{"id":7208,"date":"2026-01-23T10:07:07","date_gmt":"2026-01-23T01:07:07","guid":{"rendered":"https:\/\/readtrends.com\/ko\/obesity-vascular-dementia-hypertension\/"},"modified":"2026-01-23T10:07:07","modified_gmt":"2026-01-23T01:07:07","slug":"obesity-vascular-dementia-hypertension","status":"publish","type":"post","link":"https:\/\/readtrends.com\/ko\/obesity-vascular-dementia-hypertension\/","title":{"rendered":"\ube44\ub9cc\uc774 \ud608\uad00\uc131 \uce58\ub9e4 \uc704\ud5d8 \ub192\uc778\ub2e4\u2026\uace0\ud608\uc555\uc774 \uc8fc\uc694 \ub9e4\uac1c\uc694\uc778"},"content":{"rendered":"<article>\n<h2>\ud575\uc2ec \uc694\uc57d<\/h2>\n<p>\ub374\ub9c8\ud06c \ucf54\ud39c\ud558\uac90\ub300 \uc5f0\uad6c\ud300\uc774 23\uc77c \ubc1c\ud45c\ud55c \ubd84\uc11d\uc5d0\uc11c \uccb4\uc9c8\ub7c9\uc9c0\uc218(BMI)\uac00 \ub192\uc740 \uc0ac\ub78c\uc740 \ud608\uad00\uc131 \uce58\ub9e4 \ubc1c\uc0dd \uc704\ud5d8\uc774 \uc720\uc758\ud558\uac8c \uc99d\uac00\ud558\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\ub2e4. \uc5f0\uad6c\ub294 \ucf54\ud39c\ud558\uac90\uc2dc \uc2ec\uc7a5\uc5f0\uad6c(CCHS) 12\ub9cc6,655\uba85\uacfc \uc601\uad6d \ubc14\uc774\uc624\ubc45\ud06c 37\ub9cc7,755\uba85\uc744 \ud3ec\ud568\ud55c \uc57d 50\ub9cc \uba85 \uaddc\ubaa8\uc758 \uc720\uc804\uccb4 \ub370\uc774\ud130\ub97c \uba58\ub378 \ubb34\uc791\uc704\ud654(MR)\ub85c \ubd84\uc11d\ud588\ub2e4. \uc5f0\uad6c \uacb0\uacfc BMI\uac00 1 \ud45c\uc900\ud3b8\ucc28\ub9cc\ud07c \uc99d\uac00\ud560 \ub54c \ud608\uad00\uc131 \uce58\ub9e4 \ubc1c\uc0dd \uc704\ud5d8\uc774 \uc57d 1.63\ubc30\ub85c \ucd94\uc815\ub410\uace0, \uc774 \uc5f0\uad00\uc131\uc758 \uc0c1\ub2f9 \ubd80\ubd84\uc774 \uace0\ud608\uc555(\uc218\ucd95\uae30 18%, \uc774\uc644\uae30 25%)\uc744 \ud1b5\ud574 \ub9e4\uac1c\ub418\ub294 \uac83\uc73c\ub85c \ubd84\uc11d\ub410\ub2e4. \uc5f0\uad6c\uc9c4\uc740 \ube44\ub9cc\uacfc \ud608\uc555 \uad00\ub9ac\ub97c \ud1b5\ud55c \uc608\ubc29\uc801 \uac1c\uc785\uc758 \uc911\uc694\uc131\uc744 \uc81c\uc2dc\ud588\ub2e4.<\/p>\n<h2>\ud575\uc2ec \uc0ac\uc2e4<\/h2>\n<ul>\n<li>\uc5f0\uad6c \uc8fc\uccb4: \ub374\ub9c8\ud06c \ucf54\ud39c\ud558\uac90\ub300 \ub8e8\ud2b8 \ud504\ub9ac\ucf00-\uc288\ubbf8\ud2b8 \uad50\uc218\ud300\uc774 \uad6d\uc81c \ud559\uc220\uc9c0 The Journal of Clinical Endocrinology &#038; Metabolism\uc5d0 23\uc77c \uacf5\uac1c\ud55c \uc5f0\uad6c \ub17c\ubb38 \uacb0\uacfc\uc774\ub2e4.<\/li>\n<li>\ub300\uc0c1 \ud45c\ubcf8: \ucf54\ud39c\ud558\uac90\uc2dc \uc2ec\uc7a5\uc5f0\uad6c(CCHS) 12\ub9cc6,655\uba85, \uc601\uad6d \ubc14\uc774\uc624\ubc45\ud06c(UK Biobank) 37\ub9cc7,755\uba85 \ub4f1 \ucd1d \uc57d 50\ub9cc \uba85\uc758 \uc720\uc804\uccb4 \ubc0f \uc784\uc0c1 \ub370\uc774\ud130\uac00 \ubd84\uc11d\ub410\ub2e4.<\/li>\n<li>\uc5f0\uad6c\ubc29\ubc95: \uba58\ub378 \ubb34\uc791\uc704\ud654(MR) \uae30\ubc95\uc744 \uc0ac\uc6a9\ud574 BMI\ub97c \uc99d\uac00\uc2dc\ud0a4\ub294 \uc720\uc804 \ubcc0\uc774\ub97c \ub3c4\uad6c\ubcc0\uc218\ub85c \ud65c\uc6a9, BMI\uc640 \ud608\uad00\uc131 \uce58\ub9e4 \uc0ac\uc774\uc758 \uc778\uacfc\uad00\uacc4\ub97c \ud3c9\uac00\ud588\ub2e4.<\/li>\n<li>\uc8fc\uc694 \uacb0\uacfc(\uc885\ud569): BMI\uac00 1 \ud45c\uc900\ud3b8\ucc28 \uc99d\uac00\ud560 \ub54c \ud608\uad00\uc131 \uce58\ub9e4 \ubc1c\uc0dd \uc704\ud5d8\uc740 \uc57d 1.63\ubc30\ub85c \ucd94\uc815\ub410\uc73c\uba70, \ubbfc\uac10\ub3c4 \ubd84\uc11d\uc5d0\uc11c 1.54~1.98\ubc30 \ubc94\uc704\ub97c \ubcf4\uc600\ub2e4.<\/li>\n<li>\ub9e4\uac1c \ubd84\uc11d: BMI\uac00 \ud608\uad00\uc131 \uce58\ub9e4 \uc704\ud5d8\uc744 \ub192\uc774\ub294 \ud6a8\uacfc \uc911 \uc57d 18%\ub294 \uc218\ucd95\uae30 \ud608\uc555\uc744 \ud1b5\ud574, \uc57d 25%\ub294 \uc774\uc644\uae30 \ud608\uc555\uc744 \ud1b5\ud574 \ub9e4\uac1c\ub418\ub294 \uac83\uc73c\ub85c \ucd94\uc815\ub410\ub2e4.<\/li>\n<li>\uc784\uc0c1\uc801 \uc2dc\uc0ac\uc810: \uc5f0\uad6c\uc9c4\uc740 \ub192\uc740 BMI\uc640 \uace0\ud608\uc555\uc758 \uad00\ub9ac\ub97c \ud1b5\ud574 \ud608\uad00\uc131 \uce58\ub9e4 \uc608\ubc29 \uac00\ub2a5\uc131\uc744 \uc81c\uc2dc\ud588\uc73c\ub098, \uc778\uc9c0 \uc800\ud558\uac00 \uc774\ubbf8 \uc9c4\ud589\ub41c \uc0c1\ud0dc\uc5d0\uc11c \uccb4\uc911\uac10\ub7c9 \uc57d\ubb3c\uc758 \ud6a8\uacfc\ub294 \uc77c\uad00\ub418\uac8c \ud655\uc778\ub418\uc9c0 \uc54a\uc558\ub2e4\uace0 \ubc1d\ud614\ub2e4.<\/li>\n<\/ul>\n<h2>\uc0ac\uac74 \ubc30\uacbd<\/h2>\n<p>\uce58\ub9e4\ub294 \uc2dc\uac04\uc774 \uc9c0\ub0a8\uc5d0 \ub530\ub77c \uc2e0\uacbd\uc138\ud3ec \uc190\uc0c1\uc774 \uc9c4\ud589\ub418\uc5b4 \uae30\uc5b5, \uc5b8\uc5b4, \ubb38\uc81c \ud574\uacb0 \ub2a5\ub825 \ub4f1\uc744 \uc800\ud558\uc2dc\ucf1c \uacf5\uc911\ubcf4\uac74 \uce21\uba74\uc5d0\uc11c \ud070 \ubd80\ub2f4\uc744 \uc900\ub2e4. \ud2b9\ud788 \ud608\uad00\uc131 \uce58\ub9e4\ub294 \ub1cc\ud608\uad00 \ubcd1\ubcc0\uc774\ub098 \ud608\ub958\uc7a5\uc560\uc640 \uc5f0\uad00\ub41c \uce58\ub9e4 \uc720\ud615\uc73c\ub85c, \uace0\ud608\uc555\u00b7\ub2f9\ub1e8\u00b7\uace0\uc9c0\ud608\uc99d \ub4f1 \ud608\uad00 \uc704\ud5d8\uc694\uc778\uacfc \ubc00\uc811\ud55c \uad00\ub828\uc774 \uc788\ub2e4. \uc778\uad6c \uace0\ub839\ud654\uc640 \ud568\uaed8 \uce58\ub9e4 \uc720\ubcd1\ub960\uc774 \uc99d\uac00\ud558\ub294 \uc0c1\ud669\uc5d0\uc11c, \uce58\ub9e4\uc758 \uc608\ubc29 \uac00\ub2a5\ud55c \uc704\ud5d8\uc694\uc778\uc744 \uaddc\uba85\ud558\ub824\ub294 \uc5f0\uad6c\ub294 \uc815\ucc45\u00b7\uc784\uc0c1\uc758 \uc6b0\uc120 \uacfc\uc81c\uac00 \ub410\ub2e4. \uc774\uc804 \uad00\ucc30\uc5f0\uad6c\ub4e4\uc740 \ube44\ub9cc\uacfc \uc778\uc9c0\uae30\ub2a5 \uc800\ud558\uc758 \uc5f0\uad00\uc131\uc744 \ubcf4\uace0\ud588\uc9c0\ub9cc, \uc778\uacfc\uad00\uacc4 \uaddc\uba85\uc744 \uc704\ud574\uc11c\ub294 \uc5ed\ud559\uc801 \uad50\ub780\uc744 \ubc30\uc81c\ud55c \ucd94\uac00 \uc5f0\uad6c\uac00 \uc694\uad6c\ub410\ub2e4.<\/p>\n<p>\uba58\ub378 \ubb34\uc791\uc704\ud654(Mendelian randomization)\ub294 \uc720\uc804\uc801 \ubcc0\uc774\ub97c \ub3c4\uad6c\ubcc0\uc218\ub85c \uc0ac\uc6a9\ud574 \ub178\ucd9c(\uc608: \ub192\uc740 BMI)\uacfc \uacb0\uacfc(\uc608: \uce58\ub9e4) \uc0ac\uc774\uc758 \uc778\uacfc\uad00\uacc4\ub97c \ud3c9\uac00\ud558\ub294 \ubc29\ubc95\uc774\ub2e4. \uc774 \uae30\ubc95\uc740 \uad00\ucc30\uc5f0\uad6c\uc5d0\uc11c \ud754\ud55c \uc5ed\uc778\uacfc\uc131(reverse causation)\uacfc \ud63c\ub780(confounding)\uc744 \uc904\uc77c \uc218 \uc788\uc5b4 \uc778\uacfc\ucd94\ub860\uc744 \ubcf4\uac15\ud55c\ub2e4. \ub2e4\ub9cc MR\uc758 \uc804\uc81c(\uc608: \uc720\uc804\uc801 \ub3c4\uad6c\uac00 \uc624\uc9c1 \uad00\uc2ec \ub178\ucd9c\uc744 \ud1b5\ud574\uc11c\ub9cc \uacb0\uacfc\uc5d0 \uc601\ud5a5\uc744 \uc900\ub2e4\ub294 \uac00\uc815)\ub294 \uc5c4\uaca9\ud558\uba70, \uc774\ub97c \uac80\uc99d\ud558\uae30 \uc704\ud55c \ubbfc\uac10\ub3c4 \ubd84\uc11d\uc774 \ud544\uc218\uc801\uc774\ub2e4.<\/p>\n<h2>\uc8fc\uc694 \uc0ac\uac74<\/h2>\n<p>\uc5f0\uad6c\ud300\uc740 \ucf54\ud39c\ud558\uac90\uacfc \uc601\uad6d\uc758 \ub300\uaddc\ubaa8 \ucf54\ud638\ud2b8\uc5d0\uc11c \ud655\ubcf4\ud55c \uc720\uc804\uccb4 \ub370\uc774\ud130\ub97c \uc774\uc6a9\ud574 BMI \uad00\ub828 \uc720\uc804 \ubcc0\uc774\ub97c \uc120\uc815\ud558\uace0, \uc774\ub97c \ud1b5\ud574 BMI\uac00 \ud608\uad00\uc131 \uce58\ub9e4 \uc704\ud5d8\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5\uc744 \ub2e8\uacc4\uc801\uc73c\ub85c \ud3c9\uac00\ud588\ub2e4. \ubd84\uc11d \uacb0\uacfc BMI \uc99d\uac00\uc640 \ud608\uad00\uc131 \uce58\ub9e4 \uc0ac\uc774\uc5d0 \uc77c\uad00\ub41c \uc815(+)\uc758 \uc778\uacfc \ubc29\ud5a5\uc131\uc774 \ud655\uc778\ub410\ub2e4. \ub450 \ud45c\ubcf8\uc758 \uacb0\uacfc\ub97c \uc885\ud569\ud55c \uba54\ud0c0\ubd84\uc11d\uc5d0\uc11c BMI 1\ud45c\uc900\ud3b8\ucc28 \uc99d\uac00 \uc2dc \ud608\uad00\uc131 \uce58\ub9e4 \uc704\ud5d8\uc740 1.63\ubc30\ub85c \ucd94\uc815\ub410\uace0, \ubbfc\uac10\ub3c4 \ubd84\uc11d\uc5d0\uc11c\ub3c4 \uc720\uc0ac\ud55c \ubc94\uc704(1.54~1.98)\uac00 \uad00\ucc30\ub410\ub2e4.<\/p>\n<p>\uc5f0\uad6c\uc9c4\uc740 \ucd94\uac00\ub85c \ub9e4\uac1c\ubd84\uc11d(mediation analysis)\uc744 \uc218\ud589\ud574 BMI\uac00 \uce58\ub9e4 \uc704\ud5d8\uc744 \ub192\uc774\ub294 \uacbd\ub85c\ub97c \ubd84\ud574\ud588\ub2e4. \uadf8 \uacb0\uacfc \uc218\ucd95\uae30 \ud608\uc555\uc744 \ud1b5\ud55c \ub9e4\uac1c\ud6a8\uacfc\ub294 \uc57d 18%, \uc774\uc644\uae30 \ud608\uc555\uc744 \ud1b5\ud55c \ub9e4\uac1c\ud6a8\uacfc\ub294 \uc57d 25%\ub85c \uc0b0\uc815\ub418\uc5b4 \uace0\ud608\uc555 \uad00\ub9ac\uac00 \uc911\uc694\ud55c \uc911\uc7ac \uc9c0\uc810\uc784\uc744 \uc2dc\uc0ac\ud588\ub2e4. \ubc18\uba74 \uace0\uc9c0\ud608\uc99d\uc774\ub098 \uace0\ud608\ub2f9\uc744 \ud1b5\ud55c \ub9e4\uac1c\ube44\uc728\uc740 \uc0c1\ub300\uc801\uc73c\ub85c \uc801\uac8c \ub098\ud0c0\ub0ac\ub2e4\uace0 \ubcf4\uace0\ud588\ub2e4.<\/p>\n<p>\ud504\ub9ac\ucf00-\uc288\ubbf8\ud2b8 \uad50\uc218\ub294 \uc5f0\uad6c \uacb0\uacfc\ub97c \uadfc\uac70\ub85c \ube44\ub9cc\uacfc \uace0\ud608\uc555\uc758 \uc608\ubc29\u00b7\uce58\ub8cc\uac00 \ud608\uad00\uc131 \uce58\ub9e4 \uc704\ud5d8 \uacbd\uac10\uc5d0 \uae30\uc5ec\ud560 \uc218 \uc788\uc74c\uc744 \uac15\uc870\ud588\ub2e4. \ub2e4\ub9cc \uc5f0\uad6c\uc9c4\uc740 \uc778\uc9c0\uc800\ud558\uac00 \uc774\ubbf8 \uc9c4\ud589\ub41c \ud658\uc790\uc5d0\uc11c \uccb4\uc911\uac10\ub7c9 \uc57d\ubb3c\uc758 \uc784\uc0c1\uc801 \ud6a8\uacfc\uac00 \uba85\ud655\ud558\uc9c0 \uc54a\ub2e4\ub294 \ucd5c\uadfc \uc784\uc0c1\uc2dc\ud5d8 \uacb0\uacfc\ub3c4 \ud568\uaed8 \uc5b8\uae09\ud574, \uc608\ubc29\uc801 \uc2dc\uc810\uc758 \uccb4\uc911\uad00\ub9ac\uc758 \uc911\uc694\uc131\uc744 \ubd80\uac01\ud588\ub2e4.<\/p>\n<h2>\ubd84\uc11d \ubc0f \uc758\ubbf8<\/h2>\n<p>\uc774 \uc5f0\uad6c\ub294 \ub192\uc740 BMI\uac00 \ub2e8\uc21c\ud55c \uc5f0\uad00\uc131 \uc218\uc900\uc744 \ub118\uc5b4 \ud608\uad00\uc131 \uce58\ub9e4\uc758 \uc778\uacfc\uc801 \uc704\ud5d8\uc694\uc778\uc77c \uac00\ub2a5\uc131\uc744 \uc81c\uc2dc\ud55c\ub2e4. MR \uae30\ubc95\uc744 \ud65c\uc6a9\ud574 \uad50\ub780\uc694\uc778\uc744 \uc904\uc600\ub2e4\ub294 \uc810\uc5d0\uc11c \uad00\ucc30\uc5f0\uad6c\ubcf4\ub2e4 \uac15\ud55c \uc778\uacfc\ucd94\ub860 \uadfc\uac70\ub97c \uc81c\uacf5\ud558\uc9c0\ub9cc, \uc644\uc804\ud55c \uc778\uacfc\uc99d\uba85\uc73c\ub85c \ubcf4\uae30\ub294 \uc5b4\ub835\ub2e4. \ud2b9\ud788 MR\uc740 \uc120\uc815\ub41c \uc720\uc804\uc801 \ud45c\uc9c0\uac00 \uc678\ubd80 \uacbd\ub85c(pleiotropy)\ub97c \ud1b5\ud574 \uacb0\uacfc\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\uc9c0 \uc54a\ub294\ub2e4\ub294 \uac00\uc815\uc744 \uc804\uc81c\ub85c \ud558\ubbc0\ub85c \uc774\ub7ec\ud55c \uac00\uc815 \uc704\ubc30 \uc5ec\ubd80\ub294 \uacb0\uacfc \ud574\uc11d\uc5d0 \uc911\uc694\ud55c \ubcc0\uc218\ub2e4.<\/p>\n<p>\uc815\ucc45\uc801 \uce21\uba74\uc5d0\uc11c\ub294 BMI\uc640 \ud608\uc555 \uad00\ub9ac\uc758 \ud1b5\ud569\uc801 \uc811\uadfc\uc774 \uce58\ub9e4 \uc608\ubc29 \uc804\ub7b5\uc5d0 \ud3ec\ud568\ub420 \uadfc\uac70\ub97c \ubcf4\uac15\ud55c\ub2e4. \uace0\ud608\uc555\uc774 BMI-\uce58\ub9e4 \uc5f0\uad00\uc131\uc758 \uc911\uc694\ud55c \ub9e4\uac1c\uc784\uc744 \uace0\ub824\ud558\uba74, \ud608\uc555 \uc870\uc808\uc744 \uc911\uc2ec\uc73c\ub85c \ud55c \uc870\uae30 \uc911\uc7ac\uac00 \ud608\uad00\uc131 \uce58\ub9e4 \ubc1c\uc0dd\uc744 \uc904\uc774\ub294 \ub370 \ud6a8\uacfc\uc801\uc77c \uc218 \uc788\ub2e4. \uc784\uc0c1\uc801\uc73c\ub85c\ub294 \uccb4\uc911 \uac10\ub7c9 \uc790\uccb4\uac00 \uc9c1\uc811\uc801\uc778 \uc778\uc9c0 \uac1c\uc120\uc73c\ub85c \uc5f0\uacb0\ub418\ub294\uc9c0\uc5d0 \ub300\ud55c \ucd94\uac00 \uc784\uc0c1\uc2dc\ud5d8\uacfc \uc7a5\uae30 \ucd94\uc801 \ub370\uc774\ud130\uac00 \ud544\uc694\ud558\ub2e4.<\/p>\n<p>\uad6d\uac00\ubcc4\u00b7\uc778\uc885\ubcc4 \uc77c\ubc18\ud654 \uac00\ub2a5\uc131\uc5d0\ub3c4 \uc8fc\uc758\uac00 \ud544\uc694\ud558\ub2e4. \ubcf8 \uc5f0\uad6c\uc758 \ud45c\ubcf8\uc740 \ucf54\ud39c\ud558\uac90 \ubc0f UK Biobank\uc758 \uc8fc\ub85c \uc720\ub7fd\uacc4 \ucc38\uac00\uc790\ub85c \uad6c\uc131\ub3fc \uc788\uc5b4 \ub2e4\ub978 \uc778\uad6c\uc9d1\ub2e8\uc5d0\uc11c \ub3d9\uc77c\ud55c \ud6a8\uacfc\uac00 \uc7ac\ud604\ub418\ub294\uc9c0 \ud655\uc778\ud558\ub294 \ud6c4\uc18d \uc5f0\uad6c\uac00 \uc694\uad6c\ub41c\ub2e4. \ub610\ud55c \uc2e4\uc81c \uc0dd\ud65c\uc2b5\uad00 \uac1c\uc785\uc774 \uc720\uc804\uc801 \ub9ac\uc2a4\ud06c\ub97c \uc5bc\ub9c8\ub098 \uc0c1\uc1c4\ud560 \uc218 \uc788\ub294\uc9c0\uc5d0 \ub300\ud55c \uc5f0\uad6c\ub294 \uc815\ucc45 \uc124\uacc4\uc5d0 \ud544\uc694\ud55c \uadfc\uac70\ub97c \uc81c\uacf5\ud560 \uac83\uc774\ub2e4.<\/p>\n<h2>\ube44\uad50 \ubc0f \ub370\uc774\ud130<\/h2>\n<figure>\n<table>\n<thead>\n<tr>\n<th>\uc9c0\ud45c<\/th>\n<th>\ucd94\uc815\uac12<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>BMI 1 SD \uc99d\uac00 \uc2dc \ud608\uad00\uc131 \uce58\ub9e4 \uc704\ud5d8(\uc885\ud569)<\/td>\n<td>\uc57d 1.63\ubc30<\/td>\n<\/tr>\n<tr>\n<td>\ubbfc\uac10\ub3c4 \ubd84\uc11d \ubc94\uc704<\/td>\n<td>1.54 ~ 1.98\ubc30<\/td>\n<\/tr>\n<tr>\n<td>\ub9e4\uac1c: \uc218\ucd95\uae30 \ud608\uc555<\/td>\n<td>\uc57d 18%<\/td>\n<\/tr>\n<tr>\n<td>\ub9e4\uac1c: \uc774\uc644\uae30 \ud608\uc555<\/td>\n<td>\uc57d 25%<\/td>\n<\/tr>\n<\/tbody>\n<\/table><figcaption>\uc5f0\uad6c\uac00 \ubcf4\uace0\ud55c \uc8fc\uc694 \uc218\uce58(\ucf54\ud39c\ud558\uac90 CCHS \ubc0f UK Biobank \ud45c\ubcf8 \uae30\ubc18, \uba58\ub378 \ubb34\uc791\uc704\ud654 \uacb0\uacfc).<\/figcaption><\/figure>\n<p>\uc704 \ud45c\ub294 \ub17c\ubb38\uc5d0\uc11c \uc81c\uc2dc\ud55c \uc8fc\uc694 \ud1b5\uacc4 \uc694\uc57d\uc774\ub2e4. \ud45c\uc5d0\uc11c \ubcf4\ub4ef BMI \uc0c1\uc2b9\uc5d0 \ub530\ub978 \ud608\uad00\uc131 \uce58\ub9e4 \uc704\ud5d8 \uc99d\uac00\ub294 \uc77c\uad00\ub41c \ubc29\ud5a5\uc131\uc744 \ubcf4\uc600\uc73c\uba70, \ubbfc\uac10\ub3c4 \ubd84\uc11d\uc5d0\uc11c\ub3c4 \uc720\uc758\ubbf8\ud55c \uc0c1\uc2b9\ud3ed\uc774 \ud655\uc778\ub410\ub2e4. \ub9e4\uac1c \ube44\uc728\uc740 BMI \ud6a8\uacfc \uc911 \ud608\uc555\uc744 \ud1b5\ud574 \uc124\uba85\ub418\ub294 \ubd80\ubd84\uc758 \ube44\uc911\uc744 \ub098\ud0c0\ub0b4\uba70, \uc774\ub294 \ud608\uc555 \uad00\ub9ac\uc758 \uc608\ubc29\uc801 \uc911\uc694\uc131\uc744 \ub4b7\ubc1b\uce68\ud55c\ub2e4. \ub2e4\ub9cc \uc774 \uc218\uce58\ub4e4\uc740 \uc720\uc804\uc801 \ub3c4\uad6c\uc640 \ud45c\ubcf8 \uad6c\uc131\uc5d0 \ub530\ub77c \ubcc0\ub3d9 \uac00\ub2a5\uc131\uc774 \uc788\uc5b4 \ud574\uc11d \uc2dc \uc8fc\uc758\uac00 \ud544\uc694\ud558\ub2e4.<\/p>\n<h2>\ubc18\uc751 \ubc0f \uc778\uc6a9<\/h2>\n<blockquote>\n<p>&#8220;\uc774 \uc5f0\uad6c\ub294 \ub192\uc740 BMI\uc640 \uace0\ud608\uc555\uc774 \uce58\ub9e4\uc758 \uc9c1\uc811\uc801 \uc6d0\uc778\uc774 \ub420 \uc218 \uc788\uc74c\uc744 \ubcf4\uc5ec\uc900\ub2e4. \ube44\ub9cc\uacfc \ud608\uc555\uc744 \uc608\ubc29\ud558\uac70\ub098 \uce58\ub8cc\ud558\uba74 \uce58\ub9e4 \uc704\ud5d8\uc744 \ub0ae\ucd9c \uc218 \uc788\ub2e4\ub294 \uc815\ucc45\uc801 \uc2dc\uc0ac\uc810\uc774 \uc788\ub2e4.&#8221;<\/p>\n<p><cite>Ruth Frikke-Schmidt \uad50\uc218(\ucf54\ud39c\ud558\uac90\ub300, \uc5f0\uad6c\ucc45\uc784\uc790)<\/cite><\/p><\/blockquote>\n<p>\ud504\ub9ac\ucf00-\uc288\ubbf8\ud2b8 \uad50\uc218\uc758 \uc5b8\uae09\uc740 \uc5f0\uad6c\uc758 \uacb0\ub860\uc744 \uc694\uc57d\ud55c \uac83\uc73c\ub85c, \uc608\ubc29\uc801 \ucc28\uc6d0\uc758 \uccb4\uc911\u00b7\ud608\uc555 \uad00\ub9ac\uc758 \ud544\uc694\uc131\uc744 \uac15\uc870\ud55c\ub2e4. \uc5f0\uad6c\uc9c4\uc740 \uc774 \ubc1c\uc5b8\uc744 \ud1b5\ud574 \uacf5\uc911\ubcf4\uac74 \uac1c\uc785\uc758 \uc6b0\uc120\uc21c\uc704\ub97c \uc81c\uc548\ud588\ub2e4.<\/p>\n<blockquote>\n<p>&#8220;\ucd5c\uadfc \uc784\uc0c1\uc2dc\ud5d8\uc5d0\uc11c\ub294 \uccb4\uc911 \uac10\ub7c9 \uc57d\ubb3c\uc774 \uc54c\uce20\ud558\uc774\uba38 \ucd08\uae30 \ub2e8\uacc4\uc758 \uc778\uc9c0\uc800\ud558\ub97c \uba48\ucd94\uc9c0 \ubabb\ud588\ub2e4\ub294 \ubcf4\uace0\uac00 \uc788\ub2e4. \uadf8\ub7ec\ub098 \uc778\uc9c0\uc800\ud558\uac00 \ub098\ud0c0\ub098\uae30 \uc804 \uccb4\uc911 \uac10\ub7c9\uc740 \ud608\uad00\uc131 \uce58\ub9e4 \uc608\ubc29\uc5d0 \uc720\ub9ac\ud560 \uc218 \uc788\ub2e4.&#8221;<\/p>\n<p><cite>\uc5f0\uad6c\ud300 \ucf54\uba58\ud2b8<\/cite><\/p><\/blockquote>\n<p>\uc5f0\uad6c\ud300\uc740 \uc784\uc0c1\uc2dc\ud5d8\uacfc \uc5ed\ud559\uc801 \uc99d\uac70\ub97c \ud568\uaed8 \uace0\ub824\ud574, \uc2dc\uae30\uc801 \uce21\uba74(\uc608\ubc29 \ub300 \uce58\ub8cc)\uc758 \uc911\uc694\uc131\uc744 \uc5b8\uae09\ud588\ub2e4. \uc774\ub294 \uc784\uc0c1 \uc801\uc6a9 \uc2dc\uc810\uacfc \ub300\uc0c1\uc790 \uc120\uc815\uc5d0 \ub300\ud55c \uc2e0\uc911\ud55c \ud310\ub2e8\uc774 \ud544\uc694\ud568\uc744 \ub73b\ud55c\ub2e4.<\/p>\n<aside>\n<details>\n<summary>\uc6a9\uc5b4\/\ubc29\ubc95\ub860<\/summary>\n<p>\uba58\ub378 \ubb34\uc791\uc704\ud654(Mendelian randomization)\ub294 \uc720\uc804\uc801 \ubcc0\uc774\ub97c \uc790\uc5f0\uc2e4\ud5d8 \ub3c4\uad6c\ub85c \ud65c\uc6a9\ud574 \ub178\ucd9c\uacfc \uacb0\uacfc \uc0ac\uc774\uc758 \uc778\uacfc\uad00\uacc4\ub97c \ucd94\uc815\ud558\ub294 \ubc29\ubc95\uc774\ub2e4. \uad00\ucc30\uc5f0\uad6c\uc5d0\uc11c\uc758 \uad50\ub780\uc694\uc778\uacfc \uc5ed\uc778\uacfc\uc131 \ubb38\uc81c\ub97c \uc0c1\ub300\uc801\uc73c\ub85c \uc904\uc77c \uc218 \uc788\uc73c\ub098, \uc720\uc804\uc801 \ub3c4\uad6c\uc758 \uc801\ud569\uc131(\ub3c4\uad6c\ubcc0\uc218 \uac00\uc815 \ucda9\uc871)\uacfc \uc720\uc804\uc790 \ub2e4\ud5a5\uc131(pleiotropy) \uac80\ud1a0\uac00 \ud544\uc218\uc801\uc774\ub2e4. \ud45c\uc900\ud3b8\ucc28(SD)\ub294 \ubcc0\uc218\uc758 \ubd84\ud3ec \ud3ed\uc744 \ub098\ud0c0\ub0b4\uba70, \uc5f0\uad6c\uc5d0\uc11c\ub294 BMI 1 SD \uc0c1\uc2b9\uc744 \ub178\ucd9c \ub2e8\uc704\ub85c \uc0ac\uc6a9\ud588\ub2e4. \ub9e4\uac1c\ubd84\uc11d\uc740 \ub178\ucd9c\uc774 \uacb0\uacfc\uc5d0 \ubbf8\uce58\ub294 \uacbd\ub85c\ub97c \ubd84\ud574\ud574 \uc911\uac04 \uc694\uc778\uc758 \uae30\uc5ec\ub3c4\ub97c \ud3c9\uac00\ud55c\ub2e4.<\/p>\n<\/details>\n<\/aside>\n<h2>\ubd88\ud655\uc2e4\ud55c \ubd80\ubd84<\/h2>\n<ul>\n<li>MR \ubd84\uc11d\uc758 \uc804\uc81c\uc778 \ub3c4\uad6c\ubcc0\uc218\uc758 \ubc30\ud0c0\uc131(pleiotropy \ubd80\uc7ac)\uc774 \uc644\uc804\ud788 \ucda9\uc871\ub418\uc5c8\ub294\uc9c0\ub294 \ucd94\uac00 \uac80\uc99d\uc774 \ud544\uc694\ud558\ub2e4.<\/li>\n<li>\uc5f0\uad6c \ud45c\ubcf8\uc774 \uc8fc\ub85c \uc720\ub7fd\uacc4 \ucf54\ud638\ud2b8\uc774\ubbc0\ub85c \ub2e4\ub978 \uc778\uc885\u00b7\uc9c0\uc5ed\uc5d0\uc11c \ub3d9\uc77c\ud55c \uc778\uacfc\uad00\uacc4\uac00 \uc7ac\ud604\ub418\ub294\uc9c0\ub294 \ubd88\ud655\uc2e4\ud558\ub2e4.<\/li>\n<li>\uc720\uc804\uc801\uc73c\ub85c \ub192\uc740 BMI\uac00 \uc2e4\uc81c \uc0dd\ud65c\uc2b5\uad00 \uac1c\uc785(\uccb4\uc911 \uac10\uc18c \ub4f1)\uc5d0 \uc758\ud574 \uc5b4\ub290 \uc815\ub3c4 \uc0c1\uc1c4\ub420 \uc218 \uc788\ub294\uc9c0\uc5d0 \ub300\ud55c \uadfc\uac70\ub294 \ubd80\uc871\ud558\ub2e4.<\/li>\n<\/ul>\n<h2>\ucd1d\ud3c9<\/h2>\n<p>\uc774\ubc88 \uc5f0\uad6c\ub294 \ub300\uaddc\ubaa8 \uc720\uc804\uccb4 \uae30\ubc18 \ubd84\uc11d\uc744 \ud1b5\ud574 \ub192\uc740 BMI\uac00 \ud608\uad00\uc131 \uce58\ub9e4 \uc704\ud5d8\uc744 \uc99d\uac00\uc2dc\ud0a4\uba70, \uadf8 \uc601\ud5a5\uc758 \uc0c1\ub2f9 \ubd80\ubd84\uc774 \uace0\ud608\uc555\uc744 \ud1b5\ud574 \ub9e4\uac1c\ub41c\ub2e4\ub294 \uc810\uc744 \uc81c\uc2dc\ud588\ub2e4. \uba58\ub378 \ubb34\uc791\uc704\ud654 \ubc29\ubc95\uc744 \uc0ac\uc6a9\ud574 \uc778\uacfc\ucd94\ub860\uc744 \uac15\ud654\ud55c \uc810\uc740 \uc911\uc694\ud55c \uae30\uc5ec\uc774\ub098, \ubc29\ubc95\ub860\uc801 \ud55c\uacc4\uc640 \ud45c\ubcf8 \uad6c\uc131\uc758 \uc81c\uc57d\uc740 \uacb0\uacfc\uc758 \uc77c\ubc18\ud654 \uac00\ub2a5\uc131\uc744 \uc81c\ud55c\ud55c\ub2e4.<\/p>\n<p>\uc815\ucc45\uc801\u00b7\uc784\uc0c1\uc801\uc73c\ub85c\ub294 \uccb4\uc911\uacfc \ud608\uc555 \uc870\uc808\uc744 \ud1b5\ud569\ud55c \uc608\ubc29 \uc804\ub7b5\uc744 \uac15\ud654\ud560 \uadfc\uac70\uac00 \ub9c8\ub828\ub410\ub2e4. \ud5a5\ud6c4 \ub2e4\uc591\ud55c \uc778\uad6c\uc9d1\ub2e8\uc5d0\uc11c\uc758 \uc7ac\ud604\uc5f0\uad6c\uc640 \uac1c\uc785 \uc5f0\uad6c, \uadf8\ub9ac\uace0 \uc720\uc804\uc801 \ub9ac\uc2a4\ud06c\uc640 \uc0dd\ud65c\uc2b5\uad00 \uc694\uc778\uc758 \uc0c1\ud638\uc791\uc6a9\uc5d0 \ub300\ud55c \ucd94\uac00 \ubd84\uc11d\uc774 \ud544\uc694\ud558\ub2e4.<\/p>\n<h2>\ucd9c\ucc98<\/h2>\n<ul>\n<li><a href=\"https:\/\/academic.oup.com\/jcem\/advance-article\/doi\/10.1210\/clinem\/dgaf662\/8425616\" target=\"_blank\" rel=\"noopener\">The Journal of Clinical Endocrinology &#038; Metabolism (\ud559\uc220\uc9c0) \u2014 Ruth Frikke-Schmidt et al., &#8216;High Body Mass Index as a Causal Risk Factor for Vascular-related Dementia: a Mendelian Randomization Study&#8217;<\/a><\/li>\n<li><a href=\"https:\/\/www.koreancenter.or.kr\/news\/articleView.html?idxno=1300354\" target=\"_blank\" rel=\"noopener\">\uc5f0\ud569\ub274\uc2a4 \ud55c\ubbfc\uc871\uc13c\ud130 \uae30\uc0ac (\uc5b8\ub860 \ubcf4\ub3c4)<\/a><\/li>\n<li><a href=\"https:\/\/www.ukbiobank.ac.uk\/\" target=\"_blank\" rel=\"noopener\">UK Biobank (\uc5f0\uad6c \ub370\uc774\ud130\ubca0\uc774\uc2a4\/\uacf5\uc2dd)<\/a><\/li>\n<li><a href=\"https:\/\/www.cphs.dk\/\" target=\"_blank\" rel=\"noopener\">Copenhagen City Heart Study (CCHS, \ucf54\ud39c\ud558\uac90\uc2dc \uc2ec\uc7a5\uc5f0\uad6c, \uacf5\uc2dd)<\/a><\/li>\n<\/ul>\n<\/article>\n","protected":false},"excerpt":{"rendered":"<p>\ud575\uc2ec \uc694\uc57d \ub374\ub9c8\ud06c \ucf54\ud39c\ud558\uac90\ub300 \uc5f0\uad6c\ud300\uc774 23\uc77c \ubc1c\ud45c\ud55c \ubd84\uc11d\uc5d0\uc11c \uccb4\uc9c8\ub7c9\uc9c0\uc218(BMI)\uac00 \ub192\uc740 \uc0ac\ub78c\uc740 \ud608\uad00\uc131 \uce58\ub9e4 \ubc1c\uc0dd \uc704\ud5d8\uc774 \uc720\uc758\ud558\uac8c \uc99d\uac00\ud558\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\ub2e4. \uc5f0\uad6c\ub294 \ucf54\ud39c\ud558\uac90\uc2dc \uc2ec\uc7a5\uc5f0\uad6c(CCHS) 12\ub9cc6,655\uba85\uacfc \uc601\uad6d \ubc14\uc774\uc624\ubc45\ud06c 37\ub9cc7,755\uba85\uc744 \ud3ec\ud568\ud55c \uc57d 50\ub9cc \uba85 \uaddc\ubaa8\uc758 \uc720\uc804\uccb4 \ub370\uc774\ud130\ub97c \uba58\ub378 \ubb34\uc791\uc704\ud654(MR)\ub85c \ubd84\uc11d\ud588\ub2e4. \uc5f0\uad6c \uacb0\uacfc BMI\uac00 1 \ud45c\uc900\ud3b8\ucc28\ub9cc\ud07c \uc99d\uac00\ud560 \ub54c \ud608\uad00\uc131 \uce58\ub9e4 \ubc1c\uc0dd \uc704\ud5d8\uc774 \uc57d 1.63\ubc30\ub85c \ucd94\uc815\ub410\uace0, \uc774 \uc5f0\uad00\uc131\uc758 \uc0c1\ub2f9 \ubd80\ubd84\uc774 \uace0\ud608\uc555(\uc218\ucd95\uae30 &#8230; <a title=\"\ube44\ub9cc\uc774 \ud608\uad00\uc131 \uce58\ub9e4 \uc704\ud5d8 \ub192\uc778\ub2e4\u2026\uace0\ud608\uc555\uc774 \uc8fc\uc694 \ub9e4\uac1c\uc694\uc778\" class=\"read-more\" href=\"https:\/\/readtrends.com\/ko\/obesity-vascular-dementia-hypertension\/\" aria-label=\"\ube44\ub9cc\uc774 \ud608\uad00\uc131 \uce58\ub9e4 \uc704\ud5d8 \ub192\uc778\ub2e4\u2026\uace0\ud608\uc555\uc774 \uc8fc\uc694 \ub9e4\uac1c\uc694\uc778\uc5d0 \ub300\ud574 \ub354 \uc790\uc138\ud788 \uc54c\uc544\ubcf4\uc138\uc694\">\ub354 \uc77d\uae30<\/a><\/p>\n","protected":false},"author":1,"featured_media":7201,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"rank_math_title":"\ube44\ub9cc\uc774 \ud608\uad00\uc131 \uce58\ub9e4 \uc704\ud5d8 \ub192\uc778\ub2e4\u2014\uace0\ud608\uc555 \ub9e4\uac1c\uc131 \uac15\uc870 | \uac74\uac15\ud3ec\ucee4\uc2a4","rank_math_description":"\ucf54\ud39c\ud558\uac90\ub300 \uc5f0\uad6c\uac00 \uc57d 50\ub9cc\uba85 \uc720\uc804\uccb4 \ubd84\uc11d\uc73c\ub85c BMI \uc0c1\uc2b9\uc774 \ud608\uad00\uc131 \uce58\ub9e4 \uc704\ud5d8\uc744 1.5~2\ubc30\uac00\ub7c9 \ub192\uc774\uace0, \uadf8 \uc601\ud5a5\uc758 \uc0c1\ub2f9 \ubd80\ubd84\uc774 \uace0\ud608\uc555\uc744 \ud1b5\ud574 \ub9e4\uac1c\ub41c\ub2e4\ub294 \uacb0\uacfc\ub97c \uc81c\uc2dc\ud55c\ub2e4. \uc608\ubc29\uc801 \ud608\uc555\u00b7\uccb4\uc911 \uad00\ub9ac\uc758 \uc911\uc694\uc131\uc744 \uc9da\ub294\ub2e4.","rank_math_focus_keyword":"\ube44\ub9cc,\uce58\ub9e4,\ud608\uad00\uc131\uce58\ub9e4,\uace0\ud608\uc555,BMI","footnotes":""},"categories":[2],"tags":[],"class_list":["post-7208","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-top-stories"],"_links":{"self":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/posts\/7208","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/comments?post=7208"}],"version-history":[{"count":0,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/posts\/7208\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/media\/7201"}],"wp:attachment":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/media?parent=7208"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/categories?post=7208"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/tags?post=7208"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}