{"id":6150,"date":"2026-01-05T09:07:20","date_gmt":"2026-01-05T00:07:20","guid":{"rendered":"https:\/\/readtrends.com\/ko\/nf1-translarna-korea\/"},"modified":"2026-01-05T09:07:20","modified_gmt":"2026-01-05T00:07:20","slug":"nf1-translarna-korea","status":"publish","type":"post","link":"https:\/\/readtrends.com\/ko\/nf1-translarna-korea\/","title":{"rendered":"\uc2e0\uacbd\uc12c\uc720\uc885 1\ud615 \ud658\uc790\uc5d0\uc11c \ud2b8\ub79c\uc2a4\ub77c\ub098 \uc720\ud6a8\ud560 \uc218\ub3c4 &#8211; \uba54\ub514\uce7c\uc5c5\uc800\ubc84"},"content":{"rendered":"<article>\n<p><strong>\ud575\uc2ec \uc694\uc57d<\/strong><\/p>\n<p>\uc11c\uc6b8\uc544\uc0b0\ubcd1\uc6d0 \uc758\ud559\uc720\uc804\ud559\uc13c\ud130 \uc5f0\uad6c\ud300\uc740 \ub10c\uc13c\uc2a4 \ub3cc\uc5f0\ubcc0\uc774\ub97c \uac00\uc9c4 \uc2e0\uacbd\uc12c\uc720\uc885 1\ud615(NF1) \ud658\uc790 \uc720\ub798 \uc12c\uc720\uc544\uc138\ud3ec\uc5d0 \ud2b8\ub79c\uc2a4\ub77c\ub098(\uc131\ubd84\uba85 \uc544\ud0c8\ub8e8\ub80c)\ub97c \ucc98\ub9ac\ud55c \uacb0\uacfc \uc77c\ubd80 \uc138\ud3ec\uc5d0\uc11c NF1 \uc720\uc804\uc790 \uc0b0\ubb3c\uc778 \ub274\ub85c\ud30c\uc774\ube0c\ub85c\ubbfc\uc758 \uae30\ub2a5\uc774 \ud68c\ubcf5\ub418\uace0 \uc885\uc591 \uad00\ub828 \uc2e0\ud638(RAS-MEK-ERK)\uac00 \uc5b5\uc81c\ub418\uc5b4 \uc885\uc591 \ubc1c\uc0dd\uacfc \uc5f0\uad00\ub41c \ud45c\uc9c0\uc790\uac00 \uac10\uc18c\ud568\uc744 \ud655\uc778\ud588\ub2e4. \uc5f0\uad6c\uc5d0\ub294 \ud55c\uad6d\uc778 NF1 \ud658\uc790 22\uba85\uc758 \uc12c\uc720\uc544\uc138\ud3ec\uac00 \uc0ac\uc6a9\ub410\uace0, \uc804\uccb4 \uc138\ud3ec \uc911 \uc57d 24%\uc5d0\uc11c \uacfc\ud65c\uc131 \uc2e0\ud638 \uac10\uc18c\uac00 \uad00\ucc30\ub410\ub2e4. \uc804\uc0ac\uccb4 \ubd84\uc11d\uc740 \ud608\uc561 \ub0b4 AMPD3\uc640 TGFBR3 \uac10\uc18c\ub97c \ud2b8\ub79c\uc2a4\ub77c\ub098 \ubc18\uc751\uc131 \ubc14\uc774\uc624\ub9c8\ucee4 \ud6c4\ubcf4\ub85c \uc81c\uc2dc\ud588\ub2e4. \ud574\ub2f9 \uc5f0\uad6c \uacb0\uacfc\ub294 \ud559\uc220\uc9c0 MedComm \ucd5c\uc2e0 \ud638\uc5d0 \uac8c\uc7ac\ub410\ub2e4.<\/p>\n<h2>\ud575\uc2ec \uc0ac\uc2e4<\/h2>\n<ul>\n<li>\uc5f0\uad6c\uc9c4: \uc11c\uc6b8\uc544\uc0b0\ubcd1\uc6d0 \uc758\ud559\uc720\uc804\ud559\uc13c\ud130 \uc774\ubc94\ud76c \uad50\uc218(\uc18c\uc544\uccad\uc18c\ub144\uacfc)\u00b7\uae40\uc18c\uc601 \uc5f0\uad6c\uc6d0 \uc5f0\uad6c\ud300\uc774 \uc218\ud589\ud588\ub2e4.<\/li>\n<li>\ub300\uc0c1 \ubc0f \ud45c\ubcf8: \ub10c\uc13c\uc2a4 \ub3cc\uc5f0\ubcc0\uc774\ub97c \uac00\uc9c4 \ud55c\uad6d\uc778 \uc2e0\uacbd\uc12c\uc720\uc885 1\ud615 \ud658\uc790 22\uba85\uc758 \uc12c\uc720\uc544\uc138\ud3ec\ub97c \ud655\ubcf4\ud574 \uc2e4\ud5d8\uc744 \uc9c4\ud589\ud588\ub2e4.<\/li>\n<li>\ubc18\uc751\ub960: \ud2b8\ub79c\uc2a4\ub77c\ub098 \ucc98\ub9ac \ud6c4 \uc804\uccb4 \uc138\ud3ec \uc911 \uc57d 24%\uc5d0\uc11c \ube44\uc815\uc0c1\uc801\uc73c\ub85c \uacfc\ud65c\uc131\ud654\ub41c RAS-MEK-ERK \uc2e0\ud638\uc758 \uac10\uc18c\uac00 \uad00\ucc30\ub410\ub2e4.<\/li>\n<li>\uc720\uc804\uc790\/\ub2e8\ubc31\uc9c8 \ubcc0\ud654: \ud2b8\ub79c\uc2a4\ub77c\ub098 \ubc18\uc751 \uc138\ud3ec\uc5d0\uc11c\ub294 \ud608\uc561 \ud45c\uc9c0\uc790\ub85c AMPD3\uc640 TGFBR3 \ub2e8\ubc31\uc9c8 \uc218\uc900\uc774 \uac10\uc18c\ud588\ub2e4.<\/li>\n<li>\uc784\uc0c1\uc801 \uc758\ubbf8: \uc804\ud615\uc801\uc73c\ub85c NF1 \ud658\uc790\uc758 \uc57d 30%\uac00 \ub10c\uc13c\uc2a4 \ub3cc\uc5f0\ubcc0\uc774\ub97c \ubcf4\uc720\ud558\uba70, \uc774\ub4e4\uc740 \uc870\uae30 \uc885\ub8cc(codon stop)\ub85c \uc778\ud574 \ub274\ub85c\ud30c\uc774\ube0c\ub85c\ubbfc \uc0dd\uc131\uc774 \uacb0\ud54d\ub41c\ub2e4.<\/li>\n<li>\uae30\uc804\uc801 \uadfc\uac70: \ub274\ub85c\ud30c\uc774\ube0c\ub85c\ubbfc \uae30\ub2a5 \ud68c\ubcf5\uc740 RAS-MEK-ERK \uc2e0\ud638 \ucd95\uc758 \uc5b5\uc81c\ub97c \ud1b5\ud574 \uc138\ud3ec \uc99d\uc2dd\uacfc \uc885\uc591 \uc0dd\uc131\uc744 \ub0ae\ucd98\ub2e4.<\/li>\n<li>\ucd94\uac00 \ud45c\uc801: AMPD3 \uc5b5\uc81c\ub294 \uc288\ubc18 \uc138\ud3ec\uc5d0\uc11c ERK \uc2e0\ud638 \uac10\uc18c, \uc138\ud3ec \uc99d\uc2dd \uc5b5\uc81c, \uc138\ud3ec \uc0ac\uba78 \uc99d\uac00\ub97c \uc720\ub3c4\ud574 \uce58\ub8cc \ud45c\uc801\uc73c\ub85c\uc11c \uac00\ub2a5\uc131\uc744 \ubcf4\uc600\ub2e4.<\/li>\n<li>\uac8c\uc7ac\uc9c0: \uc5f0\uad6c \uacb0\uacfc\ub294 MedComm \ucd5c\uc2e0 \ud638(\ud559\uc220\uc9c0)\uc5d0 \uc2e4\ub838\ub2e4.<\/li>\n<\/ul>\n<h2>\uc0ac\uac74 \ubc30\uacbd<\/h2>\n<p>\uc2e0\uacbd\uc12c\uc720\uc885 1\ud615(NF1)\uc740 NF1 \uc720\uc804\uc790\uc758 \uc190\uc0c1\uc73c\ub85c \ub274\ub85c\ud30c\uc774\ube0c\ub85c\ubbfc \uacb0\ud54d\uc774 \ucd08\ub798\ub418\uc5b4 \ub2e4\uc591\ud55c \uc870\uc9c1\uc5d0\uc11c \uc591\uc131 \ubc0f \uc545\uc131 \uc885\uc591\uc774 \ubc1c\uc0dd\ud558\ub294 \uc720\uc804\uc131 \uc9c8\ud658\uc774\ub2e4. \ub274\ub85c\ud30c\uc774\ube0c\ub85c\ubbfc\uc740 RAS \uc2e0\ud638\ub97c \uc5b5\uc81c\ud574 \uc138\ud3ec \uc99d\uc2dd\uacfc \ubd84\ud654\ub97c \uc870\uc808\ud558\ub294\ub370, \uae30\ub2a5 \uc0c1\uc2e4 \uc2dc RAS-MEK-ERK \uacbd\ub85c\uac00 \uacfc\ud65c\uc131\ud654\ub418\uc5b4 \uc885\uc591 \ud615\uc131\uc744 \ucd09\uc9c4\ud55c\ub2e4. \uc784\uc0c1\uc801\uc73c\ub85c NF1 \ud658\uc790 \uac00\uc6b4\ub370 \uc57d 30%\uac00 \ub10c\uc13c\uc2a4(nonsense) \ub3cc\uc5f0\ubcc0\uc774\ub97c \ubcf4\uc720\ud558\ub294 \uac83\uc73c\ub85c \uc54c\ub824\uc838 \uc788\ub294\ub370, \uc774\ub294 \uc870\uae30 \uc885\uacb0\ucf54\ub3c8\uc73c\ub85c \uc778\ud574 \ub2e8\ubc31\uc9c8\uc774 \uc644\uc804\ud558\uac8c \uc0dd\uc131\ub418\uc9c0 \ubabb\ud558\ub294 \uc720\ud615\uc774\ub2e4. \ub10c\uc13c\uc2a4 \ub3cc\uc5f0\ubcc0\uc774 \uc9c8\ud658\uc5d0 \ub300\ud574\uc120 \uc77c\ubd80 \uc57d\ubb3c(\uc608: \ud2b8\ub79c\uc2a4\ub77c\ub098)\uc774 \uc870\uae30 \uc885\ub8cc\ub97c \ud68c\ud53c\ud558\uace0 \ubc88\uc5ed\uc744 \uc774\uc5b4\uac00\ub3c4\ub85d \ud574 \uc794\uc874 \ub2e8\ubc31\uc9c8 \uae30\ub2a5\uc744 \ud68c\ubcf5\uc2dc\ud0a4\ub294 \uc804\ub7b5\uc774 \uc81c\uc548\ub3fc\uc654\ub2e4.<\/p>\n<p>\ud2b8\ub79c\uc2a4\ub77c\ub098(\uc544\ud0c8\ub8e8\ub80c)\ub294 \uc6d0\ub798 \uadfc\uc774\uc601\uc591\uc99d\uacfc \uac19\uc740 \ub10c\uc13c\uc2a4 \ub3cc\uc5f0\ubcc0\uc774 \uc9c8\ud658\uc5d0\uc11c \ub2e8\ubc31\uc9c8 \ud569\uc131 \uc7ac\uac1c\ub97c \ucd09\uc9c4\ud558\ub294 \uc57d\ubb3c\ub85c \uc5f0\uad6c\ub410\ub2e4. \uadf8\ub7ec\ub098 \uc2e0\uacbd\uc12c\uc720\uc885 1\ud615\ucc98\ub7fc \uc885\uc591 \ud615\uc131\uacfc \uc5f0\uad00\ub41c \uc720\uc804\uc9c8\ud658\uc5d0\uc11c \ud2b8\ub79c\uc2a4\ub77c\ub098\uc758 \ud6a8\ub2a5\uc740 \uc9c1\uc811 \uc99d\uba85\ub41c \ubc14\uac00 \uc5c6\uc5c8\ub2e4. \uc774\ubc88 \uc5f0\uad6c\ub294 \ud658\uc790 \uc720\ub798 \uc138\ud3ec \ubaa8\ub378\uc744 \uc774\uc6a9\ud574 \ud2b8\ub79c\uc2a4\ub77c\ub098\uac00 NF1 \ub10c\uc13c\uc2a4 \ub3cc\uc5f0\ubcc0\uc774\ub97c \uac00\uc9c4 \uc138\ud3ec\uc5d0\uc11c \ub2e8\ubc31\uc9c8 \uae30\ub2a5\uc744 \ubd80\ubd84\uc801\uc73c\ub85c \ud68c\ubcf5\uc2dc\ud0ac \uc218 \uc788\uc74c\uc744 \uc2e4\ud5d8\uc801\uc73c\ub85c \uc81c\uc2dc\ud588\ub2e4. \uc774\ub294 \ub9de\ucda4\ud615 \uce58\ub8cc \uc804\ub7b5 \uc124\uacc4\uc5d0 \ud544\uc694\ud55c \uae30\ucd08 \uadfc\uac70\ub97c \uc81c\uacf5\ud55c\ub2e4.<\/p>\n<h2>\uc8fc\uc694 \uc0ac\uac74<\/h2>\n<p>\uc5f0\uad6c\ud300\uc740 \ub10c\uc13c\uc2a4 \ub3cc\uc5f0\ubcc0\uc774\ub97c \uac00\uc9c4 \ud55c\uad6d\uc778 NF1 \ud658\uc790 22\uba85\uc758 \ud53c\ubd80 \uc12c\uc720\uc544\uc138\ud3ec\ub97c \ud655\ubcf4\ud574 in vitro\uc5d0\uc11c \ud2b8\ub79c\uc2a4\ub77c\ub098\ub97c \ucc98\ub9ac\ud558\uace0, \uc138\ud3ec \uc2e0\ud638\uc640 \ub2e8\ubc31\uc9c8 \ubc1c\ud604 \ubcc0\ud654\ub97c \uad00\ucc30\ud588\ub2e4. \ucc98\ub9ac \ud6c4 \uc804\uccb4 \uc138\ud3ec \uc9d1\ub2e8\uc758 \uc57d 24%\uc5d0\uc11c RAS-MEK-ERK \ucd95\uc758 \uacfc\ud65c\uc131\uc774 \uc758\ubbf8 \uc788\uac8c \uc904\uc5b4\ub4dc\ub294 \uacb0\uacfc\uac00 \ub098\uc654\uace0, \uc77c\ubd80 \uc138\ud3ec\uc5d0\uc11c\ub294 \ub274\ub85c\ud30c\uc774\ube0c\ub85c\ubbfc\uc758 \uae30\ub2a5\uc801 \ud68c\ubcf5 \uc9d5\ud6c4\uac00 \uad00\ucc30\ub410\ub2e4. \uc774\ub7ec\ud55c \ubcc0\ud654\ub294 \ub2e8\uc21c \uc218\uce58\uc758 \uac10\uc18c\ubfd0 \uc544\ub2c8\ub77c \uc804\uc0ac\uccb4 \uc218\uc900\uc758 \ucc28\uc774\ub97c \ud1b5\ud574 \ubc18\uc751\uad70\uacfc \ube44\ubc18\uc751\uad70\uc744 \uad6c\ubd84\ud560 \uc218 \uc788\uac8c \ud588\ub2e4.<\/p>\n<p>\uc804\uc0ac\uccb4 \ube44\uad50 \ubd84\uc11d\uc5d0\uc11c \ud2b8\ub79c\uc2a4\ub77c\ub098\uc5d0 \ubc18\uc751\ud558\ub294 \uc0d8\ud50c\uc5d0\uc11c\ub294 \ud658\uc790 \ud608\uc561\uc5d0\uc11c AMPD3\uc640 TGFBR3 \ub2e8\ubc31\uc9c8 \uc218\uc900\uc774 \ub0ae\uc544\uc9c0\ub294 \uacbd\ud5a5\uc774 \ud655\uc778\ub410\ub2e4. \uc5f0\uad6c\uc9c4\uc740 \uc774 \ub450 \ub2e8\ubc31\uc9c8\uc744 \ud2b8\ub79c\uc2a4\ub77c\ub098 \uc57d\ud6a8 \ubaa8\ub2c8\ud130\ub9c1\uc758 \ud6c4\ubcf4 \ubc14\uc774\uc624\ub9c8\ucee4\ub85c \uc81c\uc2dc\ud588\ub2e4. \ud2b9\ud788 AMPD3\ub294 \ucd94\uac00 \uc2e4\ud5d8\uc5d0\uc11c \uce58\ub8cc \ud45c\uc801\uc73c\ub85c\uc11c\uc758 \uc2e0\ud638\ub97c \ubcf4\uc600\ub294\ub370, AMPD3\ub97c \uc5b5\uc81c\ud558\uba74 \uc288\ubc18 \uc138\ud3ec\uc5d0\uc11c ERK \uc2e0\ud638\uac00 \uac10\uc18c\ud558\uace0 \uc138\ud3ec \uc99d\uc2dd\uc774 \uc5b5\uc81c\ub418\uba70 \uc138\ud3ec \uc0ac\uba78\uc774 \uc99d\uac00\ud588\ub2e4.<\/p>\n<p>\uc774\ubc94\ud76c \uad50\uc218\ub294 \uc5f0\uad6c \uc758\uc758\ub85c &#8220;\uc77c\ubd80 NF1 \ud658\uc790\uc5d0\uc11c \ud2b8\ub79c\uc2a4\ub77c\ub098\uc758 \uce58\ub8cc \uac00\ub2a5\uc131\uc744 \ucc98\uc74c \ud655\uc778\ud588\ub2e4&#8221;\uace0 \ubc1d\ud614\uace0, \uc5f0\uad6c\ud300\uc740 \uc774 \uacb0\uacfc\uac00 \ub10c\uc13c\uc2a4 \ub3cc\uc5f0\ubcc0\uc774\ub97c \uac00\uc9c4 NF1 \ud658\uc790\uc5d0\uac8c \ub9de\ucda4\ud615 \uce58\ub8cc\ub97c \uc124\uacc4\ud558\ub294 \uae30\ucd08 \uc790\ub8cc\uac00 \ub420 \uac83\uc774\ub77c\uace0 \uc124\uba85\ud588\ub2e4. \uc5f0\uad6c\ub294 \uc138\ud3ec\u00b7\ubd84\uc790 \uc218\uc900\uc758 \uc99d\uac70\ub97c \uc81c\uacf5\ud558\uc9c0\ub9cc, \uc784\uc0c1\uc801 \uc801\uc6a9\uc744 \uc704\ud574\uc11c\ub294 \ucd94\uac00\uc801\uc778 \ub3d9\ubb3c \ubaa8\ub378 \uac80\uc99d\uacfc \uc784\uc0c1\uc2dc\ud5d8 \uc124\uacc4\uac00 \ud544\uc694\ud558\ub2e4.<\/p>\n<h2>\ubd84\uc11d \ubc0f \uc758\ubbf8<\/h2>\n<p>\uccab\uc9f8, \uc774\ubc88 \uc5f0\uad6c\ub294 \ub10c\uc13c\uc2a4 \ub3cc\uc5f0\ubcc0\uc774\ub97c \ud45c\uc801\uc73c\ub85c \ud55c \uc57d\ubb3c \uc7ac\ud65c\uc6a9(repurposing)\uc758 \uac00\ub2a5\uc131\uc744 \ubcf4\uc5ec\uc900\ub2e4. \ud2b8\ub79c\uc2a4\ub77c\ub098\ub294 \uc774\ubbf8 \ub2e4\ub978 \uc9c8\ud658\uc5d0\uc11c \uc57d\ub3d9\ud559\u00b7\uc548\uc804\uc131 \ub370\uc774\ud130\uac00 \ucd95\uc801\ub418\uc5b4 \uc788\uc5b4, NF1 \uc801\uc6a9\uc744 \uc704\ud55c \uc784\uc0c1\uc2dc\ud5d8 \uc124\uacc4 \uc2dc \ucd08\uae30 \ub2e8\uacc4\uc758 \ub9ac\uc2a4\ud06c\ub97c \uc77c\ubd80 \ub0ae\ucd9c \uc218 \uc788\ub2e4. \ub2e4\ub9cc \uc138\ud3ec \uc218\uc900\uc758 \ubc18\uc751\ub960\uc774 \uc57d 24%\uc5d0 \ubd88\uacfc\ud558\ub2e4\ub294 \uc810\uc740 \ubaa8\ub4e0 \ub10c\uc13c\uc2a4 \ud658\uc790\uc5d0\uac8c \uade0\uc77c\ud55c \ud6a8\uacfc\ub97c \uae30\ub300\ud558\uae30 \uc5b4\ub835\ub2e4\ub294 \uc810\uc744 \uc2dc\uc0ac\ud55c\ub2e4.<\/p>\n<p>\ub458\uc9f8, AMPD3\uc640 TGFBR3\uc758 \ud608\uc911 \uac10\uc18c\uac00 \ubc14\uc774\uc624\ub9c8\ucee4 \ud6c4\ubcf4\ub85c \uc81c\uc2dc\ub41c \uc810\uc740 \ud658\uc790 \uc120\ubcc4\uacfc \uce58\ub8cc \ubc18\uc751 \ubaa8\ub2c8\ud130\ub9c1\uc5d0 \uc2e4\uc6a9\uc801 \ud568\uc758\ub97c \uac16\ub294\ub2e4. \uc784\uc0c1 \uc801\uc6a9\uc744 \uc704\ud574\uc11c\ub294 \ud45c\uc900\ud654\ub41c \uce21\uc815\ubc95\uacfc \ud070 \uaddc\ubaa8\uc758 \ud658\uc790\uc9d1\ub2e8\uc5d0\uc11c\uc758 \uac80\uc99d\uc774 \ud544\uc694\ud558\ub2e4. AMPD3 \uc5b5\uc81c\uac00 \uc9c1\uc811\uc801\uc73c\ub85c \uc885\uc591 \uc138\ud3ec\uc5d0 \uc120\ud0dd\uc801 \uc601\ud5a5\uc744 \ubbf8\uce5c\ub2e4\ub294 \uc99d\uac70\ub294 \uc0c8\ub85c\uc6b4 \uce58\ub8cc \ud45c\uc801 \uac1c\ubc1c\ub85c \uc774\uc5b4\uc9c8 \uc218 \uc788\uc9c0\ub9cc, \ud45c\uc801 \uc120\ud0dd\uc131\u00b7\ubd80\uc791\uc6a9\u00b7\uc7a5\uae30 \uc601\ud5a5 \ub4f1\uc5d0 \ub300\ud55c \uba74\ubc00\ud55c \ud3c9\uac00\uac00 \uc120\ud589\ub3fc\uc57c \ud55c\ub2e4.<\/p>\n<p>\uc14b\uc9f8, \uaddc\uc81c\u00b7\uc784\uc0c1 \ub3c4\uc785 \uad00\uc810\uc5d0\uc11c \ubcf4\uba74 \ud2b8\ub79c\uc2a4\ub77c\ub098\uc758 \uae30\uc874 \ud5c8\uac00 \ubc94\uc704\uc640 \uc801\uc751\uc99d \uc678 \uc0ac\uc6a9(off-label) \ubb38\uc81c, \uadf8\ub9ac\uace0 NF1 \ud658\uc790\uad70 \ub0b4 \ub10c\uc13c\uc2a4 \ub3cc\uc5f0\ubcc0\uc774 \ubcf4\uc720\uc728(\uc57d 30%)\uc744 \uace0\ub824\ud55c \uc784\uc0c1 \uc2dc\ud5d8 \uc124\uacc4\uac00 \uad00\uac74\uc774\ub2e4. \ud658\uc790 \uc720\uc804\uccb4 \uae30\ubc18 \uc120\ubcc4, \ubc14\uc774\uc624\ub9c8\ucee4 \uae30\ubc18 \ubc18\uc751 \uc608\uce21, \uadf8\ub9ac\uace0 \uc548\uc804\uc131 \ud504\ub85c\ud30c\uc77c\uc744 \uacb0\ud569\ud55c \uc801\uc751\ud615 \uc784\uc0c1\uc2dc\ud5d8\uc774 \ud604\uc2e4\uc801 \uacbd\ub85c\uac00 \ub420 \uc218 \uc788\ub2e4.<\/p>\n<h2>\ube44\uad50 \ubc0f \ub370\uc774\ud130<\/h2>\n<figure>\n<table>\n<thead>\n<tr>\n<th>\ud56d\ubaa9<\/th>\n<th>\uc218\uce58\/\uacb0\uacfc<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\ub300\uc0c1 \ud658\uc790 \uc720\ub798 \uc0d8\ud50c<\/td>\n<td>22\uba85(\uc12c\uc720\uc544\uc138\ud3ec)<\/td>\n<\/tr>\n<tr>\n<td>\uc138\ud3ec \ubc18\uc751\ub960<\/td>\n<td>\uc57d 24%\uc5d0\uc11c RAS-MEK-ERK \uac10\uc18c \uad00\ucc30<\/td>\n<\/tr>\n<tr>\n<td>NF1\uc5d0\uc11c \ub10c\uc13c\uc2a4 \ub3cc\uc5f0\ubcc0\uc774 \ubcf4\uc720\uc728<\/td>\n<td>\uc57d 30%<\/td>\n<\/tr>\n<tr>\n<td>\ubc14\uc774\uc624\ub9c8\ucee4 \ud6c4\ubcf4<\/td>\n<td>AMPD3, TGFBR3 \uac10\uc18c<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n<p>\uc704 \ud45c\ub294 \uc5f0\uad6c\uc5d0\uc11c \ubcf4\uace0\ub41c \uc8fc\uc694 \uc218\uce58\uc640 \ube44\uad50 \ud56d\ubaa9\uc744 \uc815\ub9ac\ud55c \uac83\uc774\ub2e4. \uc5f0\uad6c \ud45c\ubcf8\uc740 22\uac1c \ud658\uc790 \uc720\ub798 \uc12c\uc720\uc544\uc138\ud3ec\ub85c \uaddc\ubaa8\uac00 \ud06c\uc9c0 \uc54a\uc544 \ud1b5\uacc4\uc801 \uc77c\ubc18\ud654\uc5d0\ub294 \ud55c\uacc4\uac00 \uc788\ub2e4. \ubc18\uc751\ub960(24%)\uc740 \uc138\ud3ec \uae30\ubc18 \uc2e4\ud5d8\uc5d0\uc11c \uad00\ucc30\ub41c \uac12\uc73c\ub85c, \ud658\uc790 \uc804\uccb4\uc5d0\uc11c\uc758 \uc784\uc0c1\uc801 \ubc18\uc751\ub960\uacfc\ub294 \ucc28\uc774\uac00 \ub0a0 \uc218 \uc788\ub2e4. \ub530\ub77c\uc11c \ub3d9\ubb3c \ubaa8\ub378 \ubc0f \uc784\uc0c1\uc2dc\ud5d8\uc744 \ud1b5\ud55c \ucd94\uac00 \uac80\uc99d\uc774 \ud544\uc694\ud558\ub2e4.<\/p>\n<h2>\ubc18\uc751 \ubc0f \uc778\uc6a9<\/h2>\n<p>\uc5f0\uad6c \ubc1c\ud45c \uc9c1\ud6c4 \uc5f0\uad6c\uc9c4\uacfc \ud559\uacc4 \ubc18\uc751\uc744 \uc815\ub9ac\ud558\uba74 \ub2e4\uc74c\uacfc \uac19\ub2e4. \uc6b0\uc120 \uc5f0\uad6c\uc9c4\uc740 \uc138\ud3ec \uc218\uc900\uc758 \uacb0\uacfc\ub97c \uadfc\uac70\ub85c \ud5a5\ud6c4 \uc784\uc0c1 \uc801\uc6a9 \uac00\ub2a5\uc131\uc744 \uc2e0\uc911\ud788 \uc804\ub9dd\ud588\ub2e4.<\/p>\n<blockquote>\n<p>&#8220;\uc774\ubc88 \uc5f0\uad6c\ub97c \ud1b5\ud574 \uc77c\ubd80 \uc2e0\uacbd\uc12c\uc720\uc885 1\ud615 \ud658\uc790\uc5d0\uc11c \ud2b8\ub79c\uc2a4\ub77c\ub098\uc758 \uce58\ub8cc \uac00\ub2a5\uc131\uc744 \ucc98\uc74c \ud655\uc778\ud588\ub2e4.&#8221;<\/p>\n<p><cite>\uc774\ubc94\ud76c \uad50\uc218, \uc11c\uc6b8\uc544\uc0b0\ubcd1\uc6d0 \uc758\ud559\uc720\uc804\ud559\uc13c\ud130<\/cite><\/p><\/blockquote>\n<p>\uc774 \ubc1c\uc5b8\uc740 \uc5f0\uad6c \uacb0\uacfc\uc758 \ud575\uc2ec \uc131\uacfc\ub97c \uc694\uc57d\ud55c \uac83\uc73c\ub85c, \uc5f0\uad6c\uc9c4\uc740 \uc774\uc5b4\uc11c \uc784\uc0c1 \uc801\uc6a9\uc744 \uc704\ud574 \ud544\uc694\ud55c \ucd94\uac00 \uc5f0\uad6c(\ub3d9\ubb3c\uc2e4\ud5d8\u00b7\ub300\uaddc\ubaa8 \ud658\uc790 \uac80\uc99d)\ub97c \uba85\ud655\ud788 \ud588\ub2e4.<\/p>\n<blockquote>\n<p>&#8220;\ub17c\ubb38\uc740 \ud2b8\ub79c\uc2a4\ub77c\ub098\uac00 \ub10c\uc13c\uc2a4 \ub3cc\uc5f0\ubcc0\uc774 NF1 \uc138\ud3ec\uc5d0\uc11c \ub2e8\ubc31\uc9c8 \uae30\ub2a5 \ud68c\ubcf5\uacfc \uc2e0\ud638 \uc5b5\uc81c\ub97c \uc720\ub3c4\ud55c\ub2e4\uace0 \uacb0\ub860\uc9c0\uc5c8\ub2e4.&#8221;<\/p>\n<p><cite>MedComm \ub17c\ubb38 \uc694\uc57d(\ud559\uc220\uc9c0)<\/cite><\/p><\/blockquote>\n<p>\uc774 \ubb38\uc7a5\uc740 \ub17c\ubb38\uc758 \uacb0\ub860\uc744 \uac04\uacb0\ud788 \uc815\ub9ac\ud55c \uac83\uc73c\ub85c, \ud559\uc220\uc9c0 \uac8c\uc7ac\ub294 \ub3d9\ub8cc\uc2ec\uc0ac(peer review)\ub97c \ud1b5\uacfc\ud588\uc74c\uc744 \ub73b\ud55c\ub2e4. \ub2e4\ub9cc \ub17c\ubb38 \uc790\uccb4\ub294 \uc138\ud3ec \uae30\ubc18 \uc5f0\uad6c\ub77c\ub294 \uc810\uc744 \uc800\uc790\ub294 \uba85\ud655\ud788 \ubc1d\ud614\ub2e4.<\/p>\n<h2>\n<aside>\n<details>\n<summary>\uc6a9\uc5b4\/\ubc29\ubc95\ub860<\/summary>\n<p>\ub10c\uc13c\uc2a4 \ub3cc\uc5f0\ubcc0\uc774(nonsense mutation)\ub294 \uc720\uc804\uc790 \uc11c\uc5f4\uc5d0 \uc870\uae30 \uc885\uacb0 \ucf54\ub3c8(stop codon)\uc744 \ub3c4\uc785\ud574 \ubc88\uc5ed\uc774 \uc911\ub2e8\ub418\uace0 \ub2e8\ubc31\uc9c8\uc774 \uacb0\ud54d\ub418\ub294 \ubcc0\uc774\ub97c \ub73b\ud55c\ub2e4. \ud2b8\ub79c\uc2a4\ub77c\ub098(\uc544\ud0c8\ub8e8\ub80c)\ub294 \ubc88\uc5ed \uae30\uacc4\uac00 \uc870\uae30 \uc885\uacb0\uc744 \uc77c\uc2dc\uc801\uc73c\ub85c \ud68c\ud53c\ud558\uac8c \ud574 \uc815\uc0c1 \ubc88\uc5ed\uc744 \uc77c\ubd80 \ubcf5\uc6d0\uc2dc\ud0a4\ub294 \uae30\uc804\uc758 \uc57d\ubb3c\uc774\ub2e4. \ub274\ub85c\ud30c\uc774\ube0c\ub85c\ubbfc\uc740 NF1 \uc720\uc804\uc790\uac00 \uc554\ud638\ud654\ud558\ub294 \ub2e8\ubc31\uc9c8\ub85c, RAS \uc2e0\ud638\ub97c \uc5b5\uc81c\ud574 \uc138\ud3ec \uc131\uc7a5 \uade0\ud615\uc744 \uc720\uc9c0\ud55c\ub2e4. \uc804\uc0ac\uccb4 \ubd84\uc11d\uc740 RNA \uc218\uc900\uc758 \ubc1c\ud604 \ubcc0\ud654\ub97c \ube44\uad50\ud574 \uc57d\ubb3c \ubc18\uc751\uad70\uacfc \ube44\ubc18\uc751\uad70\uc744 \uad6c\ubd84\ud558\ub294 \ub370 \uc0ac\uc6a9\ub41c\ub2e4. AMPD3\uc640 TGFBR3\ub294 \uc774\ubc88 \uc5f0\uad6c\uc5d0\uc11c \ud608\uc911 \ud45c\uc9c0\uc790\ub85c \uc81c\uc2dc\ub41c \ub2e8\ubc31\uc9c8\ub85c, \ucd94\uac00 \uac80\uc99d\uc774 \ud544\uc694\ud55c \ubc14\uc774\uc624\ub9c8\ucee4 \ud6c4\ubcf4\ub2e4.<\/p>\n<\/details>\n<\/aside>\n<\/h2>\n<h2>\ubd88\ud655\uc2e4\ud55c \ubd80\ubd84<\/h2>\n<ul>\n<li>\uc784\uc0c1\ud6a8\uacfc \uc5ec\ubd80: \uc138\ud3ec \uc218\uc900\uc758 \ubc18\uc751(\uc57d 24%)\uc774 \uc2e4\uc81c \ud658\uc790\uc5d0\uc11c\uc758 \uc784\uc0c1\uc801 \uc720\ud6a8\uc131\uc73c\ub85c \uadf8\ub300\ub85c \uc774\uc5b4\uc9c0\ub294\uc9c0\ub294 \ud655\uc99d\ub418\uc9c0 \uc54a\uc558\ub2e4.<\/li>\n<li>\uc7a5\uae30 \uc548\uc804\uc131: \ud2b8\ub79c\uc2a4\ub77c\ub098\ub97c NF1 \ud658\uc790\uc5d0\uac8c \uc7a5\uae30 \ud22c\uc5ec\ud588\uc744 \ub54c\uc758 \uc548\uc804\uc131 \ud504\ub85c\ud30c\uc77c\uc740 \ud655\uc778\ub418\uc9c0 \uc54a\uc558\ub2e4.<\/li>\n<li>\ubc14\uc774\uc624\ub9c8\ucee4 \uc77c\ubc18\ud654: AMPD3\u00b7TGFBR3 \uac10\uc18c\uac00 \ubaa8\ub4e0 \uc778\uad6c\uc9d1\ub2e8\uc5d0\uc11c \uc77c\uad00\ub41c \ubc18\uc751 \uc9c0\ud45c\uc778\uc9c0 \ucd94\uac00 \uac80\uc99d\uc774 \ud544\uc694\ud558\ub2e4.<\/li>\n<li>\ud45c\uc801 \ud2b9\uc774\uc131: AMPD3 \uc5b5\uc81c\uac00 NF1 \uad00\ub828 \uc885\uc591\uc5d0 \uc120\ud0dd\uc801\uc73c\ub85c \uc791\uc6a9\ud558\ub294\uc9c0, \uc815\uc0c1 \uc870\uc9c1\uc5d0 \ub300\ud55c \uc601\ud5a5\uc740 \ubb34\uc5c7\uc778\uc9c0 \ubd88\ud655\uc2e4\ud558\ub2e4.<\/li>\n<\/ul>\n<h2>\ucd1d\ud3c9<\/h2>\n<p>\uc774\ubc88 \uc5f0\uad6c\ub294 \ub10c\uc13c\uc2a4 \ub3cc\uc5f0\ubcc0\uc774\ub97c \uac00\uc9c4 NF1 \ud658\uc790\uc5d0\uc11c \ud2b8\ub79c\uc2a4\ub77c\ub098\uac00 \uc77c\ubd80 \uc138\ud3ec \uc9d1\ub2e8\uc758 \ub274\ub85c\ud30c\uc774\ube0c\ub85c\ubbfc \uae30\ub2a5\uc744 \ud68c\ubcf5\uc2dc\ud0a4\uace0 \uc885\uc591 \uc5f0\uad00 \uc2e0\ud638\ub97c \uc5b5\uc81c\ud560 \uac00\ub2a5\uc131\uc744 \uc81c\uc2dc\ud588\ub2e4\ub294 \uc810\uc5d0\uc11c \uc758\ubbf8\uac00 \ud06c\ub2e4. \uc5f0\uad6c\ub294 \ud658\uc790 \uc720\ub798 \uc138\ud3ec\uc640 \uc804\uc0ac\uccb4 \ubd84\uc11d\uc744 \uacb0\ud569\ud574 \uc57d\ubb3c \ubc18\uc751\uc758 \ubd84\uc790\uc9c0\ud45c(AMPD3, TGFBR3)\ub97c \ub3c4\ucd9c\ud55c \uc810\uc5d0\uc11c \ub9de\ucda4\uc758\ud559\uc758 \ucd08\uc11d\uc744 \ub193\uc558\ub2e4. \uadf8\ub7ec\ub098 \ud604\uc7ac \uadfc\uac70\ub294 \uc138\ud3ec\u00b7\ubd84\uc790 \uc218\uc900\uc5d0 \uad6d\ud55c\ub418\uba70, \uc784\uc0c1 \uc801\uc6a9\uc744 \uc704\ud574\uc11c\ub294 \ub3d9\ubb3c \ubaa8\ub378 \uac80\uc99d\uacfc \uc804\ud5a5\uc801 \uc784\uc0c1\uc2dc\ud5d8\uc744 \ud1b5\ud55c \ud6a8\ub2a5\u00b7\uc548\uc804\uc131 \ud3c9\uac00\uac00 \ud544\uc218\uc801\uc774\ub2e4.<\/p>\n<p>\uc784\uc0c1\uc758\uc640 \uc5f0\uad6c\uc790\ub294 \uc774\ubc88 \uacb0\uacfc\ub97c \ubc14\ud0d5\uc73c\ub85c \ub10c\uc13c\uc2a4 \ub3cc\uc5f0\ubcc0\uc774 \ubcf4\uc720 \ud658\uc790 \uc120\ubcc4, \ubc14\uc774\uc624\ub9c8\ucee4 \uae30\ubc18 \ubc18\uc751 \uc608\uce21, \uadf8\ub9ac\uace0 AMPD3\ub97c \ud3ec\ud568\ud55c \uc0c8\ub85c\uc6b4 \uce58\ub8cc \ud45c\uc801 \uac1c\ubc1c\uc744 \uc704\ud55c \ud611\ub825 \uc5f0\uad6c\ub97c \uc900\ube44\ud560 \ud544\uc694\uac00 \uc788\ub2e4. \ud658\uc790 \ub2e8\uc704\uc758 \uc2e4\uc81c \ud61c\ud0dd\uc744 \ud655\uc778\ud558\ub294 \uac83\uc774 \ucd5c\uc6b0\uc120 \uacfc\uc81c\uc774\uba70, \uaddc\uc81c\u00b7\uc724\ub9ac\uc801 \uac80\ud1a0\ub97c \ud3ec\ud568\ud55c \uc5c4\uaca9\ud55c \ub2e8\uacc4\uc801 \uac80\uc99d\uc774 \ub4a4\ub530\ub77c\uc57c \ud55c\ub2e4.<\/p>\n<h2>\ucd9c\ucc98<\/h2>\n<ul>\n<li><a href=\"https:\/\/www.monews.co.kr\/news\/articleView.html?idxno=408708\" target=\"_blank\" rel=\"noopener\">\uba54\ub514\uce7c\uc5c5\uc800\ubc84 \ubcf4\ub3c4 (\uc5b8\ub860)<\/a><\/li>\n<li><a href=\"https:\/\/onlinelibrary.wiley.com\/journal\/26888362\" target=\"_blank\" rel=\"noopener\">MedComm \uac8c\uc7ac \ub17c\ubb38 (\ud559\uc220\uc9c0\u00b7\ub3d9\ub8cc\uc2ec\uc0ac)<\/a><\/li>\n<\/ul>\n<\/article>\n","protected":false},"excerpt":{"rendered":"<p>\ud575\uc2ec \uc694\uc57d \uc11c\uc6b8\uc544\uc0b0\ubcd1\uc6d0 \uc758\ud559\uc720\uc804\ud559\uc13c\ud130 \uc5f0\uad6c\ud300\uc740 \ub10c\uc13c\uc2a4 \ub3cc\uc5f0\ubcc0\uc774\ub97c \uac00\uc9c4 \uc2e0\uacbd\uc12c\uc720\uc885 1\ud615(NF1) \ud658\uc790 \uc720\ub798 \uc12c\uc720\uc544\uc138\ud3ec\uc5d0 \ud2b8\ub79c\uc2a4\ub77c\ub098(\uc131\ubd84\uba85 \uc544\ud0c8\ub8e8\ub80c)\ub97c \ucc98\ub9ac\ud55c \uacb0\uacfc \uc77c\ubd80 \uc138\ud3ec\uc5d0\uc11c NF1 \uc720\uc804\uc790 \uc0b0\ubb3c\uc778 \ub274\ub85c\ud30c\uc774\ube0c\ub85c\ubbfc\uc758 \uae30\ub2a5\uc774 \ud68c\ubcf5\ub418\uace0 \uc885\uc591 \uad00\ub828 \uc2e0\ud638(RAS-MEK-ERK)\uac00 \uc5b5\uc81c\ub418\uc5b4 \uc885\uc591 \ubc1c\uc0dd\uacfc \uc5f0\uad00\ub41c \ud45c\uc9c0\uc790\uac00 \uac10\uc18c\ud568\uc744 \ud655\uc778\ud588\ub2e4. \uc5f0\uad6c\uc5d0\ub294 \ud55c\uad6d\uc778 NF1 \ud658\uc790 22\uba85\uc758 \uc12c\uc720\uc544\uc138\ud3ec\uac00 \uc0ac\uc6a9\ub410\uace0, \uc804\uccb4 \uc138\ud3ec \uc911 \uc57d 24%\uc5d0\uc11c \uacfc\ud65c\uc131 \uc2e0\ud638 \uac10\uc18c\uac00 \uad00\ucc30\ub410\ub2e4. \uc804\uc0ac\uccb4 \ubd84\uc11d\uc740 \ud608\uc561 \ub0b4 &#8230; <a title=\"\uc2e0\uacbd\uc12c\uc720\uc885 1\ud615 \ud658\uc790\uc5d0\uc11c \ud2b8\ub79c\uc2a4\ub77c\ub098 \uc720\ud6a8\ud560 \uc218\ub3c4 &#8211; \uba54\ub514\uce7c\uc5c5\uc800\ubc84\" class=\"read-more\" href=\"https:\/\/readtrends.com\/ko\/nf1-translarna-korea\/\" aria-label=\"\uc2e0\uacbd\uc12c\uc720\uc885 1\ud615 \ud658\uc790\uc5d0\uc11c \ud2b8\ub79c\uc2a4\ub77c\ub098 \uc720\ud6a8\ud560 \uc218\ub3c4 &#8211; \uba54\ub514\uce7c\uc5c5\uc800\ubc84\uc5d0 \ub300\ud574 \ub354 \uc790\uc138\ud788 \uc54c\uc544\ubcf4\uc138\uc694\">\ub354 \uc77d\uae30<\/a><\/p>\n","protected":false},"author":1,"featured_media":6141,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"rank_math_title":"\uc2e0\uacbd\uc12c\uc720\uc885 1\ud615\uc5d0\uc11c \ud2b8\ub79c\uc2a4\ub77c\ub098 \uc720\ud6a8\uc131 \uc81c\uc2dc \u2014 \uba54\ub514\uce7c\uc5c5\uc800\ubc84","rank_math_description":"\uc11c\uc6b8\uc544\uc0b0\ubcd1\uc6d0 \uc5f0\uad6c\uc9c4\uc774 \ub10c\uc13c\uc2a4 \ub3cc\uc5f0\ubcc0\uc774 NF1 \ud658\uc790 \uc720\ub798 \uc138\ud3ec\uc5d0\uc11c \ud2b8\ub79c\uc2a4\ub77c\ub098\uac00 \ub274\ub85c\ud30c\uc774\ube0c\ub85c\ubbfc \uae30\ub2a5\uc744 \ubd80\ubd84 \ud68c\ubcf5\uc2dc\ud0a4\uace0 \uc885\uc591 \uc2e0\ud638\ub97c \uc5b5\uc81c\ud568\uc744 \ud655\uc778\ud588\ub2e4. \ubc14\uc774\uc624\ub9c8\ucee4 \ud6c4\ubcf4\uc640 \uc784\uc0c1 \uc801\uc6a9 \uacfc\uc81c\ub97c \uc815\ub9ac\ud588\ub2e4.","rank_math_focus_keyword":"\uc2e0\uacbd\uc12c\uc720\uc8851\ud615,NF1,\ud2b8\ub79c\uc2a4\ub77c\ub098,\ub10c\uc13c\uc2a4\ub3cc\uc5f0\ubcc0\uc774,AMPD3","footnotes":""},"categories":[2],"tags":[],"class_list":["post-6150","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-top-stories"],"_links":{"self":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/posts\/6150","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/comments?post=6150"}],"version-history":[{"count":0,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/posts\/6150\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/media\/6141"}],"wp:attachment":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/media?parent=6150"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/categories?post=6150"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/tags?post=6150"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}