{"id":7013,"date":"2026-01-20T12:07:14","date_gmt":"2026-01-20T03:07:14","guid":{"rendered":"https:\/\/readtrends.com\/ko\/blood-protein-cancer-signature\/"},"modified":"2026-01-20T12:07:14","modified_gmt":"2026-01-20T03:07:14","slug":"blood-protein-cancer-signature","status":"publish","type":"post","link":"https:\/\/readtrends.com\/ko\/blood-protein-cancer-signature\/","title":{"rendered":"\u201c\ub2e8\uc21c\ud55c \ud53c\ub85c\uc778 \uc904 \uc54c\uc558\ub294\ub370 \uc554?\u201d\u2026 \ud53c \ud55c \ubc29\uc6b8\ub85c \ubaa8\ud638\ud55c \uc99d\uc0c1 \uc18d \u2018\uc554\uc138\ud3ec\u2019 \uac00\ub824\ub0b8\ub2e4 &#8211; \ubc14\uc774\uc624\ud0c0\uc784\uc988"},"content":{"rendered":"<article>\n<p><strong>\ud575\uc2ec \uc694\uc57d<\/strong><\/p>\n<p>\uc2a4\uc6e8\ub374 \uce74\ub864\ub9b0\uc2a4\uce74 \uc5f0\uad6c\uc18c \ub4f1 \uacf5\ub3d9\uc5f0\uad6c\uc9c4\uc774 \ud608\uc7a5 \ub2e8\ubc31\uc9c8 1,463\uc885\uc744 \ubd84\uc11d\ud574 29\uc885\uc758 \ub2e8\ubc31\uc9c8 \uc870\ud569\uc73c\ub85c \uad6c\uc131\ub41c \u2018\ub2e8\ubc31\uc9c8 \uc2dc\uadf8\ub2c8\ucc98\u2019\ub97c \uaddc\uba85\ud588\ub2e4. 2025\ub144 12\uc6d4 29\uc77c Nature Communications\uc5d0 \uac8c\uc7ac\ub41c \uc774 \uc5f0\uad6c\ub294 \ub2e8\uc21c\ud55c \ud53c\ub85c\u00b7\uccb4\uc911\uac10\uc18c \ub4f1 \ube44\ud2b9\uc774\uc801 \uc99d\uc0c1 \ud658\uc790 \uac00\uc6b4\ub370 \uc554 \ud658\uc790\ub97c \uc120\ubcc4\ud558\ub294 \uc778\uacf5\uc9c0\ub2a5 \ubaa8\ub378\uc744 \uc81c\uc2dc\ud588\uc73c\uba70, \ucd08\uae30 \uac80\uc99d\uc5d0\uc11c AUC 0.80~0.82\ub97c \uae30\ub85d\ud588\ub2e4. \uc5f0\uad6c\uc9c4\uc740 \uc774 \uac80\uc0ac\uac00 \uc870\uc9c1\uac80\uc0ac\ub098 \uc601\uc0c1 \uc9c4\ub2e8\uc744 \uc644\uc804\ud788 \ub300\uccb4\ud558\ub294 \uac83\uc774 \uc544\ub2c8\ub77c, \uc815\ubc00 \uac80\uc0ac\uac00 \ud544\uc694\ud55c \ud658\uc790\ub97c \uc120\ubcc4\ud558\ub294 \ubcf4\uc870 \ub3c4\uad6c\ub85c \uc124\uacc4\ub418\uc5c8\ub2e4\uace0 \uc124\uba85\ud588\ub2e4.<\/p>\n<h2>\ud575\uc2ec \uc0ac\uc2e4<\/h2>\n<ul>\n<li>\uc5f0\uad6c\uc9c4: \uce74\ub864\ub9b0\uc2a4\uce74 \uc5f0\uad6c\uc18c(Karolinska Institutet), \ub2e8\ub370\ub9ac\ub4dc \ubcd1\uc6d0(Danderyd Hospital), \uc6c1\uc0b4\ub77c \ub300\ud559\uad50(Uppsala University)\uac00 \uacf5\ub3d9\uc73c\ub85c \ucc38\uc5ec\ud588\ub2e4.<\/li>\n<li>\ub2e8\ubc31\uc9c8 \uce21\uc815: \ud608\uc7a5 \ub0b4 1,463\uc885\uc758 \ub2e8\ubc31\uc9c8\uc744 \uadfc\uc811 \uc5f0\uc7a5 \ubd84\uc11d(Proximity Extension Assay, PEA)\uc73c\ub85c \uacc4\uce21\ud588\ub2e4.<\/li>\n<li>\uc2dc\uadf8\ub2c8\ucc98: \uc554 \ud658\uc790\uc5d0\uc11c \ud2b9\uc774\uc801\uc73c\ub85c \uad00\ucc30\ub41c 29\uac00\uc9c0 \ub2e8\ubc31\uc9c8 \uc870\ud569\uc744 \u2018\ub2e8\ubc31\uc9c8 \uc2dc\uadf8\ub2c8\ucc98\u2019\ub85c \uaddc\uba85\ud588\ub2e4.<\/li>\n<li>\uc131\ub2a5: \uac1c\ubc1c\ud55c \uc778\uacf5\uc9c0\ub2a5 \ubd84\ub958 \ubaa8\ub378\uc758 AUC\ub294 0.80~0.82\ub85c \ubcf4\uace0\ub418\uc5c8\ub2e4.<\/li>\n<li>\ucf54\ud638\ud2b8: \uc5f0\uad6c \ucd08\uae30 \ubd84\uc11d \ub300\uc0c1\uc740 \uc2a4\uc6e8\ub374 \uc8fc\uc694 \ubcd1\uc6d0 \uc758\ub8b0 \ud658\uc790 \uc57d 700\uac1c\uc758 \ud608\uc561 \uc0d8\ud50c\uc744 \ud3ec\ud568\ud588\uc73c\uba70, \uc77c\ubd80\ub294 \uc804\uc774\uc131 \uc554 \ud658\uc790\uc600\ub2e4.<\/li>\n<li>\uc8fc\uc694 \uc778\uc790: AGR2, KRT-19, CEACAM5(CEA), RRM2, PARP1 \ub4f1 \uc554\uc758 \uc774\ub3d9\u00b7\uc99d\uc2dd\u00b7DNA \ud569\uc131 \uad00\ub828 \ub2e8\ubc31\uc9c8\uc774 \uc2dc\uadf8\ub2c8\ucc98\uc5d0 \ud3ec\ud568\ub418\uc5c8\ub2e4.<\/li>\n<li>\ubaa9\uc801: \ubcf8 \uac80\uc0ac\ub294 \ube44\ud2b9\uc774\uc801 \uc99d\uc0c1\uc744 \ubcf4\uc774\ub294 \ud658\uc790 \uc911 \uc815\ubc00 \uac80\uc0ac \ub300\uc0c1\uc790\ub97c \uc120\ubcc4\ud558\uae30 \uc704\ud55c \uc9c0\uc6d0 \ub3c4\uad6c\ub85c \uc124\uacc4\ub418\uc5c8\ub2e4.<\/li>\n<li>\ucd9c\ud310: \uc5f0\uad6c \uacb0\uacfc\ub294 2025\ub144 12\uc6d4 29\uc77c \uc790 Nature Communications\uc5d0 \uac8c\uc7ac\ub418\uc5c8\ub2e4.<\/li>\n<\/ul>\n<h2>\uc0ac\uac74 \ubc30\uacbd<\/h2>\n<p>\ube44\ud2b9\uc774\uc801 \uc99d\uc0c1(\uc6d0\uc778 \ubaa8\ub97c \ud53c\ub85c, \uc9c0\uc18d \ud1b5\uc99d, \uae09\uaca9\ud55c \uccb4\uc911\uac10\uc18c \ub4f1)\uc740 \ucd08\uae30 \uc554\uc758 \uc911\uc694\ud55c \uc2e0\ud638\uc77c \uc218 \uc788\uc9c0\ub9cc, \uc774\ub7ec\ud55c \uc99d\uc0c1\ub9cc\uc73c\ub85c \ud2b9\uc815 \uc7a5\uae30 \uac80\uc0ac\ub97c \ubc14\ub85c \uc2dc\ud589\ud558\uae30\ub294 \uc5b4\ub835\ub2e4. \ud604\uc7ac \uc784\uc0c1\uc5d0\uc11c\ub294 \uc720\ubc29\uc554\u00b7\ub300\uc7a5\uc554\ucc98\ub7fc \uc120\ubcc4\uac80\uc0ac\uac00 \uc815\ub9bd\ub41c \uc554\uc744 \uc81c\uc678\ud558\uba74 \uc99d\uc0c1 \ubc1c\uc0dd \ud6c4 \uc601\uc0c1\uc758\ud559\u00b7\ub0b4\uc2dc\uacbd\u00b7\uc870\uc9c1\uac80\uc0ac\ub85c \uc774\uc5b4\uc9c0\ub294 \uacbd\uc6b0\uac00 \ub9ce\uc544 \uc9c4\ub2e8 \uc9c0\uc5f0\uc774 \ubc1c\uc0dd\ud55c\ub2e4. PET-CT \uac19\uc740 \uace0\uac00 \uc7a5\ube44\uc640 \uc870\uc9c1\uac80\uc0ac\ub294 \ube44\uc6a9\uacfc \ubc29\uc0ac\uc120 \ub178\ucd9c, \uce68\uc2b5\uc131\uc758 \ubb38\uc81c\uac00 \uc788\uc5b4 \ubaa8\ub4e0 \uc758\uc2ec \ud658\uc790\uc5d0\uac8c \uc801\uc6a9\ud558\uae30 \uc5b4\ub835\ub2e4.<\/p>\n<p>\ucd5c\uadfc \ub4e4\uc5b4 \ud608\uc561 \uae30\ubc18\uc758 \uc561\uccb4\uc0dd\uac80(liquid biopsy)\uacfc \ub2e8\ubc31\uccb4\ud559(proteomics)\uc774 \ube44\uce68\uc2b5\uc801 \uc870\uae30\uc9c4\ub2e8 \uac00\ub2a5\uc131\uc73c\ub85c \uc8fc\ubaa9\ubc1b\uc544 \uc654\ub2e4. \ub2e8\ubc31\uccb4\ud559\uc740 \ub2e8\uc77c \ubc14\uc774\uc624\ub9c8\ucee4\ubcf4\ub2e4 \ubcf5\ud569 \ud328\ud134\uc744 \ud3ec\ucc29\ud558\ub294 \ub370 \uc720\ub9ac\ud558\uba70, \ub2e4\uc218\uc758 \ub2e8\ubc31\uc9c8\uc744 \ub3d9\uc2dc \uce21\uc815\ud558\ub294 \uae30\uc220 \ubc1c\uc804\uc73c\ub85c \uc0c1\uc6a9\ud654 \uac00\ub2a5\uc131\uc774 \ub192\uc544\uc84c\ub2e4. \uc774\ubc88 \uc5f0\uad6c\ub294 \uc774\ub7ec\ud55c \uae30\uc220\uc801 \uc9c4\ubcf4\ub97c \uc784\uc0c1 \uc804\ub2e8\uacc4 \ud658\uc790\uad70(\uc554 \uc758\uc2ec \uc99d\uc0c1 \ud658\uc790)\uc5d0\uc11c \uc2e4\uc6a9\uc801\uc73c\ub85c \uc801\uc6a9\ud558\ub824\ub294 \uc2dc\ub3c4\ub77c\ub294 \uc810\uc5d0\uc11c \uc758\ubbf8\uac00 \uc788\ub2e4.<\/p>\n<h2>\uc8fc\uc694 \uc0ac\uac74<\/h2>\n<p>\uc5f0\uad6c\uc9c4\uc740 \uc2a4\uc6e8\ub374 \uc8fc\uc694 \ubcd1\uc6d0\uc5d0\uc11c \uc758\ub8b0\ub41c \uc57d 700\uba85\uc758 \ud608\uc561 \uc0d8\ud50c\uc744 \ub300\uc0c1\uc73c\ub85c \uc6b0\uc120 \ud0d0\uc0c9\uc744 \uc218\ud589\ud588\uace0, PEA\ub85c 1,463\uc885\uc758 \ub2e8\ubc31\uc9c8 \uc218\uc900\uc744 \uce21\uc815\ud588\ub2e4. \ub370\uc774\ud130 \ubd84\uc11d\uc744 \ud1b5\ud574 \uc554 \ud658\uc790\uad70\uc5d0\uc11c \uacf5\ud1b5\uc801\uc73c\ub85c \uc0c1\uc2b9\u00b7\ud558\uac15\ud558\ub294 29\uac1c\uc758 \ub2e8\ubc31\uc9c8 \uc870\ud569\uc744 \uc2dd\ubcc4\ud588\uace0, \uc774\ub97c \uae30\ubc18\uc73c\ub85c \uae30\uacc4\ud559\uc2b5 \ubaa8\ub378\uc744 \ud559\uc2b5\uc2dc\ucf30\ub2e4. \ubaa8\ub378\uc740 \uc554 \ud658\uc790\uc640 \uc554\uacfc \uc720\uc0ac\ud55c \uc99d\uc0c1\uc744 \uac00\uc9c4 \uc5fc\uc99d\uc131\u00b7\uc790\uac00\uba74\uc5ed \uc9c8\ud658 \ud658\uc790 \uc0ac\uc774\ub97c \uad6c\ubd84\ud558\ub294 \ub370 \ucd08\uc810\uc744 \ub9de\ucdc4\ub2e4.<\/p>\n<p>\ubaa8\ub378 \uac80\uc99d \uacb0\uacfc AUC 0.80~0.82\ub97c \uae30\ub85d\ud574 \ud310\ubcc4\ub825\uc740 \uc720\uc758\ubbf8\ud558\ub2e4\uace0 \ud3c9\uac00\ub410\ub2e4. \ud2b9\ud788 AGR2, KRT-19, CEACAM5(CEA) \ub4f1 \uc774\ubbf8 \uc554 \uc5f0\uad6c\uc5d0\uc11c \uc8fc\ubaa9\ubc1b\ub294 \ub2e8\ubc31\uc9c8\ub4e4\uc774 \uc2dc\uadf8\ub2c8\ucc98\uc5d0 \ud3ec\ud568\ub418\uc5b4 \uae30\uacc4\ud559\uc2b5 \ubaa8\ub378\uc758 \uc0dd\ubb3c\ud559\uc801 \ud0c0\ub2f9\uc131\ub3c4 \ub4b7\ubc1b\uce68\ub418\uc5c8\ub2e4. \ub2e4\ub9cc \uc5f0\uad6c\uc9c4\uc740 \ub300\uc0c1\uc790 \uc911 \uc0c1\ub2f9\uc218\uac00 \uc804\uc774\uc131 \uc554 \ud658\uc790\uc600\uc74c\uc744 \ud55c\uacc4\ub85c \uc778\uc815\ud558\uba70, \uc870\uae30 \uc554\uc5d0\uc11c \ub3d9\uc77c\ud55c \uc131\ub2a5\uc744 \ubcf4\uc77c\uc9c0\ub294 \ucd94\uac00 \uac80\uc99d\uc774 \ud544\uc694\ud558\ub2e4\uace0 \ubc1d\ud614\ub2e4.<\/p>\n<p>\uc5f0\uad6c\uc9c4\uc740 \ud5a5\ud6c4 1\ucc28 \uc758\ub8cc\uae30\uad00(Primary Care) \ud658\uacbd\uc5d0\uc11c \uc720\ubcd1\ub960\uc774 \ub0ae\uc740 \uc9d1\ub2e8\uc744 \ub300\uc0c1\uc73c\ub85c \uc804\ud5a5\uc801 \uac80\uc99d\uc744 \uc9c4\ud589\ud574 \uc2e4\ud6a8\uc131\uc744 \ud3c9\uac00\ud560 \uacc4\ud68d\uc774\ub2e4. \ub610\ud55c \ud604\uc7ac \uc774 \uac80\uc0ac\ub294 \uc815\ubc00\uac80\uc0ac\uac00 \ud544\uc694\ud55c \ud658\uc790\ub97c \uc120\ubcc4\ud558\ub294 \ubcf4\uc870 \ub3c4\uad6c\ub85c \uac1c\ubc1c\ub418\uc5b4, \uc870\uc9c1\uac80\uc0ac\ub098 \uc601\uc0c1 \uc9c4\ub2e8\uc744 \uc644\uc804\ud788 \ub300\uccb4\ud560 \uc758\ub3c4\ub294 \uc5c6\ub2e4\uace0 \uba85\ud655\ud788 \ud588\ub2e4.<\/p>\n<h2>\ubd84\uc11d \ubc0f \uc758\ubbf8<\/h2>\n<p>\uc784\uc0c1\uc801\uc73c\ub85c \ubcf8 \uc5f0\uad6c\uc758 \uac00\uc7a5 \ud070 \uac00\uce58\ub294 &#8216;\uc99d\uc0c1\uc740 \uc788\uc9c0\ub9cc \uc6d0\uc778\uc774 \ubd88\uba85\ud655\ud55c \ud658\uc790&#8217;\ub97c \ub300\uc0c1\uc73c\ub85c \ud55c \uc120\ubcc4(triage) \ub2a5\ub825\uc5d0 \uc788\ub2e4. \uc758\ub8cc\uc790\uc6d0\uc774 \uc81c\ud55c\ub41c \ud604\uc2e4\uc5d0\uc11c \uace0\uac00\uc758 PET-CT\ub098 \ubd88\ud544\uc694\ud55c \uce68\uc2b5\uc801 \uac80\uc0ac\ub97c \uc904\uc774\uace0, \ub300\uc2e0 \uc815\ubc00\uac80\uc0ac\uac00 \ud6a8\uacfc\uc801\uc73c\ub85c \ubc30\uc815\ub418\uba74 \ud658\uc790\uc758 \uc870\uae30 \uc9c4\ub2e8 \uac00\ub2a5\uc131\uacfc \uc758\ub8cc\ube44 \ud6a8\uc728\ud654\uac00 \ub3d9\uc2dc\uc5d0 \uac1c\uc120\ub420 \uc218 \uc788\ub2e4. \ud2b9\ud788 \ub2e8\ubc31\uccb4\ud559 \uae30\ubc18 \uc811\uadfc\uc740 \uc7a5\uae30\ubcc4 \uc99d\uc0c1 \uc804\ub2e8\uacc4\uc5d0\uc11c \uc804\uc2e0\uc801 \ubcc0\ud654\ub97c \ud3ec\ucc29\ud560 \uc218 \uc788\ub2e4\ub294 \uc7a5\uc810\uc774 \uc788\ub2e4.<\/p>\n<p>\uadf8\ub7ec\ub098 \uc2e4\uc81c 1\ucc28 \uc9c4\ub8cc \ud658\uacbd\uc5d0\uc11c\uc758 \uc801\uc6a9\uc5d0\ub294 \uba87 \uac00\uc9c0 \ub3c4\uc804\uc774 \ub0a8\uc544\uc788\ub2e4. \uccab\uc9f8, \ub0ae\uc740 \uc720\ubcd1\ub960 \uc0c1\ud669\uc5d0\uc11c\ub294 \uc591\uc131\uc608\uce21\ub3c4\uac00 \ub5a8\uc5b4\uc838 \uc704\uc591\uc131\uc73c\ub85c \uc778\ud55c \ubd88\ud544\uc694\ud55c \ucd94\uac00\uac80\uc0ac\uac00 \uc99d\uac00\ud560 \uc218 \uc788\ub2e4. \ub458\uc9f8, \uc778\uc885\u00b7\uc9c0\uc5ed\u00b7\uc5f0\ub839\ubcc4 \uc0dd\ubb3c\ud559\uc801 \ucc28\uc774\uc5d0 \ub530\ub978 \uc77c\ubc18\ud654 \uac00\ub2a5\uc131\uc744 \ud655\uc778\ud574\uc57c \ud55c\ub2e4. \uc14b\uc9f8, \uc0c1\uc6a9\ud654\ub97c \uc704\ud574\uc11c\ub294 \ud45c\uc900\ud654\ub41c \uce21\uc815 \ud50c\ub7ab\ud3fc, \ud488\uc9c8\uad00\ub9ac, \uaddc\uc81c \uc2b9\uc778 \uc808\ucc28\uac00 \ud544\uc694\ud558\ub2e4.<\/p>\n<p>\uacbd\uc81c\u00b7\uc815\ucc45\uc801 \ucc28\uc6d0\uc5d0\uc11c\ub294 \ubcf4\ud5d8 \uc801\uc6a9 \ubc94\uc704, \uac80\uc0ac \ube44\uc6a9 \ub300\ube44 \ud3b8\uc775(Benefit-Cost) \ud3c9\uac00\uac00 \uad00\uac74\uc774\ub2e4. \uac80\uc0ac\uac00 \uc870\uae30 \uc9c4\ub2e8\uc73c\ub85c \uc774\uc5b4\uc838 \uc0dd\uc874\uc728 \ud5a5\uc0c1\uacfc \uce58\ub8cc\ube44 \uc808\uac10\uc73c\ub85c \uc5f0\uacb0\ub418\ub294\uc9c0\ub97c \ubcf4\uc774\ub824\uba74 \ub300\uaddc\ubaa8 \uc804\ud5a5\uc801 \uc784\uc0c1\uc2dc\ud5d8 \ubc0f \uc7a5\uae30 \ucd94\uc801 \ub370\uc774\ud130\uac00 \ud544\uc694\ud558\ub2e4. \uad6d\uc81c\uc801 \uad00\uc810\uc5d0\uc11c\ub294 \ub2e4\ub978 \uc561\uccb4\uc0dd\uac80(\uc608: ctDNA)\uacfc\uc758 \ube44\uad50\u00b7\ubcd1\uc6a9 \uac00\ub2a5\uc131\ub3c4 \ud5a5\ud6c4 \uc5f0\uad6c \uacfc\uc81c\ub85c \ub0a8\ub294\ub2e4.<\/p>\n<h2>\ube44\uad50 \ubc0f \ub370\uc774\ud130<\/h2>\n<figure>\n<table>\n<thead>\n<tr>\n<th>\ud56d\ubaa9<\/th>\n<th>\uac12<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\ub3d9\uc2dc \uce21\uc815 \ub2e8\ubc31\uc9c8 \uc218<\/td>\n<td>1,463\uc885<\/td>\n<\/tr>\n<tr>\n<td>\uc2dc\uadf8\ub2c8\ucc98 \ub2e8\ubc31\uc9c8 \uc218<\/td>\n<td>29\uc885<\/td>\n<\/tr>\n<tr>\n<td>\ucd08\uae30 \ucf54\ud638\ud2b8 \uc0d8\ud50c \uc218<\/td>\n<td>\uc57d 700\uac1c<\/td>\n<\/tr>\n<tr>\n<td>\ubaa8\ub378 \uc131\ub2a5(AUC)<\/td>\n<td>0.80\u20130.82<\/td>\n<\/tr>\n<tr>\n<td>\ud559\uc220\uc9c0 \uac8c\uc7ac\uc77c<\/td>\n<td>2025-12-29 (Nature Communications)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n<p>\uc704 \ud45c\ub294 \uc5f0\uad6c\uc5d0\uc11c \ubcf4\uace0\ub41c \ud575\uc2ec \uc218\uce58\ub9cc \uc694\uc57d\ud55c \uac83\uc774\ub2e4. 1,463\uc885 \ub3d9\uc2dc \uce21\uc815\uc774\ub77c\ub294 \uae30\uc220\uc801 \uc2a4\ucf00\uc77c\uacfc 29\uc885\uc73c\ub85c \uc555\ucd95\ub41c \uc2dc\uadf8\ub2c8\ucc98\ub294 \ud0d0\uc0c9\uc801 \ubd84\uc11d \ud6c4\uc758 \ubcc0\uc218 \ucd95\uc18c \uacb0\uacfc\uc774\uba70, AUC \uc218\uce58\ub294 \ud604\uc7ac \ud658\uc790\uad70(\uc554 \uc758\uc2ec \ud658\uc790 \ub2e4\uc218 \ud3ec\ud568)\uc5d0 \ub300\ud55c \uac80\uc99d\uac12\uc774\ub2e4. \ub530\ub77c\uc11c \ucd08\uae30 \uc131\ub2a5 \uc9c0\ud45c\ub294 \uc720\ub9dd\ud558\uc9c0\ub9cc, \uc2e4\uc81c 1\ucc28 \uc9c4\ub8cc \uc801\uc6a9\uc744 \uc704\ud574\uc11c\ub294 \ucd94\uac00\uc801\uc778 \uc678\ubd80\uac80\uc99d\uc774 \ud544\uc694\ud558\ub2e4.<\/p>\n<h2>\ubc18\uc751 \ubc0f \uc778\uc6a9<\/h2>\n<p>\uc5f0\uad6c\ub97c \uc8fc\ub3c4\ud55c \uc5f0\uad6c\uc9c4\uc758 \uc124\uba85\uc740 \uae30\uc220\uc758 \uac00\ub2a5\uc131\uacfc \ud55c\uacc4\ub97c \ub3d9\uc2dc\uc5d0 \uc81c\uc2dc\ud55c\ub2e4. \uadf8\ub4e4\uc740 \uc18c\ub7c9\uc758 \ud608\uc561\uc73c\ub85c \uc784\uc0c1\uc801 \uc758\ubbf8\uac00 \uc788\ub294 \uc815\ubcf4\ub97c \ucd94\ucd9c\ud560 \uc218 \uc788\uc74c\uc744 \uac15\uc870\ud558\uba74\uc11c\ub3c4, \uc870\uae30\uc554\uc5d0\uc11c\uc758 \uc131\ub2a5 \uac80\uc99d \ud544\uc694\uc131\uc744 \ubd84\uba85\ud788 \ud588\ub2e4.<\/p>\n<blockquote>\n<p>&#8220;\uc6b0\ub9ac\ub294 \ub2e8\ubc31\uccb4\ud559\uc774\ub77c\ub294 \ub4f1\ubd88\uc744 \ud1b5\ud574 \ubaa8\ud638\ud55c \uc99d\uc0c1\uc758 \uc2e4\uccb4\ub97c \ub354 \uc120\uba85\ud558\uac8c \ubcfc \uc218 \uc788\uac8c \ub418\uc5c8\ub2e4.&#8221;<\/p>\n<p><cite>\uc0ec\ub86f \ud0c8\ub9b0 \uad50\uc218, \uce74\ub864\ub9b0\uc2a4\uce74 \uc5f0\uad6c\uc18c(\uc5f0\uad6c\ucc45\uc784\uc790)<\/cite><\/p><\/blockquote>\n<p>\ud0c8\ub9b0 \uad50\uc218\uc758 \ubc1c\uc5b8\uc740 \uc774\ubc88 \uc811\uadfc\ubc95\uc774 \uc784\uc0c1\uc801 \uc120\ubcc4\uc5d0 \uc2e4\uc9c8\uc801 \uac00\uce58\ub97c \uc81c\uacf5\ud560 \uc218 \uc788\uc74c\uc744 \uc124\uba85\ud55c\ub2e4. \ub2e4\ub9cc \uadf8\ub140\ub3c4 \ucd94\uac00 \uac80\uc99d\uacfc 1\ucc28\uc758\ub8cc \ud658\uacbd \uc801\uc6a9 \uc5f0\uad6c\uc758 \ud544\uc694\uc131\uc744 \ud568\uaed8 \uc5b8\uae09\ud558\uc5ec \uc5f0\uad6c\uc758 \ud604\uc7ac \uc704\uce58\ub97c \uade0\ud615 \uc788\uac8c \uc81c\uc2dc\ud588\ub2e4.<\/p>\n<p>\uc678\ubd80 \uc804\ubb38\uac00\ub4e4\uc740 \uae30\uc220\uc758 \uc7a0\uc7ac\ub825\uc744 \uc778\uc815\ud558\uba74\uc11c\ub3c4 \uc784\uc0c1\uc801 \ud6a8\uc6a9\uc744 \uc99d\uba85\ud560 \uc2e4\ubb34\uc801 \uc99d\uac70\uac00 \ud544\uc694\ud558\ub2e4\ub294 \uc810\uc744 \uc9c0\uc801\ud588\ub2e4. \ud2b9\ud788 \uc800\uc720\ubcd1\ub960 \ud658\uacbd\uc5d0\uc11c\uc758 \uc591\uc131\uc608\uce21\ub3c4 \uad00\ub9ac\uc640 \uc784\uc0c1\uc801 \uc54c\uace0\ub9ac\uc998 \ud1b5\ud569 \ubc29\uc548\uc774 \uc911\uc694\ud558\ub2e4\uace0 \ud3c9\uac00\ud588\ub2e4.<\/p>\n<blockquote>\n<p>&#8220;\ub2e8\ubc31\uc9c8 \uae30\ubc18 \uc2dc\uadf8\ub2c8\ucc98\ub294 \uc720\ub9dd\ud558\uc9c0\ub9cc, 1\ucc28 \uc9c4\ub8cc\uc5d0\uc11c \uc2e4\uc81c \ud658\uc790 \ud750\ub984\uacfc \ube44\uc6a9-\ud3b8\uc775\uc744 \uac80\uc99d\ud558\ub294 \uac83\uc774 \ub2e4\uc74c \ub2e8\uacc4\ub2e4.&#8221;<\/p>\n<p><cite>\uc2a4\uc6e8\ub374 \uc784\uc0c1\uc885\uc591 \uc804\ubb38\uc758(\uc775\uba85 \uc694\uccad)<\/cite><\/p><\/blockquote>\n<p>\uc804\ubb38\uac00\uc758 \ud3c9\uac00\ub294 \uae30\uc220 \uc790\uccb4\uc758 \ud601\uc2e0\uc131\uc740 \uc778\uc815\ud558\uba74\uc11c\ub3c4, \ubcf4\uac74\uc758\ub8cc \uccb4\uacc4 \ub0b4\uc5d0\uc11c\uc758 \uc2e4\ubb34\uc801 \uc801\uc6a9 \uac00\ub2a5\uc131 \uac80\uc99d\uc774 \ud544\uc694\ud568\uc744 \uac15\uc870\ud55c\ub2e4. \uc774\ub294 \uaddc\uc81c \uc2b9\uc778\uacfc \ubcf4\ud5d8 \uc801\uc6a9 \ub17c\uc758\ub85c \uc774\uc5b4\uc9c8 \uc8fc\uc694 \uc0ac\uc548\uc774\ub2e4.<\/p>\n<aside>\n<details>\n<summary>\uc6a9\uc5b4\/\ubc29\ubc95\ub860<\/summary>\n<p>\uadfc\uc811 \uc5f0\uc7a5 \ubd84\uc11d(Proximity Extension Assay, PEA)\uc740 \ub450 \uac1c\uc758 \ud56d\uccb4\uc5d0 \ubd80\ucc29\ub41c \uc62c\ub9ac\uace0\ub274\ud074\ub808\uc624\ud0c0\uc774\ub4dc\uac00 \ud45c\uc801 \ub2e8\ubc31\uc9c8 \uadfc\ucc98\uc5d0\uc11c \uacb0\ud569\ud558\uba74 \uc2e0\ud638\ub97c \uc99d\ud3ed\ud574 \uac80\ucd9c\ud558\ub294 \ubc29\uc2dd\uc73c\ub85c, \ub0ae\uc740 \ub18d\ub3c4\uc758 \ub2e8\ubc31\uc9c8\ub3c4 \ub192\uc740 \ud2b9\uc774\ub3c4\ub85c \uce21\uc815\ud560 \uc218 \uc788\ub2e4. \ub2e8\ubc31\uccb4\ud559(proteomics)\uc740 \ub2e8\ubc31\uc9c8\uc758 \ubc1c\ud604\u00b7\ubcc0\ud615\u00b7\uc0c1\ud638\uc791\uc6a9\uc744 \ub300\uaddc\ubaa8\ub85c \ubd84\uc11d\ud558\ub294 \ud559\ubb38 \ubd84\uc57c\ub85c, \uc554\uacfc \uac19\uc740 \ubcf5\uc7a1\ud55c \uc9c8\ubcd1\uc5d0\uc11c \uc5ec\ub7ec \ub2e8\ubc31\uc9c8\uc758 \ud328\ud134\uc744 \ud1b5\ud569\ud574 \uc9c4\ub2e8 \ub9c8\ucee4\ub97c \uac1c\ubc1c\ud558\ub294 \ub370 \uc720\ub9ac\ud558\ub2e4. AUC(Area Under Curve)\ub294 \ubd84\ub958\ubaa8\ub378\uc758 \uc131\ub2a5 \uc9c0\ud45c\ub85c 1\uc5d0 \uac00\uae4c\uc6b8\uc218\ub85d \ubbfc\uac10\ub3c4\uc640 \ud2b9\uc774\ub3c4\uc758 \uade0\ud615\uc774 \uc6b0\uc218\ud568\uc744 \uc758\ubbf8\ud55c\ub2e4. \ubcf8 \uc5f0\uad6c\ub294 \uae30\uacc4\ud559\uc2b5 \ubaa8\ub378\uc744 \uc774\uc6a9\ud574 \ub2e4\ubcc0\ub7c9 \ub2e8\ubc31\uc9c8 \ub370\uc774\ud130\ub97c \ud559\uc2b5\uc2dc\ucf1c \uc554 \uc5ec\ubd80\ub97c \ud310\ubcc4\ud588\ub2e4. \ub2e4\ub9cc \ud310\ubcc4 \ubaa8\ub378\uc758 \uc784\uc0c1 \uc801\uc6a9\uc744 \uc704\ud574\uc11c\ub294 \uc804\ud5a5\uc801 \uac80\uc99d\uacfc \ud45c\uc900\ud654\ub41c \uc808\ucc28\uac00 \ud544\uc218\uc801\uc774\ub2e4.<\/p>\n<\/details>\n<\/aside>\n<h2>\ubd88\ud655\uc2e4\ud55c \ubd80\ubd84<\/h2>\n<ul>\n<li>\ucd08\uae30 \ub2e8\uacc4 \uc554 \ud658\uc790\uc5d0\uc11c\uc758 \uc131\ub2a5: \uc5f0\uad6c \ub300\uc0c1\uc5d0 \uc804\uc774\uc131 \ud658\uc790\uac00 \ub2e4\uc218 \ud3ec\ud568\ub418\uc5b4 \uc788\uc5b4 \uc870\uae30\uc554\uc5d0\uc11c \ub3d9\uc77c\ud55c AUC\ub97c \ubcf4\uc77c\uc9c0\ub294 \ud655\uc778\ub418\uc9c0 \uc54a\uc558\ub2e4.<\/li>\n<li>\uc77c\ubc18\ud654 \uac00\ub2a5\uc131: \uc2a4\uc6e8\ub374 \ucf54\ud638\ud2b8 \uae30\ubc18 \uacb0\uacfc\uc774\ubbc0\ub85c \ub2e4\ub978 \uc778\uc885\u00b7\uc9c0\uc5ed \uc9d1\ub2e8\uc5d0\uc11c\uc758 \uc720\ud6a8\uc131\uc740 \ucd94\uac00 \uac80\uc99d\uc774 \ud544\uc694\ud558\ub2e4.<\/li>\n<li>\uc784\uc0c1\uc801 \ud6a8\uacfc(\uc0dd\uc874\uc728 \uac1c\uc120): \uc774 \uac80\uc0ac\uac00 \uc2e4\uc81c\ub85c \uc870\uae30\uc9c4\ub2e8\uc744 \ud1b5\ud55c \uce58\ub8cc \uc131\uacfc \uac1c\uc120\uc73c\ub85c \uc774\uc5b4\uc9c0\ub294\uc9c0\ub294 \uc7a5\uae30 \ucd94\uc801 \uc5f0\uad6c\uac00 \ud544\uc694\ud558\ub2e4.<\/li>\n<li>\uc704\uc591\uc131\u00b7\uc704\uc74c\uc131\uc758 \uc784\uc0c1\uc801 \ube44\uc6a9: \ub0ae\uc740 \uc720\ubcd1\ub960 \ud658\uacbd\uc5d0\uc11c\uc758 \uc591\uc131\uc608\uce21\ub3c4\uc640 \ud6c4\uc18d \uac80\uc0ac \ubd80\ub2f4 \ub4f1\uc740 \uc544\uc9c1 \ubd88\ud655\uc2e4\ud558\ub2e4.<\/li>\n<\/ul>\n<h2>\ucd1d\ud3c9<\/h2>\n<p>\uc774\ubc88 \uc5f0\uad6c\ub294 \ub2e4\uc218\uc758 \ub2e8\ubc31\uc9c8 \ud328\ud134\uc744 \uc774\uc6a9\ud574 \ube44\ud2b9\uc774\uc801 \uc99d\uc0c1\uc744 \ubcf4\uc774\ub294 \ud658\uc790\uad70\uc5d0\uc11c \uc554\uc744 \uc120\ubcc4\ud560 \uac00\ub2a5\uc131\uc744 \uc81c\uc2dc\ud588\ub2e4\ub294 \uc810\uc5d0\uc11c \uc758\ubbf8\uac00 \ud06c\ub2e4. \ud2b9\ud788 PEA \uae30\ubc18\uc758 \ub300\uaddc\ubaa8 \ub2e8\ubc31\uc9c8 \uce21\uc815\uacfc \uae30\uacc4\ud559\uc2b5 \uacb0\ud569\uc740 \ud5a5\ud6c4 \uc561\uccb4\uc0dd\uac80 \ubd84\uc57c\uc758 \uc120\ud0dd\uc9c0\ub97c \ub113\ud600\uc904 \uc218 \uc788\ub2e4. \uadf8\ub7ec\ub098 \ud604\uc7ac \uc131\ub2a5 \uc9c0\ud45c\ub294 \uc720\ub9dd\ud558\uc9c0\ub9cc, \uc804\uc774\uc131 \uc911\uc2ec\uc758 \ucf54\ud638\ud2b8\u00b7\uc2a4\uc6e8\ub374 \ub2e8\uc77c \uc9c0\uc5ed \ub370\uc774\ud130\ub77c\ub294 \ud55c\uacc4\ub97c \uac16\uace0 \uc788\uc5b4 \ubcf4\ud3b8\uc801 \uc801\uc6a9\uc744 \uc704\ud574\uc11c\ub294 \ub2e4\uad6d\uac00\u00b7\ub2e4\uc9d1\ub2e8 \uc804\ud5a5\uc801 \uac80\uc99d\uc774 \uc120\ud589\ub418\uc5b4\uc57c \ud55c\ub2e4.<\/p>\n<p>\uc2e4\ubb34\uc801\uc73c\ub85c\ub294 \uc774 \uac80\uc0ac\uac00 \uc870\uc9c1\uac80\uc0ac\u00b7\uc601\uc0c1\uac80\uc0ac\ub97c \ub300\uccb4\ud558\ub294 \uac83\uc774 \uc544\ub2c8\ub77c &#8216;\ub204\uac00 \ub354 \uc815\ubc00\uac80\uc0ac\uac00 \ud544\uc694\ud55c\uac00&#8217;\ub97c \ud310\ub2e8\ud558\ub294 \ud2b8\ub9ac\uc544\uc9c0 \ub3c4\uad6c\ub85c \uc124\uacc4\ub418\uc5c8\ub2e4\ub294 \uc810\uc744 \uba85\ud655\ud788 \uc774\ud574\ud558\ub294 \uac83\uc774 \uc911\uc694\ud558\ub2e4. \uc55e\uc73c\ub85c \ud575\uc2ec \uad00\uac74\uc740 1\ucc28 \uc758\ub8cc \ud658\uacbd\uc5d0\uc11c\uc758 \uc608\uce21\uac12, \uac80\uc0ac\uc758 \ube44\uc6a9\ud6a8\uc6a9\uc131, \uaddc\uc81c\u00b7\ubcf4\ud5d8 \uc801\uc6a9 \uc5ec\ubd80\uac00 \ub420 \uac83\uc774\ub2e4. \ub3c5\uc790\ub4e4\uc740 \ud5a5\ud6c4 \uce74\ub864\ub9b0\uc2a4\uce74 \uc5f0\uad6c\uc9c4\uc758 \uc804\ud5a5\uc801 \uac80\uc99d \uacb0\uacfc\uc640 \uaddc\uc81c \uc808\ucc28 \uc9c4\ud589 \uc0c1\ud669\uc744 \uc8fc\ubaa9\ud560 \ud544\uc694\uac00 \uc788\ub2e4.<\/p>\n<h2>\ucd9c\ucc98<\/h2>\n<ul>\n<li><a href=\"https:\/\/www.biotimes.co.kr\/news\/articleView.html?idxno=26589\" target=\"_blank\" rel=\"noopener\">\ubc14\uc774\uc624\ud0c0\uc784\uc988 \uae30\uc0ac<\/a> \u2014 \uc5b8\ub860(\ubcf4\ub3c4\uc790\ub8cc \uae30\ubc18 \ucde8\uc7ac)<\/li>\n<li><a href=\"https:\/\/www.nature.com\/ncomms\/\" target=\"_blank\" rel=\"noopener\">Nature Communications<\/a> \u2014 \ud559\uc220\uc9c0(\uac8c\uc7ac\ucc98)<\/li>\n<\/ul>\n<\/article>\n","protected":false},"excerpt":{"rendered":"<p>\ud575\uc2ec \uc694\uc57d \uc2a4\uc6e8\ub374 \uce74\ub864\ub9b0\uc2a4\uce74 \uc5f0\uad6c\uc18c \ub4f1 \uacf5\ub3d9\uc5f0\uad6c\uc9c4\uc774 \ud608\uc7a5 \ub2e8\ubc31\uc9c8 1,463\uc885\uc744 \ubd84\uc11d\ud574 29\uc885\uc758 \ub2e8\ubc31\uc9c8 \uc870\ud569\uc73c\ub85c \uad6c\uc131\ub41c \u2018\ub2e8\ubc31\uc9c8 \uc2dc\uadf8\ub2c8\ucc98\u2019\ub97c \uaddc\uba85\ud588\ub2e4. 2025\ub144 12\uc6d4 29\uc77c Nature Communications\uc5d0 \uac8c\uc7ac\ub41c \uc774 \uc5f0\uad6c\ub294 \ub2e8\uc21c\ud55c \ud53c\ub85c\u00b7\uccb4\uc911\uac10\uc18c \ub4f1 \ube44\ud2b9\uc774\uc801 \uc99d\uc0c1 \ud658\uc790 \uac00\uc6b4\ub370 \uc554 \ud658\uc790\ub97c \uc120\ubcc4\ud558\ub294 \uc778\uacf5\uc9c0\ub2a5 \ubaa8\ub378\uc744 \uc81c\uc2dc\ud588\uc73c\uba70, \ucd08\uae30 \uac80\uc99d\uc5d0\uc11c AUC 0.80~0.82\ub97c \uae30\ub85d\ud588\ub2e4. \uc5f0\uad6c\uc9c4\uc740 \uc774 \uac80\uc0ac\uac00 \uc870\uc9c1\uac80\uc0ac\ub098 \uc601\uc0c1 \uc9c4\ub2e8\uc744 \uc644\uc804\ud788 \ub300\uccb4\ud558\ub294 \uac83\uc774 \uc544\ub2c8\ub77c, \uc815\ubc00 &#8230; <a title=\"\u201c\ub2e8\uc21c\ud55c \ud53c\ub85c\uc778 \uc904 \uc54c\uc558\ub294\ub370 \uc554?\u201d\u2026 \ud53c \ud55c \ubc29\uc6b8\ub85c \ubaa8\ud638\ud55c \uc99d\uc0c1 \uc18d \u2018\uc554\uc138\ud3ec\u2019 \uac00\ub824\ub0b8\ub2e4 &#8211; \ubc14\uc774\uc624\ud0c0\uc784\uc988\" class=\"read-more\" href=\"https:\/\/readtrends.com\/ko\/blood-protein-cancer-signature\/\" aria-label=\"\u201c\ub2e8\uc21c\ud55c \ud53c\ub85c\uc778 \uc904 \uc54c\uc558\ub294\ub370 \uc554?\u201d\u2026 \ud53c \ud55c \ubc29\uc6b8\ub85c \ubaa8\ud638\ud55c \uc99d\uc0c1 \uc18d \u2018\uc554\uc138\ud3ec\u2019 \uac00\ub824\ub0b8\ub2e4 &#8211; \ubc14\uc774\uc624\ud0c0\uc784\uc988\uc5d0 \ub300\ud574 \ub354 \uc790\uc138\ud788 \uc54c\uc544\ubcf4\uc138\uc694\">\ub354 \uc77d\uae30<\/a><\/p>\n","protected":false},"author":1,"featured_media":7005,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"rank_math_title":"\ud53c \ud55c \ubc29\uc6b8\ub85c \ube44\ud2b9\uc774 \uc99d\uc0c1\uc11c \uc554 \ud310\ubcc4 \u2014 \ubc14\uc774\uc624\ud0c0\uc784\uc988","rank_math_description":"\uce74\ub864\ub9b0\uc2a4\uce74 \uc5f0\uad6c\uc9c4\uc774 \ud608\uc7a5 \ub2e8\ubc31\uc9c8 1,463\uc885\uc744 \ubd84\uc11d\ud574 29\ub2e8\ubc31\uc9c8 \uc2dc\uadf8\ub2c8\ucc98\uc640 AI \ubaa8\ub378(AUC 0.80\u20130.82)\uc744 \uc81c\uc2dc\ud588\ub2e4. \ube44\ud2b9\uc774\uc801 \uc99d\uc0c1\uc758 \uc554 \uc120\ubcc4 \ubcf4\uc870\ub3c4\uad6c\ub85c\uc11c\uc758 \uac00\ub2a5\uc131\uacfc \ud55c\uacc4\ub97c 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