{"id":6536,"date":"2026-01-10T11:07:27","date_gmt":"2026-01-10T02:07:27","guid":{"rendered":"https:\/\/readtrends.com\/ko\/warm-autopsy-clonal-expansion\/"},"modified":"2026-01-10T11:07:27","modified_gmt":"2026-01-10T02:07:27","slug":"warm-autopsy-clonal-expansion","status":"publish","type":"post","link":"https:\/\/readtrends.com\/ko\/warm-autopsy-clonal-expansion\/","title":{"rendered":"\ub098\ub294 \uc65c &#8216;\ub530\ub73b\ud55c \ubd80\uac80&#8217;\uc744 \ud574\uc11c \uc138\ud3ec\ub97c \ub5bc\uc5b4\ub0b4\uace0 \ubc30\uc591\ud558\ub098? &#8211; \ud504\ub808\uc2dc\uc548"},"content":{"rendered":"<article>\n<h2>\ud575\uc2ec \uc694\uc57d<\/h2>\n<p>\uc5f0\uc138\ub300\ud559\uad50 \uc758\ub300 \uc624\uc9c0\uc6d0 \uad50\uc218\ud300\uc740 \uc0ac\ub9dd \uc9c1\ud6c4(\ubcf4\ud1b5 6\uc2dc\uac04 \uc774\ub0b4) \uc9c4\ud589\ud558\ub294 \uc774\ub978\ubc14 &#8216;\ub530\ub73b\ud55c \ubd80\uac80(warm autopsy)&#8217;\uc73c\ub85c \uc2e0\uccb4 \uac01\uc9c0\uc5d0\uc11c \uc0b4\uc544 \uc788\ub294 \uc138\ud3ec\ub97c \ub5bc\uc5b4\ub0b4 \ub2e8\uc77c \uc138\ud3ec \ud074\ub860\uc73c\ub85c \ud0a4\uc6cc(Clonal expansion) \uc720\uc804\uccb4\ub97c \uc815\ubc00 \ubd84\uc11d\ud55c\ub2e4. \uc774 \ubc29\ubc95\uc73c\ub85c \uccb4\uc138\ud3ec \ubaa8\uc790\uc774\ud06c(somatic mosaicism)\ub97c \ucd94\uc801\ud574 \ud55c \uc0ac\ub78c\uc758 \uc138\ud3ec\ub4e4\uc774 \uc5b4\ub5a4 \uc870\uc0c1 \uc138\ud3ec\uc5d0\uc11c \uae30\uc6d0\ud588\ub294\uc9c0\ub97c \uc5ed\ucd94\uc801\ud55c\ub2e4. \uc624 \uad50\uc218\ud300\uc740 \ub2e8\uc77c \uc138\ud3ec \ud074\ub860 \ud655\uc7a5\uacfc \ub300\ub7c9 \uc0d8\ud50c\ub9c1\uc5d0\uc11c \uad6d\uc81c\uc801 \uacbd\uc7c1\ub825\uc744 \uac16\ucd94\uc5c8\uc73c\uba70, SMaHT \ud504\ub85c\uc81d\ud2b8\uc640 \ub2e4\uc218 \ub124\uc774\ucc98 \ub17c\ubb38\uc5d0 \uacf5\ub3d9 \uc800\uc790\ub85c \ucc38\uc5ec\ud574 \uad00\ub828 \uc9c0\ub3c4\ub97c \uad6c\ucd95\ud558\uace0 \uc788\ub2e4.<\/p>\n<h2>\ud575\uc2ec \uc0ac\uc2e4<\/h2>\n<ul>\n<li>\ub530\ub73b\ud55c \ubd80\uac80\uc740 \ubcf4\ud1b5 \uc0ac\ub9dd 6\uc2dc\uac04 \uc774\ub0b4\uc5d0 \uc2e4\uc2dc\ud558\uba70, \uc0ac\ub9dd \uc9c1\ud6c4 \uc870\uc9c1\u00b7\uc7a5\uae30\uc5d0\uc11c \uc0b4\uc544 \uc788\ub294 \uc138\ud3ec\ub97c \ucc44\ucde8\ud55c\ub2e4.<\/li>\n<li>\ub2e8\uc77c \uc138\ud3ec\ub97c \ud074\ub860\uc73c\ub85c \ud655\uc7a5\ud574 10\ub9cc~100\ub9cc\uac1c \uaddc\ubaa8\uc758 \ub3d9\uc9c8 \ud074\ub860\uc744 \uc5bb\ub294 \ub370\ub294 \ubcf4\ud1b5 3~6\uac1c\uc6d4\uc774 \uac78\ub9b0\ub2e4.<\/li>\n<li>2021\ub144 \ub124\uc774\ucc98 \ub17c\ubb38\uc5d0\uc11c \uc624\uc9c0\uc6d0 \uad50\uc218\ud300\uc740 7\uba85\uc758 \uae30\uc99d\uc790\uc5d0\uc11c \ucd1d 374\uac1c \ud074\ub860\uc744 \ud655\uc7a5\ud588\uace0, \uc774 \uc911 334\uac1c\ub97c \ucd5c\uc885 \ubd84\uc11d\uc5d0 \uc0ac\uc6a9\ud588\ub2e4.<\/li>\n<li>\ud55c \uc0ac\ub78c \uae30\uc900\uc73c\ub85c\ub294 \uacfc\uac70 \ucd5c\ub300 126\uac1c \ud074\ub860\uc744 \uc5bb\uc5b4\ub0b8 \uc0ac\ub840\uac00 \ubcf4\uace0\ub418\uc5c8\uace0, \ud604\uc7ac\ub294 \uc804\uc2e0 \uc88c\ud45c\ub97c \uc815\ud574 4,000\uacf3\uc5d0\uc11c \uc870\uc9c1\uc744 \ub5bc\uc5b4 \ud6e8\uc52c \ub9ce\uc740 \ud074\ub860\uc744 \ud655\ubcf4\ud558\uace0 \uc788\ub2e4.<\/li>\n<li>SMaHT(Somatic Mosaicism across Human Tissues) \ub124\ud2b8\uc6cc\ud06c\ub294 2023\u20132028\ub144 \ud504\ub85c\uc81d\ud2b8\ub85c, \ucd1d \uc5f0\uad6c\ube44 \uaddc\ubaa8\ub294 \uc57d 1\uc5b54,000\ub9cc \ub2ec\ub7ec(\uc57d 140M USD)\uc774\ub2e4.<\/li>\n<li>\uccb4\uc138\ud3ec \ubaa8\uc790\uc774\ud06c\ub294 \uc218\uc815\ub780 \ubd84\uc5f4\uacfc\uc815\uc758 \ubcf5\uc81c \uc624\ub958 \ubc0f \ud658\uacbd \uc720\ub798 DNA \uc190\uc0c1\uc73c\ub85c \ubc1c\uc0dd\ud558\uba70, \uc774\ub97c \ud1b5\ud574 \ubc1c\uc0dd \ub2e8\uacc4\u00b7\ub178\ud654\u00b7\uc554 \ub4f1 \ub2e4\uc591\ud55c \uc0dd\ubb3c\ud559\uc801 \uc0ac\uac74\uc744 \uc5ed\ucd94\uc801\ud560 \uc218 \uc788\ub2e4.<\/li>\n<li>\uc624 \uad50\uc218\ub294 &#8220;\ud074\ub860 \ud655\uc7a5&#8221;\uc744 \ud1b5\ud55c wet-data \uc0dd\uc0b0 \ub2a5\ub825\uc774 \uc0c1\ub300\uc801\uc73c\ub85c \ub4dc\ubb3c\uc5b4 \uc790\uc2e0\uc758 \uadf8\ub8f9\uc774 \uad6d\uc81c\uc801\uc73c\ub85c \uacbd\uc7c1\ub825 \uc788\ub2e4\uace0 \ud3c9\uac00\ud588\ub2e4.<\/li>\n<\/ul>\n<h2>\uc0ac\uac74 \ubc30\uacbd<\/h2>\n<p>\uc804\ud1b5\uc801\uc73c\ub85c \ud55c \uac1c\uc778\uc758 \ubaa8\ub4e0 \uc138\ud3ec\ub294 \ub3d9\uc77c\ud55c \uc720\uc804\uccb4\ub97c \uac16\ub294\ub2e4\uace0 \uc5ec\uaca8\uc84c\uc73c\ub098, \ucd5c\uadfc \uc5f0\uad6c\ub294 \uccb4\uc138\ud3ec \ubaa8\uc790\uc774\ud06c\uac00 \ubcf4\ud3b8\uc801\uc784\uc744 \ubcf4\uc5ec \uacfc\uac70 \uad50\uacfc\uc11c \uc124\uba85\uc744 \uc218\uc815\ud560 \ud544\uc694\ub97c \uc81c\uae30\ud588\ub2e4. \uc218\uc815\ub780\uc774 \ubd84\uc5f4\ud558\uba74\uc11c \uac01 \ubd84\uc5f4 \uacfc\uc815\uc5d0\uc11c \ubbf8\uc138\ud55c \ub3cc\uc5f0\ubcc0\uc774\uac00 \ucd95\uc801\ub418\uace0, \ud658\uacbd\uc801 DNA \uc190\uc0c1\ub3c4 \ucd94\uac00\ub418\uc5b4 \uc131\uccb4\uc758 \ub2e4\uc591\ud55c \uc138\ud3ec \uc9d1\ub2e8\uc774 \uc11c\ub85c \ub2e4\ub978 \uc720\uc804\uccb4 \uc11c\uba85\uc744 \uac16\uac8c \ub41c\ub2e4. \uc774\ub7f0 \ub3cc\uc5f0\ubcc0\uc774\uc758 \ubd84\ud3ec\uc640 \ubc1c\uc0dd \uc2dc\uc810\uc744 \uc7ac\uad6c\uc131\ud558\uba74 \ubc30\uc544 \ubc1c\uc0dd \ucd08\uae30\uc758 \uacc4\ubcf4(lineage)\ub97c \uac70\uafb8\ub85c \ucd94\uc801\ud560 \uc218 \uc788\ub2e4.<\/p>\n<p>\uc9c1\uc811\uc801\uc778 \ubc30\uc544 \uc870\uc791\uc740 \uc724\ub9ac\uc801\u00b7\uaddc\uc81c\uc801 \uc81c\uc57d\uc774 \uc788\uc5b4 \uc0ac\ub78c \ubc30\uc544 \uc5f0\uad6c\ub294 &#8217;14\uc77c \uaddc\uc815&#8217; \ub4f1\uc73c\ub85c \uc81c\ud55c\ub41c\ub2e4. \ub530\ub77c\uc11c \uc624\uc9c0\uc6d0 \uad50\uc218 \ub4f1 \uc77c\ubd80 \uc5f0\uad6c\uc790\ub294 \uc8fd\uc740 \uc0ac\ub78c\uc758 \uc2e0\uccb4\uc5d0\uc11c \uc2dc\uc791\ud574 \ubc1c\uc0dd \ucd08\uae30\ub85c \uc62c\ub77c\uac00\ub294 &#8216;\ubb34\ub364\uc5d0\uc11c \uc694\ub78c\uc73c\ub85c(grave-to-cradle)&#8217; \ubc29\uc2dd\uc73c\ub85c \uacc4\ubcf4 \ucd94\uc801 \ubb38\uc81c\ub97c \ud480\uace0 \uc788\ub2e4. \uc774 \uc811\uadfc\uc740 \uc0dd\uc950 \ub4f1 \ubaa8\ub378\ub3d9\ubb3c\uc5d0\uc11c\uc758 \uc804\ud615\uc801 \uc2e4\ud5d8 \ubc29\ud5a5\uacfc \uc815\ubc18\ub300\uc774\uba70, \uc778\uac04 \uc5f0\uad6c\uc5d0\uc11c \uc2e4\ud604 \uac00\ub2a5\ud55c \ub300\uc548\uc73c\ub85c \uc8fc\ubaa9\ubc1b\uace0 \uc788\ub2e4.<\/p>\n<h2>\uc8fc\uc694 \uc0ac\uac74<\/h2>\n<p>\uc624 \uad50\uc218\ud300\uc758 \ud575\uc2ec \uc5ed\ub7c9\uc740 \ud604\uc7a5\uc5d0\uc11c \uc2e0\uc18d\ud788 \uc870\uc9c1\uc744 \ucc44\ucde8\ud574 \ub2e8\uc77c \uc138\ud3ec\ub97c \ubd84\ub9ac\ud55c \ub4a4 \uc624\uac00\ub178\uc774\ub4dc\ub098 \ud50c\ub808\uc774\ud2b8 \ubc30\uc591\uc744 \ud1b5\ud574 \uac01 \uc138\ud3ec\ub97c \ud074\ub860 \uc9d1\ub2e8\uc73c\ub85c \ud655\uc7a5\ud558\ub294 \uae30\uc220\uc774\ub2e4. \uc870\uc9c1 \ucc44\ucde8 \ud6c4 \uc190\ud1b1 \ud06c\uae30\uc758 \uc2dc\ub8cc\ub97c \ubc30\uc591\ud574 \ud604\ubbf8\uacbd\uc73c\ub85c \ub2e8\uc77c \uc138\ud3ec\ub97c \ud655\uc778\ud55c \ub4a4 \uac01\uac01\uc744 \uc6f0\uc5d0 \ubd84\uc8fc\ud558\uc5ec \uc99d\uc2dd\uc2dc\ud0a4\uba74, \uc131\uacf5\ud55c \ud074\ub860\uc740 \uc218\ub9cc\uc5d0\uc11c \uc218\uc2ed\ub9cc \uac1c \uaddc\ubaa8\ub85c \uc790\ub780\ub2e4. \uc774 \uacfc\uc815\uc758 \uc131\uacf5\ub960\uc744 \uace0\ub824\ud558\uba74 100\uac1c\uc758 \ub2e8\uc77c \uc138\ud3ec \ud074\ub860\uc744 \uc5bb\uc73c\ub824\uba74 \uc218\ubc31\uc5d0\uc11c \ucc9c \uacf3\uc758 \uc2dc\ub8cc\uac00 \ud544\uc694\ud558\ub2e4.<\/p>\n<p>\uc624 \uad50\uc218\ub294 2016\ub144\ubd80\ud130 \ud574\ub2f9 \uc5f0\uad6c\ub97c \ubcf8\uaca9\ud654\ud588\uace0, 2021\ub144 \ub124\uc774\ucc98\uc5d0 \uacf5\ub3d9 \uad50\uc2e0\uc800\uc790\ub85c \ubcf4\uace0\ud55c \ub17c\ubb38\uc740 \ud3ec\uc2a4\ud2b8\ubaa8\ud15c \uc2dc\ub8cc\ub85c \uc778\uac04 \uc138\ud3ec\uc758 \uacc4\ubcf4\ub97c \ucd94\uc801\ud560 \uc218 \uc788\uc74c\uc744 \ubcf4\uc5ec\uc8fc\ub294 \uc911\uc694\ud55c \uc804\ud658\uc810\uc774\uc5c8\ub2e4. \uc774\ud6c4 \uad6d\uc81c \ub124\ud2b8\uc6cc\ud06c\uac00 \ud655\uc7a5\ub418\uba70 \uc601\uad6d \uc6f0\ucef4 \ud2b8\ub7ec\uc2a4\ud2b8 \uc0dd\uc5b4\uc5f0\uad6c\uc18c, \ubbf8\uad6d\uc758 \uc608\uc77c\u00b7\uba54\uc774\uc694 \ud074\ub9ac\ub2c9 \uadf8\ub8f9 \ub4f1\uacfc \ud611\ub825\u00b7\ubd84\uc5c5 \uad6c\uc870\uac00 \ubc1c\uc804\ud588\ub2e4. \ucd5c\uadfc\uc5d0\ub294 SMaHT \ub124\ud2b8\uc6cc\ud06c\uc758 \ub9c8\ucee4 \ud398\uc774\ud37c\uc640 \uae00\ub85c\ubc8c \ud611\uc5c5\uc744 \ud1b5\ud574 \ud45c\uc900\ud654\ub41c \uc811\uadfc\uacfc \ub300\uaddc\ubaa8 \ub370\uc774\ud130 \ucd95\uc801\uc774 \uc9c4\ud589 \uc911\uc774\ub2e4.<\/p>\n<p>\ud604\uc7a5\uc5d0\uc11c\ub294 \uc751\uae09 \uc2dc\uc2e0 \uc774\uc1a1, \ud574\ubd80\uc2e4 \ud655\ubcf4, \ubd84\uc790\uc0dd\ubb3c\ud559\uc801 \uc2dc\ub8cc \ubcf4\uc874\u00b7\ucc98\ub9ac \ub2a5\ub825 \ub4f1\uc774 \ubaa8\ub450 \uac16\ucdb0\uc838\uc57c \ud55c\ub2e4. \uc624 \uad50\uc218\ub294 \ud574\ubd80\ud559\uacfc \ubd84\uc790\uc0dd\ubb3c\ud559\uc744 \ubaa8\ub450 \uc218\ud589\ud560 \uc218 \uc788\ub294 \ub4dc\ubb38 \uc778\ub825\uc73c\ub85c, \uc774 \uc735\ud569\ud615 \ub2a5\ub825\uc774 \ud604\uc7a5 \uc131\uacf5\uc758 \uc5f4\uc1e0\ub77c\uace0 \uc124\uba85\ud55c\ub2e4.<\/p>\n<h2>\ubd84\uc11d \ubc0f \uc758\ubbf8<\/h2>\n<p>\uc774 \uc5f0\uad6c\ub294 \uc138\ud3ec \uacc4\ubcf4 \uc815\ubcf4\uac00 \ub2e8\uc21c\ud55c \ubc1c\uc0dd\ud559 \uc9c8\ubb38\uc744 \ub118\uc5b4 \uc5ec\ub7ec \ubd84\uc57c\uc5d0 \ud30c\uae09\ub420 \uac00\ub2a5\uc131\uc774 \ud06c\ub2e4. \uccab\uc9f8, \ubc1c\uc0dd\ud559\uc801 \uad00\uc810\uc5d0\uc11c \uc218\uc815\ub780 \ucd08\uae30 \ubd84\uc5f4\uc774 \uc131\uccb4\uc5d0\uc11c \uad00\ucc30\ub418\ub294 \uc870\uc9c1 \ubd84\ud3ec\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5\uc744 \uc815\ub7c9\uc801\uc73c\ub85c \ubc1d\ud798\uc73c\ub85c\uc368 \ubc30\uc544 \ubc1c\ub2ec\uc758 \ud575\uc2ec \uc2dc\uc810\uc744 \uc7ac\uc815\uc758\ud560 \uc218 \uc788\ub2e4. \uc608\ucee8\ub300 A\u00b7B \ub450 \uc138\ud3ec\uc758 \uae30\uc5ec \ube44\ub300\uce6d\uc131(\ud3c9\uade0 \uc57d 66:33\uc774\ub77c\ub294 \uad00\uce21)\uc740 \uac1c\uccb4 \uac04 \ubcc0\uc774\ub97c \uc2dc\uc0ac\ud558\uba70, \ud2b9\uc815 \uc870\uc9c1\ub4e4\uc774 \uc5b4\ub290 \uc2dc\uc810\uc758 \ubd84\uc5f4\uc5d0\uc11c \uae30\uc6d0\ud558\ub294\uc9c0\uc5d0 \ub300\ud55c \ud1b5\ucc30\uc744 \uc900\ub2e4.<\/p>\n<p>\ub458\uc9f8, \uc9c8\ubcd1 \uc5f0\uad6c\uc5d0\uc11c \uccb4\uc138\ud3ec \ub3cc\uc5f0\ubcc0\uc774\uc758 \uacf5\uac04\uc801 \ubd84\ud3ec\uc640 \ubc1c\uc0dd \uc2dc\uae30\ub97c \uc54c\uba74 \uc554 \ubc1c\uc0dd\uc758 \ucd08\uae30 \ub2e8\uacc4\ub098 \uc778\uac04 \ub178\ud654\uc758 \ubd84\uc790\uc801 \uada4\uc801\uc744 \ub354 \uc815\ubc00\ud558\uac8c \ucd94\uc801\ud560 \uc218 \uc788\ub2e4. \ub2e8\uc77c \uc138\ud3ec \ud074\ub860\uc744 \ud1b5\ud55c \uace0\ud574\uc0c1\ub3c4 \uc11c\uc5f4 \ub370\uc774\ud130\ub294 \ub4dc\ubb38 \ub3cc\uc5f0\ubcc0\uc774 \uc2e0\ud638\ub97c \uc7a1\uc544\ub0b4\ub294 \ub370 \uc720\ub9ac\ud558\ub2e4. \uc14b\uc9f8, \ub300\uaddc\ubaa8 \ud45c\ubcf8\u00b7\uc88c\ud45c \uae30\ubc18\uc758 \uc9c0\ub3c4(Atlas)\uac00 \ub9c8\ub828\ub418\uba74 \uc784\uc0c1\u00b7\uc5ed\ud559 \uc5f0\uad6c\uc640\uc758 \uc5f0\uacc4\uac00 \uc26c\uc6cc\uc838 \uc9c8\ubcd1 \uc5f0\uad00 \ub3cc\uc5f0\ubcc0\uc774\uc758 \uc9c0\uc5ed\uc801 \ud2b9\uc131(\uc608: \ud2b9\uc815 \uc870\uc9c1\uc5d0\uc11c\uc758 \ucde8\uc57d\uc131)\ub3c4 \uaddc\uba85\ub420 \uc218 \uc788\ub2e4.<\/p>\n<p>\ub2e4\ub9cc \uae30\uc220\u00b7\uc724\ub9ac\uc801 \ub09c\uc81c\ub3c4 \ub0a8\uc544 \uc788\ub2e4. \uae30\uc220\uc801\uc73c\ub85c\ub294 \ud074\ub860 \ud655\uc7a5 \uc131\uacf5\ub960, \uc7a5\uae30\uac04 \ubc30\uc591\uc73c\ub85c \uc778\ud55c \uc778\uacf5\uc801 \ubcc0\uc774, \ud45c\ubcf8 \ub300\ud45c\uc131(\uae30\uc99d\uc790 \uc218\u00b7\uc5f0\ub839\u00b7\ud658\uacbd \ub2e4\uc591\uc131) \ubb38\uc81c\uac00 \uc788\uace0, \uc724\ub9ac\uc801\uc73c\ub85c\ub294 \ud3ec\uc2a4\ud2b8\ubaa8\ud15c \uc2dc\ub8cc \uc774\uc6a9\uc758 \ub3d9\uc758 \uccb4\uacc4\uc640 \ubbfc\uac10\ud55c \uc720\uc804\uccb4 \uc815\ubcf4\uc758 \uad00\ub9ac\uac00 \uc911\uc694\ud558\ub2e4. \uc815\ucc45\u00b7\uc724\ub9ac \uac00\uc774\ub4dc\ub77c\uc778\uacfc \ud22c\uba85\ud55c \uacf5\uac1c\u00b7\ub370\uc774\ud130 \uac70\ubc84\ub10c\uc2a4\uac00 \ubcd1\ud589\ub418\uc5b4\uc57c \ud55c\ub2e4.<\/p>\n<h2>\ube44\uad50 \ubc0f \ub370\uc774\ud130<\/h2>\n<figure>\n<table>\n<thead>\n<tr>\n<th>\uc5f0\ub3c4\/\uc5f0\uad6c<\/th>\n<th>\uc8fc\uc694 \uc131\uacfc<\/th>\n<th>\uc0d8\ud50c\u00b7\ud074\ub860 \uc218<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>2014 (Stratton \ub4f1, \ub9c8\uc6b0\uc2a4)<\/td>\n<td>\ub9c8\uc6b0\uc2a4\uc5d0\uc11c \uc804\uc7a5\uc720\uc804\uccb4 \uae30\ubc18 \uacc4\ubcf4 \ucd94\uc801 \uac1c\ub150 \uc81c\uc2dc<\/td>\n<td>\ubaa8\ub378\ub3d9\ubb3c \uae30\ubc18<\/td>\n<\/tr>\n<tr>\n<td>2021 (\uc624\uc9c0\uc6d0 \ub4f1, Nature)<\/td>\n<td>\ud3ec\uc2a4\ud2b8\ubaa8\ud15c \uc778\uac04 \uc2dc\ub8cc\ub85c \uacc4\ubcf4 \ucd94\uc801 \uc2e4\uc99d<\/td>\n<td>7\uba85 \uae30\uc99d\uc790, \ucd1d 374\uac1c \ud074\ub860(\ubd84\uc11d 334\uac1c); \ucd5c\ub300 1\uc778\ub2f9 126\uac1c<\/td>\n<\/tr>\n<tr>\n<td>\ud604\uc7ac (SMaHT \ub4f1)<\/td>\n<td>\uc804\uc2e0 \uc88c\ud45c \uae30\ubc18 \ub300\uaddc\ubaa8 \uc0d8\ud50c\ub9c1\u00b7\ud45c\uc900\uc9c0\ub3c4 \uad6c\ucd95<\/td>\n<td>\uc88c\ud45c 4,000\uacf3 \ubaa9\ud45c, \uc218\ubc31~\uc218\ucc9c \ud074\ub860 \ud655\ubcf4 \uc9c4\ud589<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n<p>\uc704 \ud45c\ub294 \uc8fc\uc694 \uc774\uc815\ud45c\ub97c \ube44\uad50\ud574 \ubcf4\uc5ec\uc900\ub2e4. \ub9c8\uc6b0\uc2a4 \uc2e4\ud5d8\uc5d0\uc11c \ucd9c\ubc1c\ud55c \uac1c\ub150\uc774 \ud3ec\uc2a4\ud2b8\ubaa8\ud15c \uc778\uccb4 \uc5f0\uad6c\ub85c \ub118\uc5b4\uc624\uba70 wet lab \uae30\ubc18\uc758 \ud074\ub860 \ud655\uc7a5 \uae30\uc220\uacfc \uc804\uc0b0\ubd84\uc11d\uc774 \uacb0\ud569\ub418\uc5b4 \ud655\uc7a5\ub418\uc5c8\ub2e4. \ud604\uc7ac \uc5f0\uad6c\ub294 \ud45c\ubcf8 \uc218\ub97c \ud06c\uac8c \ub298\ub824 \ud1b5\uacc4\uc801 \uc2e0\ub8b0\ub3c4\ub97c \ub192\uc774\ub294 \ub2e8\uacc4\uc5d0 \uc788\ub2e4.<\/p>\n<h2>\ubc18\uc751 \ubc0f \uc778\uc6a9<\/h2>\n<p>\uc624 \uad50\uc218\uc758 \ub9d0\uacfc \ud504\ub85c\uc81d\ud2b8 \uc18c\uac1c\ub294 \uc5f0\uad6c\uc758 \ubaa9\ud45c\uc640 \ubc29\ubc95\ub860\uc744 \uc774\ud574\ud558\ub294 \ub370 \ud575\uc2ec\uc801\uc774\ub2e4. \ub2e4\uc74c \uc778\uc6a9\uad6c\ub4e4\uc740 \ubc1c\uc5b8\uc758 \ub9e5\ub77d\uc744 \uc694\uc57d\ud55c\ub2e4.<\/p>\n<blockquote>\n<p>&#8220;\uc774 &#8216;\ud074\ub860 \ud655\uc7a5&#8217;\uc744 \uc6b0\ub9ac \ud300\uc774 \uc798\ud55c\ub2e4. \uc544\uc8fc \uc798 \ud55c\ub2e4. \uc138\uacc4\uc5d0\uc11c \uc81c\uc77c \uacbd\uc7c1\ub825 \uc788\ub294 \uac83 \uac19\ub2e4.&#8221;<\/p>\n<p><cite>\uc624\uc9c0\uc6d0 \uc5f0\uc138\ub300 \uc758\ub300 \uad50\uc218(\uc778\ud130\ubdf0 \ubc1c\uc5b8)<\/cite><\/p><\/blockquote>\n<p>\uc774 \ubc1c\uc5b8\uc740 \uc624 \uad50\uc218 \uc2a4\uc2a4\ub85c\uc758 \uae30\uc220\uc801 \uc790\uc2e0\uac10\uc744 \ub4dc\ub7ec\ub0b8 \uac83\uc73c\ub85c, \ud074\ub860 \ud655\uc7a5 \ub2a5\ub825\uc774 \ud300\uc758 \ud575\uc2ec \uacbd\uc7c1\ub825\uc784\uc744 \uac15\uc870\ud55c\ub2e4. \ub2e4\ub9cc \uc774\ub294 \uc5f0\uad6c\uc790\uc758 \ud3c9\uac00\uc774\ubbc0\ub85c \ub3c5\ub9bd\uc801 \uac80\uc99d\uc774 \ud544\uc694\ud558\ub2e4.<\/p>\n<blockquote>\n<p>&#8220;SMaHT\ub294 \uac74\uac15\ud55c \uc0ac\ub78c \ubab8\uc758 \uccb4\uc138\ud3ec \ubaa8\uc790\uc774\ud06c \ud604\uc0c1\uc744 \ubcf4\uc5ec\uc8fc\ub294 \ud45c\uc900\uc801\uc774\uace0 \uc885\ud569\uc801\uc778 \uc9c0\ub3c4\ub97c \ub9cc\ub4dc\ub294 \uac83\uc774 \ubaa9\ud45c\ub2e4.&#8221;<\/p>\n<p><cite>SMaHT \ub124\ud2b8\uc6cc\ud06c(\ud504\ub85c\uc81d\ud2b8 \uc18c\uac1c)<\/cite><\/p><\/blockquote>\n<p>\ub124\ud2b8\uc6cc\ud06c\uc758 \uacf5\uc2dd \ubaa9\ud45c \uc9c4\uc220\uc740 \ub370\uc774\ud130 \uacf5\uc720\u00b7\ud45c\uc900\ud654\uc640 \ub300\uaddc\ubaa8 \ud611\uc5c5\uc758 \ud544\uc694\uc131\uc744 \ubd84\uba85\ud788 \ud55c\ub2e4. \ub9c8\ucee4 \ud398\uc774\ud37c \ucd9c\ud310\uc740 \uc774\ub7f0 \ud611\uc5c5\uc758 \ucd9c\uc0ac\ud45c \uc5ed\ud560\uc744 \ud55c\ub2e4.<\/p>\n<blockquote>\n<p>&#8220;\ud55c \uac1c \uc138\ud3ec\ub97c 10\ub9cc \uac1c\uc5d0\uc11c 100\ub9cc \uac1c \ud074\ub860\ub4e4\ub85c \ud0a4\uc6b4\ub2e4. \ud074\ub860\uc744 \ub9cc\ub4dc\ub294 \ub370\ub294 3~6\uac1c\uc6d4 \uac78\ub9b0\ub2e4.&#8221;<\/p>\n<p><cite>\uc624\uc9c0\uc6d0 \uc5f0\uc138\ub300 \uc758\ub300 \uad50\uc218(\uc5f0\uad6c \uc124\uba85)<\/cite><\/p><\/blockquote>\n<p>\uc774 \uae30\uc220\uc801 \uc124\uba85\uc740 \uc2e4\ud5d8\uc758 \uc2dc\uac04\u00b7\uc790\uc6d0 \uc18c\ubaa8\uc640 \ubc30\uc591\uc758 \uaddc\ubaa8\ub97c \ub2e8\uc801\uc73c\ub85c \ubcf4\uc5ec\uc900\ub2e4. \ud074\ub860\uc758 \uc218\uac00 \ub9ce\uc740 \uc774\uc720\ub294 \ub4dc\ubb38 \ub3cc\uc5f0\ubcc0\uc774 \uc2e0\ud638\ub97c \ud1b5\uacc4\uc801\uc73c\ub85c \uac80\ucd9c\ud558\uae30 \uc704\ud568\uc774\ub2e4.<\/p>\n<aside>\n<details>\n<summary>\uc6a9\uc5b4\/\ubc29\ubc95\ub860<\/summary>\n<p>\ub530\ub73b\ud55c \ubd80\uac80(warm autopsy)\uc740 \uc0ac\ub9dd \uc9c1\ud6c4 \uc0b4\uc544 \uc788\ub294 \uc138\ud3ec\ub97c \ud655\ubcf4\ud558\uae30 \uc704\ud574 \uc2e0\uc18d\ud788 \uc2dc\ud589\ud558\ub294 \ud3ec\uc2a4\ud2b8\ubaa8\ud15c \ud574\ubd80 \uc808\ucc28\ub2e4. \ub2e8\uc77c \uc138\ud3ec \ud074\ub860 \ud655\uc7a5(single-cell clonal expansion)\uc740 \uac01 \ub2e8\uc77c \uc138\ud3ec\ub97c \ubc30\uc591\ud574 \ub3d9\uc9c8\uc758 \ub2e4\uc218 \uc138\ud3ec \uc9d1\ub2e8\uc744 \ub9cc\ub4dc\ub294 \uacfc\uc815\uc73c\ub85c, \uc774\ub807\uac8c \uc5bb\uc740 \ub300\ub7c9\uc758 DNA\ub97c \uc774\uc6a9\ud574 \uc5fc\uae30\uc11c\uc5f4\uc744 \uae4a\uc774(read depth) \uc788\uac8c \ubd84\uc11d\ud558\uba74 \ub4dc\ubb38 \uccb4\uc138\ud3ec \ub3cc\uc5f0\ubcc0\uc774\ub97c \uac80\ucd9c\ud560 \uc218 \uc788\ub2e4. \uccb4\uc138\ud3ec \ubaa8\uc790\uc774\ud06c(somatic mosaicism)\ub294 \ud55c \uac1c\uc778 \ub0b4\uc5d0\uc11c \uc138\ud3ec\ub4e4 \uac04\uc5d0 \uc720\uc804\uccb4 \ucc28\uc774\uac00 \uc874\uc7ac\ud558\ub294 \ud604\uc0c1\uc774\ub2e4. \uacc4\ubcf4 \ucd94\uc801(lineage tracing)\uc740 \uc774\ub7f0 \ub3cc\uc5f0\ubcc0\uc774 \ud328\ud134\uc744 \ube44\uad50\ud574 \uc138\ud3ec\uc758 \uc870\uc0c1-\ud6c4\uc190 \uad00\uacc4\ub97c \uc5ed\ucd94\uc801\ud558\ub294 \ubc29\ubc95\ub860\uc774\ub2e4.<\/p>\n<\/details>\n<\/aside>\n<h2>\ubd88\ud655\uc2e4\ud55c \ubd80\ubd84<\/h2>\n<ul>\n<li>\uc624 \uad50\uc218\uc758 &#8220;\uc138\uacc4\uc5d0\uc11c \uc81c\uc77c \uacbd\uc7c1\ub825&#8221;\uc774\ub77c\ub294 \ud3c9\uac00\ub294 \uc5f0\uad6c\uc790\uc758 \uc8fc\uad00\uc801 \ud310\ub2e8\uc73c\ub85c, \ub3c5\ub9bd\uc801 \ube44\uad50\u00b7\uc815\ub7c9\uc801 \uadfc\uac70\ub294 \ucd94\uac00 \ud655\uc778\uc774 \ud544\uc694\ud558\ub2e4.<\/li>\n<li>\ubc30\uc544 \ubc1c\uc0dd\uc758 \uc815\ud655\ud55c \uc2dc\uc810(\uc608: \uc624\ub978\ucabd-\uc67c\ucabd \uacb0\uc815 \uc2dc\uae30, \ud0dc\ubc18\u00b7\ud0dc\uc544 \ubd84\ud654 \uc2dc\uc810)\uc5d0 \ub300\ud55c \uacb0\ub860\uc740 \ud45c\ubcf8 \uc218 \uc99d\uac00\uc5d0 \ub530\ub77c \uc218\uc815\ub418\uace0 \uc788\uc5b4 \uc644\uc804 \ud655\uc815\ub418\uc9c0\ub294 \uc54a\uc558\ub2e4.<\/li>\n<li>\ub300\uaddc\ubaa8 \uc88c\ud45c \uae30\ubc18 \uc0d8\ud50c\ub9c1(4,000\uacf3)\uc5d0\uc11c \uad00\ucc30\ub418\ub294 \uacb0\uacfc\uc758 \ub300\ud45c\uc131\uc740 \uae30\uc99d\uc790\uc758 \uc5f0\ub839\u00b7\ud658\uacbd\u00b7\uc720\uc804\uc801 \ubc30\uacbd\uc5d0 \ub530\ub77c \ub2ec\ub77c\uc9c8 \uc218 \uc788\ub2e4.<\/li>\n<\/ul>\n<h2>\ucd1d\ud3c9<\/h2>\n<p>\uc624\uc9c0\uc6d0 \uad50\uc218\ud300\uc758 &#8216;\ubb34\ub364\uc5d0\uc11c \uc694\ub78c\uc73c\ub85c&#8217; \uc811\uadfc\uc740 \uc778\uac04 \ubc1c\uc0dd\ud559\uacfc \uc9c8\ubcd1 \uc5f0\uad6c\uc5d0 \uc0c8\ub85c\uc6b4 \uae38\uc744 \uc5f4\uace0 \uc788\ub2e4. \ub2e8\uc77c \uc138\ud3ec \ud074\ub860 \ud655\uc7a5\uc774\ub77c\ub294 \uace0\ub09c\ub3c4 wet-lab \uae30\uc220\uacfc \uc804\uc0b0\ubd84\uc11d\uc758 \uacb0\ud569\uc740 \uccb4\uc138\ud3ec \ubaa8\uc790\uc774\ud06c\uc758 \uc9c0\ub3c4\ub97c \uc815\ubc00\ud654\ud574 \ubc1c\uc0dd \ub2e8\uacc4\u00b7\uc870\uc9c1\ubcc4 \uae30\uc6d0\uc5d0 \uad00\ud55c \uae30\uc874 \ub17c\uc758\ub97c \uc7ac\uad6c\uc131\ud560 \uc7a0\uc7ac\ub825\uc774 \uc788\ub2e4.<\/p>\n<p>\ud5a5\ud6c4 \uad00\uac74\uc740 \ud45c\ubcf8 \ub2e4\uc591\uc131 \ud655\ubcf4, \ubc30\uc591\u00b7\uc2dc\ud000\uc2f1 \uacfc\uc815\uc5d0\uc11c\uc758 \uc778\uacf5 \ubcc0\uc774 \ud1b5\uc81c, \uadf8\ub9ac\uace0 \ub370\uc774\ud130\uc758 \ud22c\uba85\ud55c \uacf5\uc720\uc640 \uc724\ub9ac\uc801 \uac70\ubc84\ub10c\uc2a4\uc774\ub2e4. SMaHT\uc640 \uac19\uc740 \ub300\uaddc\ubaa8 \ud611\uc5c5\uc774 \uc131\uacf5\uc801\uc73c\ub85c \uc9c4\ud589\ub41c\ub2e4\uba74, \uad50\uacfc\uc11c\uc801 \uac1c\ub150\uc758 \ubcc0\ud654\uc640 \uc784\uc0c1\uc801 \uc751\uc6a9(\uc554\u00b7\ub178\ud654\u00b7\uc720\uc804\ubcd1 \uc5f0\uad6c)\uc73c\ub85c \uc774\uc5b4\uc9c8 \uac00\ub2a5\uc131\uc774 \ud06c\ub2e4.<\/p>\n<h2>\ucd9c\ucc98<\/h2>\n<ul>\n<li><a href=\"http:\/\/www.pressian.com\/pages\/articles\/2026010912001962488\" target=\"_blank\" rel=\"noopener\">\ud504\ub808\uc2dc\uc548 (\uc5b8\ub860) \u2014 \uc6d0\ubb38 \uae30\uc0ac<\/a><\/li>\n<li><a href=\"https:\/\/www.nature.com\/articles\/nature13672\" target=\"_blank\" rel=\"noopener\">Nature 2014, Michael R. Stratton \ub4f1 (\ud559\uc220\u00b7\uc5f0\uad6c) \u2014 \ub9c8\uc6b0\uc2a4 \ubaa8\ub378\uc744 \ud1b5\ud55c \uacc4\ubcf4 \ucd94\uc801 \uac1c\ub150<\/a><\/li>\n<li><a href=\"https:\/\/doi.org\/10.1038\/s12276-023-01000-0\" target=\"_blank\" rel=\"noopener\">Experimental &amp; Molecular Medicine 2023 (\ud559\uc220) \u2014 Grave-to-cradle \uac1c\ub150\ub3c4 \ubc0f \ubc29\ubc95\ub860 \uc124\uba85<\/a><\/li>\n<\/ul>\n<\/article>\n","protected":false},"excerpt":{"rendered":"<p>\ud575\uc2ec \uc694\uc57d \uc5f0\uc138\ub300\ud559\uad50 \uc758\ub300 \uc624\uc9c0\uc6d0 \uad50\uc218\ud300\uc740 \uc0ac\ub9dd \uc9c1\ud6c4(\ubcf4\ud1b5 6\uc2dc\uac04 \uc774\ub0b4) \uc9c4\ud589\ud558\ub294 \uc774\ub978\ubc14 &#8216;\ub530\ub73b\ud55c \ubd80\uac80(warm autopsy)&#8217;\uc73c\ub85c \uc2e0\uccb4 \uac01\uc9c0\uc5d0\uc11c \uc0b4\uc544 \uc788\ub294 \uc138\ud3ec\ub97c \ub5bc\uc5b4\ub0b4 \ub2e8\uc77c \uc138\ud3ec \ud074\ub860\uc73c\ub85c \ud0a4\uc6cc(Clonal expansion) \uc720\uc804\uccb4\ub97c \uc815\ubc00 \ubd84\uc11d\ud55c\ub2e4. \uc774 \ubc29\ubc95\uc73c\ub85c \uccb4\uc138\ud3ec \ubaa8\uc790\uc774\ud06c(somatic mosaicism)\ub97c \ucd94\uc801\ud574 \ud55c \uc0ac\ub78c\uc758 \uc138\ud3ec\ub4e4\uc774 \uc5b4\ub5a4 \uc870\uc0c1 \uc138\ud3ec\uc5d0\uc11c \uae30\uc6d0\ud588\ub294\uc9c0\ub97c \uc5ed\ucd94\uc801\ud55c\ub2e4. \uc624 \uad50\uc218\ud300\uc740 \ub2e8\uc77c \uc138\ud3ec \ud074\ub860 \ud655\uc7a5\uacfc \ub300\ub7c9 \uc0d8\ud50c\ub9c1\uc5d0\uc11c \uad6d\uc81c\uc801 \uacbd\uc7c1\ub825\uc744 \uac16\ucd94\uc5c8\uc73c\uba70, SMaHT &#8230; <a title=\"\ub098\ub294 \uc65c &#8216;\ub530\ub73b\ud55c \ubd80\uac80&#8217;\uc744 \ud574\uc11c \uc138\ud3ec\ub97c \ub5bc\uc5b4\ub0b4\uace0 \ubc30\uc591\ud558\ub098? &#8211; \ud504\ub808\uc2dc\uc548\" class=\"read-more\" href=\"https:\/\/readtrends.com\/ko\/warm-autopsy-clonal-expansion\/\" aria-label=\"\ub098\ub294 \uc65c &#8216;\ub530\ub73b\ud55c \ubd80\uac80&#8217;\uc744 \ud574\uc11c \uc138\ud3ec\ub97c \ub5bc\uc5b4\ub0b4\uace0 \ubc30\uc591\ud558\ub098? &#8211; \ud504\ub808\uc2dc\uc548\uc5d0 \ub300\ud574 \ub354 \uc790\uc138\ud788 \uc54c\uc544\ubcf4\uc138\uc694\">\ub354 \uc77d\uae30<\/a><\/p>\n","protected":false},"author":1,"featured_media":6530,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"rank_math_title":"\ub098\ub294 \uc65c '\ub530\ub73b\ud55c \ubd80\uac80'\uc73c\ub85c \uc138\ud3ec\ub97c \ubc30\uc591\ud558\ub098? | \ud504\ub808\uc2dc\uc548","rank_math_description":"\uc624\uc9c0\uc6d0 \uc5f0\uc138\ub300 \uad50\uc218\ud300\uc774 \uc0ac\ub9dd \uc9c1\ud6c4 '\ub530\ub73b\ud55c \ubd80\uac80'\uc73c\ub85c \ub2e8\uc77c \uc138\ud3ec\ub97c \ud074\ub860 \ud655\uc7a5\ud574 \uccb4\uc138\ud3ec \ubaa8\uc790\uc774\ud06c\ub97c \uc5ed\ucd94\uc801\ud558\ub294 \uc774\uc720\uc640 \uae30\uc220\u00b7\uc724\ub9ac\uc801 \uc758\ubbf8\ub97c \uc815\ub9ac\ud569\ub2c8\ub2e4.","rank_math_focus_keyword":"\ub530\ub73b\ud55c \ubd80\uac80, \ud074\ub860 \ud655\uc7a5, \uccb4\uc138\ud3ec \ubaa8\uc790\uc774\ud06c, \uc624\uc9c0\uc6d0, SMaHT","footnotes":""},"categories":[2],"tags":[],"class_list":["post-6536","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-top-stories"],"_links":{"self":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/posts\/6536","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/comments?post=6536"}],"version-history":[{"count":0,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/posts\/6536\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/media\/6530"}],"wp:attachment":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/media?parent=6536"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/categories?post=6536"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/tags?post=6536"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}