{"id":6884,"date":"2026-01-19T08:06:42","date_gmt":"2026-01-18T23:06:42","guid":{"rendered":"https:\/\/readtrends.com\/ko\/manganese-metallo-immunotherapy\/"},"modified":"2026-01-19T08:06:42","modified_gmt":"2026-01-18T23:06:42","slug":"manganese-metallo-immunotherapy","status":"publish","type":"post","link":"https:\/\/readtrends.com\/ko\/manganese-metallo-immunotherapy\/","title":{"rendered":"\uc804\ub0a8\ub300, \u201c\uba74\uc5ed\ud56d\uc554 \ud55c\uacc4 \ub118\uc740 \uae08\uc18d-\uba74\uc5ed\uce58\ub8cc\u201d \uae30\uc220 \uac1c\ubc1c"},"content":{"rendered":"<article>\n<h2>\ud575\uc2ec \uc694\uc57d<\/h2>\n<p>\uc804\ub0a8\ub300\ud559\uad50 \uc57d\ud559\ub300\ud559 \ub0a8\uc8fc\ud0dd \uad50\uc218\ud300\uc774 \ub9dd\uac04 \uc774\uc628(Mn2+)\uacfc \ud658\ud615\uc774\ubd84\uc790\ud575\uc0b0(CDN)\uc744 \ubc30\uc704\uacb0\ud569\ud55c \ubcf5\ud569\uccb4\ub97c \ub2e4\uacf5\uc131 \uc0dd\ubd84\ud574\uc131 \uc2e4\ub9ac\uce74 \ub098\ub178\uc785\uc790\uc5d0 \ud0d1\uc7ac\ud558\ub294 \uae08\uc18d-\uba74\uc5ed\uce58\ub8cc(metallo-immunotherapy) \uc81c\ud615\uae30\uc220\uc744 \uac1c\ubc1c\ud588\ub2e4. \uc5f0\uad6c\uc9c4\uc740 \uc774 \uae30\uc220\uc774 CDN \ub2e8\ub3c5 \uccb4\uacc4\uc758 \ubd84\ud574\u00b7\ubc30\ucd9c\uacfc \uc138\ud3ec \ud22c\uacfc\uc728 \ud55c\uacc4\ub97c \uadf9\ubcf5\ud574 \uc885\uc591 \ub0b4\uc5d0\uc11c STING \uacbd\ub85c\ub97c \uac15\ud558\uac8c \ud65c\uc131\ud654\ud558\uace0 in situ \ud56d\uc554\ubc31\uc2e0 \ud6a8\uacfc\ub97c \uc720\ub3c4\ud55c\ub2e4\uace0 \ubcf4\uace0\ud588\ub2e4. \ud751\uc0c9\uc885(\uba5c\ub77c\ub178\ub9c8) \ub3d9\ubb3c\ubaa8\ub378\uc5d0\uc11c \uad6d\uc18c \uc885\uc591 \uc81c\uc5b4\uc640 \ud3d0 \uc804\uc774 \uce58\ub8cc, \uc7ac\ubc1c \uc5b5\uc81c \ud6a8\uacfc\uac00 \ud655\uc778\ub410\uace0, aPD-1 \uba74\uc5ed\uad00\ubb38\uc5b5\uc81c\uc81c\uc640 \ubcd1\uc6a9 \uc2dc \uc2dc\ub108\uc9c0\ub3c4 \uad00\ucc30\ub410\ub2e4. \uc5f0\uad6c \uacb0\uacfc\ub294 Journal of Controlled Release\uc5d0 \uac8c\uc7ac\ub410\ub2e4.<\/p>\n<h2>\ud575\uc2ec \uc0ac\uc2e4<\/h2>\n<ul>\n<li>\uc5f0\uad6c \uc8fc\uccb4: \uc804\ub0a8\ub300\ud559\uad50 \uc57d\ud559\ub300\ud559 \ub0a8\uc8fc\ud0dd \uad50\uc218\ud300\uc774 \uc8fc\ub3c4\ud55c \uc5f0\uad6c\ub85c, \ub17c\ubb38\uc740 Journal of Controlled Release\uc5d0 \uac8c\uc7ac\ub410\ub2e4(\uc800\ub110 \uc784\ud329\ud2b8\uc9c0\uc218 11.5, JCR \uc0c1\uc704 3.3%).<\/li>\n<li>\uae30\uc220 \uac1c\uc694: \ub9dd\uac04 \uc774\uc628(Mn2+)\uacfc CDN\uc758 \ubc30\uc704\uacb0\ud569 \ubcf5\ud569\uccb4\ub97c \ub2e4\uacf5\uc131 \uc0dd\ubd84\ud574\uc131 \uc2e4\ub9ac\uce74 \ub098\ub178\uc785\uc790 \ub0b4\ubd80\uc5d0 \ud0d1\uc7ac\ud588\ub2e4.<\/li>\n<li>\uae30\uc804(\uc2e4\ud5d8 \uacb0\uacfc): \ub098\ub178\uc785\uc790\ub294 \uc885\uc591 \ubbf8\uc138\ud658\uacbd\uc5d0\uc11c \uc11c\uc11c\ud788 \ubd84\ud574\ub418\uba70 \ub9dd\uac04\uacfc CDN\uc744 \ubc29\ucd9c\ud574 \uc218\uc9c0\uc0c1\uc138\ud3ec\uc758 STING \uacbd\ub85c\ub97c \uac15\ud558\uac8c \uc790\uadf9\ud588\ub2e4.<\/li>\n<li>\uba74\uc5ed \ubc18\uc751 \ubcc0\ud654: \ud574\ub2f9 \uc81c\ud615\uc740 \ub300\uc2dd\uc138\ud3ec, NK \uc138\ud3ec, MDSC, Treg \ub4f1 \ub2e4\uc591\ud55c \uba74\uc5ed\uc138\ud3ec \ubc18\uc751\uc744 \uc870\uc808\ud574 \u2018\ucc28\uac00\uc6b4 \uc885\uc591\u2019\uc744 \u2018\ub728\uac70\uc6b4 \uc885\uc591\u2019\uc73c\ub85c \uc804\ud658\uc2dc\ucf30\ub2e4.<\/li>\n<li>\ub3d9\ubb3c\uc2e4\ud5d8 \uacb0\uacfc: \ud751\uc0c9\uc885 \ub3d9\ubb3c\ubaa8\ub378\uc5d0\uc11c \uad6d\uc18c \uc885\uc591 \uac10\uc18c \uc678\uc5d0 \uc804\uc2e0\uba74\uc5ed\ubc18\uc751\uc73c\ub85c \ud3d0 \uc804\uc774\uc554 \uc5b5\uc81c \ubc0f \uc885\uc591 \uc7ac\ubc1c \uc5b5\uc81c \ud6a8\uacfc\uac00 \ud655\uc778\ub410\ub2e4.<\/li>\n<li>\ubcd1\uc6a9\uc694\ubc95: aPD-1 \ud56d\uccb4 \uae30\ubc18 \uba74\uc5ed\uad00\ubb38\uc5b5\uc81c\uc81c\uc640 \ubcd1\uc6a9 \uc2dc \ud56d\uc554\uba74\uc5ed\uc758 \uc2dc\ub108\uc9c0\ub85c \uad6d\uc18c\uc554 \ubc0f \ud3d0 \uc804\uc774\uc554 \uce58\ub8cc \ud6a8\uacfc\uac00 \ud5a5\uc0c1\ub410\ub2e4.<\/li>\n<li>\uc9c0\uc6d0\u00b7\ud380\ub529: \ud55c\uad6d\uc5f0\uad6c\uc7ac\ub2e8\uc758 \uc911\uacac\uc5f0\uad6c \ubc0f \ud55c\uc6b0\ubb3c\ud30c\uae30 \uae30\ucd08\uc5f0\uad6c\uc758 \uc9c0\uc6d0\uc744 \ubc1b\uc558\ub2e4.<\/li>\n<\/ul>\n<h2>\uc0ac\uac74 \ubc30\uacbd<\/h2>\n<p>\ucd5c\uadfc \ud56d\uc554\uce58\ub8cc\uc758 \ud328\ub7ec\ub2e4\uc784\uc740 \uc9c1\uc811\uc801\uc73c\ub85c \uc138\ud3ec\ub97c \uc8fd\uc774\ub294 \ud654\ud559\u00b7\ud45c\uc801\uce58\ub8cc\uc5d0\uc11c \ud658\uc790\uc758 \uba74\uc5ed\uccb4\uacc4\ub97c \ud65c\uc131\ud654\ud574 \uc554\uc744 \uc81c\uac70\ud558\ub294 \uba74\uc5ed\ud56d\uc554\uc81c\ub85c \ube60\ub974\uac8c \uc774\ub3d9\ud558\uace0 \uc788\ub2e4. \uadf8\uc911 STING(Stimulator of Interferon Genes) \uacbd\ub85c\ub97c \uaca8\ub0e5\ud558\ub294 CDN(\ud658\ud615\uc774\ubd84\uc790\ud575\uc0b0)\uc740 \uac15\ub825\ud55c \uba74\uc5ed\uc6d0\uc131 \ubc18\uc751\uc744 \uc720\ub3c4\ud560 \uc218 \uc788\uc5b4 \uc784\uc0c1 \uc5f0\uad6c\uac00 \ud65c\ubc1c\ud788 \uc9c4\ud589 \uc911\uc774\ub2e4. \uadf8\ub7ec\ub098 CDN\uc740 \uc74c\uc804\ud558\ub97c \ub760\ub294 \uc791\uc740 \ubd84\uc790\ub85c\uc11c \uccb4\ub0b4\uc5d0\uc11c \uc27d\uac8c \ubd84\ud574\ub418\uac70\ub098 \ubc30\ucd9c\ub418\uace0 \uc138\ud3ec\ub9c9\uc744 \ud1b5\uacfc\ud558\uae30 \uc5b4\ub824\uc6cc \uc804\ub2ec \ud6a8\uc728\uacfc \uc720\ud6a8\uc131\uc774 \uc81c\ud55c\ub418\ub294 \ubb38\uc81c\uac00 \ubc18\ubcf5\ub3fc \uc654\ub2e4. \uc774\ub97c \ud574\uacb0\ud558\uae30 \uc704\ud55c \ub2e4\uc591\ud55c \ub098\ub178\uc804\ub2ec\uccb4 \uc5f0\uad6c\uac00 \uc9c4\ud589\ub3fc \uc654\uc73c\ub098, \uc0dd\uccb4\uc801\ud569\uc131\u00b7\ubd84\ud574\uc131\u00b7\uba74\uc5ed\uc99d\ud3ed \ub2a5\ub825\uc744 \ub3d9\uc2dc\uc5d0 \ucda9\uc871\ud558\ub294 \ud50c\ub7ab\ud3fc\uc744 \ucc3e\ub294 \uac83\uc774 \uacfc\uc81c\ub85c \ub0a8\uc558\ub2e4.<\/p>\n<p>\ub2e4\uacf5\uc131 \uc2e4\ub9ac\uce74 \ub098\ub178\uc785\uc790(MSN)\ub294 \ub192\uc740 \ud45c\uba74\uc801\uacfc \uc870\uc808 \uac00\ub2a5\ud55c \uae30\uacf5 \uad6c\uc870\ub85c \uc57d\ubb3c \ud0d1\uc7ac\uc5d0 \uc720\ub9ac\ud558\uba70, \uc801\uc808\ud55c \uc124\uacc4 \uc2dc \uc0dd\ubd84\ud574\uc131\uc744 \ud655\ubcf4\ud560 \uc218 \uc788\ub2e4. \ub610\ud55c \ub9dd\uac04 \uac19\uc740 \ud544\uc218 \ubbf8\ub124\ub784\uc740 \ucd5c\uadfc \uc5f0\uad6c\uc5d0\uc11c STING \uc2e0\ud638\ub97c \uc99d\ud3ed\ud560 \uc218 \uc788\uc74c\uc774 \ubcf4\uace0\ub3fc \uae08\uc18d \uc774\uc628\uc744 \uba74\uc5ed\ubcf4\uc870\uc81c\ub85c \ud65c\uc6a9\ud558\ub294 \uc2dc\ub3c4\uac00 \uad00\uc2ec\uc744 \ub04c\uace0 \uc788\ub2e4. \ubcf8 \uc5f0\uad6c\ub294 \uc774\ub7ec\ud55c \ubc30\uacbd\uc5d0\uc11c \ub9dd\uac04- CDN \ubcf5\ud569\uccb4\ub97c MSN \ub0b4\ubd80\uc5d0 \uace0\uc815\ud654\ud574 \uccb4\ub0b4 \uc804\ub2ec\uacfc \ubc29\ucd9c\uc744 \ub3d9\uc2dc\uc5d0 \ud574\uacb0\ud558\ub824\ub294 \uc804\ub7b5\uc744 \ucde8\ud588\ub2e4.<\/p>\n<h2>\uc8fc\uc694 \uc0ac\uac74<\/h2>\n<p>\uc5f0\uad6c\uc9c4\uc740 \uba3c\uc800 \ub9dd\uac04 \uc774\uc628\uacfc CDN\uc774 \ubc30\uc704\uacb0\ud569\uc744 \ud615\uc131\ud558\ub3c4\ub85d \ubcf5\ud569\uccb4\ub97c \ud569\uc131\ud55c \ub4a4 \uc774\ub97c \ub2e4\uacf5\uc131 \uc2e4\ub9ac\uce74 \ub098\ub178\uc785\uc790 \uae30\uacf5\uc5d0 \ud0d1\uc7ac\ud588\ub2e4. \ub098\ub178\uc785\uc790 \uc124\uacc4\ub294 \uc0dd\ubd84\ud574\uc131 \uc2e4\ub9ac\uce74 \uae30\ubc18\uc73c\ub85c \uc124\uc815\ud574 \uccb4\ub0b4 \uc794\ub958\ub97c \ucd5c\uc18c\ud654\ud558\uace0, \uc885\uc591 \ubbf8\uc138\ud658\uacbd\uc5d0\uc11c \uc810\uc9c4\uc801\uc73c\ub85c \ubd84\ud574\ub418\uba70 \ub9dd\uac04\uacfc CDN\uc744 \ubc29\ucd9c\ud558\ub3c4\ub85d \uc870\uc808\ub410\ub2e4. \ubc29\ucd9c\ub41c \uc131\ubd84\uc740 \uad6d\uc18c\uc5d0\uc11c \uc218\uc9c0\uc0c1\uc138\ud3ec\ub97c \ud65c\uc131\ud654\ud574 \ud0c0\uc785 I \uc778\ud130\ud398\ub860 \ub4f1 \ud56d\uc885\uc591 \uba74\uc5ed \uc2e0\ud638\ub97c \uc720\ub3c4\ud558\ub294 \uac83\uc73c\ub85c \ubcf4\uace0\ub410\ub2e4.<\/p>\n<p>\uc804\uc784\uc0c1 \uc2e4\ud5d8\uc5d0\uc11c\ub294 \ud751\uc0c9\uc885(\uba5c\ub77c\ub178\ub9c8) \ub3d9\ubb3c\ubaa8\ub378\uc744 \uc0ac\uc6a9\ud574 \uad6d\uc18c \uc885\uc591 \uc5b5\uc81c\ubfd0 \uc544\ub2c8\ub77c \uc804\uc2e0\uba74\uc5ed \uc720\ub3c4\uc5d0 \ub530\ub978 \ud3d0 \uc804\uc774 \uce58\ub8cc \ud6a8\uacfc\uae4c\uc9c0 \uad00\ucc30\ub410\ub2e4. \ud2b9\ud788 \ub098\ub178\uc81c\ud615 \ub2e8\ub3c5\uc73c\ub85c\ub3c4 \uc7ac\ubc1c \uc5b5\uc81c\uac00 \ud655\uc778\ub410\uace0, \ud56d-PD-1 \ud56d\uccb4\uc640 \ubcd1\uc6a9\ud588\uc744 \ub54c \uc885\uc591 \uc5b5\uc81c \ud6a8\uacfc\uac00 \ub354 \ud06c\uac8c \ud5a5\uc0c1\ub418\ub294 \uacb0\uacfc\ub97c \uc5bb\uc5c8\ub2e4. \ud604\uc7a5 \uad00\ucc30\uc5d0\uc11c\ub294 \uc885\uc591 \uc870\uc9c1 \ub0b4 \uc218\uc9c0\uc0c1\uc138\ud3ec\uc758 \ud65c\uc131\ud654\uc640 CD8+ T\uc138\ud3ec \uce68\uc724 \uc99d\uac00\uac00 \ud655\uc778\ub410\ub2e4.<\/p>\n<p>\uc5f0\uad6c\ud300\uc740 \uc774 \uae30\uc220\uc774 CDN\uc758 \uc804\ub2ec \ud55c\uacc4\ub97c \uadf9\ubcf5\ud558\uba74\uc11c \ub9dd\uac04\uc758 STING \uc99d\ud3ed \ud6a8\uacfc\ub97c \ub3d9\uc2dc\uc5d0 \uc774\uc6a9\ud574 \ud6a8\ub2a5\uc744 \ub192\uc600\ub2e4\uace0 \uc124\uba85\ud588\ub2e4. \ub610\ud55c \uc0dd\ubd84\ud574\uc131 \uc18c\uc7ac\ub97c \uc0ac\uc6a9\ud574 \uccb4\ub0b4 \uc794\ub958\uc640 \ub3c5\uc131 \uc704\ud5d8\uc744 \ub0ae\ucd94\ub824\ub294 \uc124\uacc4 \uc758\ub3c4\ub97c \uba85\ud655\ud788 \ud588\ub2e4.<\/p>\n<h2>\ubd84\uc11d \ubc0f \uc758\ubbf8<\/h2>\n<p>\uc5f0\uad6c\uc758 \uac00\uc7a5 \ud070 \uc758\uc758\ub294 \uba74\uc5ed\uad00\ubb38\uc5b5\uc81c\uc81c\uc640\uc758 \ubcd1\uc6a9\uc744 \uc5fc\ub450\uc5d0 \ub454 \ud50c\ub7ab\ud3fc\uc801 \uc811\uadfc\uc774\ub2e4. CDN\uc758 \uac15\ub825\ud55c \uba74\uc5ed\uc790\uadf9 \ub2a5\ub825\uc744 \ud604\uc2e4\uc801\uc778 \uce58\ub8cc\uc81c\ub85c \uad6c\ud604\ud558\ub824\uba74 \uc548\uc815\uc801 \uc804\ub2ec\uacfc \uc138\ud3ec\ub0b4 \uc720\uc785\uc774 \ud544\uc218\uc801\uc778\ub370, \uc774\ubc88 \ub2e4\uacf5\uc131 \uc2e4\ub9ac\uce74 \uae30\ubc18\uc758 \uba54\ud0c8-\uba74\uc5ed \uc870\ud569\uc740 \uadf8 \ud55c\uacc4\ub97c \uc2e4\ud5d8\uc801\uc73c\ub85c \uadf9\ubcf5\ud588\ub2e4. \ub9dd\uac04\uc740 STING \uc2e0\ud638\ub97c \uc99d\ud3ed\ud558\ub294 \ubcf4\uc870\uc778\uc790\ub85c \uc791\uc6a9\ud574 \uba74\uc5ed\ubc18\uc751\uc758 \uac15\ub3c4\uc640 \ubc94\uc704\ub97c \ud655\ub300\ud560 \uc218 \uc788\ub294 \uc7a5\uc810\uc774 \uc788\ub2e4.<\/p>\n<p\ub2e4\ub9cc \uc804\uc784\uc0c1 \uc131\uacf5\uc774 \uc784\uc0c1 \uc131\uacf5\uc73c\ub85c \uc9c1\uacb0\ub418\uc9c0\ub294 \uc54a\ub294\ub2e4. \uae08\uc18d \uc774\uc628 \ubc29\ucd9c\ub85c \uc778\ud55c \uc804\uc2e0\uc801 \uc548\uc804\uc131, \uc7a5\uae30 \uc794\ub958 \ubc0f \uc2e0\uacbd\u00b7\uac04 \ub3c5\uc131 \uac00\ub2a5\uc131, \uc81c\uc870 \uacf5\uc815\uc758 \uc77c\uad00\uc131 \ub4f1 \uaddc\uc81c\u00b7\uc0dd\uc0b0\uc801 \ub09c\uc81c\ub294 \ub0a8\uc544 \uc788\ub2e4. \ud2b9\ud788 \ub9dd\uac04\uc740 \ud544\uc218 \ubbf8\ub124\ub784\uc774\uc9c0\ub9cc \uacfc\ub2e4 \ub178\ucd9c \uc2dc \uc2e0\uacbd\ub3c5\uc131 \uc6b0\ub824\uac00 \uc788\uc5b4 \uccb4\ub0b4 \ub3d9\ud0dc\uc640 \ubc30\uc124 \uacbd\ub85c\uc5d0 \ub300\ud55c \ucd94\uac00\uc801 \uc548\uc804\uc131 \ub370\uc774\ud130 \ud655\ubcf4\uac00 \ud544\uc694\ud558\ub2e4.<\/p>\n<p>\uc784\uc0c1 \uc801\uc6a9\uc744 \uc704\ud574\uc11c\ub294 \ub2e4\ub978 \uc885\uc591 \ubaa8\ub378\uacfc \ub300\ub3d9\ubb3c \uc2dc\ud5d8, \uc57d\ub3d9\ud559\u00b7\uc57d\ub825\ud559(PK\/PD) \ub370\uc774\ud130, \ub3c5\uc131\uc2dc\ud5d8 \ub4f1 \ub2e4\ub2e8\uacc4 \uac80\uc99d\uc774 \uc120\ud589\ub3fc\uc57c \ud55c\ub2e4. \uc131\uacf5\ud560 \uacbd\uc6b0 CDN \uae30\ubc18 \uba74\uc5ed\uce58\ub8cc\uc81c\uc758 \uc720\ud6a8\ubc94\uc704\ub97c \ub113\ud788\uace0, \ub2e4\uc591\ud55c \uba74\uc5ed\uce58\ub8cc\uc81c\uc640 \uacb0\ud569 \uac00\ub2a5\ud55c \uc81c\ud615 \ud50c\ub7ab\ud3fc\uc73c\ub85c \ud655\uc7a5\ub420 \uc7a0\uc7ac\ub825\uc774 \ud06c\ub2e4.<\/p>\n<h2>\ube44\uad50 \ubc0f \ub370\uc774\ud130<\/h2>\n<figure>\n<table>\n<thead>\n<tr>\n<th>\ud56d\ubaa9<\/th>\n<th>CDN \ub2e8\ub3c5<\/th>\n<th>CDN+Mn(MSN \uc81c\ud615)<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\uccb4\ub0b4 \uc548\uc815\uc131<\/td>\n<td>\ube60\ub978 \ubd84\ud574\u00b7\ubc30\ucd9c<\/td>\n<td>\ub098\ub178\uc785\uc790\uc5d0 \uc758\ud574 \ubcf4\ud638\ub418\uc5b4 \uc7a5\uae30 \uc794\ub958 \uac1c\uc120<\/td>\n<\/tr>\n<tr>\n<td>\uc138\ud3ec\ub9c9 \ud22c\uacfc\uc728<\/td>\n<td>\ub0ae\uc74c<\/td>\n<td>\ud5a5\uc0c1\ub418\uc5b4 \uc138\ud3ec\ub0b4 \uc804\ub2ec \uc99d\uac00<\/td>\n<\/tr>\n<tr>\n<td>STING \ud65c\uc131<\/td>\n<td>\uc81c\ud55c\uc801<\/td>\n<td>\ub9dd\uac04\uc5d0 \uc758\ud574 \uc99d\ud3ed<\/td>\n<\/tr>\n<tr>\n<td>\ud56d\uc885\uc591 \ud6a8\uacfc(\ub3d9\ubb3c)<\/td>\n<td>\ubd80\ubd84\uc801<\/td>\n<td>\uad6d\uc18c\u00b7\uc804\uc2e0 \ubc18\uc751 \ubc0f \uc804\uc774 \uc5b5\uc81c \ud655\uc778<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n<p>\uc704 \ud45c\ub294 \ubcf8 \uc5f0\uad6c\uc5d0\uc11c \uc81c\uc2dc\ub41c \uc804\uc784\uc0c1 \ube44\uad50\ub97c \uc694\uc57d\ud55c \uac83\uc73c\ub85c, \uc815\ub7c9\uc801 \uc218\uce58(\uc608: \uc0dd\uc874\uc728, \uc885\uc591 \ud06c\uae30 \uac10\uc18c\uc728 \ub4f1)\ub294 \ubcf8\ubb38 \uc2e4\ud5d8 \ub370\uc774\ud130\ub97c \ucc38\uace0\ud574\uc57c \ud55c\ub2e4. \ube44\uad50 \uacb0\uacfc\ub294 \uc81c\ud615\ud654\uac00 \uba74\uc5ed\ud6a8\ub2a5\uacfc \uc804\ub2ec\uc131\uc744 \ub3d9\uc2dc\uc5d0 \uac1c\uc120\ud560 \uc218 \uc788\uc74c\uc744 \uc2dc\uc0ac\ud55c\ub2e4.<\/p>\n<h2>\ubc18\uc751 \ubc0f \uc778\uc6a9<\/h2>\n<p>\uc804\ub0a8\ub300\ud559\uad50 \uce21\uc740 \uc5f0\uad6c \ubcf4\ub3c4\uc790\ub8cc\ub97c \ud1b5\ud574 \uae30\uc220\uc758 \uc758\uc758\ub97c \uac15\uc870\ud558\uba70 \uc784\uc0c1 \uc804\ud658 \uac00\ub2a5\uc131\uc744 \ubc1d\ud614\ub2e4. \ub2e4\uc74c\uc740 \uc5f0\uad6c\ud300\uc758 \uc124\uba85\uc744 \uc778\uc6a9\ud55c \uac83\uc774\ub2e4.<\/p>\n<blockquote>\n<p>\u201c\ub9dd\uac04- CDN \ubcf5\ud569\uccb4\uc758 \ub098\ub178\uc81c\ud615\uc740 CDN\uc758 \uc804\ub2ec \ud55c\uacc4\ub97c \uadf9\ubcf5\ud558\uace0 \uc885\uc591 \ub0b4 STING \uc2e0\ud638\ub97c \ud6a8\uacfc\uc801\uc73c\ub85c \uc99d\ud3ed\ud568\uc73c\ub85c\uc368 in situ \ud56d\uc554\ubc31\uc2e0 \ud6a8\uacfc\ub97c \uad6c\ud604\ud588\uc2b5\ub2c8\ub2e4.\u201d<\/p>\n<p><cite>\uc804\ub0a8\ub300\ud559\uad50 \uc57d\ud559\ub300\ud559, \uc5f0\uad6c\ud300 \ubc1c\ud45c<\/cite><\/p><\/blockquote>\n<p>\uc5f0\uad6c \uc9c0\uc6d0 \uae30\uad00\uc778 \ud55c\uad6d\uc5f0\uad6c\uc7ac\ub2e8\uc740 \uae30\ucd08\uc5f0\uad6c\uc758 \uc131\uacfc \ud655\uc0b0 \uce21\uba74\uc5d0\uc11c \uc774\ubc88 \uc131\uacfc\ub97c \uc8fc\ubaa9\ud588\ub2e4.<\/p>\n<blockquote>\n<p>\u201c\uae30\ucd08\uc5f0\uad6c \uc9c0\uc6d0\uc744 \ud1b5\ud574 \ud601\uc2e0\uc801 \ub098\ub178\uc81c\ud615 \ud50c\ub7ab\ud3fc\uc774 \ub3c4\ucd9c\ub41c \uc0ac\ub840\ub85c \ud3c9\uac00\ub418\uba70, \ud6c4\uc18d \uc5f0\uad6c\ub97c \ud1b5\ud574 \uc784\uc0c1 \uc801\uc6a9 \uac00\ub2a5\uc131\uc744 \ub192\uc774\ub294 \uac83\uc774 \uc911\uc694\ud569\ub2c8\ub2e4.\u201d<\/p>\n<p><cite>\ud55c\uad6d\uc5f0\uad6c\uc7ac\ub2e8(\uacf5\uc2dd \ubc1c\ud45c)<\/cite><\/p><\/blockquote>\n<p>\ud55c\ud3b8 \ud559\uacc4\uc758 \uc678\ubd80 \uc804\ubb38\uac00\ub4e4\uc740 \uae30\ub300\uc640 \ud568\uaed8 \uc2e0\uc911\ud55c \ucd94\uac00 \uac80\uc99d\uc744 \uad8c\uace0\ud588\ub2e4.<\/p>\n<blockquote>\n<p>\u201c\uc804\uc784\uc0c1 \uacb0\uacfc\ub294 \uc720\ub9dd\ud558\uc9c0\ub9cc \uae08\uc18d \uc774\uc628\uc758 \uc7a5\uae30 \uc548\uc804\uc131, \uc81c\ud615 \ub300\ub7c9\uc0dd\uc0b0\uc131 \ub4f1 \ud574\uacb0\ud574\uc57c \ud560 \uacfc\uc81c\uac00 \ub0a8\uc544 \uc788\uc2b5\ub2c8\ub2e4.\u201d<\/p>\n<p><cite>\uba74\uc5ed\uce58\ub8cc \uad00\ub828 \ud559\uacc4 \uc77c\ubc18 \uacac\ud574(\uc885\ud569)<\/cite><\/p><\/blockquote>\n<h2>\n<aside>\ubcf4\uc870 \ubaa8\ub4c8: STING\u00b7CDN\u00b7MSN \uc6a9\uc5b4 \uc124\uba85<\/aside>\n<\/h2>\n<details>\n<summary>\uc6a9\uc5b4\/\ubc29\ubc95\ub860<\/summary>\n<p>STING\uc740 \uc138\ud3ec \ub0b4\uc758 DNA \uac10\uc9c0 \uc2e0\ud638\uacbd\ub85c\ub85c, \ud65c\uc131\ud654\ub418\uba74 \uc778\ud130\ud398\ub860 \uacc4\uc5f4\uc758 \uc0ac\uc774\ud1a0\uce74\uc778 \ubd84\ube44\ub97c \uc720\ub3c4\ud574 \ud56d\ubc14\uc774\ub7ec\uc2a4\u00b7\ud56d\uc885\uc591 \uba74\uc5ed\uc744 \ucd09\uc9c4\ud55c\ub2e4. CDN(\ud658\ud615\uc774\ubd84\uc790\ud575\uc0b0)\uc740 STING \uc218\uc6a9\uccb4\uc758 \ub0b4\uc778\uc131\u00b7\uc678\uc778\uc131 \ub9ac\uac04\ub4dc\ub85c \uc791\uc6a9\ud558\uc9c0\ub9cc \uc74c\uc804\ud558\u00b7\ubd84\ud574 \ubbfc\uac10\uc131 \ub54c\ubb38\uc5d0 \ub2e8\ub3c5 \uc57d\ubb3c\ub85c\uc11c\ub294 \uc804\ub2ec\uc774 \uc5b4\ub835\ub2e4. \ub2e4\uacf5\uc131 \uc2e4\ub9ac\uce74 \ub098\ub178\uc785\uc790(MSN)\ub294 \uaddc\uce59\uc801 \uae30\uacf5 \uad6c\uc870\ub85c \uc57d\ubb3c \ud0d1\uc7ac\uc640 \uc81c\uc5b4 \ubc29\ucd9c\uc774 \uac00\ub2a5\ud558\uba70, \uc801\uc808\ud55c \uc124\uacc4 \uc2dc \uc0dd\ubd84\ud574\uc131\uc744 \ud655\ubcf4\ud560 \uc218 \uc788\ub2e4. \ub9dd\uac04(Mn2+)\uc740 \ucd5c\uadfc \uc5f0\uad6c\uc5d0\uc11c STING \uc2e0\ud638\ub97c \uc99d\ud3ed\ud558\ub294 \ubcf4\uc870\uc778\uc790\ub85c \ud655\uc778\ub3fc \uba54\ud0c8-\uba74\uc5ed\uce58\ub8cc \uc804\ub7b5\uc5d0 \ud65c\uc6a9\ub41c\ub2e4.<\/p>\n<\/details>\n<h2>\ubd88\ud655\uc2e4\ud55c \ubd80\ubd84<\/h2>\n<ul>\n<li>\uc7a5\uae30 \uc548\uc804\uc131: \ub9dd\uac04 \ubc29\ucd9c\uc758 \uc7a5\uae30\uc801 \uc2e0\uacbd\u00b7\ub0b4\ubd84\ube44 \ub3c5\uc131 \uc5ec\ubd80\ub294 \ucd94\uac00 \uac80\uc99d\uc774 \ud544\uc694\ud558\ub2e4.<\/li>\n<li>\uc784\uc0c1 \uc804\ud658 \uc2dc \ud6a8\ub2a5 \uc720\uc9c0 \uc5ec\ubd80: \ub3d9\ubb3c\ubaa8\ub378\uc5d0\uc11c \ud655\uc778\ub41c \ud6a8\uacfc\uac00 \uc778\uac04 \uc784\uc0c1\uc5d0\uc11c \ub3d9\uc77c\ud558\uac8c \uc7ac\ud604\ub420\uc9c0\ub294 \ubd88\ud655\uc2e4\ud558\ub2e4.<\/li>\n<li>\uc81c\uc870\u00b7\uaddc\ubaa8\ud654: \uc77c\uad00\ub41c \ud488\uc9c8\uc758 \ub2e4\uacf5\uc131 \uc2e4\ub9ac\uce74 \ub098\ub178\uc785\uc790 \ub300\ub7c9\uc0dd\uc0b0 \uac00\ub2a5\uc131\uc740 \ucd94\uac00 \uac80\ud1a0 \ub300\uc0c1\uc774\ub2e4.<\/li>\n<\/ul>\n<h2>\ucd1d\ud3c9<\/h2>\n<p>\uc804\ub0a8\ub300 \uc5f0\uad6c\ud300\uc774 \uc81c\uc2dc\ud55c \uae08\uc18d-\uba74\uc5ed\uce58\ub8cc \ub098\ub178\uc81c\ud615\uc740 CDN \uae30\ubc18 STING \ud65c\uc131\ud654\ub97c \ud604\uc2e4\uc801 \uce58\ub8cc\uc635\uc158\uc73c\ub85c \uc804\ud658\ud558\ub824\ub294 \uc911\uc694\ud55c \uc2dc\ub3c4\ub2e4. \ub9dd\uac04\uc744 \ubcf4\uc870\uc778\uc790\ub85c \ud65c\uc6a9\ud574 \uba74\uc5ed\uc99d\ud3ed\uc744 \ub2ec\uc131\ud558\uace0 \uc0dd\ubd84\ud574\uc131 \uc2e4\ub9ac\uce74\ub97c \uc804\ub2ec\uccb4\ub85c \ud0d1\uc7ac\ud55c \uc811\uadfc\uc740 \uc804\ub2ec\u00b7\ud6a8\ub2a5 \ubb38\uc81c\ub97c \ub3d9\uc2dc\uc5d0 \ud574\uacb0\ud558\ub824\ub294 \uc2e4\uc6a9\uc801 \uc124\uacc4\ub85c \ud3c9\uac00\ub41c\ub2e4. \ub2e4\ub9cc \uc804\uc784\uc0c1 \uc131\uacfc\ub97c \uc784\uc0c1 \uc801\uc6a9\uc73c\ub85c \uc5f0\uacb0\ud558\uae30 \uc704\ud574\uc11c\ub294 \uc548\uc804\uc131\u00b7\uc57d\ub3d9\ud559\u00b7\ub300\ub7c9\uc0dd\uc0b0\uc131 \ub4f1 \ub2e4\ubc29\uba74\uc758 \ucd94\uac00 \uac80\uc99d\uc774 \ud544\uc694\ud558\ub2e4.<\/p>\n<p>\ud5a5\ud6c4 \ud6c4\uc18d \uc5f0\uad6c\uac00 \ubcf4\uc644\ub41c\ub2e4\uba74 \uc774 \ud50c\ub7ab\ud3fc\uc740 CDN\uc744 \ud3ec\ud568\ud55c \ub2e4\uc591\ud55c \uba74\uc5ed\uc870\uc808\uc81c\uc758 \ub098\ub178\uc81c\ud615\ud654\uc5d0 \uc751\uc6a9\ub420 \uac00\ub2a5\uc131\uc774 \ud06c\uba70, \uba74\uc5ed\uad00\ubb38\uc5b5\uc81c\uc81c\uc640\uc758 \ubcd1\uc6a9 \uc804\ub7b5\uc5d0\uc11c \uc0c8\ub85c\uc6b4 \uce58\ub8cc\ubc95\uc73c\ub85c \ubc1c\uc804\ud560 \uc7a0\uc7ac\ub825\uc744 \uac00\uc9c4\ub2e4.<\/p>\n<h2>\ucd9c\ucc98<\/h2>\n<ul>\n<li><a href=\"https:\/\/www.mdns.co.kr\/news\/articleView.html?idxno=31074\" target=\"_blank\" rel=\"noopener\">\ubb34\ub4f1\ub274\uc2a4 \ubcf4\ub3c4(\uc5b8\ub860)<\/a><\/li>\n<li><a href=\"https:\/\/www.nrf.re.kr\" target=\"_blank\" rel=\"noopener\">\ud55c\uad6d\uc5f0\uad6c\uc7ac\ub2e8(\uacf5\uc2dd)<\/a><\/li>\n<li><a href=\"https:\/\/www.elsevier.com\/journals\/journal-of-controlled-release\" target=\"_blank\" rel=\"noopener\">Journal of Controlled Release(\ud559\uc220\uc9c0, \ucd9c\ud310\uc0ac \ud398\uc774\uc9c0)<\/a><\/li>\n<\/ul>\n<\/article>\n","protected":false},"excerpt":{"rendered":"<p>\ud575\uc2ec \uc694\uc57d \uc804\ub0a8\ub300\ud559\uad50 \uc57d\ud559\ub300\ud559 \ub0a8\uc8fc\ud0dd \uad50\uc218\ud300\uc774 \ub9dd\uac04 \uc774\uc628(Mn2+)\uacfc \ud658\ud615\uc774\ubd84\uc790\ud575\uc0b0(CDN)\uc744 \ubc30\uc704\uacb0\ud569\ud55c \ubcf5\ud569\uccb4\ub97c \ub2e4\uacf5\uc131 \uc0dd\ubd84\ud574\uc131 \uc2e4\ub9ac\uce74 \ub098\ub178\uc785\uc790\uc5d0 \ud0d1\uc7ac\ud558\ub294 \uae08\uc18d-\uba74\uc5ed\uce58\ub8cc(metallo-immunotherapy) \uc81c\ud615\uae30\uc220\uc744 \uac1c\ubc1c\ud588\ub2e4. \uc5f0\uad6c\uc9c4\uc740 \uc774 \uae30\uc220\uc774 CDN \ub2e8\ub3c5 \uccb4\uacc4\uc758 \ubd84\ud574\u00b7\ubc30\ucd9c\uacfc \uc138\ud3ec \ud22c\uacfc\uc728 \ud55c\uacc4\ub97c \uadf9\ubcf5\ud574 \uc885\uc591 \ub0b4\uc5d0\uc11c STING \uacbd\ub85c\ub97c \uac15\ud558\uac8c \ud65c\uc131\ud654\ud558\uace0 in situ \ud56d\uc554\ubc31\uc2e0 \ud6a8\uacfc\ub97c \uc720\ub3c4\ud55c\ub2e4\uace0 \ubcf4\uace0\ud588\ub2e4. \ud751\uc0c9\uc885(\uba5c\ub77c\ub178\ub9c8) \ub3d9\ubb3c\ubaa8\ub378\uc5d0\uc11c \uad6d\uc18c \uc885\uc591 \uc81c\uc5b4\uc640 \ud3d0 \uc804\uc774 \uce58\ub8cc, \uc7ac\ubc1c \uc5b5\uc81c \ud6a8\uacfc\uac00 \ud655\uc778\ub410\uace0, aPD-1 &#8230; <a title=\"\uc804\ub0a8\ub300, \u201c\uba74\uc5ed\ud56d\uc554 \ud55c\uacc4 \ub118\uc740 \uae08\uc18d-\uba74\uc5ed\uce58\ub8cc\u201d \uae30\uc220 \uac1c\ubc1c\" class=\"read-more\" href=\"https:\/\/readtrends.com\/ko\/manganese-metallo-immunotherapy\/\" aria-label=\"\uc804\ub0a8\ub300, \u201c\uba74\uc5ed\ud56d\uc554 \ud55c\uacc4 \ub118\uc740 \uae08\uc18d-\uba74\uc5ed\uce58\ub8cc\u201d \uae30\uc220 \uac1c\ubc1c\uc5d0 \ub300\ud574 \ub354 \uc790\uc138\ud788 \uc54c\uc544\ubcf4\uc138\uc694\">\ub354 \uc77d\uae30<\/a><\/p>\n","protected":false},"author":1,"featured_media":6879,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"rank_math_title":"\uc804\ub0a8\ub300, \uba74\uc5ed\ud56d\uc554 \ud55c\uacc4 \uadf9\ubcf5\ud55c \uae08\uc18d-\uba74\uc5ed\uce58\ub8cc \uae30\uc220 \uac1c\ubc1c \u2014 \ubb34\ub4f1\ub274\uc2a4","rank_math_description":"\uc804\ub0a8\ub300 \ub0a8\uc8fc\ud0dd \uad50\uc218\ud300\uc774 \ub9dd\uac04\u00b7CDN \ubcf5\ud569\uccb4\ub97c \uc0dd\ubd84\ud574\uc131 \ub2e4\uacf5\uc131 \uc2e4\ub9ac\uce74 \ub098\ub178\uc785\uc790\uc5d0 \ud0d1\uc7ac\ud55c \uae08\uc18d-\uba74\uc5ed\uce58\ub8cc \uae30\uc220\uc744 \uac1c\ubc1c\ud588\ub2e4. \ud751\uc0c9\uc885 \ub3d9\ubb3c\ubaa8\ub378\uc5d0\uc11c \uc804\uc2e0\uba74\uc5ed\uacfc \uc804\uc774 \uc5b5\uc81c \ud6a8\uacfc\ub97c \ud655\uc778\ud588\ub2e4.","rank_math_focus_keyword":"\uc804\ub0a8\ub300, \uae08\uc18d-\uba74\uc5ed\uce58\ub8cc, \ub9dd\uac04, STING, \ub2e4\uacf5\uc131 \uc2e4\ub9ac\uce74, \uba74\uc5ed\ud56d\uc554\uc81c","footnotes":""},"categories":[2],"tags":[],"class_list":["post-6884","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-top-stories"],"_links":{"self":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/posts\/6884","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/comments?post=6884"}],"version-history":[{"count":0,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/posts\/6884\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/media\/6879"}],"wp:attachment":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/media?parent=6884"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/categories?post=6884"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/tags?post=6884"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}