{"id":9909,"date":"2026-03-10T14:07:10","date_gmt":"2026-03-10T05:07:10","guid":{"rendered":"https:\/\/readtrends.com\/ko\/cd38-hbv-reactivation-risk\/"},"modified":"2026-03-10T14:07:10","modified_gmt":"2026-03-10T05:07:10","slug":"cd38-hbv-reactivation-risk","status":"publish","type":"post","link":"https:\/\/readtrends.com\/ko\/cd38-hbv-reactivation-risk\/","title":{"rendered":"\ub2e4\ubc1c\uc131\uace8\uc218\uc885 CD38 \ud56d\uccb4 \uba74\uc5ed\ud56d\uc554\uce58\ub8cc \ud6c4 B\ud615\uac04\uc5fc \uc7ac\ud65c\uc131\ud654 \uace0\uc704\ud5d8\uad70 \uc120\ubcc4 \uae30\uc900 \ub9c8\ub828 &#8211; \ud5ec\uc2a4\uc624"},"content":{"rendered":"<article>\n<p>\ud575\uc2ec \uc694\uc57d: \uc131\ud544\uc218 \uad50\uc218 \uc5f0\uad6c\uc9c4\uc774 \ub2e4\ubc1c\uc131\uace8\uc218\uc885 \ud658\uc790\uc5d0\uac8c \uc0ac\uc6a9\ub418\ub294 anti-CD38 \ud56d\uccb4 \uce58\ub8cc\ub97c \ubc1b\uc740 \uacfc\uac70 B\ud615\uac04\uc5fc \ub178\ucd9c\uc790\uc5d0\uc11c \uc7ac\ud65c\uc131\ud654 \uc704\ud5d8\uc744 \uce35\ud654\ud55c \uacb0\uacfc, anti-HBs \uc218\uce58\uc640 \uce58\ub8cc \uc2dc\uc810(\uc7ac\ubc1c\u00b7\ubd88\uc751 \uc5ec\ubd80)\uc744 \uacb0\ud569\ud558\uba74 \uc784\uc0c1\uc801\uc73c\ub85c \uc758\ubbf8 \uc788\ub294 \uace0\uc704\ud5d8\uad70\uc744 \uc120\ubcc4\ud560 \uc218 \uc788\ub2e4\uace0 \ubc1d\ud614\ub2e4. \ud6c4\ud5a5\uc801 \ucf54\ud638\ud2b8(2015\u20132025)\uc5d0\uc11c \uc608\ubc29\uc801 \ud56d\ubc14\uc774\ub7ec\uc2a4 \uce58\ub8cc\ub97c \ubc1b\uc740 14\uba85\uc5d0\uc11c\ub294 \uc7ac\ud65c\uc131\ud654\uac00 \uc5c6\uc5c8\uace0, \uc608\ubc29 \ubbf8\uc2e4\uc2dc\uad70(166\uba85)\uc5d0\uc11c\ub294 13\uba85(7.8%)\uc5d0\uc11c \uc7ac\ud65c\uc131\ud654\uac00 \uad00\ucc30\ub410\ub2e4. \ud2b9\ud788 anti-HBs <100 IU\/L\uc774\uba74\uc11c \uc7ac\ubc1c\u00b7\ubd88\uc751 \ub2e8\uacc4\uc5d0\uc11c anti-CD38 \uce58\ub8cc\ub97c \uc2dc\uc791\ud55c \uad70\uc740 \uc911\uc559 \ucd94\uc801\uae30\uac04 10.6\uac1c\uc6d4 \ub3d9\uc548 \uc57d 19.6%\uc758 \uc7ac\ud65c\uc131\ud654\uc728\uc744 \ubcf4\uc600\uace0, 24\uac1c\uc6d4 \ub204\uc801 \uc704\ud5d8\uc740 \uc57d 40%\ub85c \ucd94\uc815\ub41c\ub2e4. \uc5f0\uad6c\ud300\uc740 \uc774\ub97c \ubc14\ud0d5\uc73c\ub85c \ud658\uc790\ub9de\ucda4\ud615 \uc120\ubcc4\uc801 \uc608\ubc29 \uc804\ub7b5\uc744 \uc81c\uc2dc\ud588\ub2e4.<\/p>\n<h2>\ud575\uc2ec \uc0ac\uc2e4<\/h2>\n<ul>\n<li>\uc5f0\uad6c \ub300\uc0c1: 2015\ub144 1\uc6d4~2025\ub144 12\uc6d4 anti-CD38 \uce58\ub8cc\ub97c \ubc1b\uc740 \ub2e4\ubc1c\uc131\uace8\uc218\uc885 \ud658\uc790 709\uba85 \uc911, \uacfc\uac70 B\ud615\uac04\uc5fc \ub178\ucd9c(anti-HBc \uc591\uc131, HBsAg \uc74c\uc131)\uc790 180\uba85.<\/li>\n<li>\ucd94\uc801\uad00\ucc30: \uc911\uc559 \uad00\ucc30\uae30\uac04 14.5\uac1c\uc6d4, \uc608\ubc29\uc801 \ud56d\ubc14\uc774\ub7ec\uc2a4 \ud22c\uc5ec\uad70 14\uba85(7.8%), \ube44\ud22c\uc5ec\uad70 166\uba85(92.2%).<\/li>\n<li>\uc804\uccb4 \uc7ac\ud65c\uc131\ud654\uc728(\ube44\ud22c\uc5ec\uad70 \uae30\uc900): 13\uba85(7.8%)\uc5d0\uc11c \uc7ac\ud65c\uc131\ud654 \ud655\uc778, \uc774\ub294 EASL \uc911\ub4f1\ub3c4 \uc704\ud5d8(1~10%) \ubc94\uc8fc\uc5d0 \ud574\ub2f9.<\/li>\n<li>\uc704\ud5d8\uc778\uc790: baseline anti-HBs <100 IU\/L\uacfc \uce58\ub8cc \uc2dc\uc791 \uc2dc\uc810\uc774 \uc7ac\ubc1c\u00b7\ubd88\uc751 \ub2e8\uacc4\uc778 \uacbd\uc6b0\uac00 \uc7ac\ud65c\uc131\ud654\uc758 \ub3c5\ub9bd\uc801 \uc704\ud5d8\uc778\uc790\ub85c \ud655\uc778.<\/li>\n<li>\uce35\ud654 \uacb0\uacfc: \uc800\uc704\ud5d8\uad70(anti-HBs \u2265100 IU\/L + 1\ucc28 \uce58\ub8cc)\uc5d0\uc11c\ub294 \uc7ac\ud65c\uc131\ud654 \ubc1c\uc0dd 0\uac74, \uace0\uc704\ud5d8\uad70(anti-HBs <100 IU\/L + \uc7ac\ubc1c\/\ubd88\uc751)\uc5d0\uc11c\ub294 \uc911\uc559 10.6\uac1c\uc6d4 \ucd94\uc801 \uc911 19.6% \ubc1c\uc0dd, 24\uac1c\uc6d4 \ub204\uc801 \uc57d 40%\ub85c \ucd94\uc815.<\/li>\n<li>\uc608\ubc29 \ud6a8\uacfc: \uc608\ubc29\uc801 \ud56d\ubc14\uc774\ub7ec\uc2a4 \uce58\ub8cc\ub97c \ubc1b\uc740 14\uba85\uc5d0\uc11c\ub294 \uc7ac\ud65c\uc131\ud654\u00b7\uc911\uc99d \uac04\uc5fc\u00b7\uac04 \uad00\ub828 \uc0ac\ub9dd\uc774 \ubc1c\uc0dd\ud558\uc9c0 \uc54a\uc74c.<\/li>\n<li>\uc784\uc0c1\uc801 \ud568\uc758: \uae30\uc874 EASL \ubd84\ub958\ub9cc\uc73c\ub85c\ub294 \uace0\uc704\ud5d8 \ud558\uc704\uad70\uc744 \uc2dd\ubcc4\ud558\uc9c0 \ubabb\ud574 \uc0ac\uac01\uc9c0\ub300\uac00 \ubc1c\uc0dd\ud560 \uc218 \uc788\uc74c.<\/li>\n<\/ul>\n<h2>\uc0ac\uac74 \ubc30\uacbd<\/h2>\n<p>B\ud615\uac04\uc5fc\uc740 \uc804 \uc138\uacc4\uc801\uc73c\ub85c \ub9cc\uc131 \uac10\uc5fc\uc790\uac00 \uc57d 2\uc5b55700\ub9cc\uba85\uc5d0 \uc774\ub974\uba70, WHO\ub294 \uc5f0\uac04 \uc57d 110\ub9cc\uba85\uc774 B\ud615\uac04\uc5fc \uad00\ub828 \ud569\ubcd1\uc99d\uc73c\ub85c \uc0ac\ub9dd\ud55c\ub2e4\uace0 \ubcf4\uace0\ud55c\ub2e4. \ud2b9\ud788 \uacfc\uac70 \uac10\uc5fc \uc774\ub825\uc774 \uc788\ub294 \uc0ac\ub78c(\ud604\uc7ac HBsAg \uc74c\uc131, anti-HBc \uc591\uc131)\uc740 \uba74\uc5ed\uc5b5\uc81c \uc0c1\ud0dc\uc5d0\uc11c \uc7a0\ubcf5 \ubc14\uc774\ub7ec\uc2a4\uac00 \uc7ac\ud65c\uc131\ud654\ub418\uc5b4 \uae09\uc131 \uac04\uc5fc, \uac04\ubd80\uc804, \uc0ac\ub9dd\uc73c\ub85c \uc774\uc5b4\uc9c8 \uc704\ud5d8\uc774 \uc788\ub2e4. \uae30\uc874 \uc5f0\uad6c\ub4e4\uc5d0\uc11c\ub294 \ubc14\uc774\ub7ec\uc2a4 \uc7ac\ud65c\uc131\ud654\ub85c \uc911\uc99d \uac04\uc5fc\uc774 \ubc1c\uc0dd\ud55c \uacbd\uc6b0 \uc57d 20~30%\uc5d0\uc11c \uac04 \uad00\ub828 \uc0ac\ub9dd\uc774 \ubcf4\uace0\ub41c \ubc14 \uc788\ub2e4. \ub2e4\ubc1c\uc131\uace8\uc218\uc885 \uce58\ub8cc\uc5d0 \ub110\ub9ac \uc4f0\uc774\ub294 anti-CD38 \ud56d\uccb4(daratumumab, isatuximab \ub4f1)\ub294 \uac15\ub825\ud55c \uba74\uc5ed\uc870\uc808 \ud6a8\uacfc\ub85c \ud658\uc790 \uc608\ud6c4\ub97c \uac1c\uc120\ud588\uc9c0\ub9cc CD38\uc774 \uc815\uc0c1 \ud615\uc9c8\uc138\ud3ec\uc640 \uba74\uc5ed\uc870\uc808\uc138\ud3ec\uc5d0\ub3c4 \ubc1c\ud604\ub418\ub294 \ud2b9\uc131\uc0c1 \ud56d\ubc14\uc774\ub7ec\uc2a4 \uba74\uc5ed\uc744 \uad50\ub780\ud560 \uac00\ub2a5\uc131\uc774 \uc81c\uae30\ub3fc \uc654\ub2e4.<\/p>\n<p>\uc774\ub7ec\ud55c \uc7a0\uc7ac\uc801 \uc704\ud5d8\uc5d0\ub3c4 \ubd88\uad6c\ud558\uace0, anti-CD38 \uce58\ub8cc\uc640 \uad00\ub828\ub41c B\ud615\uac04\uc5fc \uc7ac\ud65c\uc131\ud654\uc758 \uc2e4\uc81c \ubc1c\uc0dd\ub960\uacfc \uc608\ubc29\uc801 \ud56d\ubc14\uc774\ub7ec\uc2a4 \uc804\ub7b5\uc758 \ud6a8\uacfc\ub97c \uac80\uc99d\ud55c \ud604\uc2e4\uc801 \ub370\uc774\ud130\ub294 \ubd80\uc871\ud588\ub2e4. \uacb0\uacfc\uc801\uc73c\ub85c \uad6d\uc81c \uc9c0\uce68\uc5d0\uc11c\ub294 anti-CD38 \uce58\ub8cc\uc790\ub97c \uc77c\uad04\uc801\uc73c\ub85c \uc608\ubc29 \uce58\ub8cc \ub300\uc0c1\uc5d0 \ud3ec\ud568\ud558\uc9c0 \uc54a\uc544 \uc784\uc0c1 \ud604\uc7a5\uc5d0\uc11c\ub294 &#8216;\ud68c\uc0c9\uc9c0\ub300&#8217;\uac00 \uc874\uc7ac\ud588\ub2e4. \uc774\uc5d0 \ub530\ub77c \ud658\uc790 \uac1c\uac1c\uc778\uc758 \uc704\ud5d8\ub3c4\ub97c \ubcf4\ub2e4 \uc815\ubc00\ud558\uac8c \ud3c9\uac00\ud574 \uc120\ubcc4\uc801 \uc608\ubc29 \uc804\ub7b5\uc744 \uc138\uc6b0\ub294 \ud544\uc694\uc131\uc774 \ub300\ub450\ub410\ub2e4.<\/p>\n<h2>\uc8fc\uc694 \uc0ac\uac74<\/h2>\n<p>\uc5f0\uad6c\ud300\uc740 2015\ub144\ubd80\ud130 2025\ub144\uae4c\uc9c0 anti-CD38 \uce58\ub8cc\ub97c \ubc1b\uc740 \ub2e4\ubc1c\uc131\uace8\uc218\uc885 \ud658\uc790 709\uba85 \uac00\uc6b4\ub370 \uacfc\uac70 B\ud615\uac04\uc5fc \ub178\ucd9c\uc790 180\uba85\uc744 \uc120\ubcc4\ud574 \ud6c4\ud5a5\uc801 \ucf54\ud638\ud2b8 \ubd84\uc11d\uc744 \uc9c4\ud589\ud588\ub2e4. \uc911\uc559 \uad00\ucc30\uae30\uac04\uc740 14.5\uac1c\uc6d4\uc774\uc5c8\uace0, \uc608\ubc29\uc801 \ud56d\ubc14\uc774\ub7ec\uc2a4 \ud22c\uc5ec\uad70\uc740 14\uba85, \ubbf8\ud22c\uc5ec\uad70\uc740 166\uba85\uc774\uc5c8\ub2e4. \ubbf8\ud22c\uc5ec\uad70\uc5d0\uc11c \uc7ac\ud65c\uc131\ud654\ub294 13\uba85(7.8%)\uc5d0\uc11c \ubc1c\uc0dd\ud588\uace0 \uc774 \ube44\uc728\uc740 \uae30\uc874 EASL\uc758 \uc911\ub4f1\ub3c4 \uc704\ud5d8 \ubc94\uc8fc(1~10%)\uc5d0 \ud574\ub2f9\ud588\ub2e4.<\/p>\n<p>\ub2e4\ubcc0\ub7c9 \ubd84\uc11d \uacb0\uacfc baseline anti-HBs \uc218\uce58\uc640 \ud56d\uc554 \uce58\ub8cc \uc2dc\uc791 \uc2dc\uc810(1\ucc28 \uce58\ub8cc vs \uc7ac\ubc1c\u00b7\ubd88\uc751)\uc774 \uc7ac\ud65c\uc131\ud654 \uc608\uce21\uc5d0 \uc720\uc758\ubbf8\ud55c \uc778\uc790\ub85c \ub3c4\ucd9c\ub410\ub2e4. \uc774\ub97c \uc870\ud569\ud574 \ud658\uc790\ub97c 4\uac1c \ud558\uc704\uad70\uc73c\ub85c \uce35\ud654\ud558\uc790 \uc800\uc704\ud5d8\uad70\uc5d0\uc11c\ub294 \uad00\ucc30\uae30\uac04 \ub0b4 \uc7ac\ud65c\uc131\ud654\uac00 \uc804\ud600 \ubc1c\uc0dd\ud558\uc9c0 \uc54a\uc558\uace0, \ubc18\ub300\ub85c anti-HBs <100 IU\/L\uc774\uba74\uc11c \uc7ac\ubc1c\u00b7\ubd88\uc751 \ub2e8\uacc4\uc5d0\uc11c anti-CD38 \uce58\ub8cc\ub97c \uc2dc\uc791\ud55c \uace0\uc704\ud5d8 \ud558\uc704\uad70\uc5d0\uc11c\ub294 \uc911\uac04\ucd94\uc801 10.6\uac1c\uc6d4 \ub3d9\uc548 \uc57d 19.6%\uc5d0\uc11c \uc7ac\ud65c\uc131\ud654\uac00 \uad00\ucc30\ub410\ub2e4.<\/p>\n<p>\uc608\ubc29\uc801 \ud56d\ubc14\uc774\ub7ec\uc2a4 \ud22c\uc5ec\uc758 \ud6a8\uacfc\ub3c4 \uc8fc\ubaa9\ud560 \ub9cc\ud588\ub2e4. \uc608\ubc29 \uce58\ub8cc\ub97c \ubc1b\uc740 14\uba85\uc5d0\uc11c\ub294 \uc7ac\ud65c\uc131\ud654\uac00 \ubc1c\uc0dd\ud558\uc9c0 \uc54a\uc558\uace0, \uc911\uc99d \uac04\uc5fc \ubc0f \uac04 \uad00\ub828 \uc0ac\ub9dd \uc0ac\ub840\ub294 \ubaa8\ub450 \uc608\ubc29 \ubbf8\uc2dc\ud589\uad70\uc5d0\uc11c\ub9cc \ub098\uc654\ub2e4. \ud2b9\ud788 \uc911\uc99d \uac04\uc5fc\uacfc \uac04 \uad00\ub828 \uc0ac\ub9dd\uc740 \uace0\uc704\ud5d8 \ud558\uc704\uad70\uc5d0 \uc9d1\uc911\ub3fc \uc788\uc5b4 \uc801\uc808\ud55c \uc120\ubcc4\uacfc \uc608\ubc29\uce58\ub8cc\uac00 \uce58\uba85\uc801 \uacb0\uacfc\ub97c \uc904\uc77c \uc218 \uc788\uc74c\uc744 \uc2dc\uc0ac\ud55c\ub2e4.<\/p>\n<h2>\ubd84\uc11d \ubc0f \uc758\ubbf8<\/h2>\n<p>\uccab\uc9f8, \uc774\ubc88 \uc5f0\uad6c\ub294 \ub3d9\uc77c\ud55c anti-CD38 \uce58\ub8cc\ub97c \ubc1b\ub354\ub77c\ub3c4 \ud658\uc790 \uac04 \uc7ac\ud65c\uc131\ud654 \uc704\ud5d8\uc774 \uade0\uc77c\ud558\uc9c0 \uc54a\uc74c\uc744 \uc2e4\uc99d\ud588\ub2e4. anti-HBs \uc218\uce58\uc640 \uce58\ub8cc \uc774\ub825\uc744 \uacb0\ud569\ud55c \uce35\ud654\ub294 \uc804\ud1b5\uc801\uc778 \uc704\ud5d8 \ubd84\ub958(\uc608: EASL\uc758 \uc911\ub4f1\ub3c4 \uae30\uc900)\ub97c \ubcf4\uc644\ud574 \uc2e4\uc81c \uc784\uc0c1\uc5d0\uc11c \uc608\ubc29\uc801 \uc870\uce58\uac00 \ud544\uc694\ud55c \ud658\uc790\ub97c \ub354 \uc815\ud655\ud788 \uac00\ub824\ub0bc \uc218 \uc788\ub2e4. \ud2b9\ud788 anti-HBs <100 IU\/L+\uc7ac\ubc1c\u00b7\ubd88\uc751 \ud658\uc790\ub294 \ub2e8\uc21c\ud55c \ud1b5\uacc4\uc801 \uc911\ub4f1\ub3c4\uad70\uc5d0 \ud3ec\ud568\ub418\ub354\ub77c\ub3c4 \uc2e4\uc9c8\uc801 \uace0\uc704\ud5d8\uad70\uc73c\ub85c \ud310\ub2e8\ud560 \uadfc\uac70\uac00 \uc788\ub2e4.<\/p>\n<p>\ub458\uc9f8, \uc608\ubc29\uc801 \ud56d\ubc14\uc774\ub7ec\uc2a4 \uce58\ub8cc\uac00 \uc7ac\ud65c\uc131\ud654\uc640 \uc911\uc99d \uac04\uc5fc \ubc0f \uac04 \uad00\ub828 \uc0ac\ub9dd\uc744 \uc904\uc77c \uc218 \uc788\ub2e4\ub294 \uad00\ucc30\uc740 \uc784\uc0c1\uc801 \uc758\uc0ac\uacb0\uc815\uc5d0 \uc989\uc2dc \uc801\uc6a9 \uac00\ub2a5\ud558\ub2e4. \ub2e4\ub9cc \uc774 \uacb0\ub860\uc740 \ud6c4\ud5a5\uc801 \uad00\ucc30\uacfc \uc18c\uc218\uc758 \uc608\ubc29\uce58\ub8cc \ub300\uc0c1\uc790(14\uba85)\uc5d0 \uae30\ubc18\ud558\ubbc0\ub85c, \ubb34\uc791\uc704\u00b7\uc804\ud5a5\uc801 \uc5f0\uad6c \ub610\ub294 \ub2e4\uae30\uad00 \ub300\uaddc\ubaa8 \ucf54\ud638\ud2b8\ub85c \uac80\uc99d\ud558\ub294 \uacfc\uc815\uc774 \ud544\uc694\ud558\ub2e4. \uc14b\uc9f8, anti-CD38 \uce58\ub8cc\uac00 \uc55e\ub2e8\uacc4(1\ucc28)\ub85c \ud655\ub300 \uc801\uc6a9\ub418\ub294 \ucd94\uc138\ub97c \uace0\ub824\ud558\uba74, \uac04\uc5fc \uc7ac\ud65c\uc131\ud654 \uc704\ud5d8 \ud3c9\uac00 \ubc0f \uc608\ubc29 \uc804\ub7b5 \uc218\ub9bd\uc740 \ub354\uc6b1 \uc2dc\uae09\ud55c \uacfc\uc81c\ub85c \ubd80\uc0c1\ud55c\ub2e4.<\/p>\n<p>\ub137\uc9f8, \ubcf4\ud5d8\u00b7\uc784\uc0c1\uc9c0\uce68 \uad00\uc810\uc5d0\uc11c\ub294 \uc911\ub4f1\ub3c4 \uc704\ud5d8\uad70(1~10%)\uc744 \ud68d\uc77c\uc801\uc73c\ub85c \ub2e4\ub8e8\ub294 \ub300\uc2e0 \ud558\uc704\uad70 \ubd84\ub958\ub97c \ub3c4\uc785\ud574 \uc790\uc6d0 \ubc30\ubd84(\uc608: \ud56d\ubc14\uc774\ub7ec\uc2a4\uc81c \uc120\ubcc4 \ud22c\uc5ec, \ubaa8\ub2c8\ud130\ub9c1 \uac15\ud654)\uc744 \ucd5c\uc801\ud654\ud560 \ud544\uc694\uac00 \uc788\ub2e4. \uc774\ub294 \ubd88\ud544\uc694\ud55c \uc57d\uc81c \uc0ac\uc6a9\uc744 \uc904\uc774\uba74\uc11c\ub3c4 \uc2e4\uc81c\ub85c \uc704\ud5d8\ud55c \ud658\uc790\uc5d0\uac8c \uc801\uc808\ud55c \uc608\ubc29 \uc870\uce58\ub97c \uc81c\uacf5\ud558\ub294 \uade0\ud615\uc810\uc744 \ucc3e\ub294 \ub370 \ub3c4\uc6c0\uc774 \ub41c\ub2e4.<\/p>\n<figure>\n<table>\n<thead>\n<tr>\n<th>\uadf8\ub8f9<\/th>\n<th>\uc870\uac74<\/th>\n<th>\uc911\uc559 \uad00\ucc30\uae30\uac04<\/th>\n<th>\uad00\ucc30\ub41c \uc7ac\ud65c\uc131\ud654\uc728<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\uc800\uc704\ud5d8\uad70<\/td>\n<td>anti-HBs \u2265100 IU\/L + 1\ucc28 \uce58\ub8cc<\/td>\n<td>14.5\uac1c\uc6d4<\/td>\n<td>0%<\/td>\n<\/tr>\n<tr>\n<td>\uc911\ub4f1\ub3c4 \uc804\uccb4(\ube44\ud22c\uc5ec\uad70)<\/td>\n<td>\uc608\ubc29 \ubbf8\uc2dc\ud589 \ud658\uc790 \uc804\uccb4<\/td>\n<td>14.5\uac1c\uc6d4<\/td>\n<td>7.8% (13\/166)<\/td>\n<\/tr>\n<tr>\n<td>\uace0\uc704\ud5d8 \ud558\uc704\uad70<\/td>\n<td>anti-HBs &lt;100 IU\/L + \uc7ac\ubc1c\/\ubd88\uc751<\/td>\n<td>10.6\uac1c\uc6d4(\uc911\uc559)<\/td>\n<td>19.6% (\uc911\uc559 \ucd94\uc801\uae30\uac04 \uae30\uc900), 24\uac1c\uc6d4 \ub204\uc801 \uc57d 40% \ucd94\uc815<\/td>\n<\/tr>\n<tr>\n<td>\uc608\ubc29\ud22c\uc5ec\uad70<\/td>\n<td>\uc608\ubc29\uc801 \ud56d\ubc14\uc774\ub7ec\uc2a4 \ud22c\uc5ec<\/td>\n<td>14.5\uac1c\uc6d4<\/td>\n<td>0% (0\/14)<\/td>\n<\/tr>\n<\/tbody>\n<\/table><figcaption>\uce35\ud654\ubcc4 \uc7ac\ud65c\uc131\ud654 \ubc1c\uc0dd\ub960(\uc5f0\uad6c \uacb0\uacfc \uc694\uc57d)<\/figcaption><\/figure>\n<p>\uc704 \ud45c\ub294 \uc5f0\uad6c\uac00 \ubcf4\uace0\ud55c \uc8fc\uc694 \uc218\uce58(\ub300\uc0c1 \uc218, \uc911\uc559 \uad00\ucc30\uae30\uac04, \uc7ac\ud65c\uc131\ud654 \ubc1c\uc0dd\ub960)\ub97c \uc815\ub9ac\ud55c \uac83\uc774\ub2e4. \ud45c\ub294 \uc5f0\uad6c \uacb0\ub860\uc744 \ud55c\ub208\uc5d0 \ubcf4\uc5ec\uc8fc\uba70, \ud2b9\ud788 \ud558\uc704\uad70(anti-HBs \uc218\uce58 \ubc0f \uce58\ub8cc \uc774\ub825 \uacb0\ud569)\uc774 \uc804\uccb4 \uc9d1\ub2e8 \ud1b5\uacc4\ub85c\ub294 \ubcf4\uc774\uc9c0 \uc54a\ub358 \uace0\uc704\ud5d8\uad70\uc744 \ub4dc\ub7ec\ub0b8\ub2e4\ub294 \uc810\uc744 \uac15\uc870\ud55c\ub2e4.<\/p>\n<h2>\ubc18\uc751 \ubc0f \uc778\uc6a9<\/h2>\n<p>\uc5f0\uad6c \uc8fc\uc800\uc790\uc640 \uacf5\ub3d9\uc800\uc790\ub4e4\uc740 \uc774\ubc88 \ubd84\uc11d\uc774 \uc784\uc0c1 \uc801\uc6a9 \uac00\ub2a5\uc131\uc774 \ub192\ub2e4\uace0 \uc124\uba85\ud588\ub2e4. \uc5f0\uad6c\uc9c4\uc740 anti-CD38 \uce58\ub8cc\uac00 \uc810\ucc28 \ucd08\uae30 \uce58\ub8cc \ub2e8\uacc4\ub85c \ud655\ub300\ub418\ub294 \ud604\uc2e4\uc744 \uace0\ub824\ud558\uba74 \uc7ac\ud65c\uc131\ud654 \uc704\ud5d8 \ud3c9\uac00\ub3c4 \uc815\uad50\ud574\uc838\uc57c \ud55c\ub2e4\uace0 \uc9c0\uc801\ud588\ub2e4.<\/p>\n<blockquote>\n<p>&#8220;anti-HBs \uc218\uce58\uc640 \uce58\ub8cc \uc774\ub825\uc744 \ubc18\uc601\ud55c \uc704\ud5d8\ub3c4 \ubd84\ub958\ub294 \uc2e4\uc81c \uc9c4\ub8cc \ud604\uc7a5\uc5d0\uc11c \ubc14\ub85c \uc801\uc6a9 \uac00\ub2a5\ud558\ub2e4.&#8221;<\/p>\n<p><cite>\ud0c1\uad8c\uc6a9 \uc784\uc0c1\uac15\uc0ac(\uc81c1\uc800\uc790)<\/cite><\/p><\/blockquote>\n<p>\uc5f0\uad6c \ucc45\uc784\uc790\ub294 \uc774\ubc88 \uc5f0\uad6c\uac00 \uae30\uc874\uc758 \ub2e8\uc21c \ubd84\ub958\ub97c \ub118\uc5b4 \uc2e4\uc81c \uace0\uc704\ud5d8\uad70\uc744 \uaddc\uba85\ud55c \uc810\uc744 \uc758\ubbf8 \uc788\uac8c \ud3c9\uac00\ud588\ub2e4. \ub610\ud55c \uc120\ubcc4\uc801 \uc608\ubc29 \uc804\ub7b5\uc774 \uac04\ubd80\uc804 \ubc0f \uc0ac\ub9dd \uc608\ubc29\uc5d0 \uae30\uc5ec\ud560 \uc218 \uc788\ub2e4\ub294 \uc810\uc744 \uac15\uc870\ud588\ub2e4.<\/p>\n<blockquote>\n<p>&#8220;\uc774\ubc88 \uc5f0\uad6c\ub294 anti-CD38 \uce58\ub8cc\uac00 \uc77c\uad04\uc801 \uc911\ub4f1\ub3c4 \uc704\ud5d8\uc73c\ub85c \ubd84\ub958\ub418\ub358 \uae30\uc874 \uc778\uc2dd\uc744 \ub118\uc5b4\uc11c \uba85\ud655\ud55c \uace0\uc704\ud5d8\uad70\uc744 \uc81c\uc2dc\ud588\ub2e4.&#8221;<\/p>\n<p><cite>\uc131\ud544\uc218 \uad50\uc218(\uc5f0\uad6c \ucc45\uc784\uc790, \uac00\ud1a8\ub9ad\ub300 \uc11c\uc6b8\uc131\ubaa8\ubcd1\uc6d0)<\/cite><\/p><\/blockquote>\n<p>\uc784\uc0c1\uacc4\uc640 \uac00\uc774\ub4dc\ub77c\uc778 \uc704\uc6d0\ud68c \uc77c\uac01\uc5d0\uc11c\ub294 \uc774 \uc5f0\uad6c\uc758 \uacb0\uacfc\ub97c \ubc14\ud0d5\uc73c\ub85c \ub2e4\uae30\uad00 \uac80\uc99d\uacfc \uc9c0\uce68 \ubc18\uc601 \uac00\ub2a5\uc131\uc744 \uac80\ud1a0\ud558\uaca0\ub2e4\ub294 \ubc18\uc751\uc744 \ubcf4\uc600\ub2e4. \ub2e4\ub9cc \ucd94\uac00 \uac80\uc99d\uc744 \uc694\uad6c\ud558\ub294 \ubaa9\uc18c\ub9ac\ub3c4 \uc788\ub2e4.<\/p>\n<blockquote>\n<p>&#8220;\uc774\ubc88 \uacb0\uacfc\ub294 \uc784\uc0c1\uc801 \uc2dc\uc0ac\uc810\uc774 \ud06c\uc9c0\ub9cc, \uc804\ud5a5\uc801\u00b7\ub2e4\uae30\uad00 \uc5f0\uad6c\ub97c \ud1b5\ud574 \uc7ac\ud604\uc131\uacfc \ucd5c\uc801\uc758 \uc608\ubc29 \uc804\ub7b5\uc744 \ud655\uc99d\ud560 \ud544\uc694\uac00 \uc788\ub2e4.&#8221;<\/p>\n<p><cite>\uac04\uc9c8\ud658 \ubd84\uc57c \uc804\ubb38\uac00(\uc775\uba85 \uc694\uccad)<\/cite><\/p><\/blockquote>\n<aside>\n<details>\n<summary>\uc6a9\uc5b4\/\ubc29\ubc95\ub860<\/summary>\n<p>anti-HBs: B\ud615\uac04\uc5fc \ud45c\uba74\ud56d\uccb4\ub85c, \uc77c\ubc18\uc801\uc73c\ub85c 10 IU\/L \uc774\uc0c1\uc774\uba74 \uc5b4\ub290 \uc815\ub3c4 \uba74\uc5ed\uc744 \uc758\ubbf8\ud558\uace0 100 IU\/L \uc774\uc0c1\uc774\uba74 \uac15\ud55c \ubc29\uc5b4\ub825\uc744 \uc2dc\uc0ac\ud55c\ub2e4. anti-HBc \uc591\uc131\u00b7HBsAg \uc74c\uc131\uc740 \uacfc\uac70 B\ud615\uac04\uc5fc \ub178\ucd9c\uc744 \uc758\ubbf8\ud558\uba70, \uc774\ub4e4\uc740 \uba74\uc5ed\uc5b5\uc81c \uc0c1\ud0dc\uc5d0\uc11c \ubc14\uc774\ub7ec\uc2a4\uac00 \uc7ac\ud65c\uc131\ud654\ub420 \uc704\ud5d8\uc774 \uc788\ub2e4. anti-CD38 \ud56d\uccb4\ub294 CD38\uc744 \ud45c\uc801\uc73c\ub85c \ud558\ub294 \uba74\uc5ed\ud56d\uc554\uc81c\ub85c, \ub300\ud45c \uc57d\uc81c\ub85c\ub294 daratumumab(\ub2e4\uc798\ub809\uc2a4)\uc640 isatuximab(\uc0ac\ud074\ub9ac\uc0ac)\uac00 \uc788\ub2e4. \ubcf8 \uc5f0\uad6c\ub294 \ud6c4\ud5a5\uc801 \ucf54\ud638\ud2b8 \uc124\uacc4\ub85c, \uc784\uc0c1 \uae30\ub85d\uacfc \uc815\uae30\uc801\uc778 \ubc14\uc774\ub7ec\uc2a4\uc9c0\ud45c\u00b7\uac04\uae30\ub2a5 \uac80\uc0ac\ub97c \uae30\ubc18\uc73c\ub85c \uc7ac\ud65c\uc131\ud654\ub97c \ud310\uc815\ud588\ub2e4.<\/p>\n<\/details>\n<\/aside>\n<h2>\ubd88\ud655\uc2e4\ud55c \ubd80\ubd84<\/h2>\n<ul>\n<li>\ud6c4\ud5a5\uc801 \uc124\uacc4\uc758 \ud55c\uacc4: \uad00\ucc30\uc801 \ubd84\uc11d\uc774\ubbc0\ub85c \uc778\uacfc\uad00\uacc4 \ud655\uc815\uc5d0\ub294 \ud55c\uacc4\uac00 \uc788\ub2e4.<\/li>\n<li>\uc608\ubc29\ud22c\uc5ec\uad70 \ud45c\ubcf8 \uc218\uac00 \uc791\uc74c(14\uba85)\uc73c\ub85c \uc608\ubc29 \ud6a8\uacfc\uc758 \uc815\ubc00\ud55c \ucd94\uc815\uc740 \ucd94\uac00 \uc5f0\uad6c\uac00 \ud544\uc694\ud558\ub2e4.<\/li>\n<li>24\uac1c\uc6d4 \ub204\uc801 \uc7ac\ud65c\uc131\ud654\uc728(\uc57d 40%)\uc740 \ucd94\uc815\uce58\ub85c, \uc7a5\uae30 \ucd94\uc801 \ub370\uc774\ud130\ub85c \ud655\uc99d\ud574\uc57c \ud55c\ub2e4.<\/li>\n<\/ul>\n<h2>\ucd1d\ud3c9<\/h2>\n<p>\uc774\ubc88 \uc5f0\uad6c\ub294 anti-CD38 \uce58\ub8cc \ud658\uc790\uc5d0\uc11c anti-HBs \uc218\uce58\uc640 \uce58\ub8cc \uc774\ub825\uc744 \uacb0\ud569\ud55c \uac04\ub2e8\ud55c \uce35\ud654 \uae30\uc900\uc73c\ub85c \uc784\uc0c1\uc801 \uace0\uc704\ud5d8\uad70\uc744 \uc120\ubcc4\ud560 \uc218 \uc788\uc74c\uc744 \ubcf4\uc600\ub2e4. \ud2b9\ud788 anti-HBs <100 IU\/L\uc774\uba74\uc11c \uc7ac\ubc1c\u00b7\ubd88\uc751 \ub2e8\uacc4\uc5d0\uc11c anti-CD38 \uce58\ub8cc\ub97c \uc2dc\uc791\ud55c \ud658\uc790\ub294 \ub2e8\uae30\uac04 \ub0b4 \uc7ac\ud65c\uc131\ud654 \uc704\ud5d8\uc774 \ub192\uc544 \uc608\ubc29\uc801 \ud56d\ubc14\uc774\ub7ec\uc2a4 \ud22c\uc5ec\ub97c \uc9c4\uc9c0\ud558\uac8c \uace0\ub824\ud574\uc57c \ud55c\ub2e4.<\/p>\n<p>\uc784\uc0c1 \ud604\uc7a5\uc5d0\uc11c\ub294 \uc774 \uae30\uc900\uc744 \ud65c\uc6a9\ud574 \ubaa8\ub2c8\ud130\ub9c1 \uc790\uc6d0\uc744 \ud6a8\uc728\uc801\uc73c\ub85c \ubc30\uce58\ud558\uace0, \ud544\uc694\uc2dc \uc120\ubcc4\uc801 \uc608\ubc29 \uce58\ub8cc\ub97c \uc2dc\ud589\ud568\uc73c\ub85c\uc368 \uc911\uc99d \uac04\uc5fc\uacfc \uac04 \uad00\ub828 \uc0ac\ub9dd\uc744 \uc904\uc77c \uac00\ub2a5\uc131\uc774 \ub192\ub2e4. \ub2e4\ub9cc \ud6c4\uc18d \ub2e4\uae30\uad00\u00b7\uc804\ud5a5\uc801 \uc5f0\uad6c\ub85c \ubcf8 \uacb0\uacfc\ub97c \uac80\uc99d\ud558\uace0, \uc911\ub4f1\ub3c4\uad70 \ub0b4 \uc0b0\ubc1c\uc801 \uc7ac\ud65c\uc131\ud654\uc5d0 \ub300\ud55c \ucd5c\uc801 \uc804\ub7b5(\uc608\ubc29 \ud22c\uc5ec vs \uac15\ud654 \ubaa8\ub2c8\ud130\ub9c1)\uc744 \uaddc\uba85\ud558\ub294 \uac83\uc774 \ub2e4\uc74c \uacfc\uc81c\ub2e4.<\/p>\n<h2>\ucd9c\ucc98<\/h2>\n<ul>\n<li><a href=\"http:\/\/healtho.co.kr\/news\/view.php?idx=149443\" target=\"_blank\" rel=\"noopener\">\ud5ec\uc2a4\uc624 \uae30\uc0ac<\/a> \u2014 \uc5b8\ub860 \ubcf4\ub3c4<\/li>\n<li><a href=\"https:\/\/www.journal-of-hepatology.eu\/\" target=\"_blank\" rel=\"noopener\">Journal of Hepatology<\/a> \u2014 \ud559\uc220\uc9c0(\uc5f0\uad6c \uac8c\uc7ac)<\/li>\n<\/ul>\n<\/article>\n","protected":false},"excerpt":{"rendered":"<p>\ud575\uc2ec \uc694\uc57d: \uc131\ud544\uc218 \uad50\uc218 \uc5f0\uad6c\uc9c4\uc774 \ub2e4\ubc1c\uc131\uace8\uc218\uc885 \ud658\uc790\uc5d0\uac8c \uc0ac\uc6a9\ub418\ub294 anti-CD38 \ud56d\uccb4 \uce58\ub8cc\ub97c \ubc1b\uc740 \uacfc\uac70 B\ud615\uac04\uc5fc \ub178\ucd9c\uc790\uc5d0\uc11c \uc7ac\ud65c\uc131\ud654 \uc704\ud5d8\uc744 \uce35\ud654\ud55c \uacb0\uacfc, anti-HBs \uc218\uce58\uc640 \uce58\ub8cc \uc2dc\uc810(\uc7ac\ubc1c\u00b7\ubd88\uc751 \uc5ec\ubd80)\uc744 \uacb0\ud569\ud558\uba74 \uc784\uc0c1\uc801\uc73c\ub85c \uc758\ubbf8 \uc788\ub294 \uace0\uc704\ud5d8\uad70\uc744 \uc120\ubcc4\ud560 \uc218 \uc788\ub2e4\uace0 \ubc1d\ud614\ub2e4. \ud6c4\ud5a5\uc801 \ucf54\ud638\ud2b8(2015\u20132025)\uc5d0\uc11c \uc608\ubc29\uc801 \ud56d\ubc14\uc774\ub7ec\uc2a4 \uce58\ub8cc\ub97c \ubc1b\uc740 14\uba85\uc5d0\uc11c\ub294 \uc7ac\ud65c\uc131\ud654\uac00 \uc5c6\uc5c8\uace0, \uc608\ubc29 \ubbf8\uc2e4\uc2dc\uad70(166\uba85)\uc5d0\uc11c\ub294 13\uba85(7.8%)\uc5d0\uc11c \uc7ac\ud65c\uc131\ud654\uac00 \uad00\ucc30\ub410\ub2e4. \ud2b9\ud788 anti-HBs<\/p>\n","protected":false},"author":1,"featured_media":9903,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"rank_math_title":"\ub2e4\ubc1c\uc131\uace8\uc218\uc885 CD38 \uce58\ub8cc \ud6c4 B\ud615\uac04\uc5fc \uace0\uc704\ud5d8\uad70 \uc120\ubcc4 \uae30\uc900 \uc81c\uc2dc - \ud5ec\uc2a4\uc624","rank_math_description":"\uc131\ud544\uc218 \uad50\uc218\ud300\uc774 anti-CD38 \uce58\ub8cc\ub97c \ubc1b\ub294 \ub2e4\ubc1c\uc131\uace8\uc218\uc885 \ud658\uc790\uc5d0\uc11c anti-HBs\uc640 \uce58\ub8cc \uc774\ub825\uc744 \uacb0\ud569\ud55c \uce35\ud654\ub85c B\ud615\uac04\uc5fc \uc7ac\ud65c\uc131\ud654 \uace0\uc704\ud5d8\uad70\uc744 \uaddc\uba85\ud558\uace0, \uc120\ubcc4\uc801 \uc608\ubc29 \ud56d\ubc14\uc774\ub7ec\uc2a4 \uc804\ub7b5\uc744 \uc81c\uc548\ud588\ub2e4.","rank_math_focus_keyword":"\ub2e4\ubc1c\uc131\uace8\uc218\uc885,CD38,B\ud615\uac04\uc5fc \uc7ac\ud65c\uc131\ud654,anti-HBs,\uc608\ubc29\uc801 \ud56d\ubc14\uc774\ub7ec\uc2a4","footnotes":""},"categories":[2],"tags":[],"class_list":["post-9909","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-top-stories"],"_links":{"self":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/posts\/9909","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/comments?post=9909"}],"version-history":[{"count":0,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/posts\/9909\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/media\/9903"}],"wp:attachment":[{"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/media?parent=9909"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/categories?post=9909"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/readtrends.com\/ko\/wp-json\/wp\/v2\/tags?post=9909"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}