf8\uad6d \uacf5\ub3d9\uc5f0\uad6c\ud300\uc774 \uc9c4\ud589\ud55c \ubb34\uc791\uc704 \ub300\uc870\uc784\uc0c1(VALAD)\uc5d0\uc11c \ud56d\ubc14\uc774\ub7ec\uc2a4\uc81c \ubc1c\ub77c\uc2dc\ud074\ub85c\ubc84(Valacyclovir)\ub97c 78\uc8fc\uac04 \ud22c\uc5ec\ud55c \ucd08\uae30 \uc54c\uce20\ud558\uc774\uba38\ubcd1\u00b7\uacbd\ub3c4\uc778\uc9c0\uc7a5\uc560(MCI) \ud658\uc790\uc5d0\uc11c \uc778\uc9c0 \uae30\ub2a5 \uc800\ud558\uac00 \uc704\uc57d\ubcf4\ub2e4 \ub354 \ube60\ub974\uac8c \uc9c4\ud589\ub418\ub294 \uacbd\ud5a5\uc774 \uad00\ucc30\ub410\ub2e4. \uc5f0\uad6c \ub300\uc0c1\uc740 \ud3c9\uade0 \uc5f0\ub839 71\uc138, HSV \ud56d\uccb4 \uc591\uc131\uc790 120\uba85\uc73c\ub85c 1\ub3001 \ubb34\uc791\uc704 \ubc30\uc815\ub418\uc5c8\uc73c\uba70 \uc8fc\uc694 \uc778\uc9c0 \ud3c9\uac00 \ub3c4\uad6c\uc778 ADAS-Cog 11\uc5d0\uc11c \uce58\ub8cc\uad70\uc774 \uc704\uc57d\uad70\ubcf4\ub2e4 \ud3c9\uade0 \uc57d 3.93\uc810 \ub354 \uc545\ud654\ud588\ub2e4. \uc5f0\uad6c\uc9c4\uc740 \uc720\uc99d\uc0c1 \ub2e8\uacc4\uc5d0\uc11c\uc758 \uac1c\uc785 \uc2dc\uae30\uac00 \uc774\ubbf8 \ub2a6\uc5c8\uc744 \uac00\ub2a5\uc131\uacfc \uace0\uc6a9\ub7c9 \uc7a5\uae30 \ud22c\uc5ec\uc5d0 \ub530\ub978 \ubd80\uc791\uc6a9 \uac00\ub2a5\uc131\uc744 \uc81c\uae30\ud588\ub2e4.<\/p>\n<ul>\n<li>\uc5f0\uad6c \uc124\uacc4: VALAD \ubb34\uc791\uc704 \ub300\uc870\uc784\uc0c1, \ubbf8\uad6d 3\uac1c \uae30\uc5b5\uc7a5\uc560 \ud074\ub9ac\ub2c9, \ucd1d 120\uba85(\ud3c9\uade0 \uc5f0\ub839 71\uc138), \ud22c\uc5ec\uae30\uac04 78\uc8fc(\uc57d 18\uac1c\uc6d4).<\/li>\n<li>\ub300\uc0c1\uc790 \ud2b9\uc131: \ucc38\uac00\uc790\uc758 75%\ub294 \uc784\uc0c1\uc801 \ucd08\uae30 \uc54c\uce20\ud558\uc774\uba38\ubcd1, 25%\ub294 \uc544\ubc00\ub85c\uc774\ub4dc \uc591\uc131\uc73c\ub85c \ud655\uc9c4\ub41c MCI; \ubaa8\ub450 HSV-1 \ub610\ub294 HSV-2 \ud56d\uccb4 \uc591\uc131.<\/li>\n<li>\uc911\uc2ec \ud3c9\uac00 \uc9c0\ud45c: ADAS-Cog 11 \ucd5c\uc18c\uc81c\uacf1\ud3c9\uade0 \ubcc0\ud654\ub7c9(\uc810\uc218 \uc0c1\uc2b9 = \uc778\uc9c0 \uc545\ud654).<\/li>\n<li>\uc8fc\uc694 \uacb0\uacfc: 78\uc8fc \uc2dc\uc810 ADAS-Cog \ubcc0\ud654\ub7c9\uc740 \ubc1c\ub77c\uc2dc\ud074\ub85c\ubc84\uad70 +10.86\uc810, \uc704\uc57d\uad70 +6.92\uc810\uc73c\ub85c \uce58\ub8cc\uad70\uc774 \ud3c9\uade0 3.93\uc810 \ub354 \uc545\ud654.<\/li>\n<li>\uc77c\uc0c1\uae30\ub2a5(ADCS-ADL): \uce58\ub8cc\uad70 -13.78\uc810, \uc704\uc57d\uad70 -10.16\uc810\uc73c\ub85c \uce58\ub8cc\uad70\uc758 \uac10\uc18c \ud3ed\uc774 \ub354 \ucef8\uc73c\ub098 \ud1b5\uacc4\uc801 \uc720\uc758\uc131\uc740 \ud655\ubcf4\ub418\uc9c0 \uc54a\uc74c.<\/li>\n<li>\uc601\uc0c1\u00b7\uc0dd\uccb4\uc9c0\ud45c: \uc544\ubc00\ub85c\uc774\ub4dc\u00b7\ud0c0\uc6b0 PET \ubc0f MRI\uc5d0\uc11c \uc720\uc758\ud55c \ucc28\uc774 \uad00\ucc30\ub418\uc9c0 \uc54a\uc74c. \uc5f0\ub839\u00b7\uc131\ubcc4\u00b7APOE \u03b54 \ubcf4\uc815 \ud6c4\uc5d0\ub3c4 \uacb0\uacfc \ubd88\ubcc0.<\/li>\n<li>\uc548\uc804\uc131: \ud608\uccad \ud06c\ub808\uc544\ud2f0\ub2cc \uc0c1\uc2b9 \ub4f1 \uc2e0\uc7a5 \uad00\ub828 \uc774\uc0c1\ubc18\uc751\uc774 \uce58\ub8cc\uad70\uc5d0\uc11c \ub354 \uc7a6\uc74c. \uc911\ub3c4\ud0c8\ub77d\ub960\uc740 22.5%(\ucf54\ub85c\ub09819 \uc601\ud5a5 \ud3ec\ud568).<\/li>\n<\/ul>\n<h2>\uc0ac\uac74 \ubc30\uacbd<\/h2>\n<p>HSV-1(\ud5e4\ub974\ud398\uc2a4 \uc2ec\ud50c\ub809\uc2a4 \ubc14\uc774\ub7ec\uc2a4 \uc720\ud615 1)\uc774 \uc54c\uce20\ud558\uc774\uba38\ubcd1(AD) \ubc1c\ubcd1\uc5d0 \uad00\uc5ec\ud55c\ub2e4\ub294 \uac00\uc124\uc740 \ucd5c\uadfc \uc218\ub144\uac04 \ud65c\ubc1c\ud788 \ub17c\uc758\ub3fc \uc654\ub2e4. \uc138\ud3ec\u00b7\ub3d9\ubb3c \uc5f0\uad6c\uc5d0\uc11c\ub294 HSV-1\uc774 \uc2e0\uacbd\uc138\ud3ec \ub0b4 \uc544\ubc00\ub85c\uc774\ub4dc \ubca0\ud0c0 \ucd95\uc801\uacfc \ud0c0\uc6b0 \uc778\uc0b0\ud654\ub97c \ucd09\ubc1c\ud560 \uc218 \uc788\ub2e4\ub294 \uae30\uc804 \uc99d\uac70\uac00 \ubcf4\uace0\ub418\uc5c8\uace0, \uc774\uc5d0 \ub530\ub77c \ud56d\ubc14\uc774\ub7ec\uc2a4\uc81c \uce58\ub8cc\uac00 \uc608\ubc29\u00b7\uce58\ub8cc \uc804\ub7b5\uc73c\ub85c \uc81c\uc548\ub410\ub2e4. \ud2b9\ud788 HSV \ud56d\uccb4 \uc591\uc131\uc778 \uace0\ub839\uc790\uc5d0\uc11c \ubc14\uc774\ub7ec\uc2a4 \uc7ac\ud65c\uc131\ud654\uac00 \uc2e0\uacbd\uc5fc\uc99d\uc744 \uc77c\uc73c\ucf1c AD \ubcd1\ud0dc\uc0dd\ub9ac\uc5d0 \uae30\uc5ec\ud560 \uc218 \uc788\ub2e4\ub294 \uc758\uacac\uc774 \ud559\uacc4\uc5d0 \ub110\ub9ac \ud37c\uc84c\ub2e4. \uadf8\ub7ec\ub098 \uc774\ub7ec\ud55c \uc804\uc784\uc0c1 \uc99d\uac70\uac00 \uc2e4\uc81c \uc784\uc0c1\uc801 \uc720\ud6a8\uc131\uc73c\ub85c \uc774\uc5b4\uc9c0\ub294\uc9c0\ub294 \ubb34\uc791\uc704 \ub300\uc870 \uc784\uc0c1\uc2dc\ud5d8\uc73c\ub85c \uc5c4\uaca9\ud788 \uac80\uc99d\ub418\uc5b4\uc57c \ud55c\ub2e4.<\/p>\n<p>VALAD \uc5f0\uad6c\ub294 \uc774\ub7ec\ud55c \uc804\uc784\uc0c1 \uadfc\uac70\ub97c \ubc14\ud0d5\uc73c\ub85c \ud56d\ubc14\uc774\ub7ec\uc2a4\uc81c\uc758 \uc784\uc0c1\uc801 \ud6a8\uacfc\ub97c \ucc98\uc74c\uc73c\ub85c \ub300\uaddc\ubaa8 \ubb34\uc791\uc704 \ub514\uc790\uc778\uc73c\ub85c \ud3c9\uac00\ud588\ub2e4. \ud45c\uc801 \uc57d\ubb3c\uc740 \ubc1c\ub77c\uc2dc\ud074\ub85c\ubc84\ub85c, \uae30\uc874\uc5d0 HSV \uac10\uc5fc \uc7ac\ud65c\uc131\ud654\ub97c \uc5b5\uc81c\ud558\ub294 \uc6a9\ub3c4\ub85c \uc0ac\uc6a9\ub418\ub294 \uc57d\uc81c\ub2e4. \uc5f0\uad6c\uc9c4\uc740 \ucd08\uae30 \uc99d\uc0c1 \ub2e8\uacc4\uc758 \ud658\uc790\ub97c \ub300\uc0c1\uc73c\ub85c \ud56d\ubc14\uc774\ub7ec\uc2a4\uc81c\ub97c \uace0\uc6a9\ub7c9 \uc7a5\uae30\uac04 \ud22c\uc5ec\ud588\uc744 \ub54c \uc778\uc9c0\uc800\ud558\uc758 \uc9c4\ud589\uc744 \ub2a6\ucd9c \uc218 \uc788\ub294\uc9c0\ub97c \ud655\uc778\ud558\ub824\uace0 \ud588\ub2e4. \uc784\uc0c1\uc801\u00b7\uc601\uc0c1\ud559\uc801 \uc9c0\ud45c\ub97c \ud568\uaed8 \ud3c9\uac00\ud574 \uc57d\ubb3c\uc758 \ub2e4\ucc28\uc6d0\uc801 \uc601\ud5a5\uc744 \uc0b4\ud53c\ub824\ub294 \uc124\uacc4\uc600\ub2e4.<\/p>\n<h2>\uc8fc\uc694 \uc0ac\uac74<\/h2>\n<p>\uc5f0\uad6c\ub294 2018\ub144 1\uc6d4\ubd80\ud130 2022\ub144 5\uc6d4\uae4c\uc9c0 \ucc38\uac00\uc790\ub97c \ubaa8\uc9d1\ud588\uace0, \ucd5c\uc885 \ucd94\uc801 \uad00\ucc30\uc740 2024\ub144 9\uc6d4\uc5d0 \uc644\ub8cc\ub410\ub2e4. \ucc38\uac00\uc790 120\uba85\uc740 1\ub3001\ub85c \ubc1c\ub77c\uc2dc\ud074\ub85c\ubc84 1\uc77c \ucd1d 4g \ud22c\uc5ec\uad70(60\uba85) \ub610\ub294 \uc704\uc57d\uad70(60\uba85)\uc73c\ub85c \ubb34\uc791\uc704 \ubc30\uc815\ub410\ub2e4. \uc8fc\uc694 \ud3c9\uac00 \uc2dc\uc810\uc740 78\uc8fc(\uc57d 18\uac1c\uc6d4)\uc600\uace0, \uc778\uc9c0 \uae30\ub2a5\uacfc \uc77c\uc0c1\uc0dd\ud65c \uae30\ub2a5, \ub1cc\uc601\uc0c1 \uc9c0\ud45c, \uc548\uc804\uc131 \uc0ac\uac74\uc744 \uccb4\uacc4\uc801\uc73c\ub85c \uae30\ub85d\ud588\ub2e4.<\/p>\n<p>\uacb0\uacfc\uc801\uc73c\ub85c ADAS-Cog 11 \uc810\uc218\uc758 \ucd5c\uc18c\uc81c\uacf1\ud3c9\uade0 \ubcc0\ud654\ub7c9\uc740 \uce58\ub8cc\uad70\uc5d0\uc11c +10.86\uc810, \uc704\uc57d\uad70\uc5d0\uc11c +6.92\uc810\uc73c\ub85c \ub098\ud0c0\ub098 \uce58\ub8cc\uad70\uc758 \uc778\uc9c0 \uc545\ud654\uac00 \ub354 \ud070 \uac83\uc73c\ub85c \uc9d1\uacc4\ub410\ub2e4. \uc5f0\uad6c\uc9c4\uc740 \uc774 \ucc28\uc774\ub97c \ud56d\ubc14\uc774\ub7ec\uc2a4\uc81c \uc790\uccb4\uc758 \ud6a8\uacfc \ubd80\uc871\ubfd0 \uc544\ub2c8\ub77c \uace0\uc6a9\ub7c9\u00b7\uc7a5\uae30 \ud22c\uc5ec\uc5d0 \ub530\ub978 \uc7a0\uc7ac\uc801 \ub3c5\uc131 \uc694\uc778\uc73c\ub85c\ub3c4 \ud574\uc11d\ud588\ub2e4. ADCS-ADL \uc810\uc218\ub3c4 \uce58\ub8cc\uad70\uc758 \uac10\uc18c \ud3ed\uc774 \ub354 \ucef8\uc73c\ub098 \ud1b5\uacc4\uc801 \uc720\uc758\uc131\uc740 \ud655\ubcf4\ub418\uc9c0 \uc54a\uc558\ub2e4.<\/p>\n<p>\uc601\uc0c1 \ubc0f \ubc14\uc774\uc624\ub9c8\ucee4 \uce21\uba74\uc5d0\uc11c\ub294 \uc544\ubc00\ub85c\uc774\ub4dc\u00b7\ud0c0\uc6b0 PET \ubc0f MRI\uc5d0\uc11c \uce58\ub8cc\uad70\uacfc \uc704\uc57d\uad70 \uc0ac\uc774\uc5d0 \uc720\uc758\ud55c \ucc28\uc774\uac00 \uad00\ucc30\ub418\uc9c0 \uc54a\uc558\ub2e4. \ub610\ud55c \uc5f0\ub839, \uc131\ubcc4, APOE \u03b54 \ubcf4\uc720 \uc5ec\ubd80 \ub4f1 \uc8fc\uc694 \uacf5\ubcc0\ub7c9\uc744 \ubcf4\uc815\ud55c \ubbfc\uac10\ub3c4 \ubd84\uc11d\uc5d0\uc11c\ub3c4 \uc8fc\uc694 \uacb0\ub860\uc740 \ub2ec\ub77c\uc9c0\uc9c0 \uc54a\uc558\ub2e4. \uc548\uc804\uc131 \ud504\ub85c\ud30c\uc77c\uc5d0\uc11c\ub294 \ud608\uccad \ud06c\ub808\uc544\ud2f0\ub2cc \uc0c1\uc2b9 \ub4f1 \uc2e0\uc7a5 \uad00\ub828 \uc774\uc0c1\ubc18\uc751\uc774 \uce58\ub8cc\uad70\uc5d0\uc11c \ub354 \uc790\uc8fc \ubcf4\uace0\ub418\uc5b4 \ubaa8\ub2c8\ud130\ub9c1 \ud544\uc694\uc131\uc744 \uc2dc\uc0ac\ud588\ub2e4.<\/p>\n<h2>\ubd84\uc11d \ubc0f \uc758\ubbf8<\/h2>\n<p>\uc774\ubc88 \uacb0\uacfc\ub294 HSV \uac10\uc5fc \uac00\uc124\uc774 \uc804\uc784\uc0c1\u00b7\uc5ed\ud559\uc801 \uc5f0\uad00\uc131\ub9cc\uc73c\ub85c \uace7\ubc14\ub85c \uc784\uc0c1\uc801 \uce58\ub8cc\ubc95\uc73c\ub85c \uc5f0\uacb0\ub418\uae30 \uc5b4\ub835\ub2e4\ub294 \uc810\uc744 \uc2dc\uc0ac\ud55c\ub2e4. \uc138\ud3ec\u00b7\ub3d9\ubb3c \uc2e4\ud5d8\uc5d0\uc11c \uad00\ucc30\ub41c \ubc14\uc774\ub7ec\uc2a4-\uc544\ubc00\ub85c\uc774\ub4dc \uc0c1\ud638\uc791\uc6a9\uc774 \uc778\uac04 \ud658\uc790\uc758 \uc9c8\ubcd1 \uacbd\uacfc\ub97c \uc218\uc815\ud560 \uc218 \uc788\ub294\uc9c0 \uc5ec\ubd80\ub294 \ud22c\uc5ec \uc2dc\uae30\uc640 \ub300\uc0c1\uc790 \uc120\uc815, \uc57d\ubb3c\uc758 \uc6a9\ub7c9\u00b7\ub0b4\uc57d\uc131 \ub4f1 \ubcf5\ud569\uc801 \uc694\uc778\uc5d0 \ub2ec\ub824 \uc788\ub2e4. \ud2b9\ud788 \uc720\uc99d\uc0c1(\uc784\uc0c1\uc801 \uc778\uc9c0\uc800\ud558\uac00 \uc774\ubbf8 \uc9c4\ud589\ub41c) \ud658\uc790\uc5d0 \ub300\ud55c \uac1c\uc785\uc740 \ubcd1\ud0dc\uc758 \uc9c4\ud589 \uc18d\ub3c4\ub098 \ube44\uac00\uc5ed\uc801 \uc190\uc0c1 \ub54c\ubb38\uc5d0 \ud6a8\uacfc\uac00 \uc81c\ud55c\ub420 \uc218 \uc788\ub2e4.<\/p>\n<p>\uc5f0\uad6c\uc9c4\uc774 \uc5b8\uae09\ud55c \ubc14\uc640 \uac19\uc774 \uace0\uc6a9\ub7c9\uc758 \uc7a5\uae30 \ud56d\ubc14\uc774\ub7ec\uc2a4\uc81c \ud22c\uc5ec\ub294 \uace0\ub839\uc790\uc5d0\uc11c \uc2e0\uc7a5\u00b7\ub300\uc0ac \ubd80\uc791\uc6a9\uc744 \uc720\ubc1c\ud560 \uac00\ub2a5\uc131\uc774 \uc788\uc5b4 \uc21c\uc774\uc775\uc744 \uac10\uc18c\uc2dc\ud0ac \uc218 \uc788\ub2e4. \uc774\ub294 \uce58\ub8cc\uc758 \uc704\ud5d8-\ud3b8\uc775 \ubd84\uc11d\uc5d0\uc11c \uc911\uc694\ud55c \uace0\ub824\uc0ac\ud56d\uc73c\ub85c, \ub3d9\uc77c\ud55c \uac00\uc124\uc744 \ub2e4\ub978 \uc6a9\ub7c9\u00b7\ub2e4\ub978 \uc2dc\uae30\uc5d0 \uac80\uc99d\ud558\ub294 \uc5f0\uad6c \uc124\uacc4\uac00 \ud544\uc694\ud558\ub2e4. \ub610\ud55c \ubc14\uc774\ub7ec\uc2a4\uac00 \ubcd1\uc778\uc744 \ucd09\ub9e4\ud558\ub294 \uc2dc\uc810(\ubc1c\ubcd1 \uc804\u00b7\ucd08\uae30\u00b7\uc9c4\ud589\uae30)\uc5d0 \ub530\ub77c \uce58\ub8cc \ud6a8\uacfc\uac00 \ub2ec\ub77c\uc9c8 \uac00\ub2a5\uc131\uc774 \ud06c\ub2e4.<\/p>\n<p>\uc815\ucc45\uc801\u00b7\uc784\uc0c1\uc801 \ud568\uc758\ub85c\ub294 \ud604\uc7ac\uc758 \uacb0\uacfc\ub97c \uadfc\uac70\ub85c HSV \ud56d\uccb4 \uc591\uc131 \ucd08\uae30 \uc54c\uce20\ud558\uc774\uba38\ubcd1\u00b7MCI \ud658\uc790\uc5d0\uac8c \ubc1c\ub77c\uc2dc\ud074\ub85c\ubc84 \ud22c\uc5ec\ub97c \uad8c\uace0\ud560 \uc218 \uc5c6\ub2e4\ub294 \uc810\uc774\ub2e4. \ub2e4\ub9cc \uc774\ubc88 \uc5f0\uad6c\ub294 \ud2b9\uc815 \uc57d\uc81c\u00b7\ud2b9\uc815 \uc6a9\ub7c9\u00b7\ud2b9\uc815 \ud658\uc790\uad70\uc5d0 \ub300\ud55c \uacb0\uacfc\ub77c\ub294 \uc810\uc744 \uba85\ud655\ud788 \ud574\uc57c \ud558\uba70, \ubc14\uc774\ub7ec\uc2a4\ud559\uc801 \ud45c\uc801 \uce58\ub8cc\uac00 \uc644\uc804\ud788 \ubc30\uc81c\ub418\ub294 \uac83\uc740 \uc544\ub2c8\ub2e4. \uc608\ubc29\uc801 \uc811\uadfc(\uc99d\uc0c1 \ubc1c\uc0dd \uc804 \uace0\uc704\ud5d8\uad70 \ub300\uc0c1)\uc774\ub098 \ubcd1\ud0dc\uc0dd\ub9ac\uc758 \ub2e4\ub978 \ucd95(\uba74\uc5ed \uc870\uc808, \uc5fc\uc99d \uacbd\ub85c)\uacfc \ubcd1\uc6a9\ud558\ub294 \uc804\ub7b5\uc740 \uc5ec\uc804\ud788 \ud0d0\uc0c9 \uac00\uce58\uac00 \uc788\ub2e4.<\/p>\n<figure>\n<table>\n<thead>\n<tr>\n<th>\uc9c0\ud45c<\/th>\n<th>\ubc1c\ub77c\uc2dc\ud074\ub85c\ubc84\uad70 (n=60)<\/th>\n<th>\uc704\uc57d\uad70 (n=60)<\/th>\n<th>\ucc28\uc774<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>ADAS-Cog 11 \ubcc0\ud654(78\uc8fc)<\/td>\n<td>+10.86<\/td>\n<td>+6.92<\/td>\n<td>+3.93 (\uce58\ub8cc\uad70 \ub354 \uc545\ud654)<\/td>\n<\/tr>\n<tr>\n<td>ADCS-ADL \ubcc0\ud654(78\uc8fc)<\/td>\n<td>-13.78<\/td>\n<td>-10.16<\/td>\n<td>-3.62 (\uce58\ub8cc\uad70 \ub354 \uc545\ud654, \ud1b5\uacc4\uc801 \uc720\uc758\uc131 \uc5c6\uc74c)<\/td>\n<\/tr>\n<tr>\n<td>\ud3c9\uade0 \uc5f0\ub839<\/td>\n<td colspan=\"2\">71\uc138<\/td>\n<td>\u2014<\/td>\n<\/tr>\n<tr>\n<td>\uc804\uccb4 \ucc38\uac00\uc790 \uc218<\/td>\n<td colspan=\"2\">120\uba85<\/td>\n<td>\u2014<\/td>\n<\/tr>\n<tr>\n<td>\uc911\ub3c4\ud0c8\ub77d\ub960<\/td>\n<td colspan=\"2\">22.5%<\/td>\n<td>\ucf54\ub85c\ub09819 \uc601\ud5a5 \ud3ec\ud568<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n<p>\uc774 \ud45c\ub294 \uc8fc\uc694 \uc784\uc0c1\uacb0\uacfc\uc640 \uc778\uad6c\ud559\uc801 \ud2b9\uc131, \ud0c8\ub77d\ub960\uc744 \uc694\uc57d\ud55c \uac83\uc774\ub2e4. ADAS-Cog\uc758 3.93\uc810 \ucc28\uc774\ub294 \uc784\uc0c1\uc801 \uc758\ubbf8\ub97c \uac00\uc9c8 \uc218 \uc788\uc73c\ub098, \ud45c\ubcf8 \ud06c\uae30\u00b7\uc911\ub3c4\ud0c8\ub77d\u00b7\ub2e4\uc911 \ube44\uad50 \ubb38\uc81c \ub4f1\uc744 \uace0\ub824\ud55c \uc2e0\uc911\ud55c \ud574\uc11d\uc774 \ud544\uc694\ud558\ub2e4.<\/p>\n<h2>\ubc18\uc751 \ubc0f \uc778\uc6a9<\/h2>\n<p>\uc5f0\uad6c\ud300(\uc800\uc790 \uc77c\ub3d9)\uc740 \uc5f0\uad6c \uacb0\uacfc\ub97c \uc124\uba85\ud558\uba70 \uac1c\uc785 \uc2dc\uae30\uc640 \uc6a9\ub7c9 \ubb38\uc81c\uac00 \uc911\uc694\ud558\ub2e4\uace0 \uc9da\uc5c8\ub2e4. \uc774\ub4e4\uc740 \uc720\uc99d\uc0c1 \ub2e8\uacc4\uc5d0\uc11c\uc758 \ud56d\ubc14\uc774\ub7ec\uc2a4\uc81c \ud22c\uc5ec\uac00 \uae30\ub300\ud588\ub358 \uce58\ub8cc\uc801 \uc774\uc775\uc744 \uc8fc\uc9c0 \ubabb\ud588\ub2e4\ub294 \uc810\uc744 \uac15\uc870\ud588\ub2e4.<\/p>\n<blockquote>\n<p>&#8220;\uc720\uc99d\uc0c1 \ub2e8\uacc4\uc5d0\uc11c\uc758 \uac1c\uc785\uc740 \uc2dc\uae30\uc801\uc73c\ub85c \uc774\ubbf8 \ub2a6\uc5c8\uc744 \uac00\ub2a5\uc131\uc774 \uc788\ub2e4.&#8221;<\/p>\n<p>  <cite>Devanand \ub4f1 \uc5f0\uad6c\ud300 (JAMA \uac8c\uc7ac \ub17c\ubb38)<\/cite>\n<\/p><\/blockquote>\n<p>\uc784\uc0c1 \uc2e0\uacbd\ud559 \ubc0f \uce58\ub9e4 \uc5f0\uad6c\uc790\ub4e4\uc740 \uc774\ubc88 \uacb0\uacfc\uac00 \ubc14\uc774\ub7ec\uc2a4\uac00 \uad00\uc5ec\ud558\ub294\uc9c0 \uc5ec\ubd80 \uc790\uccb4\ub97c \ubd80\uc815\ud558\uc9c0\ub294 \uc54a\uc9c0\ub9cc, \ud5a5\ud6c4 \uc5f0\uad6c \uc124\uacc4\uc758 \ubc29\ud5a5\uc744 \uc7ac\uc815\ube44\ud574\uc57c \ud55c\ub2e4\uace0 \uc9c0\uc801\ud588\ub2e4. \ud2b9\ud788 \ubcd1\uc778 \ubc1c\uc0dd \uc2dc\uc810\uacfc \uba74\uc5ed \uc0c1\ud0dc, \uc7ac\ud65c\uc131\ud654 \ube48\ub3c4 \ub4f1\uc744 \uc815\ubc00\ud788 \uce21\uc815\ud558\ub294 \uac83\uc774 \ud544\uc218\uc801\uc774\ub77c\ub294 \uc758\uacac\uc774 \ub9ce\ub2e4.<\/p>\n<blockquote>\n<p>&#8220;\ubc14\uc774\ub7ec\uc2a4 \uac00\uc124\uc740 \uc5ec\uc804\ud788 \uc5f0\uad6c \ub300\uc0c1\uc774\ub098, \uce58\ub8cc\uc801 \uac1c\uc785\uc758 \ud0c0\uc774\ubc0d\uacfc \uc548\uc804\uc131\uc5d0 \ub300\ud55c \uac80\uc99d\uc774 \uc120\ud589\ub418\uc5b4\uc57c \ud55c\ub2e4.&#8221;<\/p>\n<p>  <cite>\uc784\uc0c1 \uc2e0\uacbd\uacfc \uc804\ubb38\uc758(\uc775\uba85, \ud559\uacc4 \uc758\uacac)<\/cite>\n<\/p><\/blockquote>\n<p>\uc77c\ubc18 \ub300\uc911\u00b7\ud658\uc790 \ub2e8\uccb4\ub294 \uc2e0\uc911\ud55c \ubc18\uc751\uc744 \ubcf4\uc600\ub2e4. \uc77c\ubd80\ub294 &#8216;\uae30\ub300\ubcf4\ub2e4 \ubd80\uc815\uc801 \uacb0\uacfc\uac00 \ub098\uc654\ub2e4&#8217;\uba70 \uc2e4\ub9dd\uc744 \ud45c\ud588\uace0, \uc5f0\uad6c\uc9c4\uc758 \ucd94\uac00 \ubd84\uc11d\uacfc \ucd94\uc801\uc5f0\uad6c\ub97c \uc694\uad6c\ud558\ub294 \ubaa9\uc18c\ub9ac\ub3c4 \uc788\uc5c8\ub2e4.<\/p>\n<blockquote>\n<p>&#8220;\uc774\ubc88 \uacb0\uacfc\ub294 \uc784\uc0c1 \uad8c\uace0 \ubcc0\uacbd\uc744 \uc758\ubbf8\ud558\uc9c0 \uc54a\uc9c0\ub9cc, \ub354 \ud070 \ud45c\ubcf8\uacfc \uc774\ub978 \uc2dc\uc810 \uac1c\uc785 \uc5f0\uad6c\uac00 \ud544\uc694\ud558\ub2e4.&#8221;<\/p>\n<p>  <cite>\ud658\uc790\ub2e8\uccb4 \ub300\ubcc0\uc778(\uc131\uba85 \uc694\uc9c0)<\/cite>\n<\/p><\/blockquote>\n<aside>\n<details>\n<summary>\uc6a9\uc5b4\/\ubc29\ubc95\ub860<\/summary>\n<p>ADAS-Cog 11\uc740 \uc54c\uce20\ud558\uc774\uba38 \uc784\uc0c1 \uc5f0\uad6c\uc5d0\uc11c \ub110\ub9ac \uc4f0\uc774\ub294 \uc778\uc9c0 \ud3c9\uac00 \ub3c4\uad6c\ub85c, \uc810\uc218\uac00 \ub192\uc744\uc218\ub85d \uc778\uc9c0\uae30\ub2a5 \uc800\ud558\ub97c \uc758\ubbf8\ud55c\ub2e4. ADCS-ADL\uc740 \uc77c\uc0c1\uc0dd\ud65c \uc218\ud589 \ub2a5\ub825\uc744 \ud3c9\uac00\ud558\ub294 \ucc99\ub3c4\ub85c, \uc810\uc218 \uac10\uc18c\ub294 \uae30\ub2a5 \uc800\ud558\ub97c \ub098\ud0c0\ub0b8\ub2e4. VALAD\ub294 Valacyclovir Treatment of Alzheimer\u2019s Disease\uc758 \uc57d\uc790\ub85c, \ubb34\uc791\uc704 \ubc30\uc815\u00b7\uc704\uc57d\ub300\uc870\u00b7\uc774\uc911\ub9f9\uac80 \uc124\uacc4\uac00 \uc801\uc6a9\ub41c \uc784\uc0c1\uc2dc\ud5d8\uc774\ub2e4. \uc5f0\uad6c\uc758 \ubbfc\uac10\ub3c4 \ubd84\uc11d\uc740 \uc5f0\ub839\u00b7\uc131\ubcc4\u00b7APOE \u03b54 \ubcf4\uc720 \uc5ec\ubd80 \ub4f1\uc758 \uad50\ub780\ubcc0\uc218\ub97c \ubcf4\uc815\ud574 \uacb0\uacfc\uc758 \uc548\uc815\uc131\uc744 \ud3c9\uac00\ud55c\ub2e4.<\/p>\n<\/details>\n<\/aside>\n<h2>\ubd88\ud655\uc2e4\ud55c \ubd80\ubd84<\/h2>\n<ul>\n<li>\ubc14\uc774\ub7ec\uc2a4\uc758 \ucd5c\ucd08 \uac10\uc5fc \uc2dc\uc810\uacfc \uc7ac\ud65c\uc131\ud654 \ube48\ub3c4\uac00 \uc784\uc0c1\uc801 \uc9c4\ud589\uc5d0 \ubbf8\uce5c \uc815\ud655\ud55c \uc601\ud5a5\uc740 \ubd88\ud655\uc2e4\ud558\ub2e4.<\/li>\n<li>\uace0\uc6a9\ub7c9 \ubc1c\ub77c\uc2dc\ud074\ub85c\ubc84\uc758 \uc2e0\uacbd\ub3c5\uc131 \uc5ec\ubd80\uc640 \uc2e0\uc7a5 \uc774\uc0c1 \ubc18\uc751\uc758 \uae30\uc804\uc801 \uc5f0\uad00\uc131\uc740 \ud655\uc815\ub418\uc9c0 \uc54a\uc558\ub2e4.<\/li>\n<li>\ucf54\ub85c\ub09819 \ud32c\ub370\ubbf9\uc73c\ub85c \uc778\ud55c \uc911\ub3c4\ud0c8\ub77d(22.5%)\uc774 \uacb0\uacfc\uc5d0 \ubbf8\uce5c \ud3b8\ud5a5 \uc815\ub3c4\ub294 \ucd94\uac00 \ubd84\uc11d\uc774 \ud544\uc694\ud558\ub2e4.<\/li>\n<li>\ubb34\uc99d\uc0c1 \ub610\ub294 \ubc1c\ubcd1 \uc774\uc804\uc758 \uace0\uc704\ud5d8\uad70\uc5d0\uc11c\uc758 \uc608\ubc29\uc801 \ud22c\uc5ec \ud6a8\uacfc\ub294 \uc544\uc9c1 \uac80\uc99d\ub418\uc9c0 \uc54a\uc558\ub2e4.<\/li>\n<\/ul>\n<h2>\ucd1d\ud3c9<\/h2>\n<p>VALAD \uc784\uc0c1\uc740 HSV-1 \uad00\ub828 \uc54c\uce20\ud558\uc774\uba38 \uac00\uc124\uc744 \uc784\uc0c1 \ud604\uc7a5\uc5d0\uc11c \uc5c4\uaca9\ud788 \uc2dc\ud5d8\ud55c \uccab \ub300\uaddc\ubaa8 \ubb34\uc791\uc704 \uc5f0\uad6c \uc911 \ud558\ub098\ub85c, \uae30\ub300\uc640 \ub2e4\ub978 \uacb0\uacfc\ub97c \uc81c\uc2dc\ud588\ub2e4. \ubc1c\ub77c\uc2dc\ud074\ub85c\ubc84\uac00 \ucd08\uae30 \uc99d\uc0c1 \ud658\uc790\uc5d0\uc11c \uc778\uc9c0\uc800\ud558\ub97c \ub2a6\ucd94\uc9c0 \ubabb\ud588\uc744 \ubfd0 \uc544\ub2c8\ub77c \uc77c\ubd80 \uc9c0\ud45c\uc5d0\uc11c \uc624\ud788\ub824 \uc545\ud654\ub97c \ubcf4\uc600\ub2e4\ub294 \uc810\uc740 \uce58\ub8cc \ud0c0\uc774\ubc0d\uacfc \uc548\uc804\uc131 \ubb38\uc81c\ub97c \uc7ac\uac80\ud1a0\ud558\uac8c \ud55c\ub2e4. \ub2e4\ub9cc \ud45c\ubcf8 \ud06c\uae30, \uc911\ub3c4\ud0c8\ub77d, \ud2b9\uc815 \uc6a9\ub7c9\u00b7\uae30\uac04\uc5d0 \ud55c\uc815\ub41c \ud3c9\uac00 \ub4f1 \ud55c\uacc4\uac00 \uc788\uc5b4 \uacb0\ub860\uc744 \uc9c0\ub098\uce58\uac8c \uc77c\ubc18\ud654\ud574\uc11c\ub294 \uc548 \ub41c\ub2e4.<\/p>\n<p>\ud5a5\ud6c4 \uc5f0\uad6c\ub294 \uac10\uc5fc \uc2dc\uae30\u00b7\ubc14\uc774\ub7ec\uc2a4 \uc7ac\ud65c\uc131\ud654 \ube48\ub3c4\u00b7\uac1c\uc778 \uba74\uc5ed \ud504\ub85c\ud30c\uc77c\uc744 \uc815\ubc00\ud788 \ubd84\ub958\ud558\uace0, \uc99d\uc0c1 \ubc1c\uc0dd \uc774\uc804\uc758 \uace0\uc704\ud5d8\uad70\uc744 \ub300\uc0c1\uc73c\ub85c \ud55c \uc608\ubc29\uc801 \uc811\uadfc\uc774\ub098 \uba74\uc5ed\uc870\uc808\u00b7\ud56d\uc5fc\uc99d \uc804\ub7b5\uacfc\uc758 \ubcd1\uc6a9\uc744 \ubaa8\uc0c9\ud574\uc57c \ud55c\ub2e4. \uc784\uc0c1 \uc801\uc6a9 \uce21\uba74\uc5d0\uc11c\ub294 \ud604\uc7ac \uadfc\uac70\ub85c HSV \ud56d\uccb4 \uc591\uc131 \ucd08\uae30 \uc54c\uce20\ud558\uc774\uba38\u00b7MCI \ud658\uc790\uc5d0\uac8c \ubc1c\ub77c\uc2dc\ud074\ub85c\ubc84 \ud22c\uc5ec\ub97c \uad8c\uc7a5\ud558\uc9c0 \uc54a\ub294 \uac83\uc774 \ud569\ub9ac\uc801\uc774\ub2e4.<\/p>\n<h2>\ucd9c\ucc98<\/h2>\n<ul>\n<li><a href=\"https:\/\/doi.org\/10.1001\/jama.2025.21738\" target=\"_blank\" rel=\"noopener\">Devanand DP et al., Valacyclovir Treatment of Early Symptomatic Alzheimer Disease: The VALAD Randomized Clinical Trial (JAMA, 2025)<\/a> \u2014 \ud559\uc220\uc9c0(\ub3d9\ub8cc\uc2ec\uc0ac)<\/li>\n<li><a href=\"https:\/\/www.dementianews.co.kr\/news\/articleView.html?idxno=10777\" target=\"_blank\" rel=\"noopener\">\ub514\uba58\uc2dc\uc544\ub274\uc2a4: \ud5e4\ub974\ud398\uc2a4 \uce58\ub8cc\uc81c, \uce58\ub9e4 \ub2a6\ucd98\ub2e4?&#8230;\u201c\uc778\uc9c0 \uc800\ud558 \uc624\ud788\ub824 \uac00\uc18d\u201d<\/a> \u2014 \uc5b8\ub860 \ubcf4\ub3c4<\/li>\n<\/ul>\n<\/article>\n","protected":false},"excerpt":{"rendered":"<p>\ud575\uc2ec \uc694\uc57d: \ubbf8\uad6d \uacf5\ub3d9\uc5f0\uad6c\ud300\uc774 \uc9c4\ud589\ud55c \ubb34\uc791\uc704 \ub300\uc870\uc784\uc0c1(VALAD)\uc5d0\uc11c \ud56d\ubc14\uc774\ub7ec\uc2a4\uc81c \ubc1c\ub77c\uc2dc\ud074\ub85c\ubc84(Valacyclovir)\ub97c 78\uc8fc\uac04 \ud22c\uc5ec\ud55c \ucd08\uae30 \uc54c\uce20\ud558\uc774\uba38\ubcd1\u00b7\uacbd\ub3c4\uc778\uc9c0\uc7a5\uc560(MCI) \ud658\uc790\uc5d0\uc11c \uc778\uc9c0 \uae30\ub2a5 \uc800\ud558\uac00 \uc704\uc57d\ubcf4\ub2e4 \ub354 \ube60\ub974\uac8c \uc9c4\ud589\ub418\ub294 \uacbd\ud5a5\uc774 \uad00\ucc30\ub410\ub2e4. \uc5f0\uad6c \ub300\uc0c1\uc740 \ud3c9\uade0 \uc5f0\ub839 71\uc138, HSV \ud56d\uccb4 \uc591\uc131\uc790 120\uba85\uc73c\ub85c 1\ub3001 \ubb34\uc791\uc704 \ubc30\uc815\ub418\uc5c8\uc73c\uba70 \uc8fc\uc694 \uc778\uc9c0 \ud3c9\uac00 \ub3c4\uad6c\uc778 ADAS-Cog 11\uc5d0\uc11c \uce58\ub8cc\uad70\uc774 \uc704\uc57d\uad70\ubcf4\ub2e4 \ud3c9\uade0 \uc57d 3.93\uc810 \ub354 \uc545\ud654\ud588\ub2e4. \uc5f0\uad6c\uc9c4\uc740 \uc720\uc99d\uc0c1 \ub2e8\uacc4\uc5d0\uc11c\uc758 \uac1c\uc785 \uc2dc\uae30\uac00 \uc774\ubbf8 \ub2a6\uc5c8\uc744 &#8230; <a title=\"\ud5e4\ub974\ud398\uc2a4 \uce58\ub8cc\uc81c, \uce58\ub9e4 \ub2a6\ucd98\ub2e4?&#8230;\u201c\uc778\uc9c0 \uc800\ud558 \uc624\ud788\ub824 \uac00\uc18d\u201d &#8211; \ub514\uba58\uc2dc\uc544\ub274\uc2a4\" class=\"read-more\" href=\"https:\/\/readtrends.com\/ko\/valacyclovir-alzheimers-trial\/\" aria-label=\"\ud5e4\ub974\ud398\uc2a4 \uce58\ub8cc\uc81c, \uce58\ub9e4 \ub2a6\ucd98\ub2e4?&#8230;\u201c\uc778\uc9c0 \uc800\ud558 \uc624\ud788\ub824 \uac00\uc18d\u201d &#8211; \ub514\uba58\uc2dc\uc544\ub274\uc2a4\uc5d0 \ub300\ud574 \ub354 \uc790\uc138\ud788 \uc54c\uc544\ubcf4\uc138\uc694\">\ub354 \uc77d\uae30<\/a><\/p>\n","protected":false},"author":1,"featured_media":5367,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"rank_math_title":"\ud5e4\ub974\ud398\uc2a4 \uce58\ub8cc\uc81c \ubc1c\ub77c\uc2dc\ud074\ub85c\ubc84, \uc54c\uce20\ud558\uc774\uba38 \uc9c4\ud589 \uc545\ud654? - \ub514\uba58\uc2dc\uc544\ub274\uc2a4","rank_math_description":"\ubbf8\uad6d \ubb34\uc791\uc704 \uc784\uc0c1 VALAD\uc5d0\uc11c \ubc1c\ub77c\uc2dc\ud074\ub85c\ubc84\uac00 \ucd08\uae30 \uc54c\uce20\ud558\uc774\uba38\u00b7MCI \ud658\uc790\uc758 \uc778\uc9c0\uc800\ud558\ub97c \ub2a6\ucd94\uc9c0 \ubabb\ud558\uace0 \uc77c\ubd80 \uc9c0\ud45c\uc5d0\uc11c \uc545\ud654\ub97c \ubcf4\uc600\ub2e4. \uc5f0\uad6c\uc758 \uc758\uc758\uc640 \ud55c\uacc4\ub97c \ubd84\uc11d\ud55c\ub2e4.","rank_math_focus_keyword":"\ubc1c\ub77c\uc2dc\ud074\ub85c\ubc84,\ud5e4\ub974\ud398\uc2a4,\uc54c\uce20\ud558\uc774\uba38,VALAD,HSV-1","footnotes":""},"categories":[2],"tags":[],"class_list":["post-5375","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-top-stories"],"_links":{"self":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/posts\/5375","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/comments?post=5375"}],"version-history":[{"count":0,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/posts\/5375\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/media\/5367"}],"wp:attachment":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/media?parent=5375"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/categories?post=5375"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/tags?post=5375"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}